Click here to switch to the map view.

The map label for this gene is oxyR [H]

Identifier: 99081901

GI number: 99081901

Start: 2164175

End: 2165095

Strand: Reverse

Name: oxyR [H]

Synonym: TM1040_2061

Alternate gene names: 99081901

Gene position: 2165095-2164175 (Counterclockwise)

Preceding gene: 99081904

Following gene: 99081897

Centisome position: 67.64

GC content: 63.63

Gene sequence:

>921_bases
ATGCCAGAGCTGAGCCTGCGTCACTTGCGATACTTTGCGGTTCTGAGCCGAGCGCTGCAGTTTCGACGCGCGGCGCGGCA
ATTGGGGATCAGCCAGCCCTCGCTCAGCCTTCAGATCGCCGCGCTTGAGGAAATCGTCGGCGCGCCGCTGCTGGAGCGGC
GGCGCAATGGGTTGATCCTGACCGCTGCGGGGCGAGATGTGGCCGCCAGGGCGGAGCGTATTCTGGCCGATTGCGAGCTG
CTGGTGAACGCGTCGGCCACCCGCCGCGCAGGGTTGAGCGGCACATTGCGGTTGGGATCGTCTCCCACCATTGGACCCTA
TATTCTGCCACAGGTGCTCAAGCGTCTGCATGAGACCTATCCCGATTTCCGGCTCATCATTCGCGATGGCCCTTCGCGCG
ATTTGTTGGAGGATCTGGTTGCGGGCAAGCATGATCTCATCCTGACCCAAGCGCCGATCCAGCGCGATGACATCCGTTTT
CACCCGCTGTTCCGCGAGCCGCTCTATCTTGTGGTGCCGCGGGGTCATCCGCTTGCAACGGCGGGTGTCGCCCGCCGGCG
TGATCTGGGGCAGGAACAGTTTCTCAGCCTCAACCCCGCCTATGCGCTGCGGCGGCAGGTGGAGGGGCTGGCGCAGACGG
TTGGCGCGCGGATGCAGGACGACATTGATGGCACCAGCCTCGACGCGATCCGCCAGATGGTTGCGCTCGGCATGGGGGTG
ACGCTGATGCCGCAGTCCTACACGCGCTCCGAAATCGACAACCGCAAGGATGATGTCTGCGTGGTCACCCTGAAGCCAGG
CCTAGAGCGCCATATCGGCCTTGCGTGGCGCGTCTCCAGTGGCAACCCGGCGAGCTTTGAAGAACTGGCAGAAGCCATTG
CTGTGATGGGCAAAACAGACCCCAAGGCCGCCATCACTTGA

Upstream 100 bases:

>100_bases
CATGGTTCCCTCGATATGGGGGAGGGCTTGCCTTGATCCAATACAATCTTATTGTGAAATAGTATTGGAAAAAACTATCA
ATGGAACCTGTGGGTATCAT

Downstream 100 bases:

>100_bases
AGGGGACCATCCAGTAAACGCGCCCATGCGTTAAATGGCGCCCGGGGGAGGTTATTGTTCGAGCGGCCAGGCGCGCCCAT
AGGCCACAAGCCGGTGGTTC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MPELSLRHLRYFAVLSRALQFRRAARQLGISQPSLSLQIAALEEIVGAPLLERRRNGLILTAAGRDVAARAERILADCEL
LVNASATRRAGLSGTLRLGSSPTIGPYILPQVLKRLHETYPDFRLIIRDGPSRDLLEDLVAGKHDLILTQAPIQRDDIRF
HPLFREPLYLVVPRGHPLATAGVARRRDLGQEQFLSLNPAYALRRQVEGLAQTVGARMQDDIDGTSLDAIRQMVALGMGV
TLMPQSYTRSEIDNRKDDVCVVTLKPGLERHIGLAWRVSSGNPASFEELAEAIAVMGKTDPKAAIT

Sequences:

>Translated_306_residues
MPELSLRHLRYFAVLSRALQFRRAARQLGISQPSLSLQIAALEEIVGAPLLERRRNGLILTAAGRDVAARAERILADCEL
LVNASATRRAGLSGTLRLGSSPTIGPYILPQVLKRLHETYPDFRLIIRDGPSRDLLEDLVAGKHDLILTQAPIQRDDIRF
HPLFREPLYLVVPRGHPLATAGVARRRDLGQEQFLSLNPAYALRRQVEGLAQTVGARMQDDIDGTSLDAIRQMVALGMGV
TLMPQSYTRSEIDNRKDDVCVVTLKPGLERHIGLAWRVSSGNPASFEELAEAIAVMGKTDPKAAIT
>Mature_305_residues
PELSLRHLRYFAVLSRALQFRRAARQLGISQPSLSLQIAALEEIVGAPLLERRRNGLILTAAGRDVAARAERILADCELL
VNASATRRAGLSGTLRLGSSPTIGPYILPQVLKRLHETYPDFRLIIRDGPSRDLLEDLVAGKHDLILTQAPIQRDDIRFH
PLFREPLYLVVPRGHPLATAGVARRRDLGQEQFLSLNPAYALRRQVEGLAQTVGARMQDDIDGTSLDAIRQMVALGMGVT
LMPQSYTRSEIDNRKDDVCVVTLKPGLERHIGLAWRVSSGNPASFEELAEAIAVMGKTDPKAAIT

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=292, Percent_Identity=34.5890410958904, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI1787879, Length=274, Percent_Identity=30.6569343065693, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1788887, Length=250, Percent_Identity=34, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI157672245, Length=307, Percent_Identity=29.6416938110749, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI145693105, Length=239, Percent_Identity=23.4309623430962, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1788748, Length=242, Percent_Identity=26.8595041322314, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789204, Length=243, Percent_Identity=28.3950617283951, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87081904, Length=217, Percent_Identity=31.7972350230415, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787601, Length=178, Percent_Identity=28.0898876404494, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI2367136, Length=250, Percent_Identity=28, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787530, Length=243, Percent_Identity=25.1028806584362, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788297, Length=257, Percent_Identity=26.4591439688716, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1787806, Length=249, Percent_Identity=25.3012048192771, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790208, Length=255, Percent_Identity=27.4509803921569, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1789506, Length=244, Percent_Identity=21.7213114754098, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788481, Length=241, Percent_Identity=24.896265560166, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1788296, Length=222, Percent_Identity=25.2252252252252, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33728; Mature: 33596

Theoretical pI: Translated: 9.91; Mature: 9.91

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELSLRHLRYFAVLSRALQFRRAARQLGISQPSLSLQIAALEEIVGAPLLERRRNGLIL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCHHHHHHCCCEEE
TAAGRDVAARAERILADCELLVNASATRRAGLSGTLRLGSSPTIGPYILPQVLKRLHETY
EECCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCC
PDFRLIIRDGPSRDLLEDLVAGKHDLILTQAPIQRDDIRFHPLFREPLYLVVPRGHPLAT
CCEEEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCCCEECEECCCCEEEEEECCCCCHH
AGVARRRDLGQEQFLSLNPAYALRRQVEGLAQTVGARMQDDIDGTSLDAIRQMVALGMGV
HHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHCCCC
TLMPQSYTRSEIDNRKDDVCVVTLKPGLERHIGLAWRVSSGNPASFEELAEAIAVMGKTD
EECCCCHHHHHHCCCCCCEEEEEECCCCHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCC
PKAAIT
CCCCCC
>Mature Secondary Structure 
PELSLRHLRYFAVLSRALQFRRAARQLGISQPSLSLQIAALEEIVGAPLLERRRNGLIL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHCCHHHHHHCCCEEE
TAAGRDVAARAERILADCELLVNASATRRAGLSGTLRLGSSPTIGPYILPQVLKRLHETY
EECCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCC
PDFRLIIRDGPSRDLLEDLVAGKHDLILTQAPIQRDDIRFHPLFREPLYLVVPRGHPLAT
CCEEEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCCCEECEECCCCEEEEEECCCCCHH
AGVARRRDLGQEQFLSLNPAYALRRQVEGLAQTVGARMQDDIDGTSLDAIRQMVALGMGV
HHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHCCCC
TLMPQSYTRSEIDNRKDDVCVVTLKPGLERHIGLAWRVSSGNPASFEELAEAIAVMGKTD
EECCCCHHHHHHCCCCCCEEEEEECCCCHHHCCEEEEECCCCCCCHHHHHHHHHHHCCCC
PKAAIT
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]