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The map label for this gene is csgA [H]

Identifier: 99082155

GI number: 99082155

Start: 2436816

End: 2437457

Strand: Reverse

Name: csgA [H]

Synonym: TM1040_2315

Alternate gene names: 99082155

Gene position: 2437457-2436816 (Counterclockwise)

Preceding gene: 99082156

Following gene: 99082154

Centisome position: 76.15

GC content: 62.15

Gene sequence:

>642_bases
ATGCATGTGGTCGTGACAGGCAGCAGCCGCGGTATCGGGCGCGAGTTGAAGACAAGGCTGTCGGAGCGCGGGGACCGGGT
GACGGGCACCTCGCGCGATCATTCCTCGGGCACGCGCCTTGATGTGAGCGATCCGGGCCAGCAGGCGCGCTTTGCGGCAC
AGATCAAAGGCGACCCGGTGGATCTCTTGATCTGCAACGCGGGGGTTTATCTCGATAAATCCATGGCGCTCAAGGACTAT
ACGGCAGAGGTTTGGGCAAAATCGCTGGCGGTGAACGTCACGGGCGTGTTCCTGACCGTGCAGGCGATGCTGCCCAATCT
CAAGCTGGCCGACGAGCCCAAGATCGCGATCATCTCTTCGCAGATGGCCAGCCACGCGCGCGCGCCGGGAGGCTCCTATG
CCTATCGCGCGTCCAAGGCGGCGGCGCTCAACATCGGGCGTAACCTGGCCACCGACCTCAAGCCTGAAGGCATTGCCGTG
GGGATCTATCATCCCGGATGGGTGCGCACTGATATGGGGGGTCAGGACGGTGACATCACCGTCGAGGAAAGCGCGCTGGG
GTTGATCAACGAATTTGACGTGCTGTCGCTGGACACGACGGGATGTTTTCACACCTGGGATGGTCAGGTTCACGCCTACT
AG

Upstream 100 bases:

>100_bases
CCCTTTGCGCCCACGCGCAAGACCAACTAGACGCAGGCCTCGCGCTCCAAAAGGAAGGGCGCAGGCCAAATGAGGCAGAG
CAGGCAAAAGGAGACCGCCA

Downstream 100 bases:

>100_bases
GGCTGCCGGTCGAGAGCGCTGGGTCTTTGCCATCGCGGCAAATCCGGGCTATGTGCGGGGCGAACCCCATCTGAACCACC
ACCTCCGGCCCGCTGATCCG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MHVVVTGSSRGIGRELKTRLSERGDRVTGTSRDHSSGTRLDVSDPGQQARFAAQIKGDPVDLLICNAGVYLDKSMALKDY
TAEVWAKSLAVNVTGVFLTVQAMLPNLKLADEPKIAIISSQMASHARAPGGSYAYRASKAAALNIGRNLATDLKPEGIAV
GIYHPGWVRTDMGGQDGDITVEESALGLINEFDVLSLDTTGCFHTWDGQVHAY

Sequences:

>Translated_213_residues
MHVVVTGSSRGIGRELKTRLSERGDRVTGTSRDHSSGTRLDVSDPGQQARFAAQIKGDPVDLLICNAGVYLDKSMALKDY
TAEVWAKSLAVNVTGVFLTVQAMLPNLKLADEPKIAIISSQMASHARAPGGSYAYRASKAAALNIGRNLATDLKPEGIAV
GIYHPGWVRTDMGGQDGDITVEESALGLINEFDVLSLDTTGCFHTWDGQVHAY
>Mature_213_residues
MHVVVTGSSRGIGRELKTRLSERGDRVTGTSRDHSSGTRLDVSDPGQQARFAAQIKGDPVDLLICNAGVYLDKSMALKDY
TAEVWAKSLAVNVTGVFLTVQAMLPNLKLADEPKIAIISSQMASHARAPGGSYAYRASKAAALNIGRNLATDLKPEGIAV
GIYHPGWVRTDMGGQDGDITVEESALGLINEFDVLSLDTTGCFHTWDGQVHAY

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=190, Percent_Identity=30, Blast_Score=67, Evalue=8e-12,
Organism=Escherichia coli, GI1787335, Length=185, Percent_Identity=30.2702702702703, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI2367175, Length=200, Percent_Identity=29.5, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1786812, Length=179, Percent_Identity=29.0502793296089, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17558990, Length=240, Percent_Identity=33.75, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17558994, Length=231, Percent_Identity=32.9004329004329, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17558992, Length=246, Percent_Identity=32.520325203252, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI193207563, Length=228, Percent_Identity=31.140350877193, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17542178, Length=240, Percent_Identity=31.25, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17559962, Length=228, Percent_Identity=27.1929824561404, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532177, Length=245, Percent_Identity=27.3469387755102, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17541382, Length=227, Percent_Identity=31.2775330396476, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322779, Length=242, Percent_Identity=30.5785123966942, Blast_Score=79, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24640547, Length=245, Percent_Identity=27.3469387755102, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24643142, Length=185, Percent_Identity=32.4324324324324, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 22772; Mature: 22772

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVVVTGSSRGIGRELKTRLSERGDRVTGTSRDHSSGTRLDVSDPGQQARFAAQIKGDPV
CEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCE
DLLICNAGVYLDKSMALKDYTAEVWAKSLAVNVTGVFLTVQAMLPNLKLADEPKIAIISS
EEEEECCCEEECCCHHHHHHHHHHHHHHHEEEEEEEEEEEEHHCCCCEECCCCCEEEEEC
QMASHARAPGGSYAYRASKAAALNIGRNLATDLKPEGIAVGIYHPGWVRTDMGGQDGDIT
HHHHHHCCCCCCEEEECCCEEEEECCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCEE
VEESALGLINEFDVLSLDTTGCFHTWDGQVHAY
EECCCCCCCCCCCEEEECCCCCEEECCCEEECC
>Mature Secondary Structure
MHVVVTGSSRGIGRELKTRLSERGDRVTGTSRDHSSGTRLDVSDPGQQARFAAQIKGDPV
CEEEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCEEEEEECCCCE
DLLICNAGVYLDKSMALKDYTAEVWAKSLAVNVTGVFLTVQAMLPNLKLADEPKIAIISS
EEEEECCCEEECCCHHHHHHHHHHHHHHHEEEEEEEEEEEEHHCCCCEECCCCCEEEEEC
QMASHARAPGGSYAYRASKAAALNIGRNLATDLKPEGIAVGIYHPGWVRTDMGGQDGDIT
HHHHHHCCCCCCEEEECCCEEEEECCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCEE
VEESALGLINEFDVLSLDTTGCFHTWDGQVHAY
EECCCCCCCCCCCEEEECCCCCEEECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]