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The map label for this gene is rppH [H]

Identifier: 99082297

GI number: 99082297

Start: 2598701

End: 2599207

Strand: Reverse

Name: rppH [H]

Synonym: TM1040_2457

Alternate gene names: 99082297

Gene position: 2599207-2598701 (Counterclockwise)

Preceding gene: 99082299

Following gene: 99082296

Centisome position: 81.2

GC content: 55.42

Gene sequence:

>507_bases
ATGAGCAAAATACCCGCCAAGGAAATGACCCCAGAGCAGATCGCCGCTTTGCCATACCGCCCAAACGTGGGGGTCATGAT
GATCAATGCTGCAGGCGCAGTCTGGGTCGGGCAGCGGATGGATCGCCACAAAGAAGCATGGCAGATGCCTCAGGGCGGTA
TTGATAAGGGCGAGGATGCCCGTGTCGCGGCGTTGCGCGAGCTCGAAGAAGAAACCGGCGTCACCCCAGATCTGGTCGAA
GTCATTGCCGAAAGCGATGGCTGGCTACCCTATGACTTGCCCCATGACGTTGTGCCGCATTTCTGGGGCGGAAAGTATCG
TGGTCAGGAGCAGAAATGGTTTCTGTTGCGTTTTCTTGGGCGTGACGATCAGATCAATATTGCAACCGACAGCCCCGAGT
TTTCAGCATGGTGCTGGCAGCCCGTGGAGCAGTTGGTGGACAAGGTTGTTCCTTTCAAAAAGGAGGTCTACGCCCGTGTT
GTCGAGGAATTCAAAGCCCATTTGTAA

Upstream 100 bases:

>100_bases
GCGCATGGAATGTCACCTGCAGACGCGGCGTCACCCCCTTGCGTGCCCCGGCGGCAAACGGTCTAAGAGGGGCGGAGCAA
CCCTCACCGGAGACTGAGGC

Downstream 100 bases:

>100_bases
CATTGCCCTCGCTGCGGGGCTGGCCCTCTTGACGGTGACCGAGGCCGGTGCGCTCAGCTGTTTGCCGATGGGGCCGGGGG
ATGTCTATCGGATCGTGTCC

Product: NUDIX hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MSKIPAKEMTPEQIAALPYRPNVGVMMINAAGAVWVGQRMDRHKEAWQMPQGGIDKGEDARVAALRELEEETGVTPDLVE
VIAESDGWLPYDLPHDVVPHFWGGKYRGQEQKWFLLRFLGRDDQINIATDSPEFSAWCWQPVEQLVDKVVPFKKEVYARV
VEEFKAHL

Sequences:

>Translated_168_residues
MSKIPAKEMTPEQIAALPYRPNVGVMMINAAGAVWVGQRMDRHKEAWQMPQGGIDKGEDARVAALRELEEETGVTPDLVE
VIAESDGWLPYDLPHDVVPHFWGGKYRGQEQKWFLLRFLGRDDQINIATDSPEFSAWCWQPVEQLVDKVVPFKKEVYARV
VEEFKAHL
>Mature_167_residues
SKIPAKEMTPEQIAALPYRPNVGVMMINAAGAVWVGQRMDRHKEAWQMPQGGIDKGEDARVAALRELEEETGVTPDLVEV
IAESDGWLPYDLPHDVVPHFWGGKYRGQEQKWFLLRFLGRDDQINIATDSPEFSAWCWQPVEQLVDKVVPFKKEVYARVV
EEFKAHL

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=151, Percent_Identity=44.3708609271523, Blast_Score=117, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19202; Mature: 19071

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIPAKEMTPEQIAALPYRPNVGVMMINAAGAVWVGQRMDRHKEAWQMPQGGIDKGEDA
CCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCH
RVAALRELEEETGVTPDLVEVIAESDGWLPYDLPHDVVPHFWGGKYRGQEQKWFLLRFLG
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHC
RDDQINIATDSPEFSAWCWQPVEQLVDKVVPFKKEVYARVVEEFKAHL
CCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKIPAKEMTPEQIAALPYRPNVGVMMINAAGAVWVGQRMDRHKEAWQMPQGGIDKGEDA
CCCCCCCCCHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCH
RVAALRELEEETGVTPDLVEVIAESDGWLPYDLPHDVVPHFWGGKYRGQEQKWFLLRFLG
HHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHC
RDDQINIATDSPEFSAWCWQPVEQLVDKVVPFKKEVYARVVEEFKAHL
CCCEEEEECCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA