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The map label for this gene is iciA [C]

Identifier: 99081732

GI number: 99081732

Start: 1992084

End: 1993004

Strand: Direct

Name: iciA [C]

Synonym: TM1040_1891

Alternate gene names: 99081732

Gene position: 1992084-1993004 (Clockwise)

Preceding gene: 99081729

Following gene: 99081733

Centisome position: 62.23

GC content: 65.58

Gene sequence:

>921_bases
ATGCGATACGATCCCCTTCAACTGGCGGCTCTTTCGGCGGTGCTCGACCTTGGCAGCTTTGATGCGGCCTCGGCGGCGCT
TGGGGTGACACCCTCGGCGATCTCACAGCGGATCAAGGCGCTGGAGGATCGCATCGGCACGCCCCTCGTCAATCGCTCAA
GCCCTTGCACTGGCACAGAAACCGGGCTTCGGATTGCCAAACATGCAGAGGATGTCGCGCTCCTTGAGCGTCGCCTTAGC
CGGGACTTGTCGCTCGAGGGCGCCGAAACACCCGCGCGGCTCAAGCTGGCGGTCAATGCGGACAGTCTTGCGACCTGGTT
TGTCGAGGCGATGGTAGCGGCGGGGGATGTGCTGTTTGATCTTGTGATCGACGATCAGGACCACAGCACCGACTGGCTGC
GCCGCGGGGTGGTCTCGGCGGCGGTCAGCGCCGAGCCGCGTCCGGTTGCGGGCTGCGATGTGCATGCGCTTGGGCATCTG
CGCTATGTCGCAACGGCCAGCCCCGCCTATATGGCGCGCTGGTTTCCGGGTGGCGTGACGCCAGAGACCGCAAGCGTCGC
GCCCTGCATGGTGTTCAACGCAAAGGATCGGCTGCAACACCGCTGGCTTGCGCGCCATGTCGCCCCCGGCCTCACACCGC
CCTCACATGCGTTGTCATCGACGCAGGCCTTTCTCGATGCGGCGGCCGCGGGGCTCGGCTGGGGCATGAACCCCGAGACA
CTGGCCGAACCGCATCTGGCCTCTGGTGCCCTGGTCGAACTGATCCCACAGAGCCCGCTTGAAACACCACTCTATTGGCA
TGTGAGTCGGATCATGGCCCCCGCGCTTGTAGAGATCACCCAAGCCGTGCGCCGTGCTGCCAGCGCCAATCTGCATCCGC
CCCCAAAGGCCTCCAACGCGCGTGCTGGCCGTGGCGGGTGA

Upstream 100 bases:

>100_bases
CCTTTGGGCTGTGTGCGCCGCAGTCCTGCGGCTGCCTTTGACTAACCAGCCGGGGTGGCGTAATCAAATTAAAGATACTG
TGGCATATTAAGACTGGCTA

Downstream 100 bases:

>100_bases
GTTGATGCTAGGCTTGGCCTATGCTGTCAGTGCCCCACCTCCCCAAAGGATCGTTTGCCCATAGCGTCTGGCTGCATCTG
GTGTTGCCGCGTGCCGCAGT

Product: chromosome replication initiation inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MRYDPLQLAALSAVLDLGSFDAASAALGVTPSAISQRIKALEDRIGTPLVNRSSPCTGTETGLRIAKHAEDVALLERRLS
RDLSLEGAETPARLKLAVNADSLATWFVEAMVAAGDVLFDLVIDDQDHSTDWLRRGVVSAAVSAEPRPVAGCDVHALGHL
RYVATASPAYMARWFPGGVTPETASVAPCMVFNAKDRLQHRWLARHVAPGLTPPSHALSSTQAFLDAAAAGLGWGMNPET
LAEPHLASGALVELIPQSPLETPLYWHVSRIMAPALVEITQAVRRAASANLHPPPKASNARAGRGG

Sequences:

>Translated_306_residues
MRYDPLQLAALSAVLDLGSFDAASAALGVTPSAISQRIKALEDRIGTPLVNRSSPCTGTETGLRIAKHAEDVALLERRLS
RDLSLEGAETPARLKLAVNADSLATWFVEAMVAAGDVLFDLVIDDQDHSTDWLRRGVVSAAVSAEPRPVAGCDVHALGHL
RYVATASPAYMARWFPGGVTPETASVAPCMVFNAKDRLQHRWLARHVAPGLTPPSHALSSTQAFLDAAAAGLGWGMNPET
LAEPHLASGALVELIPQSPLETPLYWHVSRIMAPALVEITQAVRRAASANLHPPPKASNARAGRGG
>Mature_306_residues
MRYDPLQLAALSAVLDLGSFDAASAALGVTPSAISQRIKALEDRIGTPLVNRSSPCTGTETGLRIAKHAEDVALLERRLS
RDLSLEGAETPARLKLAVNADSLATWFVEAMVAAGDVLFDLVIDDQDHSTDWLRRGVVSAAVSAEPRPVAGCDVHALGHL
RYVATASPAYMARWFPGGVTPETASVAPCMVFNAKDRLQHRWLARHVAPGLTPPSHALSSTQAFLDAAAAGLGWGMNPET
LAEPHLASGALVELIPQSPLETPLYWHVSRIMAPALVEITQAVRRAASANLHPPPKASNARAGRGG

Specific function: Specific Inhibitor Of Chromosomal Initiation Of Replication In VItro. Binds The Three 13-Mers In The Origin (Oric) To Block Initiation Of Replication. [C]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789283, Length=271, Percent_Identity=36.5313653136531, Blast_Score=150, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR017685
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32397; Mature: 32397

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYDPLQLAALSAVLDLGSFDAASAALGVTPSAISQRIKALEDRIGTPLVNRSSPCTGTE
CCCCHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
TGLRIAKHAEDVALLERRLSRDLSLEGAETPARLKLAVNADSLATWFVEAMVAAGDVLFD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHEEE
LVIDDQDHSTDWLRRGVVSAAVSAEPRPVAGCDVHALGHLRYVATASPAYMARWFPGGVT
EEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHEEECCHHHHHHHCCCCCC
PETASVAPCMVFNAKDRLQHRWLARHVAPGLTPPSHALSSTQAFLDAAAAGLGWGMNPET
CCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
LAEPHLASGALVELIPQSPLETPLYWHVSRIMAPALVEITQAVRRAASANLHPPPKASNA
HCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
RAGRGG
CCCCCC
>Mature Secondary Structure
MRYDPLQLAALSAVLDLGSFDAASAALGVTPSAISQRIKALEDRIGTPLVNRSSPCTGTE
CCCCHHHHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
TGLRIAKHAEDVALLERRLSRDLSLEGAETPARLKLAVNADSLATWFVEAMVAAGDVLFD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHEEE
LVIDDQDHSTDWLRRGVVSAAVSAEPRPVAGCDVHALGHLRYVATASPAYMARWFPGGVT
EEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHEEECCHHHHHHHCCCCCC
PETASVAPCMVFNAKDRLQHRWLARHVAPGLTPPSHALSSTQAFLDAAAAGLGWGMNPET
CCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHH
LAEPHLASGALVELIPQSPLETPLYWHVSRIMAPALVEITQAVRRAASANLHPPPKASNA
HCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
RAGRGG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]