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The map label for this gene is atpB [H]

Identifier: 99082434

GI number: 99082434

Start: 2732910

End: 2733713

Strand: Reverse

Name: atpB [H]

Synonym: TM1040_2594

Alternate gene names: 99082434

Gene position: 2733713-2732910 (Counterclockwise)

Preceding gene: 99082435

Following gene: 99082433

Centisome position: 85.4

GC content: 57.34

Gene sequence:

>804_bases
ATGGGCAAACTGTTCTTTTACGTAGCTTTGGCTTTGGTGCTCGTATCGGGCCTGGTGTTCGCACCGGAAAAGGCAGAGCT
TGCGATTCACCCGATGGACCAGTTCACCGTGACGCCGCTGTTCGGTGGTGACCACATCGCGTGGTACACGCCCACCAACG
TGACGCTCTGGATGTTCCTCGCCGTGGCGGCCATCATCGGCCTTCTGGTGTTCGGCTCTTCCAACCGCGGCATCGTTCCT
TCTCGCGCTCAGTCGGTTGCGGAACTGGCTTATGGGTTCATCTACAAGATGGTCGAAGACGTGACCGGCAAAGACGCGGT
AAAGTTCTTCCCCTACATCATGACGCTCTTCATGTTCATCGTGACGGCCAACTTCCTTGGCCTCATCCCGATGTCCTTCA
CTACGACATCGCATTTTGCCGTAACCGCGATCCTCGCGATGCTGGTTTTCGTGACCGTGACCATCACTGGCTTTGTGCTG
CATGGTGCAAAATTCCTCGGCCTGTTCTGGGTCAGCTCCGCTCCGCTGGCGCTGCGTCCGATCTTGGCCATTATCGAACT
GATTTCCTACTTCGTACGCCCAGTCAGCCACTGCATCCGTCTTGCAGGGAACGTGATGGCGGGCCACGCGGTTCTGAAGG
TGTTCGCAGGTTTTGCTGGCGCTCTGGGCGCCGGGGCATTCCTGCCGATCTTTGCCATCACCGCGGTCTACGCACTCGAA
GTTCTCGTGGCCTTCATCCAGGCATACGTGTTCACCATTCTGACCTGTGTCTATCTGAAAGACGCGCTGCACCCGTCCCA
CTAA

Upstream 100 bases:

>100_bases
GATTCAGGACAAACAAATGGCTGAGGCGGAACAACGCGCCGACGCTGACAAAGATGCATGAATGCTGGGCGACGGCCTAA
GCGACAGGAGAAGCGGAACG

Downstream 100 bases:

>100_bases
GGGCAGGCTGCTGGTCTGAACTACTACCTCAACTTCCAATCGTAAGGAGATATCAAATGGAAGGCGATCTCGCATACATC
GGCGCTGGCCTGGCTGGCAT

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MGKLFFYVALALVLVSGLVFAPEKAELAIHPMDQFTVTPLFGGDHIAWYTPTNVTLWMFLAVAAIIGLLVFGSSNRGIVP
SRAQSVAELAYGFIYKMVEDVTGKDAVKFFPYIMTLFMFIVTANFLGLIPMSFTTTSHFAVTAILAMLVFVTVTITGFVL
HGAKFLGLFWVSSAPLALRPILAIIELISYFVRPVSHCIRLAGNVMAGHAVLKVFAGFAGALGAGAFLPIFAITAVYALE
VLVAFIQAYVFTILTCVYLKDALHPSH

Sequences:

>Translated_267_residues
MGKLFFYVALALVLVSGLVFAPEKAELAIHPMDQFTVTPLFGGDHIAWYTPTNVTLWMFLAVAAIIGLLVFGSSNRGIVP
SRAQSVAELAYGFIYKMVEDVTGKDAVKFFPYIMTLFMFIVTANFLGLIPMSFTTTSHFAVTAILAMLVFVTVTITGFVL
HGAKFLGLFWVSSAPLALRPILAIIELISYFVRPVSHCIRLAGNVMAGHAVLKVFAGFAGALGAGAFLPIFAITAVYALE
VLVAFIQAYVFTILTCVYLKDALHPSH
>Mature_266_residues
GKLFFYVALALVLVSGLVFAPEKAELAIHPMDQFTVTPLFGGDHIAWYTPTNVTLWMFLAVAAIIGLLVFGSSNRGIVPS
RAQSVAELAYGFIYKMVEDVTGKDAVKFFPYIMTLFMFIVTANFLGLIPMSFTTTSHFAVTAILAMLVFVTVTITGFVLH
GAKFLGLFWVSSAPLALRPILAIIELISYFVRPVSHCIRLAGNVMAGHAVLKVFAGFAGALGAGAFLPIFAITAVYALEV
LVAFIQAYVFTILTCVYLKDALHPSH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Homo sapiens, GI251831112, Length=153, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6226527, Length=249, Percent_Identity=34.9397590361446, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 28927; Mature: 28796

Theoretical pI: Translated: 8.65; Mature: 8.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKLFFYVALALVLVSGLVFAPEKAELAIHPMDQFTVTPLFGGDHIAWYTPTNVTLWMFL
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEECCCEEEEECCCCHHHHHHH
AVAAIIGLLVFGSSNRGIVPSRAQSVAELAYGFIYKMVEDVTGKDAVKFFPYIMTLFMFI
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VTANFLGLIPMSFTTTSHFAVTAILAMLVFVTVTITGFVLHGAKFLGLFWVSSAPLALRP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ILAIIELISYFVRPVSHCIRLAGNVMAGHAVLKVFAGFAGALGAGAFLPIFAITAVYALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VLVAFIQAYVFTILTCVYLKDALHPSH
HHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GKLFFYVALALVLVSGLVFAPEKAELAIHPMDQFTVTPLFGGDHIAWYTPTNVTLWMFL
CHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEEEEECCCEEEEECCCCHHHHHHH
AVAAIIGLLVFGSSNRGIVPSRAQSVAELAYGFIYKMVEDVTGKDAVKFFPYIMTLFMFI
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
VTANFLGLIPMSFTTTSHFAVTAILAMLVFVTVTITGFVLHGAKFLGLFWVSSAPLALRP
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
ILAIIELISYFVRPVSHCIRLAGNVMAGHAVLKVFAGFAGALGAGAFLPIFAITAVYALE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
VLVAFIQAYVFTILTCVYLKDALHPSH
HHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA