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The map label for this gene is 99081433

Identifier: 99081433

GI number: 99081433

Start: 1703050

End: 1703613

Strand: Reverse

Name: 99081433

Synonym: TM1040_1592

Alternate gene names: NA

Gene position: 1703613-1703050 (Counterclockwise)

Preceding gene: 99081434

Following gene: 99081432

Centisome position: 53.22

GC content: 58.69

Gene sequence:

>564_bases
ATGCCTCAGCATCCGACATTGAAGCCCTTTAACTTTGAGAAATGGGTGGAACAAAACGCGGATAAGCTGCGCCCTCCGGT
GGGCAATCAGCTGCTGCACAAGGAAGGCGACATGATCGTGATGGTTGTGGGAGGGCCCAACACCCGCATGGATTTTCATG
ACGACCCGGTGGAGGAATGGTTCTTCCAGCAAAAGGGCGACATGATGCTCAAGATTGCCGATGGGGGCAAAATCTATGAC
GTTCCAGTGCGGGAAGGCGAGGTCTTTATGCTGCCGCCCCATGTTCGCCACGCGCCGCAACGTCCGCAGGAGGGCTCGGT
GGGGATCGTCGTAGAGGCGCCGCGCCAGCCCGGTATGAAAGAAGGGTTCGAGTGGTACTGTTTTGAGTGCGAGGGGCTCG
TTCACCGCGAAGAGGTGGCCCTTGATGGACCCGAGGGGATCGTGACTGCGCTCCCAAAAATCTACAGCAAATTCCACGAC
AGTCTCGAGGCTCGCACCTGTCCACACTGCGGCGCGCTCCATCCCGGCAAGGGGAAGCCACCTGCAGATTGGGTGCAGCT
TTGA

Upstream 100 bases:

>100_bases
TTCGCGGAAATAAATATTTCGCATGGGCAATATTTCCTAGGGTAGCGATAAGCGCAACCCAACGCCCCCAAGTGCCGGGG
GCTGCACGCGGGAGAGACCC

Downstream 100 bases:

>100_bases
TGATCAAAACAATAAGCAAAACAGGGAATTGGCCAATGAATGTCATTTGGAAAACGATCACAGGCGCCGCATTTGTGCTG
TCGAGTACGGTTGCCCCCCA

Product: 3-hydroxyanthranilate 3,4-dioxygenase

Products: NA

Alternate protein names: 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD [H]

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MPQHPTLKPFNFEKWVEQNADKLRPPVGNQLLHKEGDMIVMVVGGPNTRMDFHDDPVEEWFFQQKGDMMLKIADGGKIYD
VPVREGEVFMLPPHVRHAPQRPQEGSVGIVVEAPRQPGMKEGFEWYCFECEGLVHREEVALDGPEGIVTALPKIYSKFHD
SLEARTCPHCGALHPGKGKPPADWVQL

Sequences:

>Translated_187_residues
MPQHPTLKPFNFEKWVEQNADKLRPPVGNQLLHKEGDMIVMVVGGPNTRMDFHDDPVEEWFFQQKGDMMLKIADGGKIYD
VPVREGEVFMLPPHVRHAPQRPQEGSVGIVVEAPRQPGMKEGFEWYCFECEGLVHREEVALDGPEGIVTALPKIYSKFHD
SLEARTCPHCGALHPGKGKPPADWVQL
>Mature_186_residues
PQHPTLKPFNFEKWVEQNADKLRPPVGNQLLHKEGDMIVMVVGGPNTRMDFHDDPVEEWFFQQKGDMMLKIADGGKIYDV
PVREGEVFMLPPHVRHAPQRPQEGSVGIVVEAPRQPGMKEGFEWYCFECEGLVHREEVALDGPEGIVTALPKIYSKFHDS
LEARTCPHCGALHPGKGKPPADWVQL

Specific function: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-HAO family [H]

Homologues:

Organism=Homo sapiens, GI188497625, Length=159, Percent_Identity=36.4779874213836, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562218, Length=170, Percent_Identity=36.4705882352941, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322485, Length=173, Percent_Identity=39.3063583815029, Blast_Score=131, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010329
- InterPro:   IPR011051
- InterPro:   IPR014710 [H]

Pfam domain/function: PF06052 3-HAO [H]

EC number: =1.13.11.6 [H]

Molecular weight: Translated: 21128; Mature: 20997

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQHPTLKPFNFEKWVEQNADKLRPPVGNQLLHKEGDMIVMVVGGPNTRMDFHDDPVEEW
CCCCCCCCCCCHHHHHHCCHHHCCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCHHHHH
FFQQKGDMMLKIADGGKIYDVPVREGEVFMLPPHVRHAPQRPQEGSVGIVVEAPRQPGMK
HHHCCCCEEEEECCCCEEEEEECCCCCEEEECCHHCCCCCCCCCCCEEEEEECCCCCCCC
EGFEWYCFECEGLVHREEVALDGPEGIVTALPKIYSKFHDSLEARTCPHCGALHPGKGKP
CCCEEEEEECCCCEECCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PADWVQL
CHHHHCC
>Mature Secondary Structure 
PQHPTLKPFNFEKWVEQNADKLRPPVGNQLLHKEGDMIVMVVGGPNTRMDFHDDPVEEW
CCCCCCCCCCHHHHHHCCHHHCCCCCCCHHHHCCCCEEEEEECCCCCCCCCCCCHHHHH
FFQQKGDMMLKIADGGKIYDVPVREGEVFMLPPHVRHAPQRPQEGSVGIVVEAPRQPGMK
HHHCCCCEEEEECCCCEEEEEECCCCCEEEECCHHCCCCCCCCCCCEEEEEECCCCCCCC
EGFEWYCFECEGLVHREEVALDGPEGIVTALPKIYSKFHDSLEARTCPHCGALHPGKGKP
CCCEEEEEECCCCEECCCEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PADWVQL
CHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA