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The map label for this gene is tesB

Identifier: 16272050

GI number: 16272050

Start: 82767

End: 83627

Strand: Direct

Name: tesB

Synonym: HI0076

Alternate gene names: 16272050

Gene position: 82767-83627 (Clockwise)

Preceding gene: 16272049

Following gene: 16272051

Centisome position: 4.52

GC content: 38.91

Gene sequence:

>861_bases
ATGTCAGATATTCTCAATAACCTTATTCATCTTCTTAAACTTGAAAAAATTGATGATTTAATCTTTCGTGGAGAAAGCCA
AGATTTAGGTTTTCGTCAAGTATTTGGTGGGCAAGTTGTGGCTCAAGCATTATCAGCGGCAATGCAGGTGGCGCCAGAAG
ATCGTATTTTACATTCTTGTCATGCCTATTTTCTTGCTCCGGGAGATAGCCAATATCCGATTATTTACGATGTAGAAACC
TTGCGTGAAGGGCGTAACTTTTCTGCATTATGCGTAAAAGCCATTCAACATAAAAATACCATTTGTCATGTAACCGCTTC
TTTCCAAGTGCCTGAAAAAGGTTTTGAACATCAAAATACAATGCCAAATGTTGGTGCGCCTGAAGACTTTACGGATGAAA
ATGTGATGCTACAAAAAGTAGCTCAAACCTTGCCAGAACCACTCAATGAAAAATTTGCAGCAGAGCGTCCATTTGAGGTG
AGAACAAAATATTTGAATAACCCATTTAACGGGACAAAATTGCCAGCCGAGCAATATTCTTGGTTTAAAACCAATGGTGA
AACGCCGCTTGATATAAAAATTCAGCAATGTTTATTAGCTTATTTTTCCGATTTTCACTGTATTTTGACCGCACTTCATC
CGCACGAAAAAGGCTTTTTACAAAAAGGAATGAAAGTGGCAACCATTGATCACAGTATTTGGTTCCATCGTCCGTTTGAT
TTAAATCACTGGCATTTGCACGCAATTGAAAGCAATAATGCCTTTGGAGGTCGTGGTTTGGCCCAAGGGCAGATTTTCTC
GCAAGATGGTCAATTAATCGCAACAACACAACAAGAAGGCTTGATCCGTTTTAGCGAATAA

Upstream 100 bases:

>100_bases
GCACGCATTTTTTAATGCGTGCTTTTTGTTTCCAACTTTGGCATTCCTAAAAATCTCCGCTAAAATAACCGCACTTTTTC
TTATCTTCTAGGAAAGCAAT

Downstream 100 bases:

>100_bases
GAGAGAAAAAATGACCGCACTTATTACACAATTTTGGCAACAAGTTGAAACTGCGCTGAAAACAGCAAATCCACAAGAAA
AATGTCGTTTAGTCAATGAT

Product: acyl-CoA thioesterase II

Products: Hydrolyzed acyl-CoA thioesters [C]

Alternate protein names: Acyl-CoA thioesterase II; TEII

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MSDILNNLIHLLKLEKIDDLIFRGESQDLGFRQVFGGQVVAQALSAAMQVAPEDRILHSCHAYFLAPGDSQYPIIYDVET
LREGRNFSALCVKAIQHKNTICHVTASFQVPEKGFEHQNTMPNVGAPEDFTDENVMLQKVAQTLPEPLNEKFAAERPFEV
RTKYLNNPFNGTKLPAEQYSWFKTNGETPLDIKIQQCLLAYFSDFHCILTALHPHEKGFLQKGMKVATIDHSIWFHRPFD
LNHWHLHAIESNNAFGGRGLAQGQIFSQDGQLIATTQQEGLIRFSE

Sequences:

>Translated_286_residues
MSDILNNLIHLLKLEKIDDLIFRGESQDLGFRQVFGGQVVAQALSAAMQVAPEDRILHSCHAYFLAPGDSQYPIIYDVET
LREGRNFSALCVKAIQHKNTICHVTASFQVPEKGFEHQNTMPNVGAPEDFTDENVMLQKVAQTLPEPLNEKFAAERPFEV
RTKYLNNPFNGTKLPAEQYSWFKTNGETPLDIKIQQCLLAYFSDFHCILTALHPHEKGFLQKGMKVATIDHSIWFHRPFD
LNHWHLHAIESNNAFGGRGLAQGQIFSQDGQLIATTQQEGLIRFSE
>Mature_285_residues
SDILNNLIHLLKLEKIDDLIFRGESQDLGFRQVFGGQVVAQALSAAMQVAPEDRILHSCHAYFLAPGDSQYPIIYDVETL
REGRNFSALCVKAIQHKNTICHVTASFQVPEKGFEHQNTMPNVGAPEDFTDENVMLQKVAQTLPEPLNEKFAAERPFEVR
TKYLNNPFNGTKLPAEQYSWFKTNGETPLDIKIQQCLLAYFSDFHCILTALHPHEKGFLQKGMKVATIDHSIWFHRPFDL
NHWHLHAIESNNAFGGRGLAQGQIFSQDGQLIATTQQEGLIRFSE

Specific function: Can hydrolyze a broad range of acyl-CoA thioesters. Its physiological function is not known

COG id: COG1946

COG function: function code I; Acyl-CoA thioesterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C/M/P thioester hydrolase family

Homologues:

Organism=Homo sapiens, GI34577075, Length=281, Percent_Identity=37.0106761565836, Blast_Score=181, Evalue=5e-46,
Organism=Escherichia coli, GI1786657, Length=269, Percent_Identity=52.0446096654275, Blast_Score=301, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17558508, Length=313, Percent_Identity=33.5463258785943, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71988741, Length=299, Percent_Identity=30.1003344481605, Blast_Score=136, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17531889, Length=270, Percent_Identity=34.0740740740741, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI115532456, Length=271, Percent_Identity=33.9483394833948, Blast_Score=129, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17531885, Length=270, Percent_Identity=34.0740740740741, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI212645202, Length=286, Percent_Identity=34.6153846153846, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI71982224, Length=300, Percent_Identity=29.3333333333333, Blast_Score=96, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TESB_HAEIN (P44498)

Other databases:

- EMBL:   L42023
- PIR:   B64047
- RefSeq:   NP_438249.1
- ProteinModelPortal:   P44498
- SMR:   P44498
- GeneID:   950974
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0076
- NMPDR:   fig|71421.1.peg.75
- TIGR:   HI_0076
- HOGENOM:   HBG736737
- OMA:   LQKGMKV
- ProtClustDB:   CLSK870160
- BioCyc:   HINF71421:HI_0076-MONOMER
- InterPro:   IPR003703
- PANTHER:   PTHR11066
- TIGRFAMs:   TIGR00189

Pfam domain/function: PF02551 Acyl_CoA_thio

EC number: 3.1.2.- [C]

Molecular weight: Translated: 32406; Mature: 32275

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: ACT_SITE 58-58 ACT_SITE 204-204

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILNNLIHLLKLEKIDDLIFRGESQDLGFRQVFGGQVVAQALSAAMQVAPEDRILHSC
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
HAYFLAPGDSQYPIIYDVETLREGRNFSALCVKAIQHKNTICHVTASFQVPEKGFEHQNT
HEEEECCCCCCCCEEEEHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCC
MPNVGAPEDFTDENVMLQKVAQTLPEPLNEKFAAERPFEVRTKYLNNPFNGTKLPAEQYS
CCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHCC
WFKTNGETPLDIKIQQCLLAYFSDFHCILTALHPHEKGFLQKGMKVATIDHSIWFHRPFD
EEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEECCEEEECCCC
LNHWHLHAIESNNAFGGRGLAQGQIFSQDGQLIATTQQEGLIRFSE
CCCEEEEEEECCCCCCCCCCCCCEEECCCCCEEEEECCCCCEEECC
>Mature Secondary Structure 
SDILNNLIHLLKLEKIDDLIFRGESQDLGFRQVFGGQVVAQALSAAMQVAPEDRILHSC
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
HAYFLAPGDSQYPIIYDVETLREGRNFSALCVKAIQHKNTICHVTASFQVPEKGFEHQNT
HEEEECCCCCCCCEEEEHHHHHCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCC
MPNVGAPEDFTDENVMLQKVAQTLPEPLNEKFAAERPFEVRTKYLNNPFNGTKLPAEQYS
CCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCHHHCC
WFKTNGETPLDIKIQQCLLAYFSDFHCILTALHPHEKGFLQKGMKVATIDHSIWFHRPFD
EEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEECCEEEECCCC
LNHWHLHAIESNNAFGGRGLAQGQIFSQDGQLIATTQQEGLIRFSE
CCCEEEEEEECCCCCCCCCCCCCEEECCCCCEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA thioesters [C]

Specific reaction: Hydrolyzes a broad range of acyl-CoA thioesters [C]

General reaction: Hydrolase; Acting on ester bonds; Thiolester hydrolases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800