Click here to switch to the map view.

The map label for this gene is ribD [H]

Identifier: 99081975

GI number: 99081975

Start: 2241583

End: 2242659

Strand: Reverse

Name: ribD [H]

Synonym: TM1040_2135

Alternate gene names: 99081975

Gene position: 2242659-2241583 (Counterclockwise)

Preceding gene: 99081976

Following gene: 99081971

Centisome position: 70.06

GC content: 66.57

Gene sequence:

>1077_bases
ATGGGGCTCGCCCTGTCGCTCGGGCGGCGAGGGCAGGGTCGGACTTGGCCAAACCCGGCGGTCGGCTGTGTAATTGTCCA
AAAGGGTCGCGTGGTGGGCCGGGGCTGGACCCAGCCCGGAGGCCGTCCCCACGCCGAACCCATGGCGCTGGCGCAGGCGG
GAGCCGCAGCGCGCGGCGCCACTGCCTATGTGAGCCTCGAACCCTGTGCCCATCACGGCAAAACCCCCCCCTGCGCGCAA
GCGCTGATCGAGGCCGGTGTTGCCCGTGTCGTCGCCGCCATCGAAGACAGCGACCCGCGTGTCAGCGGTCAGGGCTTTGA
GATGCTGCGCGCGGCGGGGATTTCCGTTACCACCGGAGTGCGCGCCGAGGAAGCTGGCTTTGATCACGAAGGGTTCTTTC
TAAAAACGGAACAGGGCCGCCCTTTTGTGACGCTGAAACTCGCCGCGAGTTTTGATGGTCGTATTGCCACCGGCTCCGGT
CAAAGCCAGTGGATCACCGGGCCGGAGGCGCGCCGTGTGGTGCATGCGATGCGTGCGCGTCACGATGCTGTCATGGTCGG
GGCAGGGACGGCACGCGCGGATGACCCTTCGCTCACCGTGCGCGATCTGGGGATTGACCAGCAGCCGGCGCGGGTGGTGG
TCTCGCGCCATCTTGACCTGCCGCTCATCAGCAAGCTTGCGCGCAGCGCAGCGGAGGTCCCGCTCTATCTTTGCCATGGC
ACAGGCGCGGATACCGAACGTCTGCGGGCCTGGGACGGGCTGGGAGCGCATCTGTTGCCGTGCAACGCTCTTGGCACCCA
GCTTGACCCGCATGATGTGCTGCAGCAACTGGGCAGCGTAGGACTCACACGCGTGTTCTGCGAAGGAGGAGGCGCGCTGG
CGGCCAGCCTGCTGGCGCATGACCTCGTGGATGAGTTGGTGGGCTTCAGTGCTGGTCTGACGATCGGTGCCGAAGGGCTG
CCCTCCATCGGGGCGCTTGGCATTGGCCACCTTTCAGAGGCCCCAAGGTTCGACCTTCATGAGACACGCCCGATTGGCGC
CGACATCCTGCACCGCTGGCGTCGCCCTCAGAACTGA

Upstream 100 bases:

>100_bases
CCCCCCTGCGCCGCCCGAGAGCTGAGATCCCGGCCTCGCTGCCTGCGCAGAGTCTGGCAAAAGGTCTGATCCATTGAGCA
AAAGCGACGACCACCGTTTT

Downstream 100 bases:

>100_bases
GCGGATAGCGCAGGCTTTCTTCTAACTCAAATATCCCGGAGCGCGAGGCAGCGCCTCGCTTCCCCCTCAGCGCCAGAGCG
GAGCAAATGAGGCAAAGAGC

Product: 5-amino-6-(5-phosphoribosylamino)uracil reductase / diaminohydroxyphosphoribosylaminopyrimidine deaminase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MGLALSLGRRGQGRTWPNPAVGCVIVQKGRVVGRGWTQPGGRPHAEPMALAQAGAAARGATAYVSLEPCAHHGKTPPCAQ
ALIEAGVARVVAAIEDSDPRVSGQGFEMLRAAGISVTTGVRAEEAGFDHEGFFLKTEQGRPFVTLKLAASFDGRIATGSG
QSQWITGPEARRVVHAMRARHDAVMVGAGTARADDPSLTVRDLGIDQQPARVVVSRHLDLPLISKLARSAAEVPLYLCHG
TGADTERLRAWDGLGAHLLPCNALGTQLDPHDVLQQLGSVGLTRVFCEGGGALAASLLAHDLVDELVGFSAGLTIGAEGL
PSIGALGIGHLSEAPRFDLHETRPIGADILHRWRRPQN

Sequences:

>Translated_358_residues
MGLALSLGRRGQGRTWPNPAVGCVIVQKGRVVGRGWTQPGGRPHAEPMALAQAGAAARGATAYVSLEPCAHHGKTPPCAQ
ALIEAGVARVVAAIEDSDPRVSGQGFEMLRAAGISVTTGVRAEEAGFDHEGFFLKTEQGRPFVTLKLAASFDGRIATGSG
QSQWITGPEARRVVHAMRARHDAVMVGAGTARADDPSLTVRDLGIDQQPARVVVSRHLDLPLISKLARSAAEVPLYLCHG
TGADTERLRAWDGLGAHLLPCNALGTQLDPHDVLQQLGSVGLTRVFCEGGGALAASLLAHDLVDELVGFSAGLTIGAEGL
PSIGALGIGHLSEAPRFDLHETRPIGADILHRWRRPQN
>Mature_357_residues
GLALSLGRRGQGRTWPNPAVGCVIVQKGRVVGRGWTQPGGRPHAEPMALAQAGAAARGATAYVSLEPCAHHGKTPPCAQA
LIEAGVARVVAAIEDSDPRVSGQGFEMLRAAGISVTTGVRAEEAGFDHEGFFLKTEQGRPFVTLKLAASFDGRIATGSGQ
SQWITGPEARRVVHAMRARHDAVMVGAGTARADDPSLTVRDLGIDQQPARVVVSRHLDLPLISKLARSAAEVPLYLCHGT
GADTERLRAWDGLGAHLLPCNALGTQLDPHDVLQQLGSVGLTRVFCEGGGALAASLLAHDLVDELVGFSAGLTIGAEGLP
SIGALGIGHLSEAPRFDLHETRPIGADILHRWRRPQN

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG0117

COG function: function code H; Pyrimidine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=355, Percent_Identity=41.6901408450704, Blast_Score=258, Evalue=5e-70,
Organism=Escherichia coli, GI145693172, Length=152, Percent_Identity=34.8684210526316, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 37547; Mature: 37416

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLALSLGRRGQGRTWPNPAVGCVIVQKGRVVGRGWTQPGGRPHAEPMALAQAGAAARGA
CCCEECCCCCCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCHHHHHHHCCCCCCC
TAYVSLEPCAHHGKTPPCAQALIEAGVARVVAAIEDSDPRVSGQGFEMLRAAGISVTTGV
EEEEEECHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEECCC
RAEEAGFDHEGFFLKTEQGRPFVTLKLAASFDGRIATGSGQSQWITGPEARRVVHAMRAR
CHHHCCCCCCCEEEEECCCCCEEEEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHC
HDAVMVGAGTARADDPSLTVRDLGIDQQPARVVVSRHLDLPLISKLARSAAEVPLYLCHG
CCEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEC
TGADTERLRAWDGLGAHLLPCNALGTQLDPHDVLQQLGSVGLTRVFCEGGGALAASLLAH
CCCCHHHHHHHCCCCCEEEECHHHCCCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHHH
DLVDELVGFSAGLTIGAEGLPSIGALGIGHLSEAPRFDLHETRPIGADILHRWRRPQN
HHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
GLALSLGRRGQGRTWPNPAVGCVIVQKGRVVGRGWTQPGGRPHAEPMALAQAGAAARGA
CCEECCCCCCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCHHHHHHHCCCCCCC
TAYVSLEPCAHHGKTPPCAQALIEAGVARVVAAIEDSDPRVSGQGFEMLRAAGISVTTGV
EEEEEECHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCEEECCC
RAEEAGFDHEGFFLKTEQGRPFVTLKLAASFDGRIATGSGQSQWITGPEARRVVHAMRAR
CHHHCCCCCCCEEEEECCCCCEEEEEEEECCCCEEEECCCCCCCCCCHHHHHHHHHHHHC
HDAVMVGAGTARADDPSLTVRDLGIDQQPARVVVSRHLDLPLISKLARSAAEVPLYLCHG
CCEEEEECCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEC
TGADTERLRAWDGLGAHLLPCNALGTQLDPHDVLQQLGSVGLTRVFCEGGGALAASLLAH
CCCCHHHHHHHCCCCCEEEECHHHCCCCCHHHHHHHHHHCCEEEEEECCCHHHHHHHHHH
DLVDELVGFSAGLTIGAEGLPSIGALGIGHLSEAPRFDLHETRPIGADILHRWRRPQN
HHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]