Click here to switch to the map view.

The map label for this gene is norM [H]

Identifier: 99081577

GI number: 99081577

Start: 1830497

End: 1831915

Strand: Reverse

Name: norM [H]

Synonym: TM1040_1736

Alternate gene names: 99081577

Gene position: 1831915-1830497 (Counterclockwise)

Preceding gene: 99081578

Following gene: 99081574

Centisome position: 57.23

GC content: 62.09

Gene sequence:

>1419_bases
ATGGCGCGCATAGATCCCACCCCCCAGATGAGCTACGGCGGCCATATCCGCGCCGTGTCCATTCTTGGTCTGCCGTTGAT
CGGCGGGCATCTGGCGCAGTTTGCCATTGGTCTCACCGATACGGTGATGCTGGGCTGGTACGGGGTGAACGAGCTGGCTG
CAGTGACACTGGCCGGGTCGTTCTTCTTTGTGTGGTTCATCCTCGGCGCTGGGTTTGCCTTTGCGGTGATGCCGATGGTG
GCCTCGGCCACTGCGACCGACGACCATCGCCGGATCCGGCGGGCAACCCGGATGGGGCTGTGGCTTTCGATTGTCTATGG
CGTGCTGTCCATGCCCTTGATGTGGTATTCCGAGACGATCCTGCTGGCGGCCGGGCAAGAGGCGCAGGTGGCGGCTGATG
CAGGCACCTATCTGCGGATTGCAGGCTGGGGGATCTTTCCGGCGCTTCTGGTCATGGTGTTCAAATCCTATCTGGCGGGC
TTGGAGCGCACGCAGGTGGTCCTTTGGATCACTGTGCTCGCGGCGGTGATCAATGCCATCGTGAACTATGTGCTGATTTT
TGGGCATCTGGGCCTGCCGGAGATGGGCCTTCAGGGCGCGGCCCTTGCGTCGCTGGCGACACAGACCGTGTCGGTCGTCG
CCGTGGTCGCCTATGCGCTCTGGCGTTTGCCGGAGCATGACCTGCTGCGCAACCTGCAACGCCCTGACTGGGAGATGATG
CGCGAGATCGTGCGCCATGGCCTGCCCATCGGCCTGACCACCTTGTGCGAAGTGAGCTTGTTTTCAGCCTCTGCCCTGAT
GATGGGCTGGCTTGGTACCGTGCCGCTGGCGGCACATGGGATCGCCGTCTCTGTTGCAGGGCTGACATTCATGGCGCATC
TTGGGCTCTCCAATGCGGCCACCATCCGGGTTGGAAACGCGCTCGGACGGGGGGATAAGACCCATATGGTGCGGGGGGCA
ATTGTTGTGACCCTGGCCTCGCTCGGGATCGCGGTGGCGACTGCGATGGTGTTTTTCCTCGCGCCTGAACCCCTTATCCT
GCTCTTTCTCGATCCAGAAGATCCGCAAAAGACCGAGATCCTTGCGATTGGTGTATCGCTGCTGGCGATGGCGGGGCTGT
TTCAGCTGATGGACGGGATGCAGGCGATTGCACTTGGTCTGTTGCGGGGGCTTCTTGATACGGGGGTGCCGATGGTGATG
GCCGCACTCAGCTATTGGGCGGTGGGGGTTCCGACCTCGTACATCCTTGGCTTTCGGGCCGAGATGGGCGGCGTAGGTGT
CTGGATCGGTTTGATCCTCGGTCTTAGCACCGCCGGCGTTTTGTTGCTGTTGCGCTTCTGGTTCCACGCGTTGCGTCGGG
TGCCCACAGCGCCCACAGGAGAGATGCGCGCGGATGAGATCATGGCCGATCCCGTCTAG

Upstream 100 bases:

>100_bases
TATTCTGCCCAATCCTTGTGCAATTGTATCGGTACGCAAACTGTCTTGTCGACACATTGCGAGCGGCCTAATGGCTGAAG
TGTTGAAGGAGACCGTTACG

Downstream 100 bases:

>100_bases
ACCAGCAACCGAGCCCAAAGGCGAGACCACAATTGCCGCAAGGACAGCGCGGCGATTTCTCTCTTGGTGCTAGCCAGATG
CTTTTTCGGCCTTGGCCAGA

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MARIDPTPQMSYGGHIRAVSILGLPLIGGHLAQFAIGLTDTVMLGWYGVNELAAVTLAGSFFFVWFILGAGFAFAVMPMV
ASATATDDHRRIRRATRMGLWLSIVYGVLSMPLMWYSETILLAAGQEAQVAADAGTYLRIAGWGIFPALLVMVFKSYLAG
LERTQVVLWITVLAAVINAIVNYVLIFGHLGLPEMGLQGAALASLATQTVSVVAVVAYALWRLPEHDLLRNLQRPDWEMM
REIVRHGLPIGLTTLCEVSLFSASALMMGWLGTVPLAAHGIAVSVAGLTFMAHLGLSNAATIRVGNALGRGDKTHMVRGA
IVVTLASLGIAVATAMVFFLAPEPLILLFLDPEDPQKTEILAIGVSLLAMAGLFQLMDGMQAIALGLLRGLLDTGVPMVM
AALSYWAVGVPTSYILGFRAEMGGVGVWIGLILGLSTAGVLLLLRFWFHALRRVPTAPTGEMRADEIMADPV

Sequences:

>Translated_472_residues
MARIDPTPQMSYGGHIRAVSILGLPLIGGHLAQFAIGLTDTVMLGWYGVNELAAVTLAGSFFFVWFILGAGFAFAVMPMV
ASATATDDHRRIRRATRMGLWLSIVYGVLSMPLMWYSETILLAAGQEAQVAADAGTYLRIAGWGIFPALLVMVFKSYLAG
LERTQVVLWITVLAAVINAIVNYVLIFGHLGLPEMGLQGAALASLATQTVSVVAVVAYALWRLPEHDLLRNLQRPDWEMM
REIVRHGLPIGLTTLCEVSLFSASALMMGWLGTVPLAAHGIAVSVAGLTFMAHLGLSNAATIRVGNALGRGDKTHMVRGA
IVVTLASLGIAVATAMVFFLAPEPLILLFLDPEDPQKTEILAIGVSLLAMAGLFQLMDGMQAIALGLLRGLLDTGVPMVM
AALSYWAVGVPTSYILGFRAEMGGVGVWIGLILGLSTAGVLLLLRFWFHALRRVPTAPTGEMRADEIMADPV
>Mature_471_residues
ARIDPTPQMSYGGHIRAVSILGLPLIGGHLAQFAIGLTDTVMLGWYGVNELAAVTLAGSFFFVWFILGAGFAFAVMPMVA
SATATDDHRRIRRATRMGLWLSIVYGVLSMPLMWYSETILLAAGQEAQVAADAGTYLRIAGWGIFPALLVMVFKSYLAGL
ERTQVVLWITVLAAVINAIVNYVLIFGHLGLPEMGLQGAALASLATQTVSVVAVVAYALWRLPEHDLLRNLQRPDWEMMR
EIVRHGLPIGLTTLCEVSLFSASALMMGWLGTVPLAAHGIAVSVAGLTFMAHLGLSNAATIRVGNALGRGDKTHMVRGAI
VVTLASLGIAVATAMVFFLAPEPLILLFLDPEDPQKTEILAIGVSLLAMAGLFQLMDGMQAIALGLLRGLLDTGVPMVMA
ALSYWAVGVPTSYILGFRAEMGGVGVWIGLILGLSTAGVLLLLRFWFHALRRVPTAPTGEMRADEIMADPV

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=417, Percent_Identity=24.4604316546763, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI38261960, Length=449, Percent_Identity=22.71714922049, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI22907060, Length=432, Percent_Identity=25.462962962963, Blast_Score=89, Evalue=8e-18,
Organism=Escherichia coli, GI48994890, Length=455, Percent_Identity=32.0879120879121, Blast_Score=208, Evalue=7e-55,
Organism=Escherichia coli, GI226510954, Length=440, Percent_Identity=26.1363636363636, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 50420; Mature: 50289

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00141 ASP_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIDPTPQMSYGGHIRAVSILGLPLIGGHLAQFAIGLTDTVMLGWYGVNELAAVTLAGS
CCCCCCCCCCCCCCCEEEEHHHCCHHHHHHHHHHHHCCHHHHHHEECCHHHHHHHHHHHH
FFFVWFILGAGFAFAVMPMVASATATDDHRRIRRATRMGLWLSIVYGVLSMPLMWYSETI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEE
LLAAGQEAQVAADAGTYLRIAGWGIFPALLVMVFKSYLAGLERTQVVLWITVLAAVINAI
EEECCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VNYVLIFGHLGLPEMGLQGAALASLATQTVSVVAVVAYALWRLPEHDLLRNLQRPDWEMM
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHH
REIVRHGLPIGLTTLCEVSLFSASALMMGWLGTVPLAAHGIAVSVAGLTFMAHLGLSNAA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
TIRVGNALGRGDKTHMVRGAIVVTLASLGIAVATAMVFFLAPEPLILLFLDPEDPQKTEI
EEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
LAIGVSLLAMAGLFQLMDGMQAIALGLLRGLLDTGVPMVMAALSYWAVGVPTSYILGFRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHH
EMGGVGVWIGLILGLSTAGVLLLLRFWFHALRRVPTAPTGEMRADEIMADPV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCC
>Mature Secondary Structure 
ARIDPTPQMSYGGHIRAVSILGLPLIGGHLAQFAIGLTDTVMLGWYGVNELAAVTLAGS
CCCCCCCCCCCCCCEEEEHHHCCHHHHHHHHHHHHCCHHHHHHEECCHHHHHHHHHHHH
FFFVWFILGAGFAFAVMPMVASATATDDHRRIRRATRMGLWLSIVYGVLSMPLMWYSETI
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCEE
LLAAGQEAQVAADAGTYLRIAGWGIFPALLVMVFKSYLAGLERTQVVLWITVLAAVINAI
EEECCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
VNYVLIFGHLGLPEMGLQGAALASLATQTVSVVAVVAYALWRLPEHDLLRNLQRPDWEMM
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHH
REIVRHGLPIGLTTLCEVSLFSASALMMGWLGTVPLAAHGIAVSVAGLTFMAHLGLSNAA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
TIRVGNALGRGDKTHMVRGAIVVTLASLGIAVATAMVFFLAPEPLILLFLDPEDPQKTEI
EEEECCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHH
LAIGVSLLAMAGLFQLMDGMQAIALGLLRGLLDTGVPMVMAALSYWAVGVPTSYILGFRA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHH
EMGGVGVWIGLILGLSTAGVLLLLRFWFHALRRVPTAPTGEMRADEIMADPV
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]