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The map label for this gene is lolC [H]

Identifier: 99081687

GI number: 99081687

Start: 1946593

End: 1947876

Strand: Reverse

Name: lolC [H]

Synonym: TM1040_1846

Alternate gene names: 99081687

Gene position: 1947876-1946593 (Counterclockwise)

Preceding gene: 99081688

Following gene: 99081686

Centisome position: 60.85

GC content: 62.07

Gene sequence:

>1284_bases
ATGGCTGCGACTGCGCCTTTTTCCCGTTTCGAATGGATGATTGCCTGGCGCTATCTGCGCGCCCGCCGCAGCGAAGGCGG
TGTCTCGGTGATGACCTGGATTTCCCTTATTGGGATCACACTGGCGGTCTTTGCGCTGATCGCCACCCTTGCGGTGCGCT
CGGGCTTTCGGTCGGAATTCGTGGGCACCATTCTGGGCGCCAATGCCCATGCCACGGTCTATGCTCATGGCACGGTCACG
GCGGCTGGCACGCTGGATCGACGCATCACCGATTATGCGGCATTGGCTGAGGCAGTGGGGCAGGTGCCCGGCGTGTTGCA
GGCCGCGCCCTTGATCAAGGGGCAGGTGATGGCCAGCCGGGGGGATCGCAACGCCGGCGTGCAGGTCTATGGCATCCACG
CCGAAGACCTGGCCAAAATTCCGGGTGTTGCCCAAAGCGACGTGGCCTATGGCGATCTTGGCCGCTTTGACGACGGCATC
GCGCTTGGCTCCGGTGTGGCCCGCACGCTGGGCCTTGGGATCGGGGACAAGGTCAAGCTGATCTCACCCAACGGGGTCAA
GACCGCCTTTGGCACCAGCCCGCGCGTGAATGCCTATGAGGTGGTCTATGTCTTTACCGCAGGGCGCTATGACATCGACA
ACACCCGCGCCTATCTGCCCTTTGCCGAGGCGCAGAGCTATTTCAACCGCGAAGGTGTTGCCGACGAGATCGAGGTCATG
GTGGCCGATCCCGAAGCTGTCGATCAATATGTGCTGCCTTTGCTGCAGGCCGCAGGGCAGGGATATGGCGTCTGGAGCTG
GCGCGACAGCTCCGGCGGGTTTCTGCGCGCCCTGGAGGTCGAGGACAACGTGATGTTCGTGATCCTGTCGATCCTGGTGC
TGATCGCGACGATGAACATCGTCTCTGGCCTCATCATGCTGGTGAAAAACAAGGGCCGGGACATCGGCATCCTGCGTACC
ATCGGCCTCAGCGAAGGGTCGGTGATGCGGGTGTTCTTCATCTGCGGGTCGATCACCGGCGTGATCGGCACCGTGCTGGG
CGTGATCCTCGGCTGCCTTTTTGCGATATATATCGACCCGATCTTTTCTTTTGTGAACTATGTGATGGGCGGCGGGGTCT
GGGATCCGTCGATCCGGGGCATCTATGCACTGCCTGCGGAACTGCGCGCAGGCGATGTGATCTCGGCCGTGAGTCTGTCG
CTGGGCTTGTCGTTTGTCGTGACCATCTTCCCGGCCCGACGTGCGGCACGGCTCAACCCGGTGGAGGCGCTGCGCTATGA
GTGA

Upstream 100 bases:

>100_bases
AGGCTTGCTTGACCCGGTCTCTGCACGCCCCTAGGGTCTGCGCGAGATCTGCATCGCGGCTGCGATGCCCTATGTTCACC
GCGAGAGGAACACCTCCTAA

Downstream 100 bases:

>100_bases
GGTGACGCTGAAAATCGAAGGCCTGAGGAAGACCTATCTGGCTGGCACCCCTGGTGAGGTTGCGGTTCTGCGCGGCGTGG
ATCTGACCCTGCATGCGGGC

Product: LolC/E family lipoprotein releasing system, transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MAATAPFSRFEWMIAWRYLRARRSEGGVSVMTWISLIGITLAVFALIATLAVRSGFRSEFVGTILGANAHATVYAHGTVT
AAGTLDRRITDYAALAEAVGQVPGVLQAAPLIKGQVMASRGDRNAGVQVYGIHAEDLAKIPGVAQSDVAYGDLGRFDDGI
ALGSGVARTLGLGIGDKVKLISPNGVKTAFGTSPRVNAYEVVYVFTAGRYDIDNTRAYLPFAEAQSYFNREGVADEIEVM
VADPEAVDQYVLPLLQAAGQGYGVWSWRDSSGGFLRALEVEDNVMFVILSILVLIATMNIVSGLIMLVKNKGRDIGILRT
IGLSEGSVMRVFFICGSITGVIGTVLGVILGCLFAIYIDPIFSFVNYVMGGGVWDPSIRGIYALPAELRAGDVISAVSLS
LGLSFVVTIFPARRAARLNPVEALRYE

Sequences:

>Translated_427_residues
MAATAPFSRFEWMIAWRYLRARRSEGGVSVMTWISLIGITLAVFALIATLAVRSGFRSEFVGTILGANAHATVYAHGTVT
AAGTLDRRITDYAALAEAVGQVPGVLQAAPLIKGQVMASRGDRNAGVQVYGIHAEDLAKIPGVAQSDVAYGDLGRFDDGI
ALGSGVARTLGLGIGDKVKLISPNGVKTAFGTSPRVNAYEVVYVFTAGRYDIDNTRAYLPFAEAQSYFNREGVADEIEVM
VADPEAVDQYVLPLLQAAGQGYGVWSWRDSSGGFLRALEVEDNVMFVILSILVLIATMNIVSGLIMLVKNKGRDIGILRT
IGLSEGSVMRVFFICGSITGVIGTVLGVILGCLFAIYIDPIFSFVNYVMGGGVWDPSIRGIYALPAELRAGDVISAVSLS
LGLSFVVTIFPARRAARLNPVEALRYE
>Mature_426_residues
AATAPFSRFEWMIAWRYLRARRSEGGVSVMTWISLIGITLAVFALIATLAVRSGFRSEFVGTILGANAHATVYAHGTVTA
AGTLDRRITDYAALAEAVGQVPGVLQAAPLIKGQVMASRGDRNAGVQVYGIHAEDLAKIPGVAQSDVAYGDLGRFDDGIA
LGSGVARTLGLGIGDKVKLISPNGVKTAFGTSPRVNAYEVVYVFTAGRYDIDNTRAYLPFAEAQSYFNREGVADEIEVMV
ADPEAVDQYVLPLLQAAGQGYGVWSWRDSSGGFLRALEVEDNVMFVILSILVLIATMNIVSGLIMLVKNKGRDIGILRTI
GLSEGSVMRVFFICGSITGVIGTVLGVILGCLFAIYIDPIFSFVNYVMGGGVWDPSIRGIYALPAELRAGDVISAVSLSL
GLSFVVTIFPARRAARLNPVEALRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=401, Percent_Identity=28.927680798005, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1787360, Length=424, Percent_Identity=28.3018867924528, Blast_Score=128, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45577; Mature: 45446

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATAPFSRFEWMIAWRYLRARRSEGGVSVMTWISLIGITLAVFALIATLAVRSGFRSEF
CCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VGTILGANAHATVYAHGTVTAAGTLDRRITDYAALAEAVGQVPGVLQAAPLIKGQVMASR
HHHHHCCCCCEEEEECCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCHHEECC
GDRNAGVQVYGIHAEDLAKIPGVAQSDVAYGDLGRFDDGIALGSGVARTLGLGIGDKVKL
CCCCCCEEEEEECHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEE
ISPNGVKTAFGTSPRVNAYEVVYVFTAGRYDIDNTRAYLPFAEAQSYFNREGVADEIEVM
ECCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCHHHHHHHHCCCCCCCEEEEE
VADPEAVDQYVLPLLQAAGQGYGVWSWRDSSGGFLRALEVEDNVMFVILSILVLIATMNI
EECHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHH
VSGLIMLVKNKGRDIGILRTIGLSEGSVMRVFFICGSITGVIGTVLGVILGCLFAIYIDP
HHHHHHHHHCCCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFSFVNYVMGGGVWDPSIRGIYALPAELRAGDVISAVSLSLGLSFVVTIFPARRAARLNP
HHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCC
VEALRYE
HHHHCCC
>Mature Secondary Structure 
AATAPFSRFEWMIAWRYLRARRSEGGVSVMTWISLIGITLAVFALIATLAVRSGFRSEF
CCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VGTILGANAHATVYAHGTVTAAGTLDRRITDYAALAEAVGQVPGVLQAAPLIKGQVMASR
HHHHHCCCCCEEEEECCEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHCCHHHCHHEECC
GDRNAGVQVYGIHAEDLAKIPGVAQSDVAYGDLGRFDDGIALGSGVARTLGLGIGDKVKL
CCCCCCEEEEEECHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEEE
ISPNGVKTAFGTSPRVNAYEVVYVFTAGRYDIDNTRAYLPFAEAQSYFNREGVADEIEVM
ECCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEEECCHHHHHHHHCCCCCCCEEEEE
VADPEAVDQYVLPLLQAAGQGYGVWSWRDSSGGFLRALEVEDNVMFVILSILVLIATMNI
EECHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHHHHHH
VSGLIMLVKNKGRDIGILRTIGLSEGSVMRVFFICGSITGVIGTVLGVILGCLFAIYIDP
HHHHHHHHHCCCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFSFVNYVMGGGVWDPSIRGIYALPAELRAGDVISAVSLSLGLSFVVTIFPARRAARLNP
HHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHCCCCC
VEALRYE
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]