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The map label for this gene is era [H]

Identifier: 16271988

GI number: 16271988

Start: 13423

End: 14331

Strand: Reverse

Name: era [H]

Synonym: HI0013

Alternate gene names: 16271988

Gene position: 14331-13423 (Counterclockwise)

Preceding gene: 16271989

Following gene: 16271986

Centisome position: 0.78

GC content: 38.61

Gene sequence:

>909_bases
ATGACCGAACAATTCGACAAAACCTATTGCGGCTTTATTGCTATCGTAGGTCGCCCAAATGTGGGTAAATCAACGCTCTT
AAATAAAATTTTAGGACAAAAAATTTCAATTACATCGCGTAAAGCACAAACTACCCGTCACCGCATTGTTGGGATTAAAA
CTGAAGGTGCGTATCAAGAAATCTACGTGGATACACCGGGGCTTCATATTGAAGAAAAACGGGCGATTAACCGCTTAATG
AACCGCGCCGCAAGTAGTGCTATCGGCGATGTTGATTTAATTATTTTTGTCGTAGATGGTACACACTGGAATGCAGATGA
TGAGATGGTGCTAAACAAACTACGTAATGCAAAAGCACCCGTTGTGCTTGCTATCAACAAAGTAGATAACATCAAGAATA
AAGATGATTTGTTGCCGTTTATTACAGATCTTAGCAGTAAATTTAACTTTGCTCACATTGTGCCAATTTCTGCACAGCGT
GGTAATAATGTTCATGAATTAGAGAAAATTGTACGCCAATCTTTACGTGAAGGTGTGCATCATTTTCCAGAAGATTATGT
CACAGATCGTTCGCAACGTTTTATGGCCTCGGAAATAATCCGTGAAAAATTAATGCGTTTTACCGGTGAAGAATTGCCTT
ATTCTGTTACTGTTGAAATCGAACAATTCAAAGTAAATGAACGTGGCACTTATGAAATAAATGGCTTAATTCTCGTTGAA
CGTGAAGGTCAGAAAAAAATGGTCATTGGTGCGGGCGGTCAAAAAATTAAAACTATTGGTATGGAAGCTAGAGCCGATAT
GGAACGTTTATTTGATAACAAAGTCCATCTTGAACTTTGGGTAAAAGTGAAATCTGGTTGGGCTGATGATGAACGTGCGC
TGCGTAGTTTAGGATATATGGATGAATAA

Upstream 100 bases:

>100_bases
GTGCGGAGAAAATTGACCGCACTTTTGTGGCAAAAGGATCTAGCCGTCGTAAAGCTGAACAAGCGGCAGCAGAACAAATT
TTAAAAGAACTGGACATCAA

Downstream 100 bases:

>100_bases
AATGCGGTAAAATTTATACGCATAATAAAAATCCCCATTATTGTGATGGGGATTTTTTTGTTTCTAATTTTTCACTGAAT
ACACTTTAAATTTTCCTGTT

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTEQFDKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIKTEGAYQEIYVDTPGLHIEEKRAINRLM
NRAASSAIGDVDLIIFVVDGTHWNADDEMVLNKLRNAKAPVVLAINKVDNIKNKDDLLPFITDLSSKFNFAHIVPISAQR
GNNVHELEKIVRQSLREGVHHFPEDYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIEQFKVNERGTYEINGLILVE
REGQKKMVIGAGGQKIKTIGMEARADMERLFDNKVHLELWVKVKSGWADDERALRSLGYMDE

Sequences:

>Translated_302_residues
MTEQFDKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIKTEGAYQEIYVDTPGLHIEEKRAINRLM
NRAASSAIGDVDLIIFVVDGTHWNADDEMVLNKLRNAKAPVVLAINKVDNIKNKDDLLPFITDLSSKFNFAHIVPISAQR
GNNVHELEKIVRQSLREGVHHFPEDYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIEQFKVNERGTYEINGLILVE
REGQKKMVIGAGGQKIKTIGMEARADMERLFDNKVHLELWVKVKSGWADDERALRSLGYMDE
>Mature_301_residues
TEQFDKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIKTEGAYQEIYVDTPGLHIEEKRAINRLMN
RAASSAIGDVDLIIFVVDGTHWNADDEMVLNKLRNAKAPVVLAINKVDNIKNKDDLLPFITDLSSKFNFAHIVPISAQRG
NNVHELEKIVRQSLREGVHHFPEDYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIEQFKVNERGTYEINGLILVER
EGQKKMVIGAGGQKIKTIGMEARADMERLFDNKVHLELWVKVKSGWADDERALRSLGYMDE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=320, Percent_Identity=26.25, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1788919, Length=298, Percent_Identity=78.1879194630873, Blast_Score=486, Evalue=1e-139,
Organism=Escherichia coli, GI87082120, Length=156, Percent_Identity=30.1282051282051, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24646434, Length=302, Percent_Identity=26.8211920529801, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34355; Mature: 34224

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQFDKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIKTEGAYQE
CCCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCEEEECCHHHHHHHEEEEEEECCCCEEE
IYVDTPGLHIEEKRAINRLMNRAASSAIGDVDLIIFVVDGTHWNADDEMVLNKLRNAKAP
EEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCC
VVLAINKVDNIKNKDDLLPFITDLSSKFNFAHIVPISAQRGNNVHELEKIVRQSLREGVH
EEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
HFPEDYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIEQFKVNERGTYEINGLILVE
HCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCEEEEEEEEEE
REGQKKMVIGAGGQKIKTIGMEARADMERLFDNKVHLELWVKVKSGWADDERALRSLGYM
ECCCEEEEEECCCCEEEEECCHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHCCCC
DE
CC
>Mature Secondary Structure 
TEQFDKTYCGFIAIVGRPNVGKSTLLNKILGQKISITSRKAQTTRHRIVGIKTEGAYQE
CCCCCCCCEEEEEEECCCCCCHHHHHHHHHCCEEEECCHHHHHHHEEEEEEECCCCEEE
IYVDTPGLHIEEKRAINRLMNRAASSAIGDVDLIIFVVDGTHWNADDEMVLNKLRNAKAP
EEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCHHHHHHHHHCCCCC
VVLAINKVDNIKNKDDLLPFITDLSSKFNFAHIVPISAQRGNNVHELEKIVRQSLREGVH
EEEEEECCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
HFPEDYVTDRSQRFMASEIIREKLMRFTGEELPYSVTVEIEQFKVNERGTYEINGLILVE
HCCHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCCCCEEEEEEEEEE
REGQKKMVIGAGGQKIKTIGMEARADMERLFDNKVHLELWVKVKSGWADDERALRSLGYM
ECCCEEEEEECCCCEEEEECCHHHHHHHHHHCCCEEEEEEEEEECCCCCHHHHHHHCCCC
DE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA