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The map label for this gene is clpP [H]

Identifier: 99081368

GI number: 99081368

Start: 1630761

End: 1631417

Strand: Reverse

Name: clpP [H]

Synonym: TM1040_1527

Alternate gene names: 99081368

Gene position: 1631417-1630761 (Counterclockwise)

Preceding gene: 99081377

Following gene: 99081367

Centisome position: 50.97

GC content: 56.77

Gene sequence:

>657_bases
ATGATCCCAAGACAGGCAGGTCCAATGATTGATCCAACAGAAACATACATGAACACACTTGTGCCGATGGTCGTTGAGCA
GACCAGCCGGGGCGAGCGCGCATATGACATTTTCTCGCGCCTGTTGAAGGAGCGTATCATCTTCCTCAACGGTCCCGTTC
ACGATGGCATGTCTTCGCTGATCGTAGCGCAGCTGTTGCACCTTGAGGCGGAAAACCCCTCGAAAGAGATTTCGATGTAC
ATCAACTCGCCGGGTGGTGTGGTGACGTCGGGCCTGTCGATCTATGACACGATGCAGTACATCAAGCCCAAGGTGTCGAC
GCTGGTGATCGGCCAGGCGGCCTCCATGGGCTCCTTGCTGCTGACCGCGGGCGAGGCTGGCATGCGCTTCTCGCTGCCCA
ATTCGCGCGTGATGGTCCACCAGCCCTCCGGCGGGTATCAGGGGCAGGCGACGGACATCATGATCCACGCCGAAGAGACC
CTGAAGCTCAAGCGTCGCTTGAACGAGATCTACGTCAAACACACCGGTCAGGACTACGACACCATTGAAAAGGCGCTGGA
ACGGGACAACTTCATGTCACCGGAACAAGCCAAGGAATTCGGACTGATCGACGAAATCGTCGAAAATCGCAGCAAGGCCG
ACGACGCAGAAAGCTAA

Upstream 100 bases:

>100_bases
GCGATAGCGCTGCAGGTGCGAAAATGCGGGTCCGCCTCTTGCAGCCCAATTTTCGCAATACTAAGACTCGGGTAATCCTC
TGTCGGGTATGGTGCCCGTC

Downstream 100 bases:

>100_bases
GCCCGGCACCACGCGGGCCTCGTGCTCCCTTAACCATAGTGTGCAGGGGAGCACAATTTGACATTGTGGCCGCTTGGGAG
CTGTCCTAAGCTGGCCTTAC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MIPRQAGPMIDPTETYMNTLVPMVVEQTSRGERAYDIFSRLLKERIIFLNGPVHDGMSSLIVAQLLHLEAENPSKEISMY
INSPGGVVTSGLSIYDTMQYIKPKVSTLVIGQAASMGSLLLTAGEAGMRFSLPNSRVMVHQPSGGYQGQATDIMIHAEET
LKLKRRLNEIYVKHTGQDYDTIEKALERDNFMSPEQAKEFGLIDEIVENRSKADDAES

Sequences:

>Translated_218_residues
MIPRQAGPMIDPTETYMNTLVPMVVEQTSRGERAYDIFSRLLKERIIFLNGPVHDGMSSLIVAQLLHLEAENPSKEISMY
INSPGGVVTSGLSIYDTMQYIKPKVSTLVIGQAASMGSLLLTAGEAGMRFSLPNSRVMVHQPSGGYQGQATDIMIHAEET
LKLKRRLNEIYVKHTGQDYDTIEKALERDNFMSPEQAKEFGLIDEIVENRSKADDAES
>Mature_218_residues
MIPRQAGPMIDPTETYMNTLVPMVVEQTSRGERAYDIFSRLLKERIIFLNGPVHDGMSSLIVAQLLHLEAENPSKEISMY
INSPGGVVTSGLSIYDTMQYIKPKVSTLVIGQAASMGSLLLTAGEAGMRFSLPNSRVMVHQPSGGYQGQATDIMIHAEET
LKLKRRLNEIYVKHTGQDYDTIEKALERDNFMSPEQAKEFGLIDEIVENRSKADDAES

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=195, Percent_Identity=62.5641025641026, Blast_Score=262, Evalue=2e-70,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=66.839378238342, Blast_Score=277, Evalue=4e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=62.9032258064516, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI20129427, Length=190, Percent_Identity=65.7894736842105, Blast_Score=274, Evalue=3e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 24223; Mature: 24223

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPRQAGPMIDPTETYMNTLVPMVVEQTSRGERAYDIFSRLLKERIIFLNGPVHDGMSSL
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCHHHHHHH
IVAQLLHLEAENPSKEISMYINSPGGVVTSGLSIYDTMQYIKPKVSTLVIGQAASMGSLL
HHHHHHHHCCCCCCCEEEEEECCCCCCEECCHHHHHHHHHHCCHHHEEEEECCCCCCCEE
LTAGEAGMRFSLPNSRVMVHQPSGGYQGQATDIMIHAEETLKLKRRLNEIYVKHTGQDYD
EEECCCCEEEECCCCEEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCHH
TIEKALERDNFMSPEQAKEFGLIDEIVENRSKADDAES
HHHHHHHHCCCCCHHHHHHCCHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MIPRQAGPMIDPTETYMNTLVPMVVEQTSRGERAYDIFSRLLKERIIFLNGPVHDGMSSL
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEECCCCHHHHHHH
IVAQLLHLEAENPSKEISMYINSPGGVVTSGLSIYDTMQYIKPKVSTLVIGQAASMGSLL
HHHHHHHHCCCCCCCEEEEEECCCCCCEECCHHHHHHHHHHCCHHHEEEEECCCCCCCEE
LTAGEAGMRFSLPNSRVMVHQPSGGYQGQATDIMIHAEETLKLKRRLNEIYVKHTGQDYD
EEECCCCEEEECCCCEEEEECCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCCCHH
TIEKALERDNFMSPEQAKEFGLIDEIVENRSKADDAES
HHHHHHHHCCCCCHHHHHHCCHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA