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The map label for this gene is pip [H]

Identifier: 99082747

GI number: 99082747

Start: 3074527

End: 3075507

Strand: Direct

Name: pip [H]

Synonym: TM1040_2907

Alternate gene names: 99082747

Gene position: 3074527-3075507 (Clockwise)

Preceding gene: 99082745

Following gene: 99082748

Centisome position: 96.05

GC content: 56.47

Gene sequence:

>981_bases
ATGGACAAATACCCGGATCAAAAGCGCGCAGTGCAGTTTCTTTATCCGCCGATCGAGCCTTTCGATCAGCGCATGCTGGA
TGTGGGGCAAGGTCACAGGATCTACATGGAGCAATGCGGAAATCCCGATGGGGTGCCGGTCATTGTCTGCCATGGCGGCC
CCGGTGGTGGTACCAGCCCGGCGATGCGTCGGTATTTTGATCCAAAGGTCTATCGTATCATTCTGTTTGATCAGCGTGGG
TGCGGTCGCTCCAGACCTTATGCGTCCTGCGAAGACAACACGACATGGCATCTGGTCGCGGATATGGAACTGATCCGCGA
GCTTTTGGAGATCGACTCTTGGATGCTGTTTGGCGGCAGCTGGGGTGCAACATTGGCGCTGATCTATGCGCAGACTCATC
CTGAGCGCACAACGCAGTTGATCCTGCGCGGGGTGTTCTTGATGACCGAAGCTGAACTCGACTGGTTCTATGGTGGGGGT
GCAGGGAAATTCTGGCCGGAAACCTGGGCCAAGTTCACCGATCTCGTGCCCAAGGACGAACGGGACGATCTGATTGCGGC
TTACCACAAGCGGCTGTTCTCTGGTGATCGCGACGAGGAAATCCGCTTTGGTCGTGCTTGGTCGGCCTGGGAAAATGCCT
TGGCGTCGGTTTATTCCAACGGTTTGTCGGGTGAGAGTCCTGGAGATTACGCGCGGGCTTTTGCGCGGCTTGAGAACCAC
TATTTCTCCAATGGTGGCTTCCTGCATATGGATGGACAGATCCTTGCCAACATGGGGCGCATTGCCCACATCCCTGGCGT
GATCGTGCAGGGGCGGTATGATATGATTTGCCCGCCGCAAGCGGCCTACAGCATTCATCAGGCTTGGCCGAACTCCGATC
TGATCATGGTACGAAACGCGGGACACGCGCTTTCGGAGCCGGGAATCAGCGCGGCTTTGGTCAGATGTATGGATCAGCTG
GCAGAGGAAATGACCCAATGA

Upstream 100 bases:

>100_bases
CGAACTTCGCGATCTCGGAGGGGTCTACCGTGGACTGTTGCGCTTGCATTCCTGTCTCCGTGTGTTTTCTTGTGTGTTCA
GAGGACAACTTAGGTCAGTA

Downstream 100 bases:

>100_bases
AGCGCCTGGATCGTCGTGCTTTGTTTGCAAGCGGTGCGGCTGCGGCTTTGTTGGCAGCAACCGGCGCGGGGCTTGCGCAG
ACGCCGCGTCGGGGTGGGAC

Product: prolyl aminopeptidase

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MDKYPDQKRAVQFLYPPIEPFDQRMLDVGQGHRIYMEQCGNPDGVPVIVCHGGPGGGTSPAMRRYFDPKVYRIILFDQRG
CGRSRPYASCEDNTTWHLVADMELIRELLEIDSWMLFGGSWGATLALIYAQTHPERTTQLILRGVFLMTEAELDWFYGGG
AGKFWPETWAKFTDLVPKDERDDLIAAYHKRLFSGDRDEEIRFGRAWSAWENALASVYSNGLSGESPGDYARAFARLENH
YFSNGGFLHMDGQILANMGRIAHIPGVIVQGRYDMICPPQAAYSIHQAWPNSDLIMVRNAGHALSEPGISAALVRCMDQL
AEEMTQ

Sequences:

>Translated_326_residues
MDKYPDQKRAVQFLYPPIEPFDQRMLDVGQGHRIYMEQCGNPDGVPVIVCHGGPGGGTSPAMRRYFDPKVYRIILFDQRG
CGRSRPYASCEDNTTWHLVADMELIRELLEIDSWMLFGGSWGATLALIYAQTHPERTTQLILRGVFLMTEAELDWFYGGG
AGKFWPETWAKFTDLVPKDERDDLIAAYHKRLFSGDRDEEIRFGRAWSAWENALASVYSNGLSGESPGDYARAFARLENH
YFSNGGFLHMDGQILANMGRIAHIPGVIVQGRYDMICPPQAAYSIHQAWPNSDLIMVRNAGHALSEPGISAALVRCMDQL
AEEMTQ
>Mature_326_residues
MDKYPDQKRAVQFLYPPIEPFDQRMLDVGQGHRIYMEQCGNPDGVPVIVCHGGPGGGTSPAMRRYFDPKVYRIILFDQRG
CGRSRPYASCEDNTTWHLVADMELIRELLEIDSWMLFGGSWGATLALIYAQTHPERTTQLILRGVFLMTEAELDWFYGGG
AGKFWPETWAKFTDLVPKDERDDLIAAYHKRLFSGDRDEEIRFGRAWSAWENALASVYSNGLSGESPGDYARAFARLENH
YFSNGGFLHMDGQILANMGRIAHIPGVIVQGRYDMICPPQAAYSIHQAWPNSDLIMVRNAGHALSEPGISAALVRCMDQL
AEEMTQ

Specific function: Specifically catalyzes the removal of N-terminal proline residues from peptides [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005944
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 36748; Mature: 36748

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKYPDQKRAVQFLYPPIEPFDQRMLDVGQGHRIYMEQCGNPDGVPVIVCHGGPGGGTSP
CCCCCCHHHHHEEECCCCCHHHHHHHHCCCCCEEEHHHCCCCCCCEEEEEECCCCCCCCH
AMRRYFDPKVYRIILFDQRGCGRSRPYASCEDNTTWHLVADMELIRELLEIDSWMLFGGS
HHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHCCEEEECCC
WGATLALIYAQTHPERTTQLILRGVFLMTEAELDWFYGGGAGKFWPETWAKFTDLVPKDE
CCCEEEEEEECCCCHHHHHHHHHHHHHEEECCCCEEEECCCCCCCHHHHHHHHHCCCCCC
RDDLIAAYHKRLFSGDRDEEIRFGRAWSAWENALASVYSNGLSGESPGDYARAFARLENH
CHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
YFSNGGFLHMDGQILANMGRIAHIPGVIVQGRYDMICPPQAAYSIHQAWPNSDLIMVRNA
EECCCCEEEECCHHHHHCCCHHHCCCEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEECC
GHALSEPGISAALVRCMDQLAEEMTQ
CCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDKYPDQKRAVQFLYPPIEPFDQRMLDVGQGHRIYMEQCGNPDGVPVIVCHGGPGGGTSP
CCCCCCHHHHHEEECCCCCHHHHHHHHCCCCCEEEHHHCCCCCCCEEEEEECCCCCCCCH
AMRRYFDPKVYRIILFDQRGCGRSRPYASCEDNTTWHLVADMELIRELLEIDSWMLFGGS
HHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHCCEEEECCC
WGATLALIYAQTHPERTTQLILRGVFLMTEAELDWFYGGGAGKFWPETWAKFTDLVPKDE
CCCEEEEEEECCCCHHHHHHHHHHHHHEEECCCCEEEECCCCCCCHHHHHHHHHCCCCCC
RDDLIAAYHKRLFSGDRDEEIRFGRAWSAWENALASVYSNGLSGESPGDYARAFARLENH
CHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
YFSNGGFLHMDGQILANMGRIAHIPGVIVQGRYDMICPPQAAYSIHQAWPNSDLIMVRNA
EECCCCEEEECCHHHHHCCCHHHCCCEEEECCCCCCCCCHHHHHHHHCCCCCCEEEEECC
GHALSEPGISAALVRCMDQLAEEMTQ
CCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9348090; 11011150; 10467172 [H]