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The map label for this gene is lysC [H]

Identifier: 99081775

GI number: 99081775

Start: 2036243

End: 2037481

Strand: Reverse

Name: lysC [H]

Synonym: TM1040_1934

Alternate gene names: 99081775

Gene position: 2037481-2036243 (Counterclockwise)

Preceding gene: 99081776

Following gene: 99081774

Centisome position: 63.65

GC content: 59.81

Gene sequence:

>1239_bases
ATGCCCCTACTTGTGATGAAATTCGGCGGCACATCCGTCGCCAATCTGGACCGCATTCGCCGCGCTGCCAAACGCGTTGG
TGTCGAAGTGGCCAAAGGCTATGACGTGATCGTCATTGTCTCCGCCATGTCCGGCAAGACCAACGAGCTGGTCGGTTGGG
TGGGGGAGACCTCGCCGCTCTATGATGCGCGTGAATATGATGCGGTTGTATCCTCTGGTGAGAATGTGACCGCGGGCCTC
ATGGCGTTGACGCTGCAAGAGATGGACGTGCCCGCGCGCAGCTGGCAGGGCTGGCAAGTGCCGCTCAAGACCAACTCGGC
CCACAGCCAGGCCCGGATCGAAGAGATCGGCACAGAGAACATCAACCAGAAGTTCGGCGAAGGCATGAAAGTGGCCGTTG
TTGCGGGCTTTCAGGGGATTTCTCCCGAAGGTCGCATCACCACCCTCGGGCGCGGCGGCTCTGACACCACAGCGGTGGCT
TTTGCGGCGGCCTTCGGGGCGGAGCGCTGCGATATCTACACCGATGTGGACGGCGTCTATACCACCGACCCGCGCATCTG
CGAAAAGGCACGCAAGCTCGACAAGATCGCCTTTGAGGAAATGCTGGAGCTGGCATCCTTGGGCGCCAAGGTGCTGCAAA
CCCGCTCCGTCGAGCTGGCGATGCGCTACAAGGTGAAACTGCGCGTGCTCTCGAGCTTTGAAGAACAGTCCGACGAGGCC
GGAACCCTGGTCTGCGACGAGGAGGAAATCATGGAATCCAATGTTGTTAACGGCGTTGCCTACTCGCGGGATGAGGCCAA
ACTGACCTGTCTTTCGGTCGCGGACCGTCCGGGCATCGCGGCGACCATTTTTGGCTGCCTCTCGGATGCCGGCGTCAACG
TCGATATGATCGTGCAGAACATCTCTGAAGATGGGCGCACGGATATGACGTTCTCTTGCCCCACGGATCAGGTACAGCGC
GCGGAAATGGCCCTGAACGCCTACAAAGAGAAGGGCGAGCTGAACTTTGCTGAACTCGTGGCGGACACCGGTGTTGCGAA
GATTTCGGTGGTGGGCATCGGCATGCGATCGCAGTCCGGTGTGGCCGCCAAGATGTTCAAGGTCCTCTCGGATGAGGGCA
TCAACATCAAGGTGATCACCACCTCCGAGATCAAGATTTCGGTGCTGGTGGACCGCAAATACATGGAGCTCGCCGTGCAG
GCCCTGCACGACGCCTTTGAGCTCGACAAAGCCAGCTGA

Upstream 100 bases:

>100_bases
TGCGCCTTGAAATAAAGGGCTGGGCCATCTTGCTCTTGCGCGGGCGCTCGCCTAAGAACGCGCGAACCTTAACCCCGCAA
GCGGAGGGAAATCACACCTC

Downstream 100 bases:

>100_bases
TCACGACTTTTGTGCAAAGACAGAAACGCCGGAGGGAGACCTTCGGCGTTTTTTGTTTCGGGCTAATTCATTGAGTTTAC
TCACTCTCTTTGCTGCAGTG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MPLLVMKFGGTSVANLDRIRRAAKRVGVEVAKGYDVIVIVSAMSGKTNELVGWVGETSPLYDAREYDAVVSSGENVTAGL
MALTLQEMDVPARSWQGWQVPLKTNSAHSQARIEEIGTENINQKFGEGMKVAVVAGFQGISPEGRITTLGRGGSDTTAVA
FAAAFGAERCDIYTDVDGVYTTDPRICEKARKLDKIAFEEMLELASLGAKVLQTRSVELAMRYKVKLRVLSSFEEQSDEA
GTLVCDEEEIMESNVVNGVAYSRDEAKLTCLSVADRPGIAATIFGCLSDAGVNVDMIVQNISEDGRTDMTFSCPTDQVQR
AEMALNAYKEKGELNFAELVADTGVAKISVVGIGMRSQSGVAAKMFKVLSDEGINIKVITTSEIKISVLVDRKYMELAVQ
ALHDAFELDKAS

Sequences:

>Translated_412_residues
MPLLVMKFGGTSVANLDRIRRAAKRVGVEVAKGYDVIVIVSAMSGKTNELVGWVGETSPLYDAREYDAVVSSGENVTAGL
MALTLQEMDVPARSWQGWQVPLKTNSAHSQARIEEIGTENINQKFGEGMKVAVVAGFQGISPEGRITTLGRGGSDTTAVA
FAAAFGAERCDIYTDVDGVYTTDPRICEKARKLDKIAFEEMLELASLGAKVLQTRSVELAMRYKVKLRVLSSFEEQSDEA
GTLVCDEEEIMESNVVNGVAYSRDEAKLTCLSVADRPGIAATIFGCLSDAGVNVDMIVQNISEDGRTDMTFSCPTDQVQR
AEMALNAYKEKGELNFAELVADTGVAKISVVGIGMRSQSGVAAKMFKVLSDEGINIKVITTSEIKISVLVDRKYMELAVQ
ALHDAFELDKAS
>Mature_411_residues
PLLVMKFGGTSVANLDRIRRAAKRVGVEVAKGYDVIVIVSAMSGKTNELVGWVGETSPLYDAREYDAVVSSGENVTAGLM
ALTLQEMDVPARSWQGWQVPLKTNSAHSQARIEEIGTENINQKFGEGMKVAVVAGFQGISPEGRITTLGRGGSDTTAVAF
AAAFGAERCDIYTDVDGVYTTDPRICEKARKLDKIAFEEMLELASLGAKVLQTRSVELAMRYKVKLRVLSSFEEQSDEAG
TLVCDEEEIMESNVVNGVAYSRDEAKLTCLSVADRPGIAATIFGCLSDAGVNVDMIVQNISEDGRTDMTFSCPTDQVQRA
EMALNAYKEKGELNFAELVADTGVAKISVVGIGMRSQSGVAAKMFKVLSDEGINIKVITTSEIKISVLVDRKYMELAVQA
LHDAFELDKAS

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=463, Percent_Identity=30.2375809935205, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1786183, Length=284, Percent_Identity=34.1549295774648, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1790376, Length=460, Percent_Identity=24.7826086956522, Blast_Score=82, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6320893, Length=309, Percent_Identity=25.8899676375405, Blast_Score=96, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44472; Mature: 44341

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00324 ASPARTOKINASE ; PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLVMKFGGTSVANLDRIRRAAKRVGVEVAKGYDVIVIVSAMSGKTNELVGWVGETSPL
CCEEEEEECCCCHHHHHHHHHHHHHHCEEEECCCEEEEEEEECCCCCCCEEEECCCCCCC
YDAREYDAVVSSGENVTAGLMALTLQEMDVPARSWQGWQVPLKTNSAHSQARIEEIGTEN
CCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCH
INQKFGEGMKVAVVAGFQGISPEGRITTLGRGGSDTTAVAFAAAFGAERCDIYTDVDGVY
HHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCEE
TTDPRICEKARKLDKIAFEEMLELASLGAKVLQTRSVELAMRYKVKLRVLSSFEEQSDEA
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCC
GTLVCDEEEIMESNVVNGVAYSRDEAKLTCLSVADRPGIAATIFGCLSDAGVNVDMIVQN
CEEEECHHHHHHHHHHCCEEECCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHH
ISEDGRTDMTFSCPTDQVQRAEMALNAYKEKGELNFAELVADTGVAKISVVGIGMRSQSG
HCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEEEECCCCCCC
VAAKMFKVLSDEGINIKVITTSEIKISVLVDRKYMELAVQALHDAFELDKAS
HHHHHHHHHCCCCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PLLVMKFGGTSVANLDRIRRAAKRVGVEVAKGYDVIVIVSAMSGKTNELVGWVGETSPL
CEEEEEECCCCHHHHHHHHHHHHHHCEEEECCCEEEEEEEECCCCCCCEEEECCCCCCC
YDAREYDAVVSSGENVTAGLMALTLQEMDVPARSWQGWQVPLKTNSAHSQARIEEIGTEN
CCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCH
INQKFGEGMKVAVVAGFQGISPEGRITTLGRGGSDTTAVAFAAAFGAERCDIYTDVDGVY
HHHHHCCCCEEEEEECCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEEEECCCCEE
TTDPRICEKARKLDKIAFEEMLELASLGAKVLQTRSVELAMRYKVKLRVLSSFEEQSDEA
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCC
GTLVCDEEEIMESNVVNGVAYSRDEAKLTCLSVADRPGIAATIFGCLSDAGVNVDMIVQN
CEEEECHHHHHHHHHHCCEEECCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHH
ISEDGRTDMTFSCPTDQVQRAEMALNAYKEKGELNFAELVADTGVAKISVVGIGMRSQSG
HCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEEEEEECCCCCCC
VAAKMFKVLSDEGINIKVITTSEIKISVLVDRKYMELAVQALHDAFELDKAS
HHHHHHHHHCCCCCEEEEEEECCEEEEEEECHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]