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The map label for this gene is glcD [H]

Identifier: 99082342

GI number: 99082342

Start: 2644053

End: 2645501

Strand: Reverse

Name: glcD [H]

Synonym: TM1040_2502

Alternate gene names: 99082342

Gene position: 2645501-2644053 (Counterclockwise)

Preceding gene: 99082345

Following gene: 99082341

Centisome position: 82.65

GC content: 58.87

Gene sequence:

>1449_bases
ATGGAGATGCCACCCCCCAATGCCGCCATCCTGTCCTTGAAGGCAGAGCTTTTGCAGCGCCTGCAACAGGTGTTGCCAAA
GGATGCGCTGATTTCGGATGAAGCAGAGACACGCGCGTATGAGTGTGACGCGCTGACGGCCTATAAATGTCCGCCGATGC
TGGCGGTTCTGCCGCGCTCTACTCAGGAAGTGTCAGACGTTCTGCGGATATGTCACCAGATGAATGTACCCGTTGTACCG
CGTGGAGCTGGAACATCGCTGGCGGGGGGCGCATTGCCTACCGCAGACTGCGTAATCCTCGGGGTGGCGCGGATGAACGA
GGTGCTGGAGACGGACTACGACAATCGTGTCATCCGTGTTCAGACCGGGCGCACCAACCTGTCGGTGTCCGGCGCCGTGG
AAGAAGAGGATTTCTTTTATGCGCCTGACCCCTCTTCACAGCTCGCCTGTGCGATTGCTGGCAACATCGCAATGAATTCC
GGTGGGGCGCATTGTCTCAAATACGGGGTGACGACCAACAACCTTCTTGGGGTCACCATGGTGATGATGGACGGAACGGT
TGTCGAAATAGGTGGCGCGCATCTGGATGCCGGTGGGCTTGATCTCCTCGGGGTGATCTGCGGCAGTGAGGGGCAGCTGG
GCGTGGTGACCGAAGCCACCCTCCGGATTTTGCGCAAACCCGAAGGGGCGCGGCCCGTGCTTGTGGCCTTTGACAGCAAT
GAAGTCGCTGGGGCCTGTGTTTCTGATATCATCAAAGCGGGCGTTCTGCCGGTGGCGATTGAGTTCATGGACCGTCCTTG
CATTGAAGCCTGCGAAGCGTTTGCCAAAGCGGGCTATCCGATGTGCGAAGCTTTGCTGATCATCGAAGTCGAAGGGTCAG
AAGCAGAAATCGACCATCAGCTGAAGCTCATCACCGAGATCGCGCGGCGCCACAACCCGGTGGAGTTGCGCGAAGCGGGG
GATTCCGAGGAAGCCGCGCGCATCTGGCTTGGACGCAAATCCGCGTTTGGTGCGATGGGACAGATCAACGACTACATGTG
TCTTGATGGGACGATTCCCGTTTCTGCCCTGCCGCAGGTTCTGCGTCGCATCGGGGAGATGAGCGCGGAGTTCGGCCTGA
AAGTGGCAAACGTGTTTCACGCAGGGGATGGCAACATGCACCCGCTGATCCTGTTTGATGCCAACAAACCCGGTGATCTG
GAGCTGTGCGAAGCCTTCGGGGCCGAGATCCTGAAGCTCTGTGTCGAGGTCGGGGGGTGTCTGACCGGCGAACACGGCGT
TGGGATCGAAAAGCGAGATCTGATGCTGCATCAATATGCACTTGCTGACATCGAAGCCCAGTTGCGCGTGAAGGATGTGT
TTGACCCGAAGTGGCTGTTGAACCCGGCAAAGGTCTTTCCGCTGTCAACCACGCAGAGCCGGCGCAACGTCGCGATTGCG
GCGCAGTAG

Upstream 100 bases:

>100_bases
GGCGCTCGATCCAAATCATAGGGCGACCCTAGCTTAGTCAGTTCAGCCTTGCCAGAGGTGATAGATTGGTAATATTATTT
TACCAAAGAGGAGAGCCCGC

Downstream 100 bases:

>100_bases
CTCAAAGCGGGGGCGTTGCCCCCGAACCCCCAAGGATAATTGGAAAAAGGTGAAATGATGACAGCGCAGAGCGAGGCAGA
GCTTGCCGACATCATTGCCG

Product: D-lactate dehydrogenase (cytochrome)

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MEMPPPNAAILSLKAELLQRLQQVLPKDALISDEAETRAYECDALTAYKCPPMLAVLPRSTQEVSDVLRICHQMNVPVVP
RGAGTSLAGGALPTADCVILGVARMNEVLETDYDNRVIRVQTGRTNLSVSGAVEEEDFFYAPDPSSQLACAIAGNIAMNS
GGAHCLKYGVTTNNLLGVTMVMMDGTVVEIGGAHLDAGGLDLLGVICGSEGQLGVVTEATLRILRKPEGARPVLVAFDSN
EVAGACVSDIIKAGVLPVAIEFMDRPCIEACEAFAKAGYPMCEALLIIEVEGSEAEIDHQLKLITEIARRHNPVELREAG
DSEEAARIWLGRKSAFGAMGQINDYMCLDGTIPVSALPQVLRRIGEMSAEFGLKVANVFHAGDGNMHPLILFDANKPGDL
ELCEAFGAEILKLCVEVGGCLTGEHGVGIEKRDLMLHQYALADIEAQLRVKDVFDPKWLLNPAKVFPLSTTQSRRNVAIA
AQ

Sequences:

>Translated_482_residues
MEMPPPNAAILSLKAELLQRLQQVLPKDALISDEAETRAYECDALTAYKCPPMLAVLPRSTQEVSDVLRICHQMNVPVVP
RGAGTSLAGGALPTADCVILGVARMNEVLETDYDNRVIRVQTGRTNLSVSGAVEEEDFFYAPDPSSQLACAIAGNIAMNS
GGAHCLKYGVTTNNLLGVTMVMMDGTVVEIGGAHLDAGGLDLLGVICGSEGQLGVVTEATLRILRKPEGARPVLVAFDSN
EVAGACVSDIIKAGVLPVAIEFMDRPCIEACEAFAKAGYPMCEALLIIEVEGSEAEIDHQLKLITEIARRHNPVELREAG
DSEEAARIWLGRKSAFGAMGQINDYMCLDGTIPVSALPQVLRRIGEMSAEFGLKVANVFHAGDGNMHPLILFDANKPGDL
ELCEAFGAEILKLCVEVGGCLTGEHGVGIEKRDLMLHQYALADIEAQLRVKDVFDPKWLLNPAKVFPLSTTQSRRNVAIA
AQ
>Mature_482_residues
MEMPPPNAAILSLKAELLQRLQQVLPKDALISDEAETRAYECDALTAYKCPPMLAVLPRSTQEVSDVLRICHQMNVPVVP
RGAGTSLAGGALPTADCVILGVARMNEVLETDYDNRVIRVQTGRTNLSVSGAVEEEDFFYAPDPSSQLACAIAGNIAMNS
GGAHCLKYGVTTNNLLGVTMVMMDGTVVEIGGAHLDAGGLDLLGVICGSEGQLGVVTEATLRILRKPEGARPVLVAFDSN
EVAGACVSDIIKAGVLPVAIEFMDRPCIEACEAFAKAGYPMCEALLIIEVEGSEAEIDHQLKLITEIARRHNPVELREAG
DSEEAARIWLGRKSAFGAMGQINDYMCLDGTIPVSALPQVLRRIGEMSAEFGLKVANVFHAGDGNMHPLILFDANKPGDL
ELCEAFGAEILKLCVEVGGCLTGEHGVGIEKRDLMLHQYALADIEAQLRVKDVFDPKWLLNPAKVFPLSTTQSRRNVAIA
AQ

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=449, Percent_Identity=28.5077951002227, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI37595754, Length=472, Percent_Identity=27.1186440677966, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI119964728, Length=459, Percent_Identity=29.6296296296296, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI4501993, Length=245, Percent_Identity=26.1224489795918, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1789351, Length=456, Percent_Identity=47.8070175438597, Blast_Score=431, Evalue=1e-122,
Organism=Escherichia coli, GI1787977, Length=550, Percent_Identity=24.3636363636364, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI48994907, Length=491, Percent_Identity=21.9959266802444, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71992373, Length=475, Percent_Identity=24.8421052631579, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI71992381, Length=472, Percent_Identity=24.1525423728814, Blast_Score=168, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17534361, Length=467, Percent_Identity=26.1241970021413, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71992392, Length=371, Percent_Identity=24.2587601078167, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17556096, Length=218, Percent_Identity=24.7706422018349, Blast_Score=72, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6320027, Length=430, Percent_Identity=30.2325581395349, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6320764, Length=481, Percent_Identity=26.4033264033264, Blast_Score=160, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6320023, Length=481, Percent_Identity=24.3243243243243, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI18921117, Length=483, Percent_Identity=26.7080745341615, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24639277, Length=483, Percent_Identity=26.7080745341615, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24639275, Length=483, Percent_Identity=26.7080745341615, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24653753, Length=217, Percent_Identity=27.6497695852535, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 51600; Mature: 51600

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMPPPNAAILSLKAELLQRLQQVLPKDALISDEAETRAYECDALTAYKCPPMLAVLPRS
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCEEECCCEEEECCCCCEEECCCC
TQEVSDVLRICHQMNVPVVPRGAGTSLAGGALPTADCVILGVARMNEVLETDYDNRVIRV
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEE
QTGRTNLSVSGAVEEEDFFYAPDPSSQLACAIAGNIAMNSGGAHCLKYGVTTNNLLGVTM
EECCCEEEEECCCCCCCEEECCCCCCCEEEEEECCEEECCCCCEEEEECCCCCCCCEEEE
VMMDGTVVEIGGAHLDAGGLDLLGVICGSEGQLGVVTEATLRILRKPEGARPVLVAFDSN
EEECCEEEEECCCEECCCCCEEEEEEECCCCCEEEEHHHHHHHHHCCCCCCCEEEEECCC
EVAGACVSDIIKAGVLPVAIEFMDRPCIEACEAFAKAGYPMCEALLIIEVEGSEAEIDHQ
CCCHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHH
LKLITEIARRHNPVELREAGDSEEAARIWLGRKSAFGAMGQINDYMCLDGTIPVSALPQV
HHHHHHHHHCCCCEEHHCCCCCHHHHHEEECCCHHCCCCCCCCCEEEECCCCCHHHHHHH
LRRIGEMSAEFGLKVANVFHAGDGNMHPLILFDANKPGDLELCEAFGAEILKLCVEVGGC
HHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
LTGEHGVGIEKRDLMLHQYALADIEAQLRVKDVFDPKWLLNPAKVFPLSTTQSRRNVAIA
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCHHCCCCHHEEECCCCCCCCCEEEE
AQ
EC
>Mature Secondary Structure
MEMPPPNAAILSLKAELLQRLQQVLPKDALISDEAETRAYECDALTAYKCPPMLAVLPRS
CCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCEEECCCEEEECCCCCEEECCCC
TQEVSDVLRICHQMNVPVVPRGAGTSLAGGALPTADCVILGVARMNEVLETDYDNRVIRV
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEE
QTGRTNLSVSGAVEEEDFFYAPDPSSQLACAIAGNIAMNSGGAHCLKYGVTTNNLLGVTM
EECCCEEEEECCCCCCCEEECCCCCCCEEEEEECCEEECCCCCEEEEECCCCCCCCEEEE
VMMDGTVVEIGGAHLDAGGLDLLGVICGSEGQLGVVTEATLRILRKPEGARPVLVAFDSN
EEECCEEEEECCCEECCCCCEEEEEEECCCCCEEEEHHHHHHHHHCCCCCCCEEEEECCC
EVAGACVSDIIKAGVLPVAIEFMDRPCIEACEAFAKAGYPMCEALLIIEVEGSEAEIDHQ
CCCHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHH
LKLITEIARRHNPVELREAGDSEEAARIWLGRKSAFGAMGQINDYMCLDGTIPVSALPQV
HHHHHHHHHCCCCEEHHCCCCCHHHHHEEECCCHHCCCCCCCCCEEEECCCCCHHHHHHH
LRRIGEMSAEFGLKVANVFHAGDGNMHPLILFDANKPGDLELCEAFGAEILKLCVEVGGC
HHHHHHHHHHHCCEEEEEEECCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCC
LTGEHGVGIEKRDLMLHQYALADIEAQLRVKDVFDPKWLLNPAKVFPLSTTQSRRNVAIA
CCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEECCCCHHCCCCHHEEECCCCCCCCCEEEE
AQ
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]