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The map label for this gene is exo I [H]

Identifier: 99082579

GI number: 99082579

Start: 2883772

End: 2885655

Strand: Reverse

Name: exo I [H]

Synonym: TM1040_2739

Alternate gene names: 99082579

Gene position: 2885655-2883772 (Counterclockwise)

Preceding gene: 99082580

Following gene: 99082577

Centisome position: 90.15

GC content: 61.09

Gene sequence:

>1884_bases
ATGCATTTTCACCTCGATAGCCTCTGGCATGCCGAAGAAGGCGCGATGGAGTTCGCGCTGACCAATTGTGGCACAACCCC
CGTGACCAACCCGCGCCTCGTTTACGCAACGCTCACGCGGTGTTTGCGGCCTTCGAACTGCACCGGGGCACGGCTTGTGC
GGCGGCAGGCAAACTTTCACGAATACGCCTCGGACGAGGGATTCGTGCTCGCACCGGGAGAGACTTGGCGGTTCACGGAG
CATAGCCTCACCCGTCCGGCGCTTCATTCCAATGAGGGGCCAAAATCAGCGGGAGTCCTCTTGGAGGATGACACGCTCGT
GCTGGCATTTGCCGGGGACTTGCAGGCCTCTGTGGTGGAAGGTCACGCAACAGCTGTGCAAAATGCGGCTCTAACATGCG
GGATTCTGCCCGAACCCAAGCGTGTCGCTATCTCGAACTGGGCTGAGACCGCCCCTGTGCATCTCGCGCTTCAGAGTGAT
GACGCAGCGGTGATGCAGTTGGTATCGCGCGTCTCTGAGCTGACTCGCCGTTTGCATCCGCTTGCGCCGACACCGTTTGT
GTTGACCGCCAAGGAGGACGTGGCACTGCTCTGCATTACGCCGGATCAGACACTCCCCGCAGATGGCTATCGTATCACTT
GGGACGAAGGGAAAACCACCCTGCATCACGGCAGCGGGCGGGGGCTGTTTTACGGTCTGGTGTCGCTGGCGCAGATGCTC
ACCCATGCCCACGCTGAGCCTCAGCGCTATGGCGTGCCGCTCAGCGGAGAGATCGAGGACGCCCCCCGCCACGGTTGGCG
CGGTGCGCATCTGGATGTCTCGCGCCAGTTTTACCCGCTCGATCAGGTTCTGCGCTACGTGGACATCATGGCGTGGCACA
AGATGAACCGGTTCCATTGGCACCTGACTGACGATGAAGGCTGGCGGCTGGAGATCAAAGCCTATCCGCAGCTCACTGAG
ACCGCCGCACATACCGGCATGGACCTGCCCGTCTTGCCGCAGCTTGGCCCAGACATGACCGGGCAGAGCGGTTTTTACAC
CCAGGACGAGGCCCGTCAGGTGGTGAAACACGCCGCGCAGTTCGGCATCGAAGTAATGCCGGAGATCGACGTGCCCGGTC
ACTGTGCTTGCGTTCTGGGCGCGTTGCCTGATCTGGTCGATCCCGAAGAGCCCGAGAGCTACTGGTCGGTGCAGGGGTTT
GCCAACAACGCGCTCAACCCGGCGATCGAGGAGTCTTATACCTTTGCCGAGACCGTTTTGGCCGAGGTCTGCGAGATCTT
CCCGTTTGAGGTCGTTCATGTGGGGGGCGATGAGGTGGCCGAGGGCGCTTGGATGCAATCGCCCAAAGCGCAGGCGATGA
TGCGCGAAACGGGTCTAAAGGACACGCCGCAATTGCAGGCTTATTTCCTGCGTCACATCCAGACCTATCTGGCGGGGCTT
GGTCGCAAGCTTGGCGGTTGGGAAGAGGTGGCCCATGGCGGTGGTCTTGATCCCGAGCACAGCCTTTTGTTTGCCTGGAC
CACAATCGAGAAAACCGCGGAGCTGGCGCAAGAAGGCTATGACGTCATCAGCACGCCTGGGCAGGCCTACTACCTTGATA
TGGCGCTGTCGGATGCGTGGTATGCACCGGGCGCCAGCTGGGCGGGTTTCACCCCGCTCGACAAGACTTATGCGTTTGAG
GCCGACAATGGCGACCCAGTGCTTCAGGGGCGGCTCAAAGGTGTGCAGGCCTGCGTCTGGAGTGAGCATCTGACCACAAT
GGCCCGGCGCAATCACATGATCTTTCCGCGCCTCAGCGCCATTGCAGAGGCCGGGTGGAGCGCAGCCGAAAACAAAGCCT
ATGACCGGTTCAAGTCGCTTGCAGAGTTGATGCCGCGCCTCTGA

Upstream 100 bases:

>100_bases
AGGCCTGCGGCGCGGTGGTCATCCCGAACTCAGACGACGGTGTCTTTGACAATGCCCTCGTCTGAACGCTCCAGAACATA
GACCCAACAGGACAGTTCAA

Downstream 100 bases:

>100_bases
GGCGGAAGGCAAGCCAATGGCCTCGGGGATCGCTCGGGGCCATTGTCATCCCGGTGTTATCCCAGCCGTGGAAAGACCGA
TGTATTCTTCACGGTGCTAT

Product: Beta-N-acetylhexosaminidase

Products: NA

Alternate protein names: Beta-N-acetylhexosaminidase; N-acetyl-beta-glucosaminidase [H]

Number of amino acids: Translated: 627; Mature: 627

Protein sequence:

>627_residues
MHFHLDSLWHAEEGAMEFALTNCGTTPVTNPRLVYATLTRCLRPSNCTGARLVRRQANFHEYASDEGFVLAPGETWRFTE
HSLTRPALHSNEGPKSAGVLLEDDTLVLAFAGDLQASVVEGHATAVQNAALTCGILPEPKRVAISNWAETAPVHLALQSD
DAAVMQLVSRVSELTRRLHPLAPTPFVLTAKEDVALLCITPDQTLPADGYRITWDEGKTTLHHGSGRGLFYGLVSLAQML
THAHAEPQRYGVPLSGEIEDAPRHGWRGAHLDVSRQFYPLDQVLRYVDIMAWHKMNRFHWHLTDDEGWRLEIKAYPQLTE
TAAHTGMDLPVLPQLGPDMTGQSGFYTQDEARQVVKHAAQFGIEVMPEIDVPGHCACVLGALPDLVDPEEPESYWSVQGF
ANNALNPAIEESYTFAETVLAEVCEIFPFEVVHVGGDEVAEGAWMQSPKAQAMMRETGLKDTPQLQAYFLRHIQTYLAGL
GRKLGGWEEVAHGGGLDPEHSLLFAWTTIEKTAELAQEGYDVISTPGQAYYLDMALSDAWYAPGASWAGFTPLDKTYAFE
ADNGDPVLQGRLKGVQACVWSEHLTTMARRNHMIFPRLSAIAEAGWSAAENKAYDRFKSLAELMPRL

Sequences:

>Translated_627_residues
MHFHLDSLWHAEEGAMEFALTNCGTTPVTNPRLVYATLTRCLRPSNCTGARLVRRQANFHEYASDEGFVLAPGETWRFTE
HSLTRPALHSNEGPKSAGVLLEDDTLVLAFAGDLQASVVEGHATAVQNAALTCGILPEPKRVAISNWAETAPVHLALQSD
DAAVMQLVSRVSELTRRLHPLAPTPFVLTAKEDVALLCITPDQTLPADGYRITWDEGKTTLHHGSGRGLFYGLVSLAQML
THAHAEPQRYGVPLSGEIEDAPRHGWRGAHLDVSRQFYPLDQVLRYVDIMAWHKMNRFHWHLTDDEGWRLEIKAYPQLTE
TAAHTGMDLPVLPQLGPDMTGQSGFYTQDEARQVVKHAAQFGIEVMPEIDVPGHCACVLGALPDLVDPEEPESYWSVQGF
ANNALNPAIEESYTFAETVLAEVCEIFPFEVVHVGGDEVAEGAWMQSPKAQAMMRETGLKDTPQLQAYFLRHIQTYLAGL
GRKLGGWEEVAHGGGLDPEHSLLFAWTTIEKTAELAQEGYDVISTPGQAYYLDMALSDAWYAPGASWAGFTPLDKTYAFE
ADNGDPVLQGRLKGVQACVWSEHLTTMARRNHMIFPRLSAIAEAGWSAAENKAYDRFKSLAELMPRL
>Mature_627_residues
MHFHLDSLWHAEEGAMEFALTNCGTTPVTNPRLVYATLTRCLRPSNCTGARLVRRQANFHEYASDEGFVLAPGETWRFTE
HSLTRPALHSNEGPKSAGVLLEDDTLVLAFAGDLQASVVEGHATAVQNAALTCGILPEPKRVAISNWAETAPVHLALQSD
DAAVMQLVSRVSELTRRLHPLAPTPFVLTAKEDVALLCITPDQTLPADGYRITWDEGKTTLHHGSGRGLFYGLVSLAQML
THAHAEPQRYGVPLSGEIEDAPRHGWRGAHLDVSRQFYPLDQVLRYVDIMAWHKMNRFHWHLTDDEGWRLEIKAYPQLTE
TAAHTGMDLPVLPQLGPDMTGQSGFYTQDEARQVVKHAAQFGIEVMPEIDVPGHCACVLGALPDLVDPEEPESYWSVQGF
ANNALNPAIEESYTFAETVLAEVCEIFPFEVVHVGGDEVAEGAWMQSPKAQAMMRETGLKDTPQLQAYFLRHIQTYLAGL
GRKLGGWEEVAHGGGLDPEHSLLFAWTTIEKTAELAQEGYDVISTPGQAYYLDMALSDAWYAPGASWAGFTPLDKTYAFE
ADNGDPVLQGRLKGVQACVWSEHLTTMARRNHMIFPRLSAIAEAGWSAAENKAYDRFKSLAELMPRL

Specific function: Hydrolyzes rapidly p-nitrophenyl-N-acetyl-beta-D- glucosaminide (PNP-beta-GlcNAc) and 4-methylumbelliferyl-beta- GlcNAc, and slightly active on p-nitrophenyl-beta-GalNAc. Hydrolyzes aryl-N-acetyl-beta-D-glucosaminide (aryl-beta-GlcNAc), aryl-beta-GalNAc a

COG id: COG3525

COG function: function code G; N-acetyl-beta-hexosaminidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 20 family [H]

Homologues:

Organism=Homo sapiens, GI4504373, Length=427, Percent_Identity=27.8688524590164, Blast_Score=156, Evalue=7e-38,
Organism=Homo sapiens, GI189181666, Length=436, Percent_Identity=27.7522935779816, Blast_Score=155, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17569815, Length=421, Percent_Identity=27.5534441805226, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24657468, Length=459, Percent_Identity=28.1045751633987, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI17647501, Length=459, Percent_Identity=28.1045751633987, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI281365639, Length=459, Percent_Identity=28.1045751633987, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24657474, Length=459, Percent_Identity=28.1045751633987, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24653074, Length=399, Percent_Identity=25.8145363408521, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45551090, Length=399, Percent_Identity=25.8145363408521, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI17933586, Length=397, Percent_Identity=25.9445843828715, Blast_Score=108, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015882
- InterPro:   IPR001540
- InterPro:   IPR015883
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00728 Glyco_hydro_20; PF02838 Glyco_hydro_20b [H]

EC number: =3.2.1.52 [H]

Molecular weight: Translated: 69286; Mature: 69286

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFHLDSLWHAEEGAMEFALTNCGTTPVTNPRLVYATLTRCLRPSNCTGARLVRRQANFH
CCCCCCHHHCCCCCCEEEEEECCCCCCCCCCEEHHHHHHHHCCCCCCCHHHHHHHHHCHH
EYASDEGFVLAPGETWRFTEHSLTRPALHSNEGPKSAGVLLEDDTLVLAFAGDLQASVVE
HHCCCCCEEECCCCCEECCHHCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCHHHHH
GHATAVQNAALTCGILPEPKRVAISNWAETAPVHLALQSDDAAVMQLVSRVSELTRRLHP
HHHHHHHCCCEEECCCCCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCC
LAPTPFVLTAKEDVALLCITPDQTLPADGYRITWDEGKTTLHHGSGRGLFYGLVSLAQML
CCCCCEEEEECCCEEEEEECCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHH
THAHAEPQRYGVPLSGEIEDAPRHGWRGAHLDVSRQFYPLDQVLRYVDIMAWHKMNRFHW
HHHCCCHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCEEE
HLTDDEGWRLEIKAYPQLTETAAHTGMDLPVLPQLGPDMTGQSGFYTQDEARQVVKHAAQ
EEECCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
FGIEVMPEIDVPGHCACVLGALPDLVDPEEPESYWSVQGFANNALNPAIEESYTFAETVL
CCCEEEECCCCCCHHHHHHHCCCCCCCCCCCCHHEEECCCCCCCCCCHHHHHHHHHHHHH
AEVCEIFPFEVVHVGGDEVAEGAWMQSPKAQAMMRETGLKDTPQLQAYFLRHIQTYLAGL
HHHHHHCCEEEEECCCCHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GRKLGGWEEVAHGGGLDPEHSLLFAWTTIEKTAELAQEGYDVISTPGQAYYLDMALSDAW
CCCCCCHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCEECCCCCEEEEEEEECCCC
YAPGASWAGFTPLDKTYAFEADNGDPVLQGRLKGVQACVWSEHLTTMARRNHMIFPRLSA
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
IAEAGWSAAENKAYDRFKSLAELMPRL
HHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHFHLDSLWHAEEGAMEFALTNCGTTPVTNPRLVYATLTRCLRPSNCTGARLVRRQANFH
CCCCCCHHHCCCCCCEEEEEECCCCCCCCCCEEHHHHHHHHCCCCCCCHHHHHHHHHCHH
EYASDEGFVLAPGETWRFTEHSLTRPALHSNEGPKSAGVLLEDDTLVLAFAGDLQASVVE
HHCCCCCEEECCCCCEECCHHCCCCCCCCCCCCCCCCCEEEECCCEEEEEECCCCHHHHH
GHATAVQNAALTCGILPEPKRVAISNWAETAPVHLALQSDDAAVMQLVSRVSELTRRLHP
HHHHHHHCCCEEECCCCCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCC
LAPTPFVLTAKEDVALLCITPDQTLPADGYRITWDEGKTTLHHGSGRGLFYGLVSLAQML
CCCCCEEEEECCCEEEEEECCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHH
THAHAEPQRYGVPLSGEIEDAPRHGWRGAHLDVSRQFYPLDQVLRYVDIMAWHKMNRFHW
HHHCCCHHHCCCCCCCCCCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHCCCCEEE
HLTDDEGWRLEIKAYPQLTETAAHTGMDLPVLPQLGPDMTGQSGFYTQDEARQVVKHAAQ
EEECCCCCEEEEEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
FGIEVMPEIDVPGHCACVLGALPDLVDPEEPESYWSVQGFANNALNPAIEESYTFAETVL
CCCEEEECCCCCCHHHHHHHCCCCCCCCCCCCHHEEECCCCCCCCCCHHHHHHHHHHHHH
AEVCEIFPFEVVHVGGDEVAEGAWMQSPKAQAMMRETGLKDTPQLQAYFLRHIQTYLAGL
HHHHHHCCEEEEECCCCHHHCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
GRKLGGWEEVAHGGGLDPEHSLLFAWTTIEKTAELAQEGYDVISTPGQAYYLDMALSDAW
CCCCCCHHHHHCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCEECCCCCEEEEEEEECCCC
YAPGASWAGFTPLDKTYAFEADNGDPVLQGRLKGVQACVWSEHLTTMARRNHMIFPRLSA
CCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
IAEAGWSAAENKAYDRFKSLAELMPRL
HHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969205 [H]