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The map label for this gene is rnc [H]

Identifier: 16271989

GI number: 16271989

Start: 14328

End: 15011

Strand: Reverse

Name: rnc [H]

Synonym: HI0014

Alternate gene names: 16271989

Gene position: 15011-14328 (Counterclockwise)

Preceding gene: 16271990

Following gene: 16271988

Centisome position: 0.82

GC content: 41.67

Gene sequence:

>684_bases
ATGAATCATTTAGATCGACTTGAGCGTAAAATCGGCTATCGTTTTAATGATATAGCGCTCTTAAAGCAGGCACTTACGCA
TCGAAGTGCGGCAACTCAACATAATGAACGCCTAGAATTCCTAGGCGATTCCATTCTTAATTTCACTATCGCTGAAGCAC
TTTATCATCAGTTTCCACGTTGTAATGAAGGAGAACTGAGCCGTATGCGTGCTACTTTGGTACGCGAACCCACTTTAGCG
ATTTTAGCGCGCCAATTTGAATTAGGCGATTATATGTCGCTTGGTTCTGGCGAGCTAAAGAACGGTGGTTTTCGCCGTGA
ATCTATTCTTGCCGATTGTGTAGAAGCGATCATAGGTGCAATGTCTTTGGATCAAGGATTGGCTGTGACGACCCAAGTGA
TACGAAATTGGTATCAACAGTTATTGGCAGAAATTAAACCAGGCGATAATCAAAAAGATGCGAAAACGCGTTTACAAGAA
TATTTACAAGGCAAACATTTGCCATTGCCAACTTATGAAGTGGTCAATATTCAAGGGGAAGCCCATTGCCAAATTTTCAC
TGTTAAATGCAAAGTGAAAAGTGCGGAGAAAATTGACCGCACTTTTGTGGCAAAAGGATCTAGCCGTCGTAAAGCTGAAC
AAGCGGCAGCAGAACAAATTTTAAAAGAACTGGACATCAAATGA

Upstream 100 bases:

>100_bases
GTGGGTAAAGCCACTTATATTTGGATGAGCTTAGAAAAAGAAGCGAATGAATGGCCAACAGGTTTCCGTTTTGAGCGTTT
CTTTACAGCAATAAAATAAG

Downstream 100 bases:

>100_bases
CCGAACAATTCGACAAAACCTATTGCGGCTTTATTGCTATCGTAGGTCGCCCAAATGTGGGTAAATCAACGCTCTTAAAT
AAAATTTTAGGACAAAAAAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MNHLDRLERKIGYRFNDIALLKQALTHRSAATQHNERLEFLGDSILNFTIAEALYHQFPRCNEGELSRMRATLVREPTLA
ILARQFELGDYMSLGSGELKNGGFRRESILADCVEAIIGAMSLDQGLAVTTQVIRNWYQQLLAEIKPGDNQKDAKTRLQE
YLQGKHLPLPTYEVVNIQGEAHCQIFTVKCKVKSAEKIDRTFVAKGSSRRKAEQAAAEQILKELDIK

Sequences:

>Translated_227_residues
MNHLDRLERKIGYRFNDIALLKQALTHRSAATQHNERLEFLGDSILNFTIAEALYHQFPRCNEGELSRMRATLVREPTLA
ILARQFELGDYMSLGSGELKNGGFRRESILADCVEAIIGAMSLDQGLAVTTQVIRNWYQQLLAEIKPGDNQKDAKTRLQE
YLQGKHLPLPTYEVVNIQGEAHCQIFTVKCKVKSAEKIDRTFVAKGSSRRKAEQAAAEQILKELDIK
>Mature_227_residues
MNHLDRLERKIGYRFNDIALLKQALTHRSAATQHNERLEFLGDSILNFTIAEALYHQFPRCNEGELSRMRATLVREPTLA
ILARQFELGDYMSLGSGELKNGGFRRESILADCVEAIIGAMSLDQGLAVTTQVIRNWYQQLLAEIKPGDNQKDAKTRLQE
YLQGKHLPLPTYEVVNIQGEAHCQIFTVKCKVKSAEKIDRTFVAKGSSRRKAEQAAAEQILKELDIK

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=233, Percent_Identity=29.1845493562232, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI155030234, Length=233, Percent_Identity=29.1845493562232, Blast_Score=95, Evalue=6e-20,
Organism=Escherichia coli, GI1788920, Length=224, Percent_Identity=64.7321428571429, Blast_Score=281, Evalue=3e-77,
Organism=Caenorhabditis elegans, GI17506883, Length=233, Percent_Identity=31.3304721030043, Blast_Score=100, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI193202651, Length=233, Percent_Identity=31.3304721030043, Blast_Score=100, Evalue=9e-22,
Organism=Drosophila melanogaster, GI17137682, Length=235, Percent_Identity=30.6382978723404, Blast_Score=97, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25728; Mature: 25728

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHLDRLERKIGYRFNDIALLKQALTHRSAATQHNERLEFLGDSILNFTIAEALYHQFPR
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CNEGELSRMRATLVREPTLAILARQFELGDYMSLGSGELKNGGFRRESILADCVEAIIGA
CCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
MSLDQGLAVTTQVIRNWYQQLLAEIKPGDNQKDAKTRLQEYLQGKHLPLPTYEVVNIQGE
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCC
AHCQIFTVKCKVKSAEKIDRTFVAKGSSRRKAEQAAAEQILKELDIK
CEEEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNHLDRLERKIGYRFNDIALLKQALTHRSAATQHNERLEFLGDSILNFTIAEALYHQFPR
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
CNEGELSRMRATLVREPTLAILARQFELGDYMSLGSGELKNGGFRRESILADCVEAIIGA
CCCHHHHHHHHHHHCCHHHHHHHHHHHHCCHHCCCCCCCCCCCCHHHHHHHHHHHHHHHH
MSLDQGLAVTTQVIRNWYQQLLAEIKPGDNQKDAKTRLQEYLQGKHLPLPTYEVVNIQGE
HHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCC
AHCQIFTVKCKVKSAEKIDRTFVAKGSSRRKAEQAAAEQILKELDIK
CEEEEEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA