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The map label for this gene is cobC [H]

Identifier: 99082424

GI number: 99082424

Start: 2721455

End: 2722450

Strand: Direct

Name: cobC [H]

Synonym: TM1040_2584

Alternate gene names: 99082424

Gene position: 2721455-2722450 (Clockwise)

Preceding gene: 99082423

Following gene: 99082425

Centisome position: 85.02

GC content: 65.46

Gene sequence:

>996_bases
ATGGCAGAACGCTCTTCCTTTGCGGCAACGCAAGACCCGGCGCAGGCCTCGGTCTCCGGTTCCCCCCGCGATCATGGCGG
CAATCTCGCCGCCGCGATCGCACAGTATGGCGGCAGCCGCGAAGACTGGATTGATCTCTCCACAGGGATCAACCCTGCAC
CCTACCCTCTGCCGCCATTGCTGGCCGAAGACTGGACCGCTCTGCCCGATCAAGATGCCCAGCAGGCTCTGACGGATGCA
GCGCGCCGGTTCTGGCAGGTACCCGACAGCGCAGAGATCCTTGCCGCCCCCGGCGCTTCGGCGCTGATTGCACGGCTCCC
TGTCCTGCGCCCGGCACGCAGCGTGCAAATCACGACGCCCACCTACAACGAACACGCCGCTGCATTTGACAATTGTGGCT
GGCAGGTGCTTGAGGTGGGTCCAACGGACGCGCAAGTTGTGGTTCACCCCAACAATCCCGACGGCCGCCTGTGGCTGCCC
GAGGAACTCAAGGCACCTTTCTGCATCATTGACGAGAGTTTCTGTGACATCTGCCCGGAGCGGAGTCTGATCAACCGCGC
AGCACAGCCGGGCACCGTGGTCCTCAAGAGCTTTGGCAAGTTCTGGGGGCTCGCGGGGCTGCGGCTCGGGTTTGCCATCG
GCGATCCGGAGCTCATCGCCGGACTGCGCGCAGCCATGGGGCCGTGGGCGGTGTCCGGCCCGGCGCTGCGCGTGGGAACG
CACGCTCTGAACGATCAGAACTGGGCCGAGGCCAGCCGCCTTGAGCTTGCGGATGGAGCCTCGCGCCTTGACCAGCTGAT
GCAGCACGCCGGCGCACAGACCGTAGGCGGCACCGATCTCTTCCGGCTTTATGACGTTGAAGATGCCCGCGCCTGGCAGG
AGCGCCTCGCGCGTGCGCACATCTGGAGCCGCATCTTTCCCTATTCAACCCGTTTCCTGCGCCTTGGCCTGCCTCCCGCA
GACCGCTGGAGCCAACTGGAGACCGCCCTCACATGA

Upstream 100 bases:

>100_bases
CGGCTGAACATCGACGCTGGAAAGTGGCGCTGCGCTTGCTTTATCACGGGTGCAAAGGCATATCGTGCCAAGACCCTGAC
GTGACAAAGGCCGCCTCGCC

Downstream 100 bases:

>100_bases
GCACCGCCGCCCTGTTGATCCCCGCCATGATCCTCGACGCCGCATTTGGCGAGCCCAAATGGCTCTGGTCGCGGCTGCCG
CATCCCGCTGTGCTGATGGG

Product: aminotransferase

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MAERSSFAATQDPAQASVSGSPRDHGGNLAAAIAQYGGSREDWIDLSTGINPAPYPLPPLLAEDWTALPDQDAQQALTDA
ARRFWQVPDSAEILAAPGASALIARLPVLRPARSVQITTPTYNEHAAAFDNCGWQVLEVGPTDAQVVVHPNNPDGRLWLP
EELKAPFCIIDESFCDICPERSLINRAAQPGTVVLKSFGKFWGLAGLRLGFAIGDPELIAGLRAAMGPWAVSGPALRVGT
HALNDQNWAEASRLELADGASRLDQLMQHAGAQTVGGTDLFRLYDVEDARAWQERLARAHIWSRIFPYSTRFLRLGLPPA
DRWSQLETALT

Sequences:

>Translated_331_residues
MAERSSFAATQDPAQASVSGSPRDHGGNLAAAIAQYGGSREDWIDLSTGINPAPYPLPPLLAEDWTALPDQDAQQALTDA
ARRFWQVPDSAEILAAPGASALIARLPVLRPARSVQITTPTYNEHAAAFDNCGWQVLEVGPTDAQVVVHPNNPDGRLWLP
EELKAPFCIIDESFCDICPERSLINRAAQPGTVVLKSFGKFWGLAGLRLGFAIGDPELIAGLRAAMGPWAVSGPALRVGT
HALNDQNWAEASRLELADGASRLDQLMQHAGAQTVGGTDLFRLYDVEDARAWQERLARAHIWSRIFPYSTRFLRLGLPPA
DRWSQLETALT
>Mature_330_residues
AERSSFAATQDPAQASVSGSPRDHGGNLAAAIAQYGGSREDWIDLSTGINPAPYPLPPLLAEDWTALPDQDAQQALTDAA
RRFWQVPDSAEILAAPGASALIARLPVLRPARSVQITTPTYNEHAAAFDNCGWQVLEVGPTDAQVVVHPNNPDGRLWLPE
ELKAPFCIIDESFCDICPERSLINRAAQPGTVVLKSFGKFWGLAGLRLGFAIGDPELIAGLRAAMGPWAVSGPALRVGTH
ALNDQNWAEASRLELADGASRLDQLMQHAGAQTVGGTDLFRLYDVEDARAWQERLARAHIWSRIFPYSTRFLRLGLPPAD
RWSQLETALT

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=153, Percent_Identity=27.4509803921569, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 35888; Mature: 35756

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERSSFAATQDPAQASVSGSPRDHGGNLAAAIAQYGGSREDWIDLSTGINPAPYPLPPL
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCH
LAEDWTALPDQDAQQALTDAARRFWQVPDSAEILAAPGASALIARLPVLRPARSVQITTP
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCCCCCCEEEEECC
TYNEHAAAFDNCGWQVLEVGPTDAQVVVHPNNPDGRLWLPEELKAPFCIIDESFCDICPE
CCCCHHHHHHCCCEEEEEECCCCCEEEEECCCCCCCEECHHHHCCCEEEECCHHHHHCCC
RSLINRAAQPGTVVLKSFGKFWGLAGLRLGFAIGDPELIAGLRAAMGPWAVSGPALRVGT
HHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCCCCEEEECH
HALNDQNWAEASRLELADGASRLDQLMQHAGAQTVGGTDLFRLYDVEDARAWQERLARAH
HHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHH
IWSRIFPYSTRFLRLGLPPADRWSQLETALT
HHHHHCCCCCEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure 
AERSSFAATQDPAQASVSGSPRDHGGNLAAAIAQYGGSREDWIDLSTGINPAPYPLPPL
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCH
LAEDWTALPDQDAQQALTDAARRFWQVPDSAEILAAPGASALIARLPVLRPARSVQITTP
HHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHCCCCCCCCEEEEECC
TYNEHAAAFDNCGWQVLEVGPTDAQVVVHPNNPDGRLWLPEELKAPFCIIDESFCDICPE
CCCCHHHHHHCCCEEEEEECCCCCEEEEECCCCCCCEECHHHHCCCEEEECCHHHHHCCC
RSLINRAAQPGTVVLKSFGKFWGLAGLRLGFAIGDPELIAGLRAAMGPWAVSGPALRVGT
HHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCCCCEEEECH
HALNDQNWAEASRLELADGASRLDQLMQHAGAQTVGGTDLFRLYDVEDARAWQERLARAH
HHCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCEEEEEECHHHHHHHHHHHHHH
IWSRIFPYSTRFLRLGLPPADRWSQLETALT
HHHHHCCCCCEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2211520 [H]