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The map label for this gene is upp [H]

Identifier: 99081410

GI number: 99081410

Start: 1676842

End: 1677474

Strand: Reverse

Name: upp [H]

Synonym: TM1040_1569

Alternate gene names: 99081410

Gene position: 1677474-1676842 (Counterclockwise)

Preceding gene: 99081411

Following gene: 99081409

Centisome position: 52.41

GC content: 60.19

Gene sequence:

>633_bases
ATGAGTGACCACCTGACCGTCGTTGACCACCCGCTCGTACAACACAAGCTGACCATCATGCGGGACAAGGCCACGTCCAC
CTATGAATTTCGCCAGCTGTTGCGCGAGCTGACGCAGCTGTTGGCCTATGAGGTCACCCGCGAGTTGCCGCTCACGACGA
CCACCATCGAAACCCCTATGGAGGAAATGGAAGCGCCGATCCTCGCGGGCAAGAAGCTGGCACTTGTGTCGATCCTGCGC
GCAGGCAACGGCATGCTCGATGGGGTGCTCGAGCTGGTGCCCTCGGCGCGGGTGGGCTTTGTCGGCATGTACCGCGACGA
GGAAACGCTGGAGCCGGTGCAGTATTATTTCAAAGTTCCGCAGCAGATCTCTGACCGGATGGTGATTGCGGTGGACCCGA
TGCTGGCGACGGGAAATTCCTCGGTCGCTGCGGTTGACCTGCTGAAAAAAGCAGGCGCCAACAACATTCGGTTCTTGTGC
CTGCTGGCCTCGCCCGAAGGGGTGGCACGCATGAAAGAAGCGCATCCGGATGTGAAGATCATCACCGCCTCGCTGGATCG
CGGCCTCAATGAAAAGGGCTACATCATGCCCGGGCTCGGGGATGCGGGCGACCGTATGTTCGGCACCAAATAG

Upstream 100 bases:

>100_bases
CAGCTTTTTGCCCTGAACGCGCCAAGGCGCGACCGGAAAACGCCTTGCTTGTCCGGGGGCGGGGCGCTTATGAAAACAAA
AAACAAAAGGAGTGCGCCTG

Downstream 100 bases:

>100_bases
CCCAGAGATGGCCCCATGCACCAGCTGCCACGCGCGACACTCTGCGCGCAACAGCTGAGGTTTGGGGCCACCCCCGCAAT
ATGGCGACGATCAGACGGAT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSDHLTVVDHPLVQHKLTIMRDKATSTYEFRQLLRELTQLLAYEVTRELPLTTTTIETPMEEMEAPILAGKKLALVSILR
AGNGMLDGVLELVPSARVGFVGMYRDEETLEPVQYYFKVPQQISDRMVIAVDPMLATGNSSVAAVDLLKKAGANNIRFLC
LLASPEGVARMKEAHPDVKIITASLDRGLNEKGYIMPGLGDAGDRMFGTK

Sequences:

>Translated_210_residues
MSDHLTVVDHPLVQHKLTIMRDKATSTYEFRQLLRELTQLLAYEVTRELPLTTTTIETPMEEMEAPILAGKKLALVSILR
AGNGMLDGVLELVPSARVGFVGMYRDEETLEPVQYYFKVPQQISDRMVIAVDPMLATGNSSVAAVDLLKKAGANNIRFLC
LLASPEGVARMKEAHPDVKIITASLDRGLNEKGYIMPGLGDAGDRMFGTK
>Mature_209_residues
SDHLTVVDHPLVQHKLTIMRDKATSTYEFRQLLRELTQLLAYEVTRELPLTTTTIETPMEEMEAPILAGKKLALVSILRA
GNGMLDGVLELVPSARVGFVGMYRDEETLEPVQYYFKVPQQISDRMVIAVDPMLATGNSSVAAVDLLKKAGANNIRFLCL
LASPEGVARMKEAHPDVKIITASLDRGLNEKGYIMPGLGDAGDRMFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=35.1485148514851, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=35.1485148514851, Blast_Score=111, Evalue=5e-25,
Organism=Homo sapiens, GI21450816, Length=170, Percent_Identity=31.1764705882353, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI87082118, Length=203, Percent_Identity=57.6354679802956, Blast_Score=241, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=26.865671641791, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=26.865671641791, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=40.625, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI28573516, Length=206, Percent_Identity=35.4368932038835, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI28573514, Length=206, Percent_Identity=35.4368932038835, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI28573512, Length=206, Percent_Identity=35.4368932038835, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI45550449, Length=206, Percent_Identity=35.4368932038835, Blast_Score=113, Evalue=7e-26,
Organism=Drosophila melanogaster, GI21358379, Length=171, Percent_Identity=30.4093567251462, Blast_Score=80, Evalue=7e-16,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23145; Mature: 23014

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDHLTVVDHPLVQHKLTIMRDKATSTYEFRQLLRELTQLLAYEVTRELPLTTTTIETPM
CCCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCH
EEMEAPILAGKKLALVSILRAGNGMLDGVLELVPSARVGFVGMYRDEETLEPVQYYFKVP
HHHCCCHHCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCC
QQISDRMVIAVDPMLATGNSSVAAVDLLKKAGANNIRFLCLLASPEGVARMKEAHPDVKI
HHHCCCEEEEECCEEECCCCCHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHCCCCEEE
ITASLDRGLNEKGYIMPGLGDAGDRMFGTK
EEEEHHCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SDHLTVVDHPLVQHKLTIMRDKATSTYEFRQLLRELTQLLAYEVTRELPLTTTTIETPM
CCCEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHCCH
EEMEAPILAGKKLALVSILRAGNGMLDGVLELVPSARVGFVGMYRDEETLEPVQYYFKVP
HHHCCCHHCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHCC
QQISDRMVIAVDPMLATGNSSVAAVDLLKKAGANNIRFLCLLASPEGVARMKEAHPDVKI
HHHCCCEEEEECCEEECCCCCHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHCCCCEEE
ITASLDRGLNEKGYIMPGLGDAGDRMFGTK
EEEEHHCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA