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The map label for this gene is atpA

Identifier: 99081928

GI number: 99081928

Start: 2191586

End: 2193127

Strand: Reverse

Name: atpA

Synonym: TM1040_2088

Alternate gene names: 99081928

Gene position: 2193127-2191586 (Counterclockwise)

Preceding gene: 99081929

Following gene: 99081927

Centisome position: 68.52

GC content: 60.12

Gene sequence:

>1542_bases
ATGGGTATCCAAGCAGCGGAAATTTCCGCGATCCTTAAAGACCAGATCAAGAATTTTGGTCAAGAAGCCGAAGTGGCCGA
GATTGGTCGCGTGCTCTCCGTCGGTGACGGTATTGCCCGTGTCTATGGCCTCGACAACGTCCAGGCGGGCGAAATGGTCG
AATTCCCCGGCGGCATCATGGGTATGGCGCTGAACCTGGAATCCGACAACGTCGGTGTGGTTATCTTCGGCTCCGACCGC
GACATTAAAGAAGGCGACACCGTCAAGCGCACCAACTCCATCGTGGACGTGCCTGCTGGTCCCGAGCTTCTGGGTCGCGT
TGTCGACGGCCTCGGCAACCCGCTCGACGGCAAAGGCCCGATCGAAGCCAAAGAGCGCAAGGTTGCAGACGTCAAAGCGC
CGGGCATCATCCCGCGTAAATCCGTGCACGAGCCGATGGCAACCGGCCTCAAGTCCGTGGACGCGATGATCCCCGTTGGC
CGTGGCCAGCGCGAGCTGATCATTGGTGACCGTCAGACCGGTAAGACCGCGATCGCTCTGGACACCATCCTGAACCAGAA
GTCCTACAACGACGCTGCAGGCGACGACGACTCCAAGAAACTCTACTGCGTCTACGTTGCTGTGGGTCAGAAGCGTTCCA
CCGTGGCGCAGCTGGTGAAAAAGCTCGAAGAGTCCGGCGCGATGGAATACTCCATCGTTGTGGCCGCAACCGCGTCCGAC
CCGGCACCGATGCAGTTCCTTGCCCCCTACGCGGCGACCGCGATGGCCGAATACTTCCGCGACAGCGGCAAGCACGCGCT
CATCATCTATGATGACCTCTCCAAGCAGGCTGTGGCCTATCGTCAGATGTCCCTGCTGCTGCGCCGCCCGCCGGGCCGTG
AAGCTTATCCGGGTGACGTTTTCTACCTCCACTCCCGTCTGCTCGAGCGTTCCGCAAAGCTGAACGAAGACTTCGGTGCA
GGCTCGCTGACCGCGCTGCCGATCATCGAAACCCAGGGCGGCGACGTGTCTGCGTTTATTCCGACCAACGTGATCTCCAT
CACCGACGGTCAGATCTTCCTTGAGACCGAACTGTTCTACCAGGGCATCCGCCCCGCCGTGAACACCGGTCTGTCGGTTT
CGCGTGTGGGCTCCTCGGCTCAGACCGATGCGATGTCTTCCGTTGCGGGCCCTGTGAAACTGTCCCTGGCTCAGTACCGC
GAAATGGCGGCCTTTGCGCAGTTCGGTTCCGACCTCGACGCCGCAACCCAGCAGCTGCTGGCCCGTGGCGCGCGTCTCAC
CGAGCTGATGAAACAGCCGCAGTATTCGCCGCTCACCAACTCTGAAATCGTCTGCATCATCTTCGCGGGCACCAACGGCT
ACCTCGACAAAGTCGACGTCAAGGAAGTGGGTCGTTATGAAGCCGAGCTTCTGACCTTCCTGCGCTCCAAGAAGGCCGAC
TTCCTGCAGTGGATCACCGATGAGGATCCCAAGTTCAAGAAGGGTGAACCGGTCGAGAAGATGAAGGCTGTTCTGGACGA
ATTCGCAGCAGACTTCGCGTAA

Upstream 100 bases:

>100_bases
CATCGGCGGTCTCGTCGTTAAAGTGGGCTCGAAGATGATCGACAGTTCGATCCGCTCCAAGCTCAACTCCCTACAGAATG
CAATGAAAGAGGTCGGATAA

Downstream 100 bases:

>100_bases
GGAGAGAGACAGCACATGCCTTCTCTCAAGGACCTAAAAAACCGGATCTCGAGTGTGAAAAACACTCGTAAGATCACCAA
AGCCATGCAGATGGTCGCGG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MGIQAAEISAILKDQIKNFGQEAEVAEIGRVLSVGDGIARVYGLDNVQAGEMVEFPGGIMGMALNLESDNVGVVIFGSDR
DIKEGDTVKRTNSIVDVPAGPELLGRVVDGLGNPLDGKGPIEAKERKVADVKAPGIIPRKSVHEPMATGLKSVDAMIPVG
RGQRELIIGDRQTGKTAIALDTILNQKSYNDAAGDDDSKKLYCVYVAVGQKRSTVAQLVKKLEESGAMEYSIVVAATASD
PAPMQFLAPYAATAMAEYFRDSGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERSAKLNEDFGA
GSLTALPIIETQGGDVSAFIPTNVISITDGQIFLETELFYQGIRPAVNTGLSVSRVGSSAQTDAMSSVAGPVKLSLAQYR
EMAAFAQFGSDLDAATQQLLARGARLTELMKQPQYSPLTNSEIVCIIFAGTNGYLDKVDVKEVGRYEAELLTFLRSKKAD
FLQWITDEDPKFKKGEPVEKMKAVLDEFAADFA

Sequences:

>Translated_513_residues
MGIQAAEISAILKDQIKNFGQEAEVAEIGRVLSVGDGIARVYGLDNVQAGEMVEFPGGIMGMALNLESDNVGVVIFGSDR
DIKEGDTVKRTNSIVDVPAGPELLGRVVDGLGNPLDGKGPIEAKERKVADVKAPGIIPRKSVHEPMATGLKSVDAMIPVG
RGQRELIIGDRQTGKTAIALDTILNQKSYNDAAGDDDSKKLYCVYVAVGQKRSTVAQLVKKLEESGAMEYSIVVAATASD
PAPMQFLAPYAATAMAEYFRDSGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERSAKLNEDFGA
GSLTALPIIETQGGDVSAFIPTNVISITDGQIFLETELFYQGIRPAVNTGLSVSRVGSSAQTDAMSSVAGPVKLSLAQYR
EMAAFAQFGSDLDAATQQLLARGARLTELMKQPQYSPLTNSEIVCIIFAGTNGYLDKVDVKEVGRYEAELLTFLRSKKAD
FLQWITDEDPKFKKGEPVEKMKAVLDEFAADFA
>Mature_512_residues
GIQAAEISAILKDQIKNFGQEAEVAEIGRVLSVGDGIARVYGLDNVQAGEMVEFPGGIMGMALNLESDNVGVVIFGSDRD
IKEGDTVKRTNSIVDVPAGPELLGRVVDGLGNPLDGKGPIEAKERKVADVKAPGIIPRKSVHEPMATGLKSVDAMIPVGR
GQRELIIGDRQTGKTAIALDTILNQKSYNDAAGDDDSKKLYCVYVAVGQKRSTVAQLVKKLEESGAMEYSIVVAATASDP
APMQFLAPYAATAMAEYFRDSGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERSAKLNEDFGAG
SLTALPIIETQGGDVSAFIPTNVISITDGQIFLETELFYQGIRPAVNTGLSVSRVGSSAQTDAMSSVAGPVKLSLAQYRE
MAAFAQFGSDLDAATQQLLARGARLTELMKQPQYSPLTNSEIVCIIFAGTNGYLDKVDVKEVGRYEAELLTFLRSKKADF
LQWITDEDPKFKKGEPVEKMKAVLDEFAADFA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=507, Percent_Identity=68.0473372781065, Blast_Score=710, Evalue=0.0,
Organism=Homo sapiens, GI4757810, Length=507, Percent_Identity=68.0473372781065, Blast_Score=710, Evalue=0.0,
Organism=Homo sapiens, GI19913426, Length=351, Percent_Identity=28.4900284900285, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI19913428, Length=303, Percent_Identity=29.042904290429, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI32189394, Length=325, Percent_Identity=24.3076923076923, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI19913424, Length=250, Percent_Identity=26.4, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1790172, Length=521, Percent_Identity=54.126679462572, Blast_Score=554, Evalue=1e-159,
Organism=Escherichia coli, GI1788251, Length=279, Percent_Identity=30.1075268817204, Blast_Score=109, Evalue=5e-25,
Organism=Escherichia coli, GI1790170, Length=426, Percent_Identity=24.6478873239437, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71988063, Length=511, Percent_Identity=67.9060665362035, Blast_Score=709, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988080, Length=487, Percent_Identity=70.2258726899384, Blast_Score=707, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71988074, Length=511, Percent_Identity=63.2093933463796, Blast_Score=645, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17510931, Length=340, Percent_Identity=27.9411764705882, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17570191, Length=330, Percent_Identity=26.3636363636364, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71988068, Length=79, Percent_Identity=56.9620253164557, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25144756, Length=328, Percent_Identity=24.0853658536585, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=68, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17565854, Length=266, Percent_Identity=25.5639097744361, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=509, Percent_Identity=67.5834970530452, Blast_Score=718, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=334, Percent_Identity=29.0419161676647, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322581, Length=384, Percent_Identity=24.21875, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24658560, Length=509, Percent_Identity=66.9941060903733, Blast_Score=704, Evalue=0.0,
Organism=Drosophila melanogaster, GI281361666, Length=334, Percent_Identity=28.7425149700599, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24646341, Length=334, Percent_Identity=28.7425149700599, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136796, Length=334, Percent_Identity=28.7425149700599, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24638766, Length=388, Percent_Identity=23.4536082474227, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI28574560, Length=406, Percent_Identity=23.8916256157635, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI20129479, Length=251, Percent_Identity=28.2868525896414, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24583988, Length=267, Percent_Identity=25.0936329588015, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583986, Length=267, Percent_Identity=25.0936329588015, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583984, Length=267, Percent_Identity=25.0936329588015, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583992, Length=267, Percent_Identity=25.0936329588015, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_SILST (Q1GEU6)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_614082.1
- ProteinModelPortal:   Q1GEU6
- SMR:   Q1GEU6
- STRING:   Q1GEU6
- GeneID:   4077839
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_2088
- NMPDR:   fig|292414.1.peg.457
- eggNOG:   COG0056
- HOGENOM:   HBG565875
- OMA:   GSDRDIK
- PhylomeDB:   Q1GEU6
- ProtClustDB:   PRK09281
- BioCyc:   SSP292414:TM1040_2088-MONOMER
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55330; Mature: 55199

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIQAAEISAILKDQIKNFGQEAEVAEIGRVLSVGDGIARVYGLDNVQAGEMVEFPGGIM
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHCCCCCCCCCCEEECCCCEE
GMALNLESDNVGVVIFGSDRDIKEGDTVKRTNSIVDVPAGPELLGRVVDGLGNPLDGKGP
EEEEEECCCCEEEEEECCCCCCCCCCCEECCCCEEECCCCHHHHHHHHHHCCCCCCCCCC
IEAKERKVADVKAPGIIPRKSVHEPMATGLKSVDAMIPVGRGQRELIIGDRQTGKTAIAL
CCHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEH
DTILNQKSYNDAAGDDDSKKLYCVYVAVGQKRSTVAQLVKKLEESGAMEYSIVVAATASD
HHHHCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCC
PAPMQFLAPYAATAMAEYFRDSGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDV
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHH
FYLHSRLLERSAKLNEDFGAGSLTALPIIETQGGDVSAFIPTNVISITDGQIFLETELFY
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEECCCEEEEECCEEEEEHHHHH
QGIRPAVNTGLSVSRVGSSAQTDAMSSVAGPVKLSLAQYREMAAFAQFGSDLDAATQQLL
HCCCHHHHCCCCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ARGARLTELMKQPQYSPLTNSEIVCIIFAGTNGYLDKVDVKEVGRYEAELLTFLRSKKAD
HCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
FLQWITDEDPKFKKGEPVEKMKAVLDEFAADFA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GIQAAEISAILKDQIKNFGQEAEVAEIGRVLSVGDGIARVYGLDNVQAGEMVEFPGGIM
CCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHCCCCCCCCCCEEECCCCEE
GMALNLESDNVGVVIFGSDRDIKEGDTVKRTNSIVDVPAGPELLGRVVDGLGNPLDGKGP
EEEEEECCCCEEEEEECCCCCCCCCCCEECCCCEEECCCCHHHHHHHHHHCCCCCCCCCC
IEAKERKVADVKAPGIIPRKSVHEPMATGLKSVDAMIPVGRGQRELIIGDRQTGKTAIAL
CCHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEH
DTILNQKSYNDAAGDDDSKKLYCVYVAVGQKRSTVAQLVKKLEESGAMEYSIVVAATASD
HHHHCCCCCCCCCCCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEEECCC
PAPMQFLAPYAATAMAEYFRDSGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDV
CCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHH
FYLHSRLLERSAKLNEDFGAGSLTALPIIETQGGDVSAFIPTNVISITDGQIFLETELFY
HHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEECCCEEEEECCEEEEEHHHHH
QGIRPAVNTGLSVSRVGSSAQTDAMSSVAGPVKLSLAQYREMAAFAQFGSDLDAATQQLL
HCCCHHHHCCCCHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ARGARLTELMKQPQYSPLTNSEIVCIIFAGTNGYLDKVDVKEVGRYEAELLTFLRSKKAD
HCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCHH
FLQWITDEDPKFKKGEPVEKMKAVLDEFAADFA
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA