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The map label for this gene is cyaA [H]

Identifier: 99081964

GI number: 99081964

Start: 2228973

End: 2230523

Strand: Direct

Name: cyaA [H]

Synonym: TM1040_2124

Alternate gene names: 99081964

Gene position: 2228973-2230523 (Clockwise)

Preceding gene: 99081961

Following gene: 99081972

Centisome position: 69.63

GC content: 60.99

Gene sequence:

>1551_bases
ATGAAGATCACCCGCCGCATCGGCCGTTTTCTGGTCAACCAGCCGCATCTGATCAACTGGGGCATCGGCGCCGCGATTGT
TGCCCTGCCCGTGGTGGTCTGGATGGACCTGATGGCGATCACCGATCAATCGCTGCGCCGCCAGGGACAGGCTCTGGACG
CGGTCTTGGACACCGTGCGCAGCTATTATGCCCGCAATGTGATTGGCCGCTTGAATCCGGACGGGTCGACCTTTGCCACC
CACGACTATCACGACCGTGACGGGGCCATCCCGATCCCCGCGACCATGGCGATCGAGCTCGGCGATCAGATCGGCACCCA
TGGTCTGAACGTGCAGTACCGATTTGCCTCGGACTATCCCTTTCATGGCCGCGAGACGACAGAGCTGACCTGGGCGGAGG
ATCACGCGCTGAGCCGGTTTCGCGAGGGGGTGGACGATCACTACCTGTTCTACCGGGGCGAAGAATCCGGGCTGCTGACA
CATGCAGTAACGATGATCACTCCTGTGGTGATGGAAGAGGCCTGCGTTGCCTGCCACAACAACCACTCCGACAGCCCCAA
AACCGATTGGGCGGTTGGCGACATTCGCGGCGTGCAGTCCTACAGCATTGTGCAGCCGGTGGCGGTGAGCCTGTTCTCCT
TTAGCCACCTGCTGGCCTATATGGTGGTCGCTGGCGGCTTTGGTGCGTTTTTTGCACTGCATCAACTGCGACTGGCACAG
CGGTTTCGCAAGATAAGCGAGGAGCTGTCCTCCAACAATGAATTCCTCGCCGGGATCTCGATGAAGATCTCGCGCTACCT
GTCGCCGCAGGTCTATCGGTCGATCTTCTCCGGCGAAAAGGACGCCTCGATCTCCACCGAACGCAAAAAACTGACGGTGT
TCTTTTCCGACATCAAGGATTTCACCCAGACGGCAGAGACCTTGCAGCCGGAGGAGCTGACGGCGCTTCTGAACGAGTAT
TTCACCGAGATGTCCGCCATCGCGGCCAAACATGGGGCGACCATCGACAAGTTCATCGGCGATGCCATCGTGGCCTTCTT
TGGTGATCCTGAAACGCTGGGCACTGCTGAGGACGCGCGGGCTTGCGTGCGGATGGCGCTGGAGATGCAGGAGCGTTTGA
GAGAGCTGGAAAAAGAATGGCGCGCGCGTGGCATCGACAGGCCTTTCCGGGCGCGCATCGGTATCAACACGGGCTATTGC
AACGTCGGCAACTTCGGTTCGGAAGAACGGATGGATTACACCATCATCGGCGCGGAGGCCAATCTGGCCGCCCGCCTGGA
GGCGGCAGCGGAACCGGGAGGCATCGTGATGAGCCATGAGACTTATGCCCATGTGCGCGACTTCGTGGCTGCCACCCCCA
TGCCGCCGATGCAGTTCAAGGGCATCACGCGCGACGTGCATCCCTATGCCATCGCGCCGGGGCAATCGGGCAACCTGCCA
CCCACCGAGACCAGCATGGACGGCAAAAGCCTAACCGTGCATTTGGAGCGGCTCGACGACACCACGCGCGCGCAGCTGGA
GGCGATCCTCGGCAAGCCGCTGAAAGGCTGA

Upstream 100 bases:

>100_bases
GCTGCGTATAATCTGAACCATTGCGCAGGCATCCGCTTGCCAAAGCAGGAGCAAACCCGTGAACGCAGAGCTCAAGGAAA
GGCACAGGGACGCGACAGAT

Downstream 100 bases:

>100_bases
CCGATCCGCCCTGTCCAGACTGACCCTATCCGCAAACCCAAATGCAAAACGGCGCCCCCGCATGGGAGGCGCCGTTTCTG
TTTTCCGTGATCTGAGGGCC

Product: adenylate/guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MKITRRIGRFLVNQPHLINWGIGAAIVALPVVVWMDLMAITDQSLRRQGQALDAVLDTVRSYYARNVIGRLNPDGSTFAT
HDYHDRDGAIPIPATMAIELGDQIGTHGLNVQYRFASDYPFHGRETTELTWAEDHALSRFREGVDDHYLFYRGEESGLLT
HAVTMITPVVMEEACVACHNNHSDSPKTDWAVGDIRGVQSYSIVQPVAVSLFSFSHLLAYMVVAGGFGAFFALHQLRLAQ
RFRKISEELSSNNEFLAGISMKISRYLSPQVYRSIFSGEKDASISTERKKLTVFFSDIKDFTQTAETLQPEELTALLNEY
FTEMSAIAAKHGATIDKFIGDAIVAFFGDPETLGTAEDARACVRMALEMQERLRELEKEWRARGIDRPFRARIGINTGYC
NVGNFGSEERMDYTIIGAEANLAARLEAAAEPGGIVMSHETYAHVRDFVAATPMPPMQFKGITRDVHPYAIAPGQSGNLP
PTETSMDGKSLTVHLERLDDTTRAQLEAILGKPLKG

Sequences:

>Translated_516_residues
MKITRRIGRFLVNQPHLINWGIGAAIVALPVVVWMDLMAITDQSLRRQGQALDAVLDTVRSYYARNVIGRLNPDGSTFAT
HDYHDRDGAIPIPATMAIELGDQIGTHGLNVQYRFASDYPFHGRETTELTWAEDHALSRFREGVDDHYLFYRGEESGLLT
HAVTMITPVVMEEACVACHNNHSDSPKTDWAVGDIRGVQSYSIVQPVAVSLFSFSHLLAYMVVAGGFGAFFALHQLRLAQ
RFRKISEELSSNNEFLAGISMKISRYLSPQVYRSIFSGEKDASISTERKKLTVFFSDIKDFTQTAETLQPEELTALLNEY
FTEMSAIAAKHGATIDKFIGDAIVAFFGDPETLGTAEDARACVRMALEMQERLRELEKEWRARGIDRPFRARIGINTGYC
NVGNFGSEERMDYTIIGAEANLAARLEAAAEPGGIVMSHETYAHVRDFVAATPMPPMQFKGITRDVHPYAIAPGQSGNLP
PTETSMDGKSLTVHLERLDDTTRAQLEAILGKPLKG
>Mature_516_residues
MKITRRIGRFLVNQPHLINWGIGAAIVALPVVVWMDLMAITDQSLRRQGQALDAVLDTVRSYYARNVIGRLNPDGSTFAT
HDYHDRDGAIPIPATMAIELGDQIGTHGLNVQYRFASDYPFHGRETTELTWAEDHALSRFREGVDDHYLFYRGEESGLLT
HAVTMITPVVMEEACVACHNNHSDSPKTDWAVGDIRGVQSYSIVQPVAVSLFSFSHLLAYMVVAGGFGAFFALHQLRLAQ
RFRKISEELSSNNEFLAGISMKISRYLSPQVYRSIFSGEKDASISTERKKLTVFFSDIKDFTQTAETLQPEELTALLNEY
FTEMSAIAAKHGATIDKFIGDAIVAFFGDPETLGTAEDARACVRMALEMQERLRELEKEWRARGIDRPFRARIGINTGYC
NVGNFGSEERMDYTIIGAEANLAARLEAAAEPGGIVMSHETYAHVRDFVAATPMPPMQFKGITRDVHPYAIAPGQSGNLP
PTETSMDGKSLTVHLERLDDTTRAQLEAILGKPLKG

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI4557255, Length=189, Percent_Identity=29.1005291005291, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI24497587, Length=153, Percent_Identity=31.3725490196078, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI115387102, Length=156, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI148536830, Length=154, Percent_Identity=29.8701298701299, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193206632, Length=160, Percent_Identity=35, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17534657, Length=188, Percent_Identity=29.2553191489362, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17534655, Length=155, Percent_Identity=33.5483870967742, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193207841, Length=207, Percent_Identity=28.5024154589372, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281365507, Length=152, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281365509, Length=152, Percent_Identity=31.5789473684211, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 57300; Mature: 57300

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITRRIGRFLVNQPHLINWGIGAAIVALPVVVWMDLMAITDQSLRRQGQALDAVLDTVR
CCHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYYARNVIGRLNPDGSTFATHDYHDRDGAIPIPATMAIELGDQIGTHGLNVQYRFASDYP
HHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCHHHEEECCHHCCCCCCCEEEEECCCCC
FHGRETTELTWAEDHALSRFREGVDDHYLFYRGEESGLLTHAVTMITPVVMEEACVACHN
CCCCCCCEEEEHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
NHSDSPKTDWAVGDIRGVQSYSIVQPVAVSLFSFSHLLAYMVVAGGFGAFFALHQLRLAQ
CCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RFRKISEELSSNNEFLAGISMKISRYLSPQVYRSIFSGEKDASISTERKKLTVFFSDIKD
HHHHHHHHHCCCCCEEEHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHH
FTQTAETLQPEELTALLNEYFTEMSAIAAKHGATIDKFIGDAIVAFFGDPETLGTAEDAR
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHCCCHHHHH
ACVRMALEMQERLRELEKEWRARGIDRPFRARIGINTGYCNVGNFGSEERMDYTIIGAEA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCC
NLAARLEAAAEPGGIVMSHETYAHVRDFVAATPMPPMQFKGITRDVHPYAIAPGQSGNLP
CHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEECCCCCCCCC
PTETSMDGKSLTVHLERLDDTTRAQLEAILGKPLKG
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKITRRIGRFLVNQPHLINWGIGAAIVALPVVVWMDLMAITDQSLRRQGQALDAVLDTVR
CCHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SYYARNVIGRLNPDGSTFATHDYHDRDGAIPIPATMAIELGDQIGTHGLNVQYRFASDYP
HHHHHHHHHCCCCCCCEECCCCCCCCCCCCCCCHHHEEECCHHCCCCCCCEEEEECCCCC
FHGRETTELTWAEDHALSRFREGVDDHYLFYRGEESGLLTHAVTMITPVVMEEACVACHN
CCCCCCCEEEEHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCC
NHSDSPKTDWAVGDIRGVQSYSIVQPVAVSLFSFSHLLAYMVVAGGFGAFFALHQLRLAQ
CCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RFRKISEELSSNNEFLAGISMKISRYLSPQVYRSIFSGEKDASISTERKKLTVFFSDIKD
HHHHHHHHHCCCCCEEEHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHH
FTQTAETLQPEELTALLNEYFTEMSAIAAKHGATIDKFIGDAIVAFFGDPETLGTAEDAR
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHCCCHHHHH
ACVRMALEMQERLRELEKEWRARGIDRPFRARIGINTGYCNVGNFGSEERMDYTIIGAEA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCC
NLAARLEAAAEPGGIVMSHETYAHVRDFVAATPMPPMQFKGITRDVHPYAIAPGQSGNLP
CHHHHHHHCCCCCCEEEECHHHHHHHHHHHCCCCCCHHHCCCCCCCCCEEECCCCCCCCC
PTETSMDGKSLTVHLERLDDTTRAQLEAILGKPLKG
CCCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]