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The map label for this gene is pdhR [H]

Identifier: 99082429

GI number: 99082429

Start: 2729612

End: 2730379

Strand: Direct

Name: pdhR [H]

Synonym: TM1040_2589

Alternate gene names: 99082429

Gene position: 2729612-2730379 (Clockwise)

Preceding gene: 99082426

Following gene: 99082437

Centisome position: 85.28

GC content: 58.98

Gene sequence:

>768_bases
ATGCCGTTTCAGAAAGTTCAGCCGGAGAAACTCTCTTCTGCCGTTGTACGACAGATCGAAAAACTCATCCTGCGGGGAAT
CCTGCGCCCAGGTGAGCGCCTGCCCTCTGAACGCGAATTGTCTGAGCGGCTTGGCGTATCGCGCCCCTCGCTGCGAGAAG
CGCTCGGAGAGCTTCAGGAACAGGGATTACTCTGCAGCCGTGCTGGCTCGGGCGTGTTTGTCGCGGATGTCCTTGGCTCG
GCTTTCTCGCCTGCGCTGATCCAGCTGTTTGCCAGCGACGATGAGGCGGTGTTCGACTATCTCTCGTTTCGCCGCGACCT
CGAAGGCATGGCCGCAGAGCGCGCAGCCAAGTTCGGATCAGACGCAGACCTCGGTGTCATCCAGACGATCTTTGACAAGA
TGGAAGCCGCAGGCGACCCCAGCGTCTCGGAGGCTGCGGCAGAACTCGACGCACAGTTTCACTCGGCGATTCTCGAAGCG
AGCCATAACGTCGTGCTTCTGCATATGATGCGCTCCATGTTCGACATGTTGCGCAAGGGCGTGTTTTACAATCGTCGCAT
CATGTTTGGCCAGCACACCACCTATGAGGCGCTGCTGGAACAACATCGCGCCATCAACTCCGCGCTTCAATCCCGCGACG
CCAAAGCAGCACGCGCCGCAGTCGAGACCCATATGGATTACGTAAAACAGTCCCTCGAGGAGCAAATTCGCGCAGAACGC
AACGCCGAGATCGCAGCGCAGCGTCTCGAGCACGAAAGCAAGCGCTAG

Upstream 100 bases:

>100_bases
GTCAATGATTCTGACCTATTATTTCAACCTTCGTGATCTTGCAGCGGCCGGGCGTTGGTGGTCATATGAGTTGACCAATC
TTTGTTTTTCGAGGCCAGTG

Downstream 100 bases:

>100_bases
GCCGAAGTGCTCTCGAGGAAGGCCCGCGTCTGCGGCGCGAGTGCCGCGGTCAGGATCATTTCAGCGCTATCGATTTCCAC
CAGCGCACCCTCTTCCAGAT

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 255; Mature: 254

Protein sequence:

>255_residues
MPFQKVQPEKLSSAVVRQIEKLILRGILRPGERLPSERELSERLGVSRPSLREALGELQEQGLLCSRAGSGVFVADVLGS
AFSPALIQLFASDDEAVFDYLSFRRDLEGMAAERAAKFGSDADLGVIQTIFDKMEAAGDPSVSEAAAELDAQFHSAILEA
SHNVVLLHMMRSMFDMLRKGVFYNRRIMFGQHTTYEALLEQHRAINSALQSRDAKAARAAVETHMDYVKQSLEEQIRAER
NAEIAAQRLEHESKR

Sequences:

>Translated_255_residues
MPFQKVQPEKLSSAVVRQIEKLILRGILRPGERLPSERELSERLGVSRPSLREALGELQEQGLLCSRAGSGVFVADVLGS
AFSPALIQLFASDDEAVFDYLSFRRDLEGMAAERAAKFGSDADLGVIQTIFDKMEAAGDPSVSEAAAELDAQFHSAILEA
SHNVVLLHMMRSMFDMLRKGVFYNRRIMFGQHTTYEALLEQHRAINSALQSRDAKAARAAVETHMDYVKQSLEEQIRAER
NAEIAAQRLEHESKR
>Mature_254_residues
PFQKVQPEKLSSAVVRQIEKLILRGILRPGERLPSERELSERLGVSRPSLREALGELQEQGLLCSRAGSGVFVADVLGSA
FSPALIQLFASDDEAVFDYLSFRRDLEGMAAERAAKFGSDADLGVIQTIFDKMEAAGDPSVSEAAAELDAQFHSAILEAS
HNVVLLHMMRSMFDMLRKGVFYNRRIMFGQHTTYEALLEQHRAINSALQSRDAKAARAAVETHMDYVKQSLEEQIRAERN
AEIAAQRLEHESKR

Specific function: Transcriptional repressor for the pyruvate dehydrogenase complex genes aceEF and lpd [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786303, Length=233, Percent_Identity=38.1974248927039, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790032, Length=258, Percent_Identity=35.6589147286822, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1789353, Length=227, Percent_Identity=34.3612334801762, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1790780, Length=237, Percent_Identity=33.3333333333333, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI48994955, Length=234, Percent_Identity=27.3504273504274, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI48994961, Length=218, Percent_Identity=27.5229357798165, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87082208, Length=230, Percent_Identity=25.2173913043478, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789621, Length=235, Percent_Identity=25.1063829787234, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1787821, Length=236, Percent_Identity=26.271186440678, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011711
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07729 FCD; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 28446; Mature: 28315

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFQKVQPEKLSSAVVRQIEKLILRGILRPGERLPSERELSERLGVSRPSLREALGELQE
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCCCHHHHHHHHHHHH
QGLLCSRAGSGVFVADVLGSAFSPALIQLFASDDEAVFDYLSFRRDLEGMAAERAAKFGS
CCCHHHCCCCCCHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DADLGVIQTIFDKMEAAGDPSVSEAAAELDAQFHSAILEASHNVVLLHMMRSMFDMLRKG
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
VFYNRRIMFGQHTTYEALLEQHRAINSALQSRDAKAARAAVETHMDYVKQSLEEQIRAER
HHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAEIAAQRLEHESKR
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
PFQKVQPEKLSSAVVRQIEKLILRGILRPGERLPSERELSERLGVSRPSLREALGELQE
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCCCHHHHHHHHHHHH
QGLLCSRAGSGVFVADVLGSAFSPALIQLFASDDEAVFDYLSFRRDLEGMAAERAAKFGS
CCCHHHCCCCCCHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
DADLGVIQTIFDKMEAAGDPSVSEAAAELDAQFHSAILEASHNVVLLHMMRSMFDMLRKG
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHC
VFYNRRIMFGQHTTYEALLEQHRAINSALQSRDAKAARAAVETHMDYVKQSLEEQIRAER
HHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAEIAAQRLEHESKR
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]