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The map label for this gene is hexR [H]

Identifier: 99082587

GI number: 99082587

Start: 2895144

End: 2896046

Strand: Reverse

Name: hexR [H]

Synonym: TM1040_2747

Alternate gene names: 99082587

Gene position: 2896046-2895144 (Counterclockwise)

Preceding gene: 99082595

Following gene: 99082585

Centisome position: 90.47

GC content: 64.34

Gene sequence:

>903_bases
ATGGCACCTGAGAACAGTCCCACGCAGGGAGCAGTCGATCTGATCTCCAACCTGCGGGAGTTGAACGGCAGTTTTGCCGC
GCGCGAGCAAAAGGTCGCGGACTTCGTTTCGGCGCACCTTGAAGAGATCTCCAACATGACGATTGCCGAGCTGGCGGGCG
CAGTGGGGGTCAGCACGCCGACGGTTGTGCGTTTCTGTCGGAGCATGGGCTGTGATGGCTTTCGCGAGTTCAAGCTGCGG
CTGGCGCAGAATCTCGCCGTGAGCCTGCAATACCTCGCGCCCAGTCAGCGCGAGGTTCCCGAAGGTGGTGCAGGCGCTGT
CGATCAGGTGCTCGGCGCGCTCTATGCAACCGTCAATGTGATGCGTCAGCAGCTGGTGCCAGAACGGCTGGATGCGGCGG
CGGCGGCCCTGGCCGCGGCGGGGCAGATTGTTGTGGCCGGGGTTGGCGGGGGCTCGACCATGGTTGCACAGGAGGCGGCC
AACCGTATGTTCCGGCTTGGTATTCCAGCCGTTTCGATCTCTGACAGCTATTTGCTGCAAATGCGCGCCGCAACCCTGGT
CAAGGGGGACGTCCTGCTGCTGGTCTCTGCTAGTGGCGCGGCGGATGAGATCGTCAGCGCTGCAGCGATTGCCGGCGGCT
ATGGTGCGACCGTAGTGGCGATCGCCCGACCAGGCAGCCGATTGGCGCAAGAAGCGACAGTCGCGATCGAAGCCGATCTG
CCCGAAGATCCCGACATTCTGAAGCCCACCGCGTCGCGCTATGCGCATCTGGTGATCGTCGACGCGCTTGCGATGTCCGT
GGCGCAGGCGCGGACAGCGGCCACGACAGAGAACCTGCGCCGCATCCGGGCCTCGCTCACCGCTTATCACGGTCGCACTG
GACCTCAGCCGCTCGGGGATTGA

Upstream 100 bases:

>100_bases
AGCTACAAATATCGACGCTGAAACGAAGAAATCGGGCTCGAATTGACCTGAAAATGTATCTTAGGTACAGAATCACGGGA
TGAAATTACGGGAGAGCCAG

Downstream 100 bases:

>100_bases
AACGGTCACCCGCGTTGGGCGATCAGAGTACGAAATGCTTCAAGCTGGGTTTCCAGTGCCTCGAACCGCTGCGCGAGCGC
CGGGTCTGCGGTCTCGCGTT

Product: RpiR family transcriptional regulator

Products: NA

Alternate protein names: Hex regulon repressor [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MAPENSPTQGAVDLISNLRELNGSFAAREQKVADFVSAHLEEISNMTIAELAGAVGVSTPTVVRFCRSMGCDGFREFKLR
LAQNLAVSLQYLAPSQREVPEGGAGAVDQVLGALYATVNVMRQQLVPERLDAAAAALAAAGQIVVAGVGGGSTMVAQEAA
NRMFRLGIPAVSISDSYLLQMRAATLVKGDVLLLVSASGAADEIVSAAAIAGGYGATVVAIARPGSRLAQEATVAIEADL
PEDPDILKPTASRYAHLVIVDALAMSVAQARTAATTENLRRIRASLTAYHGRTGPQPLGD

Sequences:

>Translated_300_residues
MAPENSPTQGAVDLISNLRELNGSFAAREQKVADFVSAHLEEISNMTIAELAGAVGVSTPTVVRFCRSMGCDGFREFKLR
LAQNLAVSLQYLAPSQREVPEGGAGAVDQVLGALYATVNVMRQQLVPERLDAAAAALAAAGQIVVAGVGGGSTMVAQEAA
NRMFRLGIPAVSISDSYLLQMRAATLVKGDVLLLVSASGAADEIVSAAAIAGGYGATVVAIARPGSRLAQEATVAIEADL
PEDPDILKPTASRYAHLVIVDALAMSVAQARTAATTENLRRIRASLTAYHGRTGPQPLGD
>Mature_299_residues
APENSPTQGAVDLISNLRELNGSFAAREQKVADFVSAHLEEISNMTIAELAGAVGVSTPTVVRFCRSMGCDGFREFKLRL
AQNLAVSLQYLAPSQREVPEGGAGAVDQVLGALYATVNVMRQQLVPERLDAAAAALAAAGQIVVAGVGGGSTMVAQEAAN
RMFRLGIPAVSISDSYLLQMRAATLVKGDVLLLVSASGAADEIVSAAAIAGGYGATVVAIARPGSRLAQEATVAIEADLP
EDPDILKPTASRYAHLVIVDALAMSVAQARTAATTENLRRIRASLTAYHGRTGPQPLGD

Specific function: Represses the expression of the hex regulon (zwf, eda, glp and gap) [H]

COG id: COG1737

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain [H]

Homologues:

Organism=Escherichia coli, GI1788159, Length=275, Percent_Identity=36.7272727272727, Blast_Score=152, Evalue=4e-38,
Organism=Escherichia coli, GI87082369, Length=235, Percent_Identity=26.3829787234043, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788767, Length=218, Percent_Identity=26.1467889908257, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082130, Length=216, Percent_Identity=27.3148148148148, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000281
- InterPro:   IPR001347
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01418 HTH_6; PF01380 SIS [H]

EC number: NA

Molecular weight: Translated: 31050; Mature: 30919

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS00356 HTH_LACI_1 ; PS51071 HTH_RPIR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPENSPTQGAVDLISNLRELNGSFAAREQKVADFVSAHLEEISNMTIAELAGAVGVSTP
CCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCH
TVVRFCRSMGCDGFREFKLRLAQNLAVSLQYLAPSQREVPEGGAGAVDQVLGALYATVNV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MRQQLVPERLDAAAAALAAAGQIVVAGVGGGSTMVAQEAANRMFRLGIPAVSISDSYLLQ
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEECCHHHHHH
MRAATLVKGDVLLLVSASGAADEIVSAAAIAGGYGATVVAIARPGSRLAQEATVAIEADL
HHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHEEEEECCC
PEDPDILKPTASRYAHLVIVDALAMSVAQARTAATTENLRRIRASLTAYHGRTGPQPLGD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
APENSPTQGAVDLISNLRELNGSFAAREQKVADFVSAHLEEISNMTIAELAGAVGVSTP
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCH
TVVRFCRSMGCDGFREFKLRLAQNLAVSLQYLAPSQREVPEGGAGAVDQVLGALYATVNV
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MRQQLVPERLDAAAAALAAAGQIVVAGVGGGSTMVAQEAANRMFRLGIPAVSISDSYLLQ
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHCCCEEECCHHHHHH
MRAATLVKGDVLLLVSASGAADEIVSAAAIAGGYGATVVAIARPGSRLAQEATVAIEADL
HHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHEEEEECCC
PEDPDILKPTASRYAHLVIVDALAMSVAQARTAATTENLRRIRASLTAYHGRTGPQPLGD
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 1704005; 7567469 [H]