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The map label for this gene is siaT [H]

Identifier: 99082589

GI number: 99082589

Start: 2896740

End: 2898026

Strand: Direct

Name: siaT [H]

Synonym: TM1040_2749

Alternate gene names: 99082589

Gene position: 2896740-2898026 (Clockwise)

Preceding gene: 99082588

Following gene: 99082590

Centisome position: 90.5

GC content: 59.44

Gene sequence:

>1287_bases
ATGATCGTCGGCATCTGTTTTGTCGTGCTTCTCGCAGTTGGCATGCCCATCGGCTTTGCCATTGGTCTTGCGGGTGTCAT
CGGGATTTTCACCATGGGGGGCGGCAGCACGTTCCTTGCAATTGGACCAAGCAAGATCTTCAACGGGCTCAATATTTTCC
CGTTCCTTGCGATGCCGTTCTTTATCCTGGCGGGCGAGATCATGAACAGCACCGGGATCACCGGACGATTGGTGAAGCTG
GCCGAGGTGCTTGTGGGCCGCTTTCGCGGTGGCCTTGCGCATACCAACATGCTGGCGTCGGTCTTTTTTGCGGGTCTTAC
CGGGTCTGCGACTGCGGATGCGGCCGCCTTTGGCCGTACGTTGGTGCCCGCGATGGTGAAACAGGGCTACAAACGCGATT
ACGCCTGCGCGGTCACGGCTGCCGGGTCAATCATCGGGCCGACCATTCCTCCCTCCGGGCTGATGGTGGTCTATGGCTCC
TTGATGGGGGTCTCGATTGGCGGGTTGTTCGCAGCGGGATTGCTGCCGGGCCTGGTGATCTGTGCGGTCTGCATGGGCGT
TATTGCCATTGGCGGCAAACGCGAAAACCTGCCCAAAGCAGCGCGTGGCGCAAGCTTGGGTGAAGTATGGCGCACCTTCC
TGTCGTCGATCACCGCGCTTTTGATGCCGATCATTATTCTCGGCGGTATTCTGGGCGGGATCGTCACCCCTACCGAAGCA
GCCTCCATCGCCGTGGCCTACGCCCTCTTTATCGGCTTTTTCGTCTATCGCACGCTGACCTTCCCGGATCTCTACGGGAT
GCTGATCCGCACCGCGCGCATTACCGGGGTGATCTTCGTGATCATCGCCTTTGCGAGCATCCTCGGCTGGTGGATGAGTT
TTGAGCGCATCCCGCAGGCCATCGCGGGCAGCGTGCTGGGCCTGTCGGAAAACCCCTATGCGGTGATCGCGATCATCATC
TGCATCCTCCTGGTGATCGGCATGGTGATGGACATCACCGCGATCCTGATCATCCTCGGCCCGGTGCTTGTGCCGCTCAC
AGAGCAAATCGGACTGGAGCCAATCCACGCCGGGATCATCTTTGTGCTAGCGCTCAACATCTCCTTGATGACGCCCCCCG
TTGGGGCCTGCCTCTTCGTATTGTCGTCGGTGACAGGCGAAAAGCTCGAGCGGATTTCGGTGAAGCTTGCCCCCTTCTTA
ATCGCGGAAGTGATCATTCTCTTCCTCTTCGCATTCTGGGAGGACGCGGCTCTGTTGCTGCCGCGTGCGCTCGGATTTGC
CCCCTAA

Upstream 100 bases:

>100_bases
CCGCGGCGTTGGCCTGCGTGCAAGTCGTCCTGGTGATGATCCGCGATGCAGGCGGCCAGCTCGACCTCAATGACACCGAT
TCCAAGGAAGGAGCAGGCGC

Downstream 100 bases:

>100_bases
CCGGGGCCAAACAACCCCACCTTCAAAAACCAACAGTGAGGAAAAACAAATGAAATCAGTCCTGAAGACAGCTGCCGTTG
GCGCGATCGCCGCCCTGACC

Product: TRAP dicarboxylate transporter- DctM subunit

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MIVGICFVVLLAVGMPIGFAIGLAGVIGIFTMGGGSTFLAIGPSKIFNGLNIFPFLAMPFFILAGEIMNSTGITGRLVKL
AEVLVGRFRGGLAHTNMLASVFFAGLTGSATADAAAFGRTLVPAMVKQGYKRDYACAVTAAGSIIGPTIPPSGLMVVYGS
LMGVSIGGLFAAGLLPGLVICAVCMGVIAIGGKRENLPKAARGASLGEVWRTFLSSITALLMPIIILGGILGGIVTPTEA
ASIAVAYALFIGFFVYRTLTFPDLYGMLIRTARITGVIFVIIAFASILGWWMSFERIPQAIAGSVLGLSENPYAVIAIII
CILLVIGMVMDITAILIILGPVLVPLTEQIGLEPIHAGIIFVLALNISLMTPPVGACLFVLSSVTGEKLERISVKLAPFL
IAEVIILFLFAFWEDAALLLPRALGFAP

Sequences:

>Translated_428_residues
MIVGICFVVLLAVGMPIGFAIGLAGVIGIFTMGGGSTFLAIGPSKIFNGLNIFPFLAMPFFILAGEIMNSTGITGRLVKL
AEVLVGRFRGGLAHTNMLASVFFAGLTGSATADAAAFGRTLVPAMVKQGYKRDYACAVTAAGSIIGPTIPPSGLMVVYGS
LMGVSIGGLFAAGLLPGLVICAVCMGVIAIGGKRENLPKAARGASLGEVWRTFLSSITALLMPIIILGGILGGIVTPTEA
ASIAVAYALFIGFFVYRTLTFPDLYGMLIRTARITGVIFVIIAFASILGWWMSFERIPQAIAGSVLGLSENPYAVIAIII
CILLVIGMVMDITAILIILGPVLVPLTEQIGLEPIHAGIIFVLALNISLMTPPVGACLFVLSSVTGEKLERISVKLAPFL
IAEVIILFLFAFWEDAALLLPRALGFAP
>Mature_428_residues
MIVGICFVVLLAVGMPIGFAIGLAGVIGIFTMGGGSTFLAIGPSKIFNGLNIFPFLAMPFFILAGEIMNSTGITGRLVKL
AEVLVGRFRGGLAHTNMLASVFFAGLTGSATADAAAFGRTLVPAMVKQGYKRDYACAVTAAGSIIGPTIPPSGLMVVYGS
LMGVSIGGLFAAGLLPGLVICAVCMGVIAIGGKRENLPKAARGASLGEVWRTFLSSITALLMPIIILGGILGGIVTPTEA
ASIAVAYALFIGFFVYRTLTFPDLYGMLIRTARITGVIFVIIAFASILGWWMSFERIPQAIAGSVLGLSENPYAVIAIII
CILLVIGMVMDITAILIILGPVLVPLTEQIGLEPIHAGIIFVLALNISLMTPPVGACLFVLSSVTGEKLERISVKLAPFL
IAEVIILFLFAFWEDAALLLPRALGFAP

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG1593

COG function: function code G; TRAP-type C4-dicarboxylate transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=386, Percent_Identity=38.3419689119171, Blast_Score=234, Evalue=1e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 44597; Mature: 44597

Theoretical pI: Translated: 8.58; Mature: 8.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGICFVVLLAVGMPIGFAIGLAGVIGIFTMGGGSTFLAIGPSKIFNGLNIFPFLAMPF
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHCCCCHHHHHHHHH
FILAGEIMNSTGITGRLVKLAEVLVGRFRGGLAHTNMLASVFFAGLTGSATADAAAFGRT
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LVPAMVKQGYKRDYACAVTAAGSIIGPTIPPSGLMVVYGSLMGVSIGGLFAAGLLPGLVI
HHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
CAVCMGVIAIGGKRENLPKAARGASLGEVWRTFLSSITALLMPIIILGGILGGIVTPTEA
HHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ASIAVAYALFIGFFVYRTLTFPDLYGMLIRTARITGVIFVIIAFASILGWWMSFERIPQA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAGSVLGLSENPYAVIAIIICILLVIGMVMDITAILIILGPVLVPLTEQIGLEPIHAGII
HHCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
FVLALNISLMTPPVGACLFVLSSVTGEKLERISVKLAPFLIAEVIILFLFAFWEDAALLL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
PRALGFAP
HHHHCCCC
>Mature Secondary Structure
MIVGICFVVLLAVGMPIGFAIGLAGVIGIFTMGGGSTFLAIGPSKIFNGLNIFPFLAMPF
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHHCCCCHHHHHHHHH
FILAGEIMNSTGITGRLVKLAEVLVGRFRGGLAHTNMLASVFFAGLTGSATADAAAFGRT
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
LVPAMVKQGYKRDYACAVTAAGSIIGPTIPPSGLMVVYGSLMGVSIGGLFAAGLLPGLVI
HHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
CAVCMGVIAIGGKRENLPKAARGASLGEVWRTFLSSITALLMPIIILGGILGGIVTPTEA
HHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
ASIAVAYALFIGFFVYRTLTFPDLYGMLIRTARITGVIFVIIAFASILGWWMSFERIPQA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IAGSVLGLSENPYAVIAIIICILLVIGMVMDITAILIILGPVLVPLTEQIGLEPIHAGII
HHCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
FVLALNISLMTPPVGACLFVLSSVTGEKLERISVKLAPFLIAEVIILFLFAFWEDAALLL
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
PRALGFAP
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]