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The map label for this gene is aphA [H]

Identifier: 99081906

GI number: 99081906

Start: 2169776

End: 2170804

Strand: Reverse

Name: aphA [H]

Synonym: TM1040_2066

Alternate gene names: 99081906

Gene position: 2170804-2169776 (Counterclockwise)

Preceding gene: 99081907

Following gene: 99081905

Centisome position: 67.82

GC content: 63.46

Gene sequence:

>1029_bases
ATGAAAGCGATCTATGATCCCCGCCAACGCGCCCATAACCCCAGCCAGTTCATGGCCTTTGGGGTGATGAAGCCCAATCC
CGAACAACCCGAACGCACCGAGATCCTGCGCAGCGGCGCGGAGGCGGCAGGCTGTACCTTCACAGCGCCCGAGGATGCGG
GCCTTGGCCCCATCGCGGCGCTGCATTCGCCGGAATACCTGACCTTCCTGCAGACCATCCACGCCCGCTGGAGCGAGATC
GAAGGCGCAGGCCCCGAGGTGATTTCTCATATCAAGCCGGGAGATCGCCGTGACAGTTATCCGCGGTCTGCGCTAGGGCA
GGCGGGCTATCATCAGGCCGATACCTCCTGTCCGATCAATGCCGACACTTGGGGCTCTGCCTATTGGTCGGCGCAGACTG
CGATCACCGCCGCCGACCTGATTGCAAAGGGCGAGCGCGCCGCCTATGCGCTCTGCCGCCCGCCGGGGCATCACGCGTTT
GGAGATATGGCGGGGGGGTTTTGTTTCCTCAATAACTCCGGCATCGCGGCGCAGCTGTTGCGGGATCGGGGCCTCAGGCC
CGCAATTCTGGACGTGGATGTCCACCACGGCAACGGCACGCAGGGGCTGTTTTATGATCGCGACGACGTGCTGACGCTCT
CGATCCACGCCGACCCTGCGGACTTCTACCCGTTCTTCTGGGGCCACAGTTCTGAGCGCGGCGAGGGCCGGGGGCGGGGC
TATAACCTCAACCTGCCGCTGCCGCGTGGTACCGAAGATGCACCGTTCCTGGATGCACTGGACACCTGTCTTGACCGGGT
GCGCGCCTTTGGGTGCGATGTGCTTGTGATCGCGCTGGGCCTTGATGCCTCCGTGGACGATCCGTTTCAGGGCTTTCAGG
TTACCGGCGACGGGTTTTCGCGCATTGGCGAGGCAATTGCCCGCGCCGGCCTTCCAACGCTTTTTGTGCAGGAAGGCGGT
TACATCTCCGACAGCCTCGGTCATAACCTCACCCGCGTGCTTGGCGGATTTACCTCTGCTGCACGCTGA

Upstream 100 bases:

>100_bases
TTTGCATGGCTGCCGACGCTGCTGATCACCACATTTGTGCCCGAGGTGGCGCTGTGGCTGCCCAATTTTGTCTTTGGCTA
AGGCCGCAAGGAGACCCCGC

Downstream 100 bases:

>100_bases
GATTTCCTTTAATCCTCAAACCATAAGAGACTACTATGAGCGATATCACCTACGCCCACACCACCCAGCGCATGAGCCAG
ATCGTCACCCATGGCGACAC

Product: histone deacetylase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKAIYDPRQRAHNPSQFMAFGVMKPNPEQPERTEILRSGAEAAGCTFTAPEDAGLGPIAALHSPEYLTFLQTIHARWSEI
EGAGPEVISHIKPGDRRDSYPRSALGQAGYHQADTSCPINADTWGSAYWSAQTAITAADLIAKGERAAYALCRPPGHHAF
GDMAGGFCFLNNSGIAAQLLRDRGLRPAILDVDVHHGNGTQGLFYDRDDVLTLSIHADPADFYPFFWGHSSERGEGRGRG
YNLNLPLPRGTEDAPFLDALDTCLDRVRAFGCDVLVIALGLDASVDDPFQGFQVTGDGFSRIGEAIARAGLPTLFVQEGG
YISDSLGHNLTRVLGGFTSAAR

Sequences:

>Translated_342_residues
MKAIYDPRQRAHNPSQFMAFGVMKPNPEQPERTEILRSGAEAAGCTFTAPEDAGLGPIAALHSPEYLTFLQTIHARWSEI
EGAGPEVISHIKPGDRRDSYPRSALGQAGYHQADTSCPINADTWGSAYWSAQTAITAADLIAKGERAAYALCRPPGHHAF
GDMAGGFCFLNNSGIAAQLLRDRGLRPAILDVDVHHGNGTQGLFYDRDDVLTLSIHADPADFYPFFWGHSSERGEGRGRG
YNLNLPLPRGTEDAPFLDALDTCLDRVRAFGCDVLVIALGLDASVDDPFQGFQVTGDGFSRIGEAIARAGLPTLFVQEGG
YISDSLGHNLTRVLGGFTSAAR
>Mature_342_residues
MKAIYDPRQRAHNPSQFMAFGVMKPNPEQPERTEILRSGAEAAGCTFTAPEDAGLGPIAALHSPEYLTFLQTIHARWSEI
EGAGPEVISHIKPGDRRDSYPRSALGQAGYHQADTSCPINADTWGSAYWSAQTAITAADLIAKGERAAYALCRPPGHHAF
GDMAGGFCFLNNSGIAAQLLRDRGLRPAILDVDVHHGNGTQGLFYDRDDVLTLSIHADPADFYPFFWGHSSERGEGRGRG
YNLNLPLPRGTEDAPFLDALDTCLDRVRAFGCDVLVIALGLDASVDDPFQGFQVTGDGFSRIGEAIARAGLPTLFVQEGG
YISDSLGHNLTRVLGGFTSAAR

Specific function: Acts on many types of acetylpolyamines has high affinity towards acetylputrescine, acetylcadaverine, acetylspermidine, and acetylspermine [H]

COG id: COG0123

COG function: function code BQ; Deacetylases, including yeast histone deacetylase and acetoin utilization protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histone deacetylase family [H]

Homologues:

Organism=Homo sapiens, GI17158039, Length=193, Percent_Identity=36.2694300518135, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI8923769, Length=297, Percent_Identity=28.6195286195286, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI30795204, Length=189, Percent_Identity=37.037037037037, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI30795202, Length=189, Percent_Identity=37.037037037037, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI13128864, Length=321, Percent_Identity=28.9719626168224, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI148539870, Length=208, Percent_Identity=34.1346153846154, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI169234807, Length=208, Percent_Identity=34.1346153846154, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI153085395, Length=222, Percent_Identity=34.2342342342342, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI262073088, Length=175, Percent_Identity=33.7142857142857, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI20070354, Length=315, Percent_Identity=29.2063492063492, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI62750347, Length=193, Percent_Identity=36.2694300518135, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI62750349, Length=193, Percent_Identity=36.2694300518135, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI13128860, Length=273, Percent_Identity=24.9084249084249, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI262073092, Length=231, Percent_Identity=28.1385281385281, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI226529806, Length=315, Percent_Identity=29.2063492063492, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI13128862, Length=166, Percent_Identity=31.9277108433735, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI293336691, Length=152, Percent_Identity=28.2894736842105, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17540334, Length=226, Percent_Identity=34.9557522123894, Blast_Score=118, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17540332, Length=226, Percent_Identity=34.9557522123894, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI193206283, Length=226, Percent_Identity=34.9557522123894, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17537347, Length=221, Percent_Identity=35.2941176470588, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI193209491, Length=289, Percent_Identity=30.1038062283737, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17508561, Length=301, Percent_Identity=25.5813953488372, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17534739, Length=269, Percent_Identity=25.2788104089219, Blast_Score=89, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17561978, Length=302, Percent_Identity=26.4900662251656, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI25154020, Length=181, Percent_Identity=27.6243093922652, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324307, Length=363, Percent_Identity=29.4765840220386, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6321244, Length=324, Percent_Identity=24.3827160493827, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323999, Length=166, Percent_Identity=30.1204819277108, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325325, Length=156, Percent_Identity=29.4871794871795, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI281360801, Length=232, Percent_Identity=38.3620689655172, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24641720, Length=232, Percent_Identity=38.3620689655172, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360799, Length=232, Percent_Identity=38.3620689655172, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI281360899, Length=225, Percent_Identity=35.1111111111111, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24642142, Length=217, Percent_Identity=35.9447004608295, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24642144, Length=217, Percent_Identity=35.9447004608295, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24642146, Length=217, Percent_Identity=35.9447004608295, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24657891, Length=296, Percent_Identity=27.027027027027, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24644244, Length=302, Percent_Identity=23.841059602649, Blast_Score=82, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000286 [H]

Pfam domain/function: PF00850 Hist_deacetyl [H]

EC number: NA

Molecular weight: Translated: 36816; Mature: 36816

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIYDPRQRAHNPSQFMAFGVMKPNPEQPERTEILRSGAEAAGCTFTAPEDAGLGPIAA
CCCCCCHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCEEECCCCCCCCCCHH
LHSPEYLTFLQTIHARWSEIEGAGPEVISHIKPGDRRDSYPRSALGQAGYHQADTSCPIN
HCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCC
ADTWGSAYWSAQTAITAADLIAKGERAAYALCRPPGHHAFGDMAGGFCFLNNSGIAAQLL
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHCCCCEEEECCCCHHHHHH
RDRGLRPAILDVDVHHGNGTQGLFYDRDDVLTLSIHADPADFYPFFWGHSSERGEGRGRG
HHCCCCCEEEEEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCEECCCCCCCCCCCCCC
YNLNLPLPRGTEDAPFLDALDTCLDRVRAFGCDVLVIALGLDASVDDPFQGFQVTGDGFS
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEECCCHHH
RIGEAIARAGLPTLFVQEGGYISDSLGHNLTRVLGGFTSAAR
HHHHHHHHCCCCEEEEECCCEECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAIYDPRQRAHNPSQFMAFGVMKPNPEQPERTEILRSGAEAAGCTFTAPEDAGLGPIAA
CCCCCCHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCCCEEECCCCCCCCCCHH
LHSPEYLTFLQTIHARWSEIEGAGPEVISHIKPGDRRDSYPRSALGQAGYHQADTSCPIN
HCCCHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCC
ADTWGSAYWSAQTAITAADLIAKGERAAYALCRPPGHHAFGDMAGGFCFLNNSGIAAQLL
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHCCCCEEEECCCCHHHHHH
RDRGLRPAILDVDVHHGNGTQGLFYDRDDVLTLSIHADPADFYPFFWGHSSERGEGRGRG
HHCCCCCEEEEEEEECCCCCCCEEECCCCEEEEEEECCCCCCCCEECCCCCCCCCCCCCC
YNLNLPLPRGTEDAPFLDALDTCLDRVRAFGCDVLVIALGLDASVDDPFQGFQVTGDGFS
EEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEECCCHHH
RIGEAIARAGLPTLFVQEGGYISDSLGHNLTRVLGGFTSAAR
HHHHHHHHCCCCEEEEECCCEECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8824626; 3207420 [H]