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The map label for this gene is lrp

Identifier: 161350018

GI number: 161350018

Start: 1663262

End: 1663741

Strand: Reverse

Name: lrp

Synonym: HI1596

Alternate gene names: 161350018

Gene position: 1663741-1663262 (Counterclockwise)

Preceding gene: 30995458

Following gene: 16273485

Centisome position: 90.91

GC content: 37.08

Gene sequence:

>480_bases
ATGGAAAAAAAACGAAATAAAGCATTGGATGCGATAGATATAAAAATTCTGAATGAATTACAACGCAACGGTAAGATTTC
CAATATTGATTTGTCGAAAAAAGTGGGGCTTTCGCCAACACCTTGTTTAGAGCGAGTTAAACGTTTGGAAAAACAAGGTG
TGATTATGGGGTATCGCGCACTGTTAAATCCAGAATTATTGGATGCGCCATTGTTAGTGATTGTTGAAATTACATTAGTA
CGGGGTAAGCCCGATGTGTTTGAAGAATTTAATGCAGCGATTCAAGCGTTGGAAGAAATTCAAGAATGCCATTTGGTATC
GGGCGATTTTGATTATTTATTAAAAACTCGTGTGGCAGATATGGCGGAATACCGAAAATTGCTAGGCACGACATTGTTAC
GTTTACCAGGTGTAAATGACACTCGCACTTATGTTGTGATGGAAGAAGTAAAACAAACCAATTTCCTTGTATTGAAATAA

Upstream 100 bases:

>100_bases
GCTGTGTTAGATAATTTGTAAAAAAATCATCGCCTACTGAAAATGAAAGGAAAATTCTGTAGAATAGTTGTTCCTTTTTA
TGAGCAAAGAAATAAAGAAA

Downstream 100 bases:

>100_bases
TATGATTAAACAAATTACAGAACGATTTACGCCAAGACAGTATTTAGCGGAATTTTTGCTGGGATTAACCGCACTTTTTG
GACTTTATTTGATTGTTGCT

Product: leucine-responsive transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MEKKRNKALDAIDIKILNELQRNGKISNIDLSKKVGLSPTPCLERVKRLEKQGVIMGYRALLNPELLDAPLLVIVEITLV
RGKPDVFEEFNAAIQALEEIQECHLVSGDFDYLLKTRVADMAEYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNFLVLK

Sequences:

>Translated_159_residues
MEKKRNKALDAIDIKILNELQRNGKISNIDLSKKVGLSPTPCLERVKRLEKQGVIMGYRALLNPELLDAPLLVIVEITLV
RGKPDVFEEFNAAIQALEEIQECHLVSGDFDYLLKTRVADMAEYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNFLVLK
>Mature_159_residues
MEKKRNKALDAIDIKILNELQRNGKISNIDLSKKVGLSPTPCLERVKRLEKQGVIMGYRALLNPELLDAPLLVIVEITLV
RGKPDVFEEFNAAIQALEEIQECHLVSGDFDYLLKTRVADMAEYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNFLVLK

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1787116, Length=158, Percent_Identity=77.2151898734177, Blast_Score=251, Evalue=2e-68,
Organism=Escherichia coli, GI87081742, Length=148, Percent_Identity=33.1081081081081, Blast_Score=90, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LRP_HAEIN (P45265)

Other databases:

- EMBL:   L42023
- PIR:   H64131
- RefSeq:   NP_439738.2
- ProteinModelPortal:   P45265
- SMR:   P45265
- GeneID:   950361
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1596
- TIGR:   HI_1596
- HOGENOM:   HBG740878
- OMA:   MVNNKKS
- ProtClustDB:   PRK11169
- BioCyc:   HINF71421:HI_1596-MONOMER
- GO:   GO:0005622
- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00033
- SMART:   SM00344

Pfam domain/function: PF01037 AsnC_trans_reg; SSF54909 Dimer_A_B_barrel

EC number: NA

Molecular weight: Translated: 18066; Mature: 18066

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00519 HTH_ASNC_1; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKRNKALDAIDIKILNELQRNGKISNIDLSKKVGLSPTPCLERVKRLEKQGVIMGYRA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHHHHHCCHHHHHHH
LLNPELLDAPLLVIVEITLVRGKPDVFEEFNAAIQALEEIQECHLVSGDFDYLLKTRVAD
HCCCHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MAEYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNFLVLK
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEC
>Mature Secondary Structure
MEKKRNKALDAIDIKILNELQRNGKISNIDLSKKVGLSPTPCLERVKRLEKQGVIMGYRA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHHHHHCCHHHHHHH
LLNPELLDAPLLVIVEITLVRGKPDVFEEFNAAIQALEEIQECHLVSGDFDYLLKTRVAD
HCCCHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MAEYRKLLGTTLLRLPGVNDTRTYVVMEEVKQTNFLVLK
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800