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The map label for this gene is cyoB [H]

Identifier: 99082125

GI number: 99082125

Start: 2404642

End: 2406678

Strand: Direct

Name: cyoB [H]

Synonym: TM1040_2285

Alternate gene names: 99082125

Gene position: 2404642-2406678 (Clockwise)

Preceding gene: 99082124

Following gene: 99082126

Centisome position: 75.12

GC content: 58.37

Gene sequence:

>2037_bases
ATGGCTACGATTCCTGCTGCAACAGCAGCCGCTCAGTCCAGTGACGCCCTCAACCAGACCCATTGGTTCTGGGGCAAGCT
CGGCTGGGACATCTTTCCCTTCTACGATCCAATCATCTTTGGCACCTTTATCGGGACCTGTATCCTTGCGGCCGGGGTGG
TCGGCATAGTGCTCTACTACCGCCTTCTGCCCTATCTGTGGAACGAGTGGTTCACCACGGTGGACCACAAGAAAATCGGC
ATCATGTACATGATCCTTGCGGTTGTGATGTTGGTGCGTGGCTTTGCCGATGCAGTGCTGATGCGGCTGCATCAGGCGCT
GGCCTCGGCGGGATATGTGGGCTTCTTGCCCGCTTATCACTACGATCAGGTCTTTACCGCGCATGGCGTGATCATGATCT
TCTTCGTGGCGATGCCCTTTATCACCGGCTTCATGAACTATGTGATGCCGCTACAGATCGGGGCGCGCGACGTGGCCTTT
CCGTTCCTCAACAACTTCAGCTTCTGGCTGACGGTGTCGGGTGCGGTGCTGATCATGATCTCGCTCTTTGTGGGGGAGTT
TGCCGCGACCGGCTGGCTGGCCTACGCGCCGCTTTCGGGCCTGAAGTTCAGCCCCGGCGTCGGCATGGACTACTACTTGT
GGTCGCTCAACATTGCCGGGATCGGCACCACGCTCTCGGGCATCAACCTCGTTGTGACCCTCGTCAAGATGCGCGCACCG
GGCATGACCTGGATGAAGCTGCCGATTTTCAGCTGGACCACGCTCTGTACCAACATCTTGATTGTTGTGACCTTCCCGGT
CCTCACCGCGACCCTCGCGCTGCTGACTGCGGATCGCTACCTCGGCACCCATTTCTTTACCAATGAGATGGGCGGCAACC
CGATGATGTATGTGAACCTGATCTGGATCTGGGGCCACCCGGAGGTCTACATCCTGATCCTGCCGATCTTTGGGATCTTT
TCCGAGATCGTCGCGACCTTCTGCGGCAAACGCCTCTTTGGCTATGCCTCCATGGTCTATGCGACCTGCGTCATCATGGT
CCTGAGCTACATCGTCTGGCTGCACCACTTCTTTACGATGGGGGCTGGTGCGGATGTGAACTCCTTCTTTGGGATCACAA
CGATGATCATCTCGATCCCCACGGGGGCCAAGCTCTTCAACTGGCTCTTCACCATGTACAAGGGGCGTATCCGCTTTGAA
CTTCCGATGATGTGGACCATCGCCTTTATGCTGACCTTTGTGGTCGGGGGCATGACCGGCGTGCTTCTGGCGGTGCCGCC
TGCGGACTACGTGCTGCATAACTCCTTGTTCCTGATTGCACATTTCCACAATGTGATTATCGGGGGTGTTGTGTTCGGCA
TCTTTGCGGGCATCACCTACTGGTGGCCCAAGGCCTTTGGCTTCCACCTCGATCCTTTCTGGGGCAAGGTCAGCTTCTGG
GGCTGGGTCGGCGGGTTCTGGGTGGCCTTCATGCCGCTCTATCTCCTCGGCCTGATGGGCGTCACCCGTCGTCTGAGCCA
GTTTGAAGACACCATCTATGCGGGGTATTTCTTTACCGCCCTCATCGGCGCGCTGATGATCGCGGTCGGGCTTCTGGCCT
TCCTCGTGCAGATCTTCGTGTCGATCCGCAACCGCGAGAAATTGGCGGTGGGCAATGATCCTTGGGGCGGGCGCACGCTG
GAGTGGTCCACCACCTCGCCGCCGCCCTATTACAACTTTGCCTTCACCCCGCGCGTCTACGAGCGCGACGCCTGGCACCA
TATGAAAACCCATGACGCCAAGGCGCCGACCTCGGGCTTCGTACCGATCCACATGCCGCACTACACGGCAAGCGGGATCA
TTCTGGCGGGGCTGATGACGGTAATGGGCTTTGCACTGGTCTGGCACATCTGGTGGCTCTCGGCGCTGATGTTCCTTGCA
AGCCTCGCCTATGGGATCGCCCATACCTTCAACTATAACCGCGACTATTACGTGCCCGCCGAAGAGGTCTCTGAAATCGA
GACCGGGCAGAGAACAGTCGCCACGCCTGCGGAGTAA

Upstream 100 bases:

>100_bases
CATTCAGGAAGAACAGCAGCGCGAAGACATTCTGCAGGCCATGACCCTGACCTCAGGTGACCTGCTTCCCAATTCCAACA
CAACAGAGGCGAACTGACAC

Downstream 100 bases:

>100_bases
AACATGTCACATTCTGCTGCGACACCCGCCCCAGAGGCGTTGGAGTTCTATGTCACCGAAGATCCCCATGCAGGTCATGG
GGATCACCACCACGACACCG

Product: cytochrome-c oxidase

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 678; Mature: 677

Protein sequence:

>678_residues
MATIPAATAAAQSSDALNQTHWFWGKLGWDIFPFYDPIIFGTFIGTCILAAGVVGIVLYYRLLPYLWNEWFTTVDHKKIG
IMYMILAVVMLVRGFADAVLMRLHQALASAGYVGFLPAYHYDQVFTAHGVIMIFFVAMPFITGFMNYVMPLQIGARDVAF
PFLNNFSFWLTVSGAVLIMISLFVGEFAATGWLAYAPLSGLKFSPGVGMDYYLWSLNIAGIGTTLSGINLVVTLVKMRAP
GMTWMKLPIFSWTTLCTNILIVVTFPVLTATLALLTADRYLGTHFFTNEMGGNPMMYVNLIWIWGHPEVYILILPIFGIF
SEIVATFCGKRLFGYASMVYATCVIMVLSYIVWLHHFFTMGAGADVNSFFGITTMIISIPTGAKLFNWLFTMYKGRIRFE
LPMMWTIAFMLTFVVGGMTGVLLAVPPADYVLHNSLFLIAHFHNVIIGGVVFGIFAGITYWWPKAFGFHLDPFWGKVSFW
GWVGGFWVAFMPLYLLGLMGVTRRLSQFEDTIYAGYFFTALIGALMIAVGLLAFLVQIFVSIRNREKLAVGNDPWGGRTL
EWSTTSPPPYYNFAFTPRVYERDAWHHMKTHDAKAPTSGFVPIHMPHYTASGIILAGLMTVMGFALVWHIWWLSALMFLA
SLAYGIAHTFNYNRDYYVPAEEVSEIETGQRTVATPAE

Sequences:

>Translated_678_residues
MATIPAATAAAQSSDALNQTHWFWGKLGWDIFPFYDPIIFGTFIGTCILAAGVVGIVLYYRLLPYLWNEWFTTVDHKKIG
IMYMILAVVMLVRGFADAVLMRLHQALASAGYVGFLPAYHYDQVFTAHGVIMIFFVAMPFITGFMNYVMPLQIGARDVAF
PFLNNFSFWLTVSGAVLIMISLFVGEFAATGWLAYAPLSGLKFSPGVGMDYYLWSLNIAGIGTTLSGINLVVTLVKMRAP
GMTWMKLPIFSWTTLCTNILIVVTFPVLTATLALLTADRYLGTHFFTNEMGGNPMMYVNLIWIWGHPEVYILILPIFGIF
SEIVATFCGKRLFGYASMVYATCVIMVLSYIVWLHHFFTMGAGADVNSFFGITTMIISIPTGAKLFNWLFTMYKGRIRFE
LPMMWTIAFMLTFVVGGMTGVLLAVPPADYVLHNSLFLIAHFHNVIIGGVVFGIFAGITYWWPKAFGFHLDPFWGKVSFW
GWVGGFWVAFMPLYLLGLMGVTRRLSQFEDTIYAGYFFTALIGALMIAVGLLAFLVQIFVSIRNREKLAVGNDPWGGRTL
EWSTTSPPPYYNFAFTPRVYERDAWHHMKTHDAKAPTSGFVPIHMPHYTASGIILAGLMTVMGFALVWHIWWLSALMFLA
SLAYGIAHTFNYNRDYYVPAEEVSEIETGQRTVATPAE
>Mature_677_residues
ATIPAATAAAQSSDALNQTHWFWGKLGWDIFPFYDPIIFGTFIGTCILAAGVVGIVLYYRLLPYLWNEWFTTVDHKKIGI
MYMILAVVMLVRGFADAVLMRLHQALASAGYVGFLPAYHYDQVFTAHGVIMIFFVAMPFITGFMNYVMPLQIGARDVAFP
FLNNFSFWLTVSGAVLIMISLFVGEFAATGWLAYAPLSGLKFSPGVGMDYYLWSLNIAGIGTTLSGINLVVTLVKMRAPG
MTWMKLPIFSWTTLCTNILIVVTFPVLTATLALLTADRYLGTHFFTNEMGGNPMMYVNLIWIWGHPEVYILILPIFGIFS
EIVATFCGKRLFGYASMVYATCVIMVLSYIVWLHHFFTMGAGADVNSFFGITTMIISIPTGAKLFNWLFTMYKGRIRFEL
PMMWTIAFMLTFVVGGMTGVLLAVPPADYVLHNSLFLIAHFHNVIIGGVVFGIFAGITYWWPKAFGFHLDPFWGKVSFWG
WVGGFWVAFMPLYLLGLMGVTRRLSQFEDTIYAGYFFTALIGALMIAVGLLAFLVQIFVSIRNREKLAVGNDPWGGRTLE
WSTTSPPPYYNFAFTPRVYERDAWHHMKTHDAKAPTSGFVPIHMPHYTASGIILAGLMTVMGFALVWHIWWLSALMFLAS
LAYGIAHTFNYNRDYYVPAEEVSEIETGQRTVATPAE

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=510, Percent_Identity=38.6274509803922, Blast_Score=331, Evalue=2e-90,
Organism=Escherichia coli, GI1786634, Length=655, Percent_Identity=63.3587786259542, Blast_Score=861, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=537, Percent_Identity=36.8715083798883, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6226524, Length=325, Percent_Identity=40.9230769230769, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6226523, Length=336, Percent_Identity=30.6547619047619, Blast_Score=137, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 76054; Mature: 75923

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
ATIPAATAAAQSSDALNQTHWFWGKLGWDIFPFYDPIIFGTFIGTCILAAGVVGIVLYY
CCCCCHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLLPYLWNEWFTTVDHKKIGIMYMILAVVMLVRGFADAVLMRLHQALASAGYVGFLPAYH
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH
YDQVFTAHGVIMIFFVAMPFITGFMNYVMPLQIGARDVAFPFLNNFSFWLTVSGAVLIMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEHHHHHHHHH
SLFVGEFAATGWLAYAPLSGLKFSPGVGMDYYLWSLNIAGIGTTLSGINLVVTLVKMRAP
HHHHHHHHHCCHHHCCCCCCCCCCCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHCCC
GMTWMKLPIFSWTTLCTNILIVVTFPVLTATLALLTADRYLGTHFFTNEMGGNPMMYVNL
CCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
IWIWGHPEVYILILPIFGIFSEIVATFCGKRLFGYASMVYATCVIMVLSYIVWLHHFFTM
EEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GAGADVNSFFGITTMIISIPTGAKLFNWLFTMYKGRIRFELPMMWTIAFMLTFVVGGMTG
CCCCCCHHHHHHHHHEEECCCCHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCHHC
VLLAVPPADYVLHNSLFLIAHFHNVIIGGVVFGIFAGITYWWPKAFGFHLDPFWGKVSFW
EEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHH
GWVGGFWVAFMPLYLLGLMGVTRRLSQFEDTIYAGYFFTALIGALMIAVGLLAFLVQIFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIRNREKLAVGNDPWGGRTLEWSTTSPPPYYNFAFTPRVYERDAWHHMKTHDAKAPTSGF
HHCCCCEEEECCCCCCCCEEECCCCCCCCCCCCEECCCHHHCCHHHHHHCCCCCCCCCCC
VPIHMPHYTASGIILAGLMTVMGFALVWHIWWLSALMFLASLAYGIAHTFNYNRDYYVPA
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCH
EEVSEIETGQRTVATPAE
HHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]