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The map label for this gene is mutM

Identifier: 99082869

GI number: 99082869

Start: 3198104

End: 3198955

Strand: Direct

Name: mutM

Synonym: TM1040_3029

Alternate gene names: 99082869

Gene position: 3198104-3198955 (Clockwise)

Preceding gene: 99082866

Following gene: 99082870

Centisome position: 99.91

GC content: 57.16

Gene sequence:

>852_bases
ATGCCTGAATTGCCCGAGGTCGAGACGGTGATGCGCGGTCTGCAGCCTTCCATGGAGGGTGTCGTCATTGCGCGCGCAGA
TGTGAATCGGCCAGATCTGCGTTGGCCTTTTCCCGACCGCATGACAGAGCGACTGTCTGGGCGGCGGGTGCTCTCGATGC
GGCGGCGGTCAAAATACATCCTTGCCGATCTCGACAGCGGCGAGACGCTTTTGGTTCATCTTGGCATGTCCGGGCGGATG
ACAGTGTCGGGCGACCCGCTGGGGCAGTTTGTGCATTCACATCCGCAGCTTGAGAAACATGATCATGTGGTCTTTCACAT
GGACAATGGCGCACGCGTCACGTTCAACGATCCACGCAGGTTTGGCGCGATGGATCTTCTGGAGACAGCCAAGGCCGACA
GTCATAAGTTGCTGGCAGTTCTGGGCCCGGAGCCTTTGGGGAACGATTTTCATGAAAGTCACCTTGTTTCTGCATTCAAA
GGGCGCAGGACGCCGGTGAAATCTGCGCTGCTCGATCAGGGAATCATTGCGGGCCTGGGCAATATCTACGTCTGCGAAGC
GCTTTTCAGGGCCGGCATTTCGCCACGTCGCGAAGCTGGAAAAATCAGCACATCGCGCGTCACATCGCTGGTTCCGATCA
TCCGTCAAGTGTTGCAGGATGCGATCGCCGCGGGCGGGTCCTCACTCAAGGATTTCCGCCAAGCTAATGGAGAACTTGGA
TATTTTCAGCATACCTTTGATGTCTACGGGCGCGAAGGAGAACCCTGTCGACGCGCCGGTTGCACCGGAACAGTCACTCG
AATCACTCAATCCGGCCGGTCGTCGTTCTACTGTGGCAAGTGCCAAAGATAA

Upstream 100 bases:

>100_bases
GATTTCTCGGTCATTGGCCTTGTCGTCCTCGCAGTTTCGCCCTTGTTATAGAGCGCTCACGGGGCGGCACAATGCGCCCT
TCTGTCAGGGGAGTCCTCTA

Downstream 100 bases:

>100_bases
CTTGAAAGCGAGGGCTGCCGTGATAAGGACTCAGGCTCAGGAGAAACAACCGAAAGCGAATTGTCATGGCCTATGAGACG
ATCAACGTCGATACTCAGGA

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPELPEVETVMRGLQPSMEGVVIARADVNRPDLRWPFPDRMTERLSGRRVLSMRRRSKYILADLDSGETLLVHLGMSGRM
TVSGDPLGQFVHSHPQLEKHDHVVFHMDNGARVTFNDPRRFGAMDLLETAKADSHKLLAVLGPEPLGNDFHESHLVSAFK
GRRTPVKSALLDQGIIAGLGNIYVCEALFRAGISPRREAGKISTSRVTSLVPIIRQVLQDAIAAGGSSLKDFRQANGELG
YFQHTFDVYGREGEPCRRAGCTGTVTRITQSGRSSFYCGKCQR

Sequences:

>Translated_283_residues
MPELPEVETVMRGLQPSMEGVVIARADVNRPDLRWPFPDRMTERLSGRRVLSMRRRSKYILADLDSGETLLVHLGMSGRM
TVSGDPLGQFVHSHPQLEKHDHVVFHMDNGARVTFNDPRRFGAMDLLETAKADSHKLLAVLGPEPLGNDFHESHLVSAFK
GRRTPVKSALLDQGIIAGLGNIYVCEALFRAGISPRREAGKISTSRVTSLVPIIRQVLQDAIAAGGSSLKDFRQANGELG
YFQHTFDVYGREGEPCRRAGCTGTVTRITQSGRSSFYCGKCQR
>Mature_282_residues
PELPEVETVMRGLQPSMEGVVIARADVNRPDLRWPFPDRMTERLSGRRVLSMRRRSKYILADLDSGETLLVHLGMSGRMT
VSGDPLGQFVHSHPQLEKHDHVVFHMDNGARVTFNDPRRFGAMDLLETAKADSHKLLAVLGPEPLGNDFHESHLVSAFKG
RRTPVKSALLDQGIIAGLGNIYVCEALFRAGISPRREAGKISTSRVTSLVPIIRQVLQDAIAAGGSSLKDFRQANGELGY
FQHTFDVYGREGEPCRRAGCTGTVTRITQSGRSSFYCGKCQR

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=283, Percent_Identity=43.1095406360424, Blast_Score=226, Evalue=1e-60,
Organism=Escherichia coli, GI1786932, Length=289, Percent_Identity=23.8754325259516, Blast_Score=74, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_SILST (Q1GC55)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_615023.1
- ProteinModelPortal:   Q1GC55
- SMR:   Q1GC55
- STRING:   Q1GC55
- GeneID:   4076602
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_3029
- NMPDR:   fig|292414.1.peg.1052
- eggNOG:   COG0266
- HOGENOM:   HBG690070
- OMA:   RSTFYCA
- PhylomeDB:   Q1GC55
- ProtClustDB:   PRK01103
- BioCyc:   SSP292414:TM1040_3029-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 31312; Mature: 31181

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 58-58 ACT_SITE 273-273 BINDING 100-100 BINDING 119-119 BINDING 162-162

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVMRGLQPSMEGVVIARADVNRPDLRWPFPDRMTERLSGRRVLSMRRRSKYI
CCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCEE
LADLDSGETLLVHLGMSGRMTVSGDPLGQFVHSHPQLEKHDHVVFHMDNGARVTFNDPRR
EEECCCCCEEEEEECCCCEEEECCCHHHHHHHCCCCCCCCCCEEEEECCCCEEEECCCHH
FGAMDLLETAKADSHKLLAVLGPEPLGNDFHESHLVSAFKGRRTPVKSALLDQGIIAGLG
HHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
NIYVCEALFRAGISPRREAGKISTSRVTSLVPIIRQVLQDAIAAGGSSLKDFRQANGELG
HHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCC
YFQHTFDVYGREGEPCRRAGCTGTVTRITQSGRSSFYCGKCQR
EEEEEHHHCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVMRGLQPSMEGVVIARADVNRPDLRWPFPDRMTERLSGRRVLSMRRRSKYI
CCCCHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCHHHHHHHHCCCEE
LADLDSGETLLVHLGMSGRMTVSGDPLGQFVHSHPQLEKHDHVVFHMDNGARVTFNDPRR
EEECCCCCEEEEEECCCCEEEECCCHHHHHHHCCCCCCCCCCEEEEECCCCEEEECCCHH
FGAMDLLETAKADSHKLLAVLGPEPLGNDFHESHLVSAFKGRRTPVKSALLDQGIIAGLG
HHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
NIYVCEALFRAGISPRREAGKISTSRVTSLVPIIRQVLQDAIAAGGSSLKDFRQANGELG
HHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCC
YFQHTFDVYGREGEPCRRAGCTGTVTRITQSGRSSFYCGKCQR
EEEEEHHHCCCCCCHHHHCCCCHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA