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The map label for this gene is penA [H]

Identifier: 99081857

GI number: 99081857

Start: 2119401

End: 2121182

Strand: Direct

Name: penA [H]

Synonym: TM1040_2017

Alternate gene names: 99081857

Gene position: 2119401-2121182 (Clockwise)

Preceding gene: 99081856

Following gene: 99081858

Centisome position: 66.21

GC content: 63.64

Gene sequence:

>1782_bases
ATGATCCGCACGCCCCTGCGCCCCCTCGCCCGCATCCTGCCCGCCCGCGCGCGCGGCGAGAACCCCGACCTCATCGAGCG
CGAAAACCTCGCCCAGCGCCACAGCGAGATGGAAGCCCGTGCCCGCACCCGCGCCGAGGGGCGTCTTCTGGTGCTCGCGG
CCTTTTTTGTCTGCGCCTATGTGGCGATCGGCGGACGGATGGCGATGATGGCCACCTCGGAGCCGGCAGAGCCCGTTTCC
GTGAGCGGCAGCGCCATCGCCAACCAGCGCGCCGACATCGTTGACCGCGAAGGCCGCATCCTCGCCACCAATTTCGAGAC
CTTCTCGCTCTATGCCCAGCCGCCGCAGATGGTGGAGCCGCTGGTGGCGGCGGAAAAACTGGTCTCGATCTTTCCGGATC
TCGATCACGAGCGTCTGGTCAAGGATTTCACAGGAAGCCGCAAGTTCCTCTGGATCAAGAAGAAAATCAGCCCCGAGCAA
ATGCAGGCGGTGCATGACATCGGCGATCCCGGCCTGATGTTTGGCCCGCGCGAGATGCGCCTTTACCCCAACGGCAAGCT
CGCCGCACATGTGCTGGGTGGGGCCTCTTTTGGCAAGGAAGGCGTGAACGCCGCCGAGGTGATCGGTGTTGCAGGCGTGG
AAAAACAGTTCGATGACTACCTGCGTGACCCGGCCAATGGCGGCAAGCCGCTGGAATTGAGCCTCGATCTCTCGGTGCAG
CACGCCACCGAAGAAGTACTCTATGGCGGCATGAAGCTGATGAACGCCAAGGGCGCAACCTCGATCCTGATGGATGTACA
CACCGGCGAGGTGATCTCGGTGGCCTCGCTGCCCGATTTTGATCCCAACGAGCGCCCACGCCCGCCCACCTCGGGCTTTG
ACCCGTCCGAAAGCCCGCTCTTCAACCGTGCCGTTCAGGGCGTCTATGAGCTTGGCTCGACCTTCAAGATCTTTGCCGCG
GCTCAGGCCATCGAGCTTGGCCTTGTGAACCCGGAAACCGTGATCGACACCCGCGGCCCATTGCGCTGGGGCAAATTCTC
CATCCGGGATTTTCGCAACTACGGCAACGAGATGACCGTCTCGCGCATCATCGAAAAGTCCTCCAACATCGGGACCGCGC
GGCTCGCGCAGCAGATCGGAGCCGAACGCCAGCGCGCCTTCCTCGGAGAGCTTGGCATGTTGGAGCCGACCCCGTTTGAG
ATCGTCGAAGCGTCGGGCGGCCAGCCGCTCTTGCCGAGAAACTGGTCGGAGCTGTCGACCATGACCATTTCCTATGGTCA
CGGGATTTCAACCACGCCGATGCATCTGGCGGCGGGCTATGCGGCCATTGCCAATGGCGGCCGGCTCGTGAAACCCACGA
TCCTTAAGCAGACCGGCCCCCGCCTCGGGGAGCGCGTGCTCAGCAAAGAGGTTGCCGAGGCTTCACTCGAGATGCTGCGC
AGGGTGGTGAGCAGCGGCTCTGCCTCCATGGCCGAGGTCGAAGGCTACAGCGTGGGCGGCAAGACCGGCACCGCTGACAA
GCCCAAGCCCCGTGGCGGCTATTACGAAGACAAGGTGATCGCGACCTTTGCCGCCGTTTTCCCCACGGATGCGCCGAAAT
ATGTGCTGATCGTGACCCTGGATGAACCCGAGATCATCGCCTATGGCGAGGACCGCCGCACCGCCGGCTGGACCGCCGCG
CCCGTCGCCGCCGAGATGATCGCGCGCCTTGCGCCGCTCCTTGGGCTCAGACCACAGATTGAACCTGCCCGTATCTCTGG
TGTAACCCTCACCTCAAACTAA

Upstream 100 bases:

>100_bases
CGGAACAATTTGGACGCGTGGACGAGGTGTCCTTTCCGCCCTCGGGTCTGGTGATCGAAGAAGGCGTCGAGGTCTCCTCT
TATGGACAGGAGGCCGATCA

Downstream 100 bases:

>100_bases
CAGGTGGGGACGCCATGACACAGAGACCAGCGCTCAAGCTCAGCCAGTTGGGACTGACCGCAAGAGCGGGCCTGGACCCG
CAGATCACGGGGCTTGCGGT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 593; Mature: 593

Protein sequence:

>593_residues
MIRTPLRPLARILPARARGENPDLIERENLAQRHSEMEARARTRAEGRLLVLAAFFVCAYVAIGGRMAMMATSEPAEPVS
VSGSAIANQRADIVDREGRILATNFETFSLYAQPPQMVEPLVAAEKLVSIFPDLDHERLVKDFTGSRKFLWIKKKISPEQ
MQAVHDIGDPGLMFGPREMRLYPNGKLAAHVLGGASFGKEGVNAAEVIGVAGVEKQFDDYLRDPANGGKPLELSLDLSVQ
HATEEVLYGGMKLMNAKGATSILMDVHTGEVISVASLPDFDPNERPRPPTSGFDPSESPLFNRAVQGVYELGSTFKIFAA
AQAIELGLVNPETVIDTRGPLRWGKFSIRDFRNYGNEMTVSRIIEKSSNIGTARLAQQIGAERQRAFLGELGMLEPTPFE
IVEASGGQPLLPRNWSELSTMTISYGHGISTTPMHLAAGYAAIANGGRLVKPTILKQTGPRLGERVLSKEVAEASLEMLR
RVVSSGSASMAEVEGYSVGGKTGTADKPKPRGGYYEDKVIATFAAVFPTDAPKYVLIVTLDEPEIIAYGEDRRTAGWTAA
PVAAEMIARLAPLLGLRPQIEPARISGVTLTSN

Sequences:

>Translated_593_residues
MIRTPLRPLARILPARARGENPDLIERENLAQRHSEMEARARTRAEGRLLVLAAFFVCAYVAIGGRMAMMATSEPAEPVS
VSGSAIANQRADIVDREGRILATNFETFSLYAQPPQMVEPLVAAEKLVSIFPDLDHERLVKDFTGSRKFLWIKKKISPEQ
MQAVHDIGDPGLMFGPREMRLYPNGKLAAHVLGGASFGKEGVNAAEVIGVAGVEKQFDDYLRDPANGGKPLELSLDLSVQ
HATEEVLYGGMKLMNAKGATSILMDVHTGEVISVASLPDFDPNERPRPPTSGFDPSESPLFNRAVQGVYELGSTFKIFAA
AQAIELGLVNPETVIDTRGPLRWGKFSIRDFRNYGNEMTVSRIIEKSSNIGTARLAQQIGAERQRAFLGELGMLEPTPFE
IVEASGGQPLLPRNWSELSTMTISYGHGISTTPMHLAAGYAAIANGGRLVKPTILKQTGPRLGERVLSKEVAEASLEMLR
RVVSSGSASMAEVEGYSVGGKTGTADKPKPRGGYYEDKVIATFAAVFPTDAPKYVLIVTLDEPEIIAYGEDRRTAGWTAA
PVAAEMIARLAPLLGLRPQIEPARISGVTLTSN
>Mature_593_residues
MIRTPLRPLARILPARARGENPDLIERENLAQRHSEMEARARTRAEGRLLVLAAFFVCAYVAIGGRMAMMATSEPAEPVS
VSGSAIANQRADIVDREGRILATNFETFSLYAQPPQMVEPLVAAEKLVSIFPDLDHERLVKDFTGSRKFLWIKKKISPEQ
MQAVHDIGDPGLMFGPREMRLYPNGKLAAHVLGGASFGKEGVNAAEVIGVAGVEKQFDDYLRDPANGGKPLELSLDLSVQ
HATEEVLYGGMKLMNAKGATSILMDVHTGEVISVASLPDFDPNERPRPPTSGFDPSESPLFNRAVQGVYELGSTFKIFAA
AQAIELGLVNPETVIDTRGPLRWGKFSIRDFRNYGNEMTVSRIIEKSSNIGTARLAQQIGAERQRAFLGELGMLEPTPFE
IVEASGGQPLLPRNWSELSTMTISYGHGISTTPMHLAAGYAAIANGGRLVKPTILKQTGPRLGERVLSKEVAEASLEMLR
RVVSSGSASMAEVEGYSVGGKTGTADKPKPRGGYYEDKVIATFAAVFPTDAPKYVLIVTLDEPEIIAYGEDRRTAGWTAA
PVAAEMIARLAPLLGLRPQIEPARISGVTLTSN

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=569, Percent_Identity=26.1862917398945, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1786854, Length=434, Percent_Identity=24.8847926267281, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 64234; Mature: 64234

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRTPLRPLARILPARARGENPDLIERENLAQRHSEMEARARTRAEGRLLVLAAFFVCAY
CCCCCHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VAIGGRMAMMATSEPAEPVSVSGSAIANQRADIVDREGRILATNFETFSLYAQPPQMVEP
HHHCCCEEEEECCCCCCCCCCCCHHHHCCCHHHCCCCCCEEEECCEEEEEECCCHHHHHH
LVAAEKLVSIFPDLDHERLVKDFTGSRKFLWIKKKISPEQMQAVHDIGDPGLMFGPREMR
HHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCEECCCCEE
LYPNGKLAAHVLGGASFGKEGVNAAEVIGVAGVEKQFDDYLRDPANGGKPLELSLDLSVQ
ECCCCCEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCHH
HATEEVLYGGMKLMNAKGATSILMDVHTGEVISVASLPDFDPNERPRPPTSGFDPSESPL
HHHHHHHHCCHHEECCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHH
FNRAVQGVYELGSTFKIFAAAQAIELGLVNPETVIDTRGPLRWGKFSIRDFRNYGNEMTV
HHHHHHHHHHCCCCEEEHHHHHHHEEECCCCCCEECCCCCCCCCCCHHHHHHHCCCHHHH
SRIIEKSSNIGTARLAQQIGAERQRAFLGELGMLEPTPFEIVEASGGQPLLPRNWSELST
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCCCCCCHHHEE
MTISYGHGISTTPMHLAAGYAAIANGGRLVKPTILKQTGPRLGERVLSKEVAEASLEMLR
EEEEECCCCCCCCHHHHHCHHHHCCCCEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RVVSSGSASMAEVEGYSVGGKTGTADKPKPRGGYYEDKVIATFAAVFPTDAPKYVLIVTL
HHHHCCCCCEEEECCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEE
DEPEIIAYGEDRRTAGWTAAPVAAEMIARLAPLLGLRPQIEPARISGVTLTSN
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECEEEECC
>Mature Secondary Structure
MIRTPLRPLARILPARARGENPDLIERENLAQRHSEMEARARTRAEGRLLVLAAFFVCAY
CCCCCHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
VAIGGRMAMMATSEPAEPVSVSGSAIANQRADIVDREGRILATNFETFSLYAQPPQMVEP
HHHCCCEEEEECCCCCCCCCCCCHHHHCCCHHHCCCCCCEEEECCEEEEEECCCHHHHHH
LVAAEKLVSIFPDLDHERLVKDFTGSRKFLWIKKKISPEQMQAVHDIGDPGLMFGPREMR
HHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCEECCCCEE
LYPNGKLAAHVLGGASFGKEGVNAAEVIGVAGVEKQFDDYLRDPANGGKPLELSLDLSVQ
ECCCCCEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCCCCEEEEEECCHH
HATEEVLYGGMKLMNAKGATSILMDVHTGEVISVASLPDFDPNERPRPPTSGFDPSESPL
HHHHHHHHCCHHEECCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHH
FNRAVQGVYELGSTFKIFAAAQAIELGLVNPETVIDTRGPLRWGKFSIRDFRNYGNEMTV
HHHHHHHHHHCCCCEEEHHHHHHHEEECCCCCCEECCCCCCCCCCCHHHHHHHCCCHHHH
SRIIEKSSNIGTARLAQQIGAERQRAFLGELGMLEPTPFEIVEASGGQPLLPRNWSELST
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEEECCCCCCCCCCCCHHHEE
MTISYGHGISTTPMHLAAGYAAIANGGRLVKPTILKQTGPRLGERVLSKEVAEASLEMLR
EEEEECCCCCCCCHHHHHCHHHHCCCCEEECCHHHHHCCHHHHHHHHHHHHHHHHHHHHH
RVVSSGSASMAEVEGYSVGGKTGTADKPKPRGGYYEDKVIATFAAVFPTDAPKYVLIVTL
HHHHCCCCCEEEECCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEEEEE
DEPEIIAYGEDRRTAGWTAAPVAAEMIARLAPLLGLRPQIEPARISGVTLTSN
CCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEECEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]