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The map label for this gene is hchA [H]

Identifier: 99081591

GI number: 99081591

Start: 1843111

End: 1843791

Strand: Reverse

Name: hchA [H]

Synonym: TM1040_1750

Alternate gene names: 99081591

Gene position: 1843791-1843111 (Counterclockwise)

Preceding gene: 99081596

Following gene: 99081589

Centisome position: 57.6

GC content: 61.82

Gene sequence:

>681_bases
ATGGCACGCATTTTGATCCTCTCCACCGCAGCCGATGTACTGGGCGACACCGGAAAACCGACGGGCGTGTGGTACGAAGA
GCTGGCTACCCCGTACTACGCGTTCCTCGATGCCGGTCACGAGGTCACGCTGGTGACGCTCGAAGGTAAGCCTGTACCGA
TTGATCCGAACTCCGACGAAACTGGCGATGCGGCGCCGGCCTCGGTCACGCGGTTTCGCGCAGATGCAGCGGCAACAGCC
TTGCTCGCCAAGCCCGGTCGCCTCGAAGACGAGGATGTCACCGCCTATGATGCGCTCTACATTCCGGGCGGGCACGGCGC
GATGTATGACCTCGCCGAGAGCGCGACGGCAGCAGCCGCGATTGGCAAGGCCTGGGACAGCGGCAAGGTCGTCGCGTCGG
TCTGCCATGGCCCTGCGGCCTTTGCCAAGGTTGTGGATGCCAAGGGCGAGCCCATCGTCAAGGGGCGCAAAGTGACCGCT
TTCACCAACAGTGAAGAAACGGCCGTAGGGCTCGAAAAAGCGGTACCCTTCCTGCTTGAGACCAAGCTGCGCGAACTTGG
CGCAGAGTTTGAGAATGTCGCGGATTGGCAGCCTCTTGCGGTGGCCGATGGTCAATTGGTGACCGGTCAGAACCCAGCCT
CTTCGGAAGCTGCAGCCAAGGAAGTTCTGGCGCTATTGTAA

Upstream 100 bases:

>100_bases
TGCATCAATTTCTCGATCTTCTGATCCTGCTTATATGAGGTGAGACGCGCCCCGCACACTCCTCCTGGGGCGTCACTGGA
CCACGTAAGGATATATAAAC

Downstream 100 bases:

>100_bases
GTCCATTGGGCGGTGCCTCGGATAGGGGCACCGCCCGCCTCTATATCGCAGCAAGCGATGCGCCTGCGTTCGGTGGCTTC
AGCGGCTGGCGCAGGAAAGG

Product: ThiJ/PfpI

Products: NA

Alternate protein names: Hsp31 [H]

Number of amino acids: Translated: 226; Mature: 225

Protein sequence:

>226_residues
MARILILSTAADVLGDTGKPTGVWYEELATPYYAFLDAGHEVTLVTLEGKPVPIDPNSDETGDAAPASVTRFRADAAATA
LLAKPGRLEDEDVTAYDALYIPGGHGAMYDLAESATAAAAIGKAWDSGKVVASVCHGPAAFAKVVDAKGEPIVKGRKVTA
FTNSEETAVGLEKAVPFLLETKLRELGAEFENVADWQPLAVADGQLVTGQNPASSEAAAKEVLALL

Sequences:

>Translated_226_residues
MARILILSTAADVLGDTGKPTGVWYEELATPYYAFLDAGHEVTLVTLEGKPVPIDPNSDETGDAAPASVTRFRADAAATA
LLAKPGRLEDEDVTAYDALYIPGGHGAMYDLAESATAAAAIGKAWDSGKVVASVCHGPAAFAKVVDAKGEPIVKGRKVTA
FTNSEETAVGLEKAVPFLLETKLRELGAEFENVADWQPLAVADGQLVTGQNPASSEAAAKEVLALL
>Mature_225_residues
ARILILSTAADVLGDTGKPTGVWYEELATPYYAFLDAGHEVTLVTLEGKPVPIDPNSDETGDAAPASVTRFRADAAATAL
LAKPGRLEDEDVTAYDALYIPGGHGAMYDLAESATAAAAIGKAWDSGKVVASVCHGPAAFAKVVDAKGEPIVKGRKVTAF
TNSEETAVGLEKAVPFLLETKLRELGAEFENVADWQPLAVADGQLVTGQNPASSEAAAKEVLALL

Specific function: Uses temperature-induced exposure of structured hydrophobic domains to capture and stabilize early unfolding protein intermediates under severe thermal stress. It rapidly releases them once stress has abated [H]

COG id: COG0693

COG function: function code R; Putative intracellular protease/amidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C56 family. HchA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788278, Length=241, Percent_Identity=29.4605809128631, Blast_Score=64, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320742, Length=223, Percent_Identity=30.4932735426009, Blast_Score=96, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6324967, Length=207, Percent_Identity=26.5700483091787, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324975, Length=207, Percent_Identity=26.5700483091787, Blast_Score=70, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6323984, Length=214, Percent_Identity=26.6355140186916, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017283
- InterPro:   IPR002818 [H]

Pfam domain/function: PF01965 DJ-1_PfpI [H]

EC number: NA

Molecular weight: Translated: 23467; Mature: 23335

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARILILSTAADVLGDTGKPTGVWYEELATPYYAFLDAGHEVTLVTLEGKPVPIDPNSDE
CCEEEEEECHHHHHCCCCCCCCCCHHHHCCHHEEECCCCCEEEEEEECCCEECCCCCCCC
TGDAAPASVTRFRADAAATALLAKPGRLEDEDVTAYDALYIPGGHGAMYDLAESATAAAA
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHH
IGKAWDSGKVVASVCHGPAAFAKVVDAKGEPIVKGRKVTAFTNSEETAVGLEKAVPFLLE
HHCCCCCCCCCEEHHCCHHHHHHHHCCCCCCEECCCEEEEEECCCHHHHHHHHHHHHHHH
TKLRELGAEFENVADWQPLAVADGQLVTGQNPASSEAAAKEVLALL
HHHHHHCHHHHHCCCCCCEEEECCEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ARILILSTAADVLGDTGKPTGVWYEELATPYYAFLDAGHEVTLVTLEGKPVPIDPNSDE
CEEEEEECHHHHHCCCCCCCCCCHHHHCCHHEEECCCCCEEEEEEECCCEECCCCCCCC
TGDAAPASVTRFRADAAATALLAKPGRLEDEDVTAYDALYIPGGHGAMYDLAESATAAAA
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHH
IGKAWDSGKVVASVCHGPAAFAKVVDAKGEPIVKGRKVTAFTNSEETAVGLEKAVPFLLE
HHCCCCCCCCCEEHHCCHHHHHHHHCCCCCCEECCCEEEEEECCCHHHHHHHHHHHHHHH
TKLRELGAEFENVADWQPLAVADGQLVTGQNPASSEAAAKEVLALL
HHHHHHCHHHHHCCCCCCEEEECCEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA