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The map label for this gene is xdhB [H]

Identifier: 99082544

GI number: 99082544

Start: 2846327

End: 2847790

Strand: Direct

Name: xdhB [H]

Synonym: TM1040_2704

Alternate gene names: 99082544

Gene position: 2846327-2847790 (Clockwise)

Preceding gene: 99082542

Following gene: 99082545

Centisome position: 88.92

GC content: 63.93

Gene sequence:

>1464_bases
ATGGCTCAGGGGCATGACATCCGCTTTTTGCTGAACGGAGTGGAAAAGCGCGTATCCGATGTGAAGGCAACACTGACCTT
GCTGGATTACCTGCGCCTCGATCAGCGCCTGACGGGCAGCAAGGAAGGCTGCGCCGAGGGCGACTGCGGGGCCTGCACCG
TTCTTGTCGGGCGGCTGCACCAGGGTCAGCTGCACTATGAGACCGTGAACGCCTGCATTCGCTTTCTTGCGTCCCTCAAT
GGCTGTCACATTGTCACCATCGAGCATCTCTCGGGGCCGCAAGGGCGTCTGCACCCGGTCCAAGAAGCCATGGTCGACTA
TCACGGCAGCCAGTGCGGCTTTTGCACGCCGGGTTTTGTGATGTCGCTCTACGCGCTGTGGATGTCCAACCCGGAGCCAT
CGGTGCAGGAGGTCGAGACCGCGATCCAAGGCAACCTCTGCCGCTGCACCGGCTACGAGCCAATCGTGAAAGCCGCAATG
GCGGTGACACAGTATGGATCCCCCGCGCATGACCATCTGGTGCGTGAACGGACCGATGTGACCGCGCGCCTGATGGCGCT
GCAGCCCAGCGCACGCATTGTGACCGGCCCCGAGGATGACCGCGCGATCCTGCCGCTGGATGTCGCGGATCTGGCGCAGG
TGCTGGCGGAAAACCCCAAGGCAACGATCGTGGCCGGGTCCACCGATGTGGGACTTTGGGTCACGAAATTCATGCGCCCG
ATCTCGCCGGTGGTGTTCATCACCCACCTCGAGGAGCTGAAATCCGTCGAGGTTACGGAGGAGGCTCTGACCCTTGGCGC
GGGTGTGACCTATAGCGAGAGTGAGGCCGCAATCCGTGCGGCGTTCCCGCATCTGGGCGACTACTGGGACCGGATCGCTG
GTTGGCAGGTGCGCAACATGGGGACCATCGGTGGCAATATCGCCAATGGCTCTCCTATCGGGGACACGCCGCCGGTGCTG
ATTGCGCTTGGGGCCGAAGTCGTGCTGCAAAGCGCGCGGGGCAGCCGGGTGTTGCCGCTTGAAGACTTCTTTATCGACTA
TGGCAAGCAGGACCGCGAGGCGGGTGACTTTGTTGCCGCGATCCGTATTCCGCGCGCAAAGCCGGGGCAGATGGATGCGG
CCTACAAGATCTCCAAGCGGCGGGACGAGGATATTTCCTCGGTCGCGGCCGGGATCAGCGTATGCGTGACCGATGGGGTC
ATCACCACGGCCCGGATCGCGTTTGGCGGCATGGCCGCAACCCCCAAACGCGCTGCCACCGCCGAAGCCGCCCTCGTGGG
GCAGCCATTTGCTGCGGCGTCTTTTGACGCCGCTGCCGTGGCACTGGGCCAGGACTTCACGCCGCTCAGTGACTGGCGCG
CCAGCGCAGACTACCGCATGACCGTCGCCGCGAACCTGTTGCGCCGGTTCTACCTCGAACAAGACAGCACCCAGGGCGCA
CCCGTGCGTCTGGCCATCGCGTGA

Upstream 100 bases:

>100_bases
TTTCGCAAAGCACACCGTATTTCAATGCAGTCAGACAGGTTAATCTCTGCCGCAACTCAAGAGACGCGCCCGCGTGATGC
AGGCAGAACAGGGAGGTTCA

Downstream 100 bases:

>100_bases
GGGAGGAGACACCTATGAAAGATCTGGGCAATACCACAGAGATCAAAGGTGCCGCGCATCAGGATCTCAAACACGAGAGC
GCCATCAAACAGGTGCAGGG

Product: molybdopterin dehydrogenase, FAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MAQGHDIRFLLNGVEKRVSDVKATLTLLDYLRLDQRLTGSKEGCAEGDCGACTVLVGRLHQGQLHYETVNACIRFLASLN
GCHIVTIEHLSGPQGRLHPVQEAMVDYHGSQCGFCTPGFVMSLYALWMSNPEPSVQEVETAIQGNLCRCTGYEPIVKAAM
AVTQYGSPAHDHLVRERTDVTARLMALQPSARIVTGPEDDRAILPLDVADLAQVLAENPKATIVAGSTDVGLWVTKFMRP
ISPVVFITHLEELKSVEVTEEALTLGAGVTYSESEAAIRAAFPHLGDYWDRIAGWQVRNMGTIGGNIANGSPIGDTPPVL
IALGAEVVLQSARGSRVLPLEDFFIDYGKQDREAGDFVAAIRIPRAKPGQMDAAYKISKRRDEDISSVAAGISVCVTDGV
ITTARIAFGGMAATPKRAATAEAALVGQPFAAASFDAAAVALGQDFTPLSDWRASADYRMTVAANLLRRFYLEQDSTQGA
PVRLAIA

Sequences:

>Translated_487_residues
MAQGHDIRFLLNGVEKRVSDVKATLTLLDYLRLDQRLTGSKEGCAEGDCGACTVLVGRLHQGQLHYETVNACIRFLASLN
GCHIVTIEHLSGPQGRLHPVQEAMVDYHGSQCGFCTPGFVMSLYALWMSNPEPSVQEVETAIQGNLCRCTGYEPIVKAAM
AVTQYGSPAHDHLVRERTDVTARLMALQPSARIVTGPEDDRAILPLDVADLAQVLAENPKATIVAGSTDVGLWVTKFMRP
ISPVVFITHLEELKSVEVTEEALTLGAGVTYSESEAAIRAAFPHLGDYWDRIAGWQVRNMGTIGGNIANGSPIGDTPPVL
IALGAEVVLQSARGSRVLPLEDFFIDYGKQDREAGDFVAAIRIPRAKPGQMDAAYKISKRRDEDISSVAAGISVCVTDGV
ITTARIAFGGMAATPKRAATAEAALVGQPFAAASFDAAAVALGQDFTPLSDWRASADYRMTVAANLLRRFYLEQDSTQGA
PVRLAIA
>Mature_486_residues
AQGHDIRFLLNGVEKRVSDVKATLTLLDYLRLDQRLTGSKEGCAEGDCGACTVLVGRLHQGQLHYETVNACIRFLASLNG
CHIVTIEHLSGPQGRLHPVQEAMVDYHGSQCGFCTPGFVMSLYALWMSNPEPSVQEVETAIQGNLCRCTGYEPIVKAAMA
VTQYGSPAHDHLVRERTDVTARLMALQPSARIVTGPEDDRAILPLDVADLAQVLAENPKATIVAGSTDVGLWVTKFMRPI
SPVVFITHLEELKSVEVTEEALTLGAGVTYSESEAAIRAAFPHLGDYWDRIAGWQVRNMGTIGGNIANGSPIGDTPPVLI
ALGAEVVLQSARGSRVLPLEDFFIDYGKQDREAGDFVAAIRIPRAKPGQMDAAYKISKRRDEDISSVAAGISVCVTDGVI
TTARIAFGGMAATPKRAATAEAALVGQPFAAASFDAAAVALGQDFTPLSDWRASADYRMTVAANLLRRFYLEQDSTQGAP
VRLAIA

Specific function: Presumed to be a dehydrogenase, but possibly an oxidase. Participates in limited purine salvage (requires aspartate) but does not support aerobic growth on purines as the sole carbon source (purine catabolism) [H]

COG id: COG4630

COG function: function code F; Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=516, Percent_Identity=30.4263565891473, Blast_Score=202, Evalue=5e-52,
Organism=Homo sapiens, GI71773480, Length=534, Percent_Identity=28.8389513108614, Blast_Score=193, Evalue=3e-49,
Organism=Escherichia coli, GI1789231, Length=280, Percent_Identity=28.5714285714286, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1786480, Length=168, Percent_Identity=36.3095238095238, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1789232, Length=137, Percent_Identity=37.2262773722628, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17540638, Length=535, Percent_Identity=29.1588785046729, Blast_Score=240, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI32566215, Length=539, Percent_Identity=24.4897959183673, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17539860, Length=479, Percent_Identity=26.3048016701461, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI17737937, Length=527, Percent_Identity=33.965844402277, Blast_Score=259, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24647201, Length=502, Percent_Identity=28.6852589641434, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI24647193, Length=509, Percent_Identity=28.8801571709234, Blast_Score=151, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24647199, Length=511, Percent_Identity=27.5929549902153, Blast_Score=149, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24647197, Length=508, Percent_Identity=28.1496062992126, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24647195, Length=327, Percent_Identity=30.2752293577982, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005107
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR002346 [H]

Pfam domain/function: PF03450 CO_deh_flav_C; PF00941 FAD_binding_5 [H]

EC number: =1.17.1.4 [H]

Molecular weight: Translated: 52265; Mature: 52134

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQGHDIRFLLNGVEKRVSDVKATLTLLDYLRLDQRLTGSKEGCAEGDCGACTVLVGRLH
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHC
QGQLHYETVNACIRFLASLNGCHIVTIEHLSGPQGRLHPVQEAMVDYHGSQCGFCTPGFV
CCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHH
MSLYALWMSNPEPSVQEVETAIQGNLCRCTGYEPIVKAAMAVTQYGSPAHDHLVRERTDV
HHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TARLMALQPSARIVTGPEDDRAILPLDVADLAQVLAENPKATIVAGSTDVGLWVTKFMRP
HHHHEEECCCCEEEECCCCCCEEECCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
ISPVVFITHLEELKSVEVTEEALTLGAGVTYSESEAAIRAAFPHLGDYWDRIAGWQVRNM
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHCCHHHHHHHHHCCCEEECC
GTIGGNIANGSPIGDTPPVLIALGAEVVLQSARGSRVLPLEDFFIDYGKQDREAGDFVAA
CCCCCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCEEEE
IRIPRAKPGQMDAAYKISKRRDEDISSVAAGISVCVTDGVITTARIAFGGMAATPKRAAT
EECCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCCCHHHH
AEAALVGQPFAAASFDAAAVALGQDFTPLSDWRASADYRMTVAANLLRRFYLEQDSTQGA
HHHHHCCCCCCCCCCCHHHHHHCCCCCCHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCC
PVRLAIA
CEEEEEC
>Mature Secondary Structure 
AQGHDIRFLLNGVEKRVSDVKATLTLLDYLRLDQRLTGSKEGCAEGDCGACTVLVGRLH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHC
QGQLHYETVNACIRFLASLNGCHIVTIEHLSGPQGRLHPVQEAMVDYHGSQCGFCTPGFV
CCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHH
MSLYALWMSNPEPSVQEVETAIQGNLCRCTGYEPIVKAAMAVTQYGSPAHDHLVRERTDV
HHHHHHHHCCCCCHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHH
TARLMALQPSARIVTGPEDDRAILPLDVADLAQVLAENPKATIVAGSTDVGLWVTKFMRP
HHHHEEECCCCEEEECCCCCCEEECCCHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHH
ISPVVFITHLEELKSVEVTEEALTLGAGVTYSESEAAIRAAFPHLGDYWDRIAGWQVRNM
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHCCHHHHHHHHHCCCEEECC
GTIGGNIANGSPIGDTPPVLIALGAEVVLQSARGSRVLPLEDFFIDYGKQDREAGDFVAA
CCCCCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCEEEE
IRIPRAKPGQMDAAYKISKRRDEDISSVAAGISVCVTDGVITTARIAFGGMAATPKRAAT
EECCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCCCHHHH
AEAALVGQPFAAASFDAAAVALGQDFTPLSDWRASADYRMTVAANLLRRFYLEQDSTQGA
HHHHHCCCCCCCCCCCHHHHHHCCCCCCHHHHCCCCCEEHHHHHHHHHHHHHCCCCCCCC
PVRLAIA
CEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]