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The map label for this gene is ung [H]

Identifier: 16271993

GI number: 16271993

Start: 18676

End: 19335

Strand: Direct

Name: ung [H]

Synonym: HI0018

Alternate gene names: 16271993

Gene position: 18676-19335 (Clockwise)

Preceding gene: 16271987

Following gene: 16272011

Centisome position: 1.02

GC content: 40.61

Gene sequence:

>660_bases
ATGAAAAACTGGACAGACGTTATCGGAACAGAAAAAGCGCAACCTTACTTTCAACACACACTACAACAGGTTCATCTTGC
AAGAGCAAGCGGGAAAACGATTTATCCCCCACAAGAAGATGTATTTAACGCATTCAAATATACTGCTTTTGAGGATGTAA
AAGTGGTAATTTTAGGTCAGGATCCTTATCATGGACCAAACCAAGCGCACGGCTTGGCTTTTTCAGTAAAACCTGAAGTA
GCCATTCCCCCTTCCCTATTAAATATATATAAAGAACTCACACAAGATATTTCGGGATTTCAAATGCCATCAAATGGTTA
TTTAGTCAAATGGGCAGAACAAGGGGTATTGCTACTTAACACTGTGCTTACCGTGGAACGAGGTATGGCACATTCACACG
CCAATTTAGGTTGGGAAAGGTTTACAGATAAAGTTATTGCAGTACTCAATGAACATCGTGAAAAACTGGTGTTTTTACTT
TGGGGCAGTCACGCACAAAAAAAAGGGCAAATGATTGACCGCACTCGTCACCTTGTTTTAACGGCTCCGCATCCTTCCCC
GTTGTCAGCACATCGAGGTTTCTTTGGTTGTCGTCATTTTTCCAAAACAAATTCATATTTGGAAAGCCACGGAATAAAAC
CGATAGATTGGCAAATCTAA

Upstream 100 bases:

>100_bases
TTAAATAAAATTTATATCAATAATTTAACATTAATTTAACTTTTTATTGAATGAATGTTTTTGTTTATAATGAATAAAAA
CTTATTAATAGGATAAAATA

Downstream 100 bases:

>100_bases
ACCATATATCTCTAAAAAATAACCGCACTTTAATCTCTCAAAGTGCGGTTAAATATTTCAGTATTTTAATTAGCCGTGAT
AACGCCCTACGCCTAATTCA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MKNWTDVIGTEKAQPYFQHTLQQVHLARASGKTIYPPQEDVFNAFKYTAFEDVKVVILGQDPYHGPNQAHGLAFSVKPEV
AIPPSLLNIYKELTQDISGFQMPSNGYLVKWAEQGVLLLNTVLTVERGMAHSHANLGWERFTDKVIAVLNEHREKLVFLL
WGSHAQKKGQMIDRTRHLVLTAPHPSPLSAHRGFFGCRHFSKTNSYLESHGIKPIDWQI

Sequences:

>Translated_219_residues
MKNWTDVIGTEKAQPYFQHTLQQVHLARASGKTIYPPQEDVFNAFKYTAFEDVKVVILGQDPYHGPNQAHGLAFSVKPEV
AIPPSLLNIYKELTQDISGFQMPSNGYLVKWAEQGVLLLNTVLTVERGMAHSHANLGWERFTDKVIAVLNEHREKLVFLL
WGSHAQKKGQMIDRTRHLVLTAPHPSPLSAHRGFFGCRHFSKTNSYLESHGIKPIDWQI
>Mature_219_residues
MKNWTDVIGTEKAQPYFQHTLQQVHLARASGKTIYPPQEDVFNAFKYTAFEDVKVVILGQDPYHGPNQAHGLAFSVKPEV
AIPPSLLNIYKELTQDISGFQMPSNGYLVKWAEQGVLLLNTVLTVERGMAHSHANLGWERFTDKVIAVLNEHREKLVFLL
WGSHAQKKGQMIDRTRHLVLTAPHPSPLSAHRGFFGCRHFSKTNSYLESHGIKPIDWQI

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI6224979, Length=217, Percent_Identity=57.6036866359447, Blast_Score=244, Evalue=3e-65,
Organism=Homo sapiens, GI19718751, Length=217, Percent_Identity=57.6036866359447, Blast_Score=244, Evalue=3e-65,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=70.6976744186046, Blast_Score=321, Evalue=3e-89,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=46.5437788018433, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6323620, Length=225, Percent_Identity=47.1111111111111, Blast_Score=183, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 24849; Mature: 24849

Theoretical pI: Translated: 9.28; Mature: 9.28

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNWTDVIGTEKAQPYFQHTLQQVHLARASGKTIYPPQEDVFNAFKYTAFEDVKVVILGQ
CCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCEECCEEEEEECC
DPYHGPNQAHGLAFSVKPEVAIPPSLLNIYKELTQDISGFQMPSNGYLVKWAEQGVLLLN
CCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEHH
TVLTVERGMAHSHANLGWERFTDKVIAVLNEHREKLVFLLWGSHAQKKGQMIDRTRHLVL
HHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHEEEEEEECCCCHHCCHHHHCCCEEEE
TAPHPSPLSAHRGFFGCRHFSKTNSYLESHGIKPIDWQI
ECCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKNWTDVIGTEKAQPYFQHTLQQVHLARASGKTIYPPQEDVFNAFKYTAFEDVKVVILGQ
CCCCHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCEECCEEEEEECC
DPYHGPNQAHGLAFSVKPEVAIPPSLLNIYKELTQDISGFQMPSNGYLVKWAEQGVLLLN
CCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEHH
TVLTVERGMAHSHANLGWERFTDKVIAVLNEHREKLVFLLWGSHAQKKGQMIDRTRHLVL
HHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHEEEEEEECCCCHHCCHHHHCCCEEEE
TAPHPSPLSAHRGFFGCRHFSKTNSYLESHGIKPIDWQI
ECCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA