Click here to switch to the map view.

The map label for this gene is 99082494

Identifier: 99082494

GI number: 99082494

Start: 2788187

End: 2789740

Strand: Direct

Name: 99082494

Synonym: TM1040_2654

Alternate gene names: NA

Gene position: 2788187-2789740 (Clockwise)

Preceding gene: 99082493

Following gene: 99082501

Centisome position: 87.11

GC content: 62.81

Gene sequence:

>1554_bases
ATGAACATTCAGCTCCCCTCGCGCAACGGCTATGGCATCCTTGTGGAACAACTGGACGGCCCGGTTTCGGCCTATCACGG
CAACACGCTGCTGGCCCAAAGCAGCCGTGCCAAGGTCATGTATGAAACCCGCCTGCCCCCCGTGGTCTACTTCCCCAAAG
AAGACTTGCAGGTGGACATGGATCAGGCCTGCAGCAAGACCACTTTCTGCCCCTTCAAGGGCACGGCGCATTACCGCGAC
CTGATCCTGCCCGGCAAGAAGGAGCTCTGCAGCGCGGTCTGGAGCTATGACGAAACCCTGCCCGAAGCGCGCCAGATCAA
GGGCCACGTGGGCTTCATGCCCGACGCGCTGGACCGTCTGGACCTTGGCAACAATCGCCTTCAGGCGCCAGATGACGGCA
ATATCTCTGGTCCGCTGGTGGACTGGCTGCTGCGCGAAGCCGCCTTCCTGCCCTCGCCCGAGACGTTTACCGAGGTGCTG
GTGGAGCGGCTCCAGCAACAGGGGCTACCGGTCAGTCGCCTCACCATCCTCGCCTGGGCGCTGCATCCGCGCATCGCAGG
GCATCACTATCGCTGGGAAAAAGGTGGCGCCGGGGTCGAGACCTTCTCGCCCTCCTACGAGATTCACGAAAAACCGGAGT
TCAAGAACTCCCCGCTGCGCCATGTCTCCAAGGGGCTTGGGGGCCTGCGCTACCGGCTCACTGGCAATGTCCCTTCCGAG
GATTTCCCGATCCTGCGTGATCTGCGCGAGAAAGGCATGACCGACTATGTCGCCATGCCGCTGCCCTTCTCGGATGGGCG
CATCAATGTGCTGACCCTCGCCTCGGACGCGCCAGAGGGCTTCAGCACTGCCGATCTGGGCCTGATCTTTGAGTGCTCGG
CGGTGATCGCCCGCTTTTACGAGGTCTTCATGCAGCGCGAAAACGCGCAGGCGGTGCTGGAAACCTATGTGGGCAAACGC
TCCGGTGCGCGGGTGCTTGGCGGCGACATCCGCCGCGGCGATGGCGATGAGATCGACGCCGCGATCATGTTCTGCGACCT
GCGCGGCTCCACGCAGCTCGAAGAGACCCTGCCGCGCGACAAATACGTCACCCTGCTGAACGAGTTCTTCGAGACCACAT
CCGGCCTCGTGCATGAAAACGGCGGCGAAGTGCTGAAGTTCATCGGCGATGCGGTGCTGGCGGTGTTTCCCGCCGGTCAG
AACCCGGCAGAGGCGCGCGCGCAGGCACTGAAGGCGGCCCAGGACATCGTCGCTGCCCTGGCCGAGATCGCGCCCTGCCC
CTCGCTGCCCAATCTGGAATGCGCGATCGGGATTGCTTCGGGGTCGGTGCTTTATGGCAATATCGGCTCGCAGGAACGGC
TGGATTTCACCGTTATCGGTCAGGCCGCCAATATTGCGGCGCGTCTTGGCGATTACGGCAAGACCATTGGCCATCGCATC
GTGGTGTCGCGCGACATCCTGACTCAAACCGCCGAGGCAAAGCCGCTGGGGCTTGTGAAACTGCACAATGTCTCGCAACC
GGTCGAGAGCTTTGCCATCGCGGCATCATCCTGA

Upstream 100 bases:

>100_bases
GCGCAATCCCTCAAATATGCTATCAGATGTTGAGAGGGGTCTGGAAATCCCTCCCAAACCTTCCCATATTGGGAAGGCTT
CTATCGGAGAGCACCGCCTC

Downstream 100 bases:

>100_bases
GCCGCACACCCCATCGCCCTGACCATAGCGCTGAACGACATACGCCCGCCCCGAGGTAAAACCGGGACGGGCGCGGGACT
GGCGCGCGTGCGCCAGCCAA

Product: adenylate/guanylate cyclase

Products: 3',5'-cyclic AMP; diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MNIQLPSRNGYGILVEQLDGPVSAYHGNTLLAQSSRAKVMYETRLPPVVYFPKEDLQVDMDQACSKTTFCPFKGTAHYRD
LILPGKKELCSAVWSYDETLPEARQIKGHVGFMPDALDRLDLGNNRLQAPDDGNISGPLVDWLLREAAFLPSPETFTEVL
VERLQQQGLPVSRLTILAWALHPRIAGHHYRWEKGGAGVETFSPSYEIHEKPEFKNSPLRHVSKGLGGLRYRLTGNVPSE
DFPILRDLREKGMTDYVAMPLPFSDGRINVLTLASDAPEGFSTADLGLIFECSAVIARFYEVFMQRENAQAVLETYVGKR
SGARVLGGDIRRGDGDEIDAAIMFCDLRGSTQLEETLPRDKYVTLLNEFFETTSGLVHENGGEVLKFIGDAVLAVFPAGQ
NPAEARAQALKAAQDIVAALAEIAPCPSLPNLECAIGIASGSVLYGNIGSQERLDFTVIGQAANIAARLGDYGKTIGHRI
VVSRDILTQTAEAKPLGLVKLHNVSQPVESFAIAASS

Sequences:

>Translated_517_residues
MNIQLPSRNGYGILVEQLDGPVSAYHGNTLLAQSSRAKVMYETRLPPVVYFPKEDLQVDMDQACSKTTFCPFKGTAHYRD
LILPGKKELCSAVWSYDETLPEARQIKGHVGFMPDALDRLDLGNNRLQAPDDGNISGPLVDWLLREAAFLPSPETFTEVL
VERLQQQGLPVSRLTILAWALHPRIAGHHYRWEKGGAGVETFSPSYEIHEKPEFKNSPLRHVSKGLGGLRYRLTGNVPSE
DFPILRDLREKGMTDYVAMPLPFSDGRINVLTLASDAPEGFSTADLGLIFECSAVIARFYEVFMQRENAQAVLETYVGKR
SGARVLGGDIRRGDGDEIDAAIMFCDLRGSTQLEETLPRDKYVTLLNEFFETTSGLVHENGGEVLKFIGDAVLAVFPAGQ
NPAEARAQALKAAQDIVAALAEIAPCPSLPNLECAIGIASGSVLYGNIGSQERLDFTVIGQAANIAARLGDYGKTIGHRI
VVSRDILTQTAEAKPLGLVKLHNVSQPVESFAIAASS
>Mature_517_residues
MNIQLPSRNGYGILVEQLDGPVSAYHGNTLLAQSSRAKVMYETRLPPVVYFPKEDLQVDMDQACSKTTFCPFKGTAHYRD
LILPGKKELCSAVWSYDETLPEARQIKGHVGFMPDALDRLDLGNNRLQAPDDGNISGPLVDWLLREAAFLPSPETFTEVL
VERLQQQGLPVSRLTILAWALHPRIAGHHYRWEKGGAGVETFSPSYEIHEKPEFKNSPLRHVSKGLGGLRYRLTGNVPSE
DFPILRDLREKGMTDYVAMPLPFSDGRINVLTLASDAPEGFSTADLGLIFECSAVIARFYEVFMQRENAQAVLETYVGKR
SGARVLGGDIRRGDGDEIDAAIMFCDLRGSTQLEETLPRDKYVTLLNEFFETTSGLVHENGGEVLKFIGDAVLAVFPAGQ
NPAEARAQALKAAQDIVAALAEIAPCPSLPNLECAIGIASGSVLYGNIGSQERLDFTVIGQAANIAARLGDYGKTIGHRI
VVSRDILTQTAEAKPLGLVKLHNVSQPVESFAIAASS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HAMP domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00211 Guanylate_cyc; PF00672 HAMP [H]

EC number: 4.6.1.1

Molecular weight: Translated: 56451; Mature: 56451

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00387 PPASE ; PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIQLPSRNGYGILVEQLDGPVSAYHGNTLLAQSSRAKVMYETRLPPVVYFPKEDLQVDM
CCEECCCCCCCEEEEECCCCCEEHCCCCEEEECCCCCEEEEECCCCCEEECCCCCCCCCH
DQACSKTTFCPFKGTAHYRDLILPGKKELCSAVWSYDETLPEARQIKGHVGFMPDALDRL
HHHCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHH
DLGNNRLQAPDDGNISGPLVDWLLREAAFLPSPETFTEVLVERLQQQGLPVSRLTILAWA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LHPRIAGHHYRWEKGGAGVETFSPSYEIHEKPEFKNSPLRHVSKGLGGLRYRLTGNVPSE
HCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCC
DFPILRDLREKGMTDYVAMPLPFSDGRINVLTLASDAPEGFSTADLGLIFECSAVIARFY
CCHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
EVFMQRENAQAVLETYVGKRSGARVLGGDIRRGDGDEIDAAIMFCDLRGSTQLEETLPRD
HHHHHCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCEEEEEEEECCCCCCHHHHCCCH
KYVTLLNEFFETTSGLVHENGGEVLKFIGDAVLAVFPAGQNPAEARAQALKAAQDIVAAL
HHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHH
AEIAPCPSLPNLECAIGIASGSVLYGNIGSQERLDFTVIGQAANIAARLGDYGKTIGHRI
HHHCCCCCCCCCEEEEEEECCCEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCEE
VVSRDILTQTAEAKPLGLVKLHNVSQPVESFAIAASS
EEEHHHHHHCCCCCCCCEEEECCCCHHHHHHEEECCC
>Mature Secondary Structure
MNIQLPSRNGYGILVEQLDGPVSAYHGNTLLAQSSRAKVMYETRLPPVVYFPKEDLQVDM
CCEECCCCCCCEEEEECCCCCEEHCCCCEEEECCCCCEEEEECCCCCEEECCCCCCCCCH
DQACSKTTFCPFKGTAHYRDLILPGKKELCSAVWSYDETLPEARQIKGHVGFMPDALDRL
HHHCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHH
DLGNNRLQAPDDGNISGPLVDWLLREAAFLPSPETFTEVLVERLQQQGLPVSRLTILAWA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHH
LHPRIAGHHYRWEKGGAGVETFSPSYEIHEKPEFKNSPLRHVSKGLGGLRYRLTGNVPSE
HCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEECCCCCC
DFPILRDLREKGMTDYVAMPLPFSDGRINVLTLASDAPEGFSTADLGLIFECSAVIARFY
CCHHHHHHHHCCCCCEEEECCCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
EVFMQRENAQAVLETYVGKRSGARVLGGDIRRGDGDEIDAAIMFCDLRGSTQLEETLPRD
HHHHHCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCEEEEEEEECCCCCCHHHHCCCH
KYVTLLNEFFETTSGLVHENGGEVLKFIGDAVLAVFPAGQNPAEARAQALKAAQDIVAAL
HHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHH
AEIAPCPSLPNLECAIGIASGSVLYGNIGSQERLDFTVIGQAANIAARLGDYGKTIGHRI
HHHCCCCCCCCCEEEEEEECCCEEEECCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCEE
VVSRDILTQTAEAKPLGLVKLHNVSQPVESFAIAASS
EEEHHHHHHCCCCCCCCEEEECCCCHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP

Specific reaction: ATP = 3',5'-cyclic AMP + diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]