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The map label for this gene is metC

Identifier: 16272092

GI number: 16272092

Start: 137335

End: 138525

Strand: Reverse

Name: metC

Synonym: HI0122

Alternate gene names: 16272092

Gene position: 138525-137335 (Counterclockwise)

Preceding gene: 16272094

Following gene: 16272091

Centisome position: 7.57

GC content: 37.45

Gene sequence:

>1191_bases
ATGCAAACAAAATATGATCTTTCAACAATGTTTATTCATTCTGGTCGTCAAAAACGTTTTTCACAAGGATCGGTAAACCC
TGTTTTACAGCGAGCTTCTTCATTACTATTTGACAGTATTGAAGATAAAAAACACGCTACTCAACGTAGAGCAAAAGGCG
AATTATTTTATGGCAGAAGAGGGACGCTAACACATTTTGCTTTACAAGATTTAATGTGCGAAATGGAGGGGGGGGCAGGT
TGTTATCTTTATCCTTGTGGTACAGCAGCAGTAACTAATTCGATTCTTTCTTTTGTTAAAACTGGCGATCATGTGCTAAT
GAGTGGCGCAGCTTACGAGCCAACCCAATATTTCTGTAATATTGTGCTGAAAAAAATGCAGATCGATATAACTTATTACG
ATCCTCTTATTGGTGAAGATATTGCAACGCTTATTCAACCGAATACAAAAGTACTTTTCTTAGAAGCACCGAGTTCTATT
ACAATGGAAATTCCCGATATTCCGACTATTGTGAAGGCTGCAAGAAAGGTGAACCCTAATATTGTGATTATGATTGATAA
TACTTGGTCGGCAGGTGTTCTATTTAAAGCGTTAGAGCATGATATTGATATTTCTATTCAGGCGGGTACGAAATATTTAG
TGGGTCATTCAGATATTATGATTGGTACTGCCGTTGCGAATGCGCGAACTTGGGATCAACTTAGAGAACATTCCTATTTA
ATGGGGCAAATGGTTGATGCAGATTCCGCTTATACGACTGCTCGTGGTATCCGTACATTGGGGGTACGATTAAAACAACA
TCAGGAAAGCAGTATTAAAGTGGCAAAATGGTTGAGTGAGCAACCAGAAGTAAAAACTGTGTACCATCCAGCTTTACCAA
GTTGCCCTGGTCATGAATTCTTTTTACGTGATTTTAGTGGAAGCAGTGGTTTATTTTCTTTTGAATTAACCCAGCGATTA
ACTTCAGAGCAAGTATCAAAATTTATGGATCATTTTCAACTGTTCGCTATGGCTTATTCATGGGGAGGATTTGAGTCTCT
AATTCTTTGTAATCAACCAGAAGAAATTGCACATATTCGTCCAAATATTAAACGTAATCTTACAGGTTCATTAATTCGTG
TGCATATTGGTTTTGAAAATGTGGATGAACTAATTGCAGATTTGAAAGCTGGTTTTGAGCGAATTGCTTAA

Upstream 100 bases:

>100_bases
TTCCATTGCCTAATACCGCAGATGAAGTAAAATCAGGTGCGGATAGGAATTGAAACCATAGTTATTTTTGCCCTATAAGT
TAATTTAAATAAGGAAATAT

Downstream 100 bases:

>100_bases
AAGTGCGGATAAAAAAATGCCTGTTTTACACAGGCATTTTTTATAGGATTATTTTTGTTCTGAAACTAAACCAATTTGGG
TACCGTCAGCAAAATGAATT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MQTKYDLSTMFIHSGRQKRFSQGSVNPVLQRASSLLFDSIEDKKHATQRRAKGELFYGRRGTLTHFALQDLMCEMEGGAG
CYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCNIVLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSI
TMEIPDIPTIVKAARKVNPNIVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYL
MGQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVKTVYHPALPSCPGHEFFLRDFSGSSGLFSFELTQRL
TSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIRPNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA

Sequences:

>Translated_396_residues
MQTKYDLSTMFIHSGRQKRFSQGSVNPVLQRASSLLFDSIEDKKHATQRRAKGELFYGRRGTLTHFALQDLMCEMEGGAG
CYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCNIVLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSI
TMEIPDIPTIVKAARKVNPNIVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYL
MGQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVKTVYHPALPSCPGHEFFLRDFSGSSGLFSFELTQRL
TSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIRPNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA
>Mature_396_residues
MQTKYDLSTMFIHSGRQKRFSQGSVNPVLQRASSLLFDSIEDKKHATQRRAKGELFYGRRGTLTHFALQDLMCEMEGGAG
CYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCNIVLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSI
TMEIPDIPTIVKAARKVNPNIVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYL
MGQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVKTVYHPALPSCPGHEFFLRDFSGSSGLFSFELTQRL
TSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIRPNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family

Homologues:

Organism=Homo sapiens, GI21361334, Length=325, Percent_Identity=29.2307692307692, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI299473759, Length=242, Percent_Identity=30.9917355371901, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI25453487, Length=325, Percent_Identity=27.0769230769231, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI1789383, Length=389, Percent_Identity=65.5526992287918, Blast_Score=569, Evalue=1e-163,
Organism=Escherichia coli, GI1790375, Length=391, Percent_Identity=29.4117647058824, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17560056, Length=332, Percent_Identity=32.2289156626506, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17538055, Length=390, Percent_Identity=29.4871794871795, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71980708, Length=349, Percent_Identity=31.2320916905444, Blast_Score=176, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6321170, Length=341, Percent_Identity=39.5894428152493, Blast_Score=274, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6319307, Length=405, Percent_Identity=26.4197530864197, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323333, Length=361, Percent_Identity=25.4847645429363, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6321904, Length=401, Percent_Identity=26.1845386533666, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321254, Length=307, Percent_Identity=25.7328990228013, Blast_Score=89, Evalue=8e-19,
Organism=Drosophila melanogaster, GI19922554, Length=342, Percent_Identity=30.7017543859649, Blast_Score=178, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): METC_HAEIN (P44527)

Other databases:

- EMBL:   L42023
- PIR:   E64049
- RefSeq:   NP_438294.1
- ProteinModelPortal:   P44527
- SMR:   P44527
- GeneID:   951030
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0122
- NMPDR:   fig|71421.1.peg.116
- TIGR:   HI_0122
- HOGENOM:   HBG754729
- OMA:   REQSYLM
- ProtClustDB:   PRK08114
- BioCyc:   HINF71421:HI_0122-MONOMER
- BRENDA:   4.4.1.8
- GO:   GO:0005737
- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11808:SF8
- PANTHER:   PTHR11808
- PIRSF:   PIRSF001434
- TIGRFAMs:   TIGR01324

Pfam domain/function: PF01053 Cys_Met_Meta_PP; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =4.4.1.8

Molecular weight: Translated: 44345; Mature: 44345

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTKYDLSTMFIHSGRQKRFSQGSVNPVLQRASSLLFDSIEDKKHATQRRAKGELFYGRR
CCCCCCHHHHEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
GTLTHFALQDLMCEMEGGAGCYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCN
CCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHH
IVLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITMEIPDIPTIVKAARKVNPN
HHHHHHEEEEEEECCHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCC
IVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYL
EEEEECCCCCHHHHHHHHHCCCEEEEECCCEEEECCCCEEEEEHHCCCHHHHHHHHHHHH
MGQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVKTVYHPALPSCPGHEF
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCE
FLRDFSGSSGLFSFELTQRLTSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIR
EEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCC
PNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA
CCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQTKYDLSTMFIHSGRQKRFSQGSVNPVLQRASSLLFDSIEDKKHATQRRAKGELFYGRR
CCCCCCHHHHEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
GTLTHFALQDLMCEMEGGAGCYLYPCGTAAVTNSILSFVKTGDHVLMSGAAYEPTQYFCN
CCHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHH
IVLKKMQIDITYYDPLIGEDIATLIQPNTKVLFLEAPSSITMEIPDIPTIVKAARKVNPN
HHHHHHEEEEEEECCHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCHHHHHHHHHCCCC
IVIMIDNTWSAGVLFKALEHDIDISIQAGTKYLVGHSDIMIGTAVANARTWDQLREHSYL
EEEEECCCCCHHHHHHHHHCCCEEEEECCCEEEECCCCEEEEEHHCCCHHHHHHHHHHHH
MGQMVDADSAYTTARGIRTLGVRLKQHQESSIKVAKWLSEQPEVKTVYHPALPSCPGHEF
HHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCE
FLRDFSGSSGLFSFELTQRLTSEQVSKFMDHFQLFAMAYSWGGFESLILCNQPEEIAHIR
EEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHCC
PNIKRNLTGSLIRVHIGFENVDELIADLKAGFERIA
CCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800