Click here to switch to the map view.

The map label for this gene is alr

Identifier: 99081620

GI number: 99081620

Start: 1873275

End: 1874312

Strand: Direct

Name: alr

Synonym: TM1040_1779

Alternate gene names: 99081620

Gene position: 1873275-1874312 (Clockwise)

Preceding gene: 99081619

Following gene: 99081621

Centisome position: 58.52

GC content: 63.2

Gene sequence:

>1038_bases
ATGAGTACGGCACGTTTAAAAATCAATCTGGATGCGCTGGCGATCAACTGGCGCAATCTGGATGCCAAGACCAACTGCGA
GACCGCAGCGGTGGTCAAGGCCAATGGCTATGGTCTGGAATCCGGCCGCGTCGGCAAGGCGCTGGCACAGGCAGGCGCGC
GCAATTTCTTTGTCGCCATCGCCGAAGAAGGCATTGCGCTCAGGCGCGCGCTTGGACCCGGCCCGGGTATTTCGGTCTTT
GCAGGTCATATGGAGGGCGACGCAAAACTCCTGCGTGACTTCCAGCTGACGCCGATGCTCAACTCGCTGGATCAGATGCT
GCGCCATTTCGAGAGCCTGCCGGGCCACCCCTTTGGCGTCCAGCTCGACAGCGGCATGAACCGGCTTGGCATGGAGGCCG
CCGAATGGATGGCCGTGCGCGACATCGCCCTCGATCAAAACCCCGTCCTCTTGATGTCGCATCTGGCCTGCTCGGACGAG
CCGGGCCACGGCATGAACGCATATCAGCTCAAGAATTTCATCGAGATGACCGAGGGGCTCAATATCCCCCGCTCGCTCGC
GGCCACTGGCGGCCTTCTGCTGGGGCGCGACTACCACTTTGATCTCTGCCGTCCCGGCATCGGGCTTTATGGGGGCGCAC
CCTACGCCGATGCGCTGCCCGTGGTCGAGCTTGAGGTGCCGGTGATTCAGGTGCGCGACCTCGCCCCGGGCGAGAGCGTC
GGCTACGGCAACACCTGGATTGCGCAGCGCGACAGCAAGATCGCCACCATTGCCGGCGGCTATGCCGACGGGCTGCACCG
GGCGTTCCAGCGACAGGGGATCATGGCTTATGCGGGCGGCACCCCCTGCCCCGTGGTGGGTCGGATCTCGATGGATCTCA
TCACCGTCGATGTCACCGACCTGGCCGAAGTGCCGCCCTACCTGAGCCTCATGAATGAGACGCAGACCGTGGATGTGCTG
GCAAACGCCGCTGATACCATCGGCTATGAGGTCCTGACCTCGCTCGGCAACCGCTATGCGAGGACCTACAGCGCATGA

Upstream 100 bases:

>100_bases
CCCCACCTGTGGGTGCATGACACGCGCGATCCGCTGCTCAATGCAGAGCAGGATGCGGTTTCCCCCTTGACCCTCCGGCC
CTCCGTGTCATGAACAAGCC

Downstream 100 bases:

>100_bases
CCCCCACCTCCGCCCTTGGGATGATCGGCCGCGCATCGCTGGGCCGCCTCGCCGCCCTCGGGCGGATCACGCGCTTTGCC
GCCTCAACCTTCAGCCACAT

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MSTARLKINLDALAINWRNLDAKTNCETAAVVKANGYGLESGRVGKALAQAGARNFFVAIAEEGIALRRALGPGPGISVF
AGHMEGDAKLLRDFQLTPMLNSLDQMLRHFESLPGHPFGVQLDSGMNRLGMEAAEWMAVRDIALDQNPVLLMSHLACSDE
PGHGMNAYQLKNFIEMTEGLNIPRSLAATGGLLLGRDYHFDLCRPGIGLYGGAPYADALPVVELEVPVIQVRDLAPGESV
GYGNTWIAQRDSKIATIAGGYADGLHRAFQRQGIMAYAGGTPCPVVGRISMDLITVDVTDLAEVPPYLSLMNETQTVDVL
ANAADTIGYEVLTSLGNRYARTYSA

Sequences:

>Translated_345_residues
MSTARLKINLDALAINWRNLDAKTNCETAAVVKANGYGLESGRVGKALAQAGARNFFVAIAEEGIALRRALGPGPGISVF
AGHMEGDAKLLRDFQLTPMLNSLDQMLRHFESLPGHPFGVQLDSGMNRLGMEAAEWMAVRDIALDQNPVLLMSHLACSDE
PGHGMNAYQLKNFIEMTEGLNIPRSLAATGGLLLGRDYHFDLCRPGIGLYGGAPYADALPVVELEVPVIQVRDLAPGESV
GYGNTWIAQRDSKIATIAGGYADGLHRAFQRQGIMAYAGGTPCPVVGRISMDLITVDVTDLAEVPPYLSLMNETQTVDVL
ANAADTIGYEVLTSLGNRYARTYSA
>Mature_344_residues
STARLKINLDALAINWRNLDAKTNCETAAVVKANGYGLESGRVGKALAQAGARNFFVAIAEEGIALRRALGPGPGISVFA
GHMEGDAKLLRDFQLTPMLNSLDQMLRHFESLPGHPFGVQLDSGMNRLGMEAAEWMAVRDIALDQNPVLLMSHLACSDEP
GHGMNAYQLKNFIEMTEGLNIPRSLAATGGLLLGRDYHFDLCRPGIGLYGGAPYADALPVVELEVPVIQVRDLAPGESVG
YGNTWIAQRDSKIATIAGGYADGLHRAFQRQGIMAYAGGTPCPVVGRISMDLITVDVTDLAEVPPYLSLMNETQTVDVLA
NAADTIGYEVLTSLGNRYARTYSA

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=363, Percent_Identity=34.9862258953168, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1787439, Length=357, Percent_Identity=31.0924369747899, Blast_Score=124, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_SILST (Q1GFQ4)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613774.1
- ProteinModelPortal:   Q1GFQ4
- SMR:   Q1GFQ4
- STRING:   Q1GFQ4
- GeneID:   4076808
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1779
- NMPDR:   fig|292414.1.peg.246
- eggNOG:   COG0787
- HOGENOM:   HBG712172
- OMA:   IMALNTI
- PhylomeDB:   Q1GFQ4
- ProtClustDB:   CLSK933932
- BioCyc:   SSP292414:TM1040_1779-MONOMER
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 36993; Mature: 36862

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 33-33 ACT_SITE 242-242

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTARLKINLDALAINWRNLDAKTNCETAAVVKANGYGLESGRVGKALAQAGARNFFVAI
CCCEEEEEEEEEEEEEEECCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCEEEEEE
AEEGIALRRALGPGPGISVFAGHMEGDAKLLRDFQLTPMLNSLDQMLRHFESLPGHPFGV
ECCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEE
QLDSGMNRLGMEAAEWMAVRDIALDQNPVLLMSHLACSDEPGHGMNAYQLKNFIEMTEGL
EECCCCCHHCCHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCCHHHHHHHHHHHHCC
NIPRSLAATGGLLLGRDYHFDLCRPGIGLYGGAPYADALPVVELEVPVIQVRDLAPGESV
CCCHHHHHCCCEEEECCCCCHHCCCCCCCCCCCCCCCCCCEEEEECCEEEEEECCCCCCC
GYGNTWIAQRDSKIATIAGGYADGLHRAFQRQGIMAYAGGTPCPVVGRISMDLITVDVTD
CCCCCEEEECCCCEEEEECCHHHHHHHHHHHCCEEEEECCCCCCEEEEEEEEEEEEEHHH
LAEVPPYLSLMNETQTVDVLANAADTIGYEVLTSLGNRYARTYSA
HHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STARLKINLDALAINWRNLDAKTNCETAAVVKANGYGLESGRVGKALAQAGARNFFVAI
CCEEEEEEEEEEEEEEECCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHCCCCEEEEEE
AEEGIALRRALGPGPGISVFAGHMEGDAKLLRDFQLTPMLNSLDQMLRHFESLPGHPFGV
ECCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEE
QLDSGMNRLGMEAAEWMAVRDIALDQNPVLLMSHLACSDEPGHGMNAYQLKNFIEMTEGL
EECCCCCHHCCHHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCCCCHHHHHHHHHHHHCC
NIPRSLAATGGLLLGRDYHFDLCRPGIGLYGGAPYADALPVVELEVPVIQVRDLAPGESV
CCCHHHHHCCCEEEECCCCCHHCCCCCCCCCCCCCCCCCCEEEEECCEEEEEECCCCCCC
GYGNTWIAQRDSKIATIAGGYADGLHRAFQRQGIMAYAGGTPCPVVGRISMDLITVDVTD
CCCCCEEEECCCCEEEEECCHHHHHHHHHHHCCEEEEECCCCCCEEEEEEEEEEEEEHHH
LAEVPPYLSLMNETQTVDVLANAADTIGYEVLTSLGNRYARTYSA
HHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA