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The map label for this gene is cysG [H]

Identifier: 99082060

GI number: 99082060

Start: 2332088

End: 2332825

Strand: Direct

Name: cysG [H]

Synonym: TM1040_2220

Alternate gene names: 99082060

Gene position: 2332088-2332825 (Clockwise)

Preceding gene: 99082059

Following gene: 99082061

Centisome position: 72.86

GC content: 64.77

Gene sequence:

>738_bases
ATGAGCGGGTTTGTCAGTTTTGTGTCCTCCGGGCCGGGCGATCCCGAGCTTTTGACCCTCAAGGCGGTCAAGCGGCTGGA
GGCGGCTGACGCGGTGCTGTTTGATGATCTGTCGTCCGGGCCGATCCTTTCCCATGCGCGCGCGGATGCGGATATGGTTG
GCGTCGGAAAACGCGCCGGGCGCCCCTCGCCCAAGCAAGACCACGTCAGCCAGCTCTTGGTGGAATACGCCCAGTCCGGC
GCCCATGTGGTGCGTCTGAAATCGGGCGATTCAGGTGTGTTTGGGCGCCTCGAAGAAGAAATGGTGGCGCTGCGCGCCGC
TGGCATCAAATACGAGATCATTCCCGGTGTCACCGCCGCCTCGGCAGCCGCTGCGGCGGCGGGTATTCCGCTCACGCGGC
GGCTGACGGCACGGCGCCTGCAGTTTATCACGGGCCATGACGTGACCGGCGGCCTGCCCGAGCATATGAACCTCACCGCT
CTTGCAGACCCCGAGGCCACAACCGTGGTCTACATGGGCAAACGCACCTTTGCGACTTTGCTTGAGCTGCTTCTTGAGGC
AGGCCTGCCAGAGACCACACCGGCGCTGGTGGCGCTTGGGGTCTCGACCCCCGCCCAAGAGCTGCACCGGGTGACAGTGG
CTGCCCTGCCGGACCTCCTGGAGGCCATCATCTCCCCCGCGCCAGTGTTGATCCTTTATGGCCCCTTGGCCGACGATGAC
GCGCTCGTGTCGCAATGA

Upstream 100 bases:

>100_bases
CCCGGGTGATGGACGCCGACGGCAACCCGGTGCCCGAGACCGGCTCCGTCAAAGGCCATGTCACCGGTACGTTCTTTCAC
CTCATCACCGGAGAGCAGCC

Downstream 100 bases:

>100_bases
CCGCACCGGTGATCTCGCTGTGCCGGACCTGCCAAGATGCCGATCCCGCGCTGCTGCCCCAATTGGCAGCGGCGCTGCGG
GAGGCTCATCCAAGGGCCCT

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MSGFVSFVSSGPGDPELLTLKAVKRLEAADAVLFDDLSSGPILSHARADADMVGVGKRAGRPSPKQDHVSQLLVEYAQSG
AHVVRLKSGDSGVFGRLEEEMVALRAAGIKYEIIPGVTAASAAAAAAGIPLTRRLTARRLQFITGHDVTGGLPEHMNLTA
LADPEATTVVYMGKRTFATLLELLLEAGLPETTPALVALGVSTPAQELHRVTVAALPDLLEAIISPAPVLILYGPLADDD
ALVSQ

Sequences:

>Translated_245_residues
MSGFVSFVSSGPGDPELLTLKAVKRLEAADAVLFDDLSSGPILSHARADADMVGVGKRAGRPSPKQDHVSQLLVEYAQSG
AHVVRLKSGDSGVFGRLEEEMVALRAAGIKYEIIPGVTAASAAAAAAGIPLTRRLTARRLQFITGHDVTGGLPEHMNLTA
LADPEATTVVYMGKRTFATLLELLLEAGLPETTPALVALGVSTPAQELHRVTVAALPDLLEAIISPAPVLILYGPLADDD
ALVSQ
>Mature_244_residues
SGFVSFVSSGPGDPELLTLKAVKRLEAADAVLFDDLSSGPILSHARADADMVGVGKRAGRPSPKQDHVSQLLVEYAQSGA
HVVRLKSGDSGVFGRLEEEMVALRAAGIKYEIIPGVTAASAAAAAAGIPLTRRLTARRLQFITGHDVTGGLPEHMNLTAL
ADPEATTVVYMGKRTFATLLELLLEAGLPETTPALVALGVSTPAQELHRVTVAALPDLLEAIISPAPVLILYGPLADDDA
LVSQ

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=229, Percent_Identity=41.4847161572052, Blast_Score=164, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322922, Length=232, Percent_Identity=29.7413793103448, Blast_Score=86, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 25530; Mature: 25398

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00839 SUMT_1 ; PS00840 SUMT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGFVSFVSSGPGDPELLTLKAVKRLEAADAVLFDDLSSGPILSHARADADMVGVGKRAG
CCCHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHCCCCCCCC
RPSPKQDHVSQLLVEYAQSGAHVVRLKSGDSGVFGRLEEEMVALRAAGIKYEIIPGVTAA
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHH
SAAAAAAGIPLTRRLTARRLQFITGHDVTGGLPEHMNLTALADPEATTVVYMGKRTFATL
HHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHHHH
LELLLEAGLPETTPALVALGVSTPAQELHRVTVAALPDLLEAIISPAPVLILYGPLADDD
HHHHHHCCCCCCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
ALVSQ
HHCCC
>Mature Secondary Structure 
SGFVSFVSSGPGDPELLTLKAVKRLEAADAVLFDDLSSGPILSHARADADMVGVGKRAG
CCHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHCCCCCCCC
RPSPKQDHVSQLLVEYAQSGAHVVRLKSGDSGVFGRLEEEMVALRAAGIKYEIIPGVTAA
CCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEECCCHHH
SAAAAAAGIPLTRRLTARRLQFITGHDVTGGLPEHMNLTALADPEATTVVYMGKRTFATL
HHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCEEEEEECCHHHHHH
LELLLEAGLPETTPALVALGVSTPAQELHRVTVAALPDLLEAIISPAPVLILYGPLADDD
HHHHHHCCCCCCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCH
ALVSQ
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA