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The map label for this gene is siaT [H]

Identifier: 99081907

GI number: 99081907

Start: 2170824

End: 2172110

Strand: Reverse

Name: siaT [H]

Synonym: TM1040_2067

Alternate gene names: 99081907

Gene position: 2172110-2170824 (Counterclockwise)

Preceding gene: 99081908

Following gene: 99081906

Centisome position: 67.86

GC content: 59.98

Gene sequence:

>1287_bases
ATGATTATTCTCGGCAGTCTTTTTATCCTGTGTGTGCTGCTCCTCATTGGGGTGAGCGTGCCTCTGGCCTTTGGTGGCGT
GCTGGTCTTTATCGGCGTCTTTGGCGGCCATGATGTGACCGGGTTCCTGCCCACGGGGCACTGGAAGATGAATTCCATCG
TGCTGCTTGCGATTCCGCTGTTCATTCTGGCAGGTGCTATCATGGAGCGGGGGCGGATCGCGGCGCCGCTGGTGTCGGTG
GCGGAGCTTCTGGTGGGGCGCATCCACGGGGGGCTCAGCGCGGCGGCGGTGTTCGCCAGCGGTATCTTCGGCTCGATCTC
GGGCTCTGCGGCGGCGACGCTGACCTGTATCGGGTCGATTATGATGCCGCACCTGAAGGCCGCGAATTACCCGCGCGGCC
CGGCGGCGGCGCTGATTGTGGCGGCCTGTCCCTTGGGGCTCCTGATCCCGCCGTCGTCGTCGCAGATCCTTTATGCGTGG
GTGGCGCAGCAATCGGTGCTGAAGTGTTTCCTTTCGACCGTGGTGCCGGGGCTTATCCTGATTACGCTTTTGTGCATGGT
GAACTACGTACTGATGCGCAAGGCGGACCTGAAACTGCTCGAACGCCCGGCAAGCTACCCGCAGGAATTCGTGCGCCGCG
GTGGGCGGGCCTTTCCGGCGCTGTTGATGCCGATCATCATTCTTGGCGGTATCTACGGCGGCATCATGACCCCGACCGAG
GCCGCAGGCGTGGCGGTGATCTATGCCATTCCCGTTGGCCTGTTCATCTATCGCGGCCTTACGCCTCAGAATATCTGGCC
GACCCTGCGCTATGCGGGCACCACCATCGGTGTGGTGATGCTGATGGTCTTTGTGGTAGTGATCGTCAGCCGCTTTCTGG
TCTTTGAAGACATCCCCGGGATGGCCAAGGATCTGATCTTCTCGATCTCGGACAACCCGATCGTGATCTTGCTGATGGTC
AATCTGGTGATGATCCTCATCGGTATGCTGATGGATGATATTTCAGGGCTGTTGCTGTCAGCACCGCTCCTGTTGCCCAT
CGTACAAAGCGTCGGAATGGACCCGGTGCATTTTGCCGCCGTCCTTGGCGTCAACCTCGGCATGGCCAACATCACGCCGC
CCACGGCACCGCTGTTGTATCTAGGTGCAAAGGTCACCGACACACCCGTGAGCGAGATGCTGAAGCCCACCTTCATCATG
ATCCTGTTTGCATGGCTGCCGACGCTGCTGATCACCACATTTGTGCCCGAGGTGGCGCTGTGGCTGCCCAATTTTGTCTT
TGGCTAA

Upstream 100 bases:

>100_bases
GGGCTTTATAGCGCGCTGCGGTTCTTTGTTTTCCTGAAACTCCCGGCGACGCGGTTTGCGGTCTCTGCCGACAGCGACCC
CGCCCAAGGAGCCTGAGCCC

Downstream 100 bases:

>100_bases
GGCCGCAAGGAGACCCCGCATGAAAGCGATCTATGATCCCCGCCAACGCGCCCATAACCCCAGCCAGTTCATGGCCTTTG
GGGTGATGAAGCCCAATCCC

Product: TRAP dicarboxylate transporter- DctM subunit

Products: NA

Alternate protein names: N-acetylneuraminic acid permease; N-acetylneuraminic acid transporter; Neu5Ac permease [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MIILGSLFILCVLLLIGVSVPLAFGGVLVFIGVFGGHDVTGFLPTGHWKMNSIVLLAIPLFILAGAIMERGRIAAPLVSV
AELLVGRIHGGLSAAAVFASGIFGSISGSAAATLTCIGSIMMPHLKAANYPRGPAAALIVAACPLGLLIPPSSSQILYAW
VAQQSVLKCFLSTVVPGLILITLLCMVNYVLMRKADLKLLERPASYPQEFVRRGGRAFPALLMPIIILGGIYGGIMTPTE
AAGVAVIYAIPVGLFIYRGLTPQNIWPTLRYAGTTIGVVMLMVFVVVIVSRFLVFEDIPGMAKDLIFSISDNPIVILLMV
NLVMILIGMLMDDISGLLLSAPLLLPIVQSVGMDPVHFAAVLGVNLGMANITPPTAPLLYLGAKVTDTPVSEMLKPTFIM
ILFAWLPTLLITTFVPEVALWLPNFVFG

Sequences:

>Translated_428_residues
MIILGSLFILCVLLLIGVSVPLAFGGVLVFIGVFGGHDVTGFLPTGHWKMNSIVLLAIPLFILAGAIMERGRIAAPLVSV
AELLVGRIHGGLSAAAVFASGIFGSISGSAAATLTCIGSIMMPHLKAANYPRGPAAALIVAACPLGLLIPPSSSQILYAW
VAQQSVLKCFLSTVVPGLILITLLCMVNYVLMRKADLKLLERPASYPQEFVRRGGRAFPALLMPIIILGGIYGGIMTPTE
AAGVAVIYAIPVGLFIYRGLTPQNIWPTLRYAGTTIGVVMLMVFVVVIVSRFLVFEDIPGMAKDLIFSISDNPIVILLMV
NLVMILIGMLMDDISGLLLSAPLLLPIVQSVGMDPVHFAAVLGVNLGMANITPPTAPLLYLGAKVTDTPVSEMLKPTFIM
ILFAWLPTLLITTFVPEVALWLPNFVFG
>Mature_428_residues
MIILGSLFILCVLLLIGVSVPLAFGGVLVFIGVFGGHDVTGFLPTGHWKMNSIVLLAIPLFILAGAIMERGRIAAPLVSV
AELLVGRIHGGLSAAAVFASGIFGSISGSAAATLTCIGSIMMPHLKAANYPRGPAAALIVAACPLGLLIPPSSSQILYAW
VAQQSVLKCFLSTVVPGLILITLLCMVNYVLMRKADLKLLERPASYPQEFVRRGGRAFPALLMPIIILGGIYGGIMTPTE
AAGVAVIYAIPVGLFIYRGLTPQNIWPTLRYAGTTIGVVMLMVFVVVIVSRFLVFEDIPGMAKDLIFSISDNPIVILLMV
NLVMILIGMLMDDISGLLLSAPLLLPIVQSVGMDPVHFAAVLGVNLGMANITPPTAPLLYLGAKVTDTPVSEMLKPTFIM
ILFAWLPTLLITTFVPEVALWLPNFVFG

Specific function: Part of the tripartite ATP-independent periplasmic (TRAP) transport system siaPT involved in the uptake of sialic acid [H]

COG id: COG1593

COG function: function code G; TRAP-type C4-dicarboxylate transport system, large permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the TRAP transporter large permease family [H]

Homologues:

Organism=Escherichia coli, GI48994950, Length=398, Percent_Identity=30.6532663316583, Blast_Score=162, Evalue=5e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010656
- InterPro:   IPR007387
- InterPro:   IPR004681 [H]

Pfam domain/function: PF06808 DctM; PF04290 DctQ [H]

EC number: NA

Molecular weight: Translated: 45384; Mature: 45384

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILGSLFILCVLLLIGVSVPLAFGGVLVFIGVFGGHDVTGFLPTGHWKMNSIVLLAIPL
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
FILAGAIMERGRIAAPLVSVAELLVGRIHGGLSAAAVFASGIFGSISGSAAATLTCIGSI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MMPHLKAANYPRGPAAALIVAACPLGLLIPPSSSQILYAWVAQQSVLKCFLSTVVPGLIL
HHHHHHCCCCCCCHHHHHHHHHCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
ITLLCMVNYVLMRKADLKLLERPASYPQEFVRRGGRAFPALLMPIIILGGIYGGIMTPTE
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCC
AAGVAVIYAIPVGLFIYRGLTPQNIWPTLRYAGTTIGVVMLMVFVVVIVSRFLVFEDIPG
HHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MAKDLIFSISDNPIVILLMVNLVMILIGMLMDDISGLLLSAPLLLPIVQSVGMDPVHFAA
HHHHHEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VLGVNLGMANITPPTAPLLYLGAKVTDTPVSEMLKPTFIMILFAWLPTLLITTFVPEVAL
HHHHHCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLPNFVFG
HHHHHCCC
>Mature Secondary Structure
MIILGSLFILCVLLLIGVSVPLAFGGVLVFIGVFGGHDVTGFLPTGHWKMNSIVLLAIPL
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
FILAGAIMERGRIAAPLVSVAELLVGRIHGGLSAAAVFASGIFGSISGSAAATLTCIGSI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
MMPHLKAANYPRGPAAALIVAACPLGLLIPPSSSQILYAWVAQQSVLKCFLSTVVPGLIL
HHHHHHCCCCCCCHHHHHHHHHCCCCEEECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHH
ITLLCMVNYVLMRKADLKLLERPASYPQEFVRRGGRAFPALLMPIIILGGIYGGIMTPTE
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCC
AAGVAVIYAIPVGLFIYRGLTPQNIWPTLRYAGTTIGVVMLMVFVVVIVSRFLVFEDIPG
HHCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
MAKDLIFSISDNPIVILLMVNLVMILIGMLMDDISGLLLSAPLLLPIVQSVGMDPVHFAA
HHHHHEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
VLGVNLGMANITPPTAPLLYLGAKVTDTPVSEMLKPTFIMILFAWLPTLLITTFVPEVAL
HHHHHCCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLPNFVFG
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]