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The map label for this gene is dht [H]

Identifier: 99081338

GI number: 99081338

Start: 1602053

End: 1603507

Strand: Reverse

Name: dht [H]

Synonym: TM1040_1497

Alternate gene names: 99081338

Gene position: 1603507-1602053 (Counterclockwise)

Preceding gene: 99081339

Following gene: 99081337

Centisome position: 50.09

GC content: 59.93

Gene sequence:

>1455_bases
ATGACGACAGTCATCAAGAACGGCACCATTGTGACCGCGGATCTAACCTATAAGGCGGATGTCCTGATCGAGGGCGGCGT
CATCACCGAAATCGGCCCGGATCTGAAGGGCGATGAGGTGCTGGATGCCAGCGGTTGCTATGTCATGCCTGGCGGGATTG
ATCCGCATACCCATCTGGAGATGCCGTTCATGGGCACCTATTCTTCGGATGATTTTGAAAGTGGCACCCGTGCCGGGCTT
GCGGGCGGGACCACCATGGTGGTCGATTTTGCGCTTCCGCAGCCGGGTGAGAGCCTGCTCGATGCGCTCAAGCGCTGGGA
CAACAAGTCGACTCGCGCCAATTGTGACTATTCCTTCCATATGGCGGTGACCTGGTGGGGCGAGCAGGTCTTTGATGAGA
TGAAGACCGTCATCGAGACCCGGGGCATCAACACCTTCAAGCATTTCATGGCCTACAAGGGCGCCTTGATGGTGAATGAT
GATGAGCTTTATGCGTCATTTCAGCGTCTTGCGGAGTTGGGTGGCATCGCCATGGTGCATGCCGAGAACGGCGATGTGGT
GGCGGAGTTGAGTGCCAAGCTTTTGGCCGAGGGCAATACCGGCCCCGAAGCGCATGCTTATTCGCGCCCGCCGCAGGTGG
AAGGCGAAGCCACCAACCGGGCGGTCATGATTGCGGATATGGCCGGTGTGCCGCTCTATGTGGTGCACACCTCCTGTGAA
GAGAGCCACGAGGCCATTCGTCGGGCGCGCATGCTTGGCAAGCGGGTCTGGGGCGAGCCGCTCATCCAGCATCTGACACT
GGATGAGAGCGAGTATTTCAACCCCGATTGGGATCACGCTGCGCGGCGCGTGATGTCGCCACCGTTTCGCAACAAACAGC
ATCAGGACAGCCTCTGGGCGGGGCTTCAGTCCGGGTCCCTGTCGGTGGTCGCGACCGATCACTGCGCGTTCTCGACCGAG
CAGAAAAGATACGGCGTGGGCGATTTCACCAAGATCCCCAACGGCACGGGCGGGCTTGAGGACCGGATGCCGATGCTCTG
GACGCATGGTGTCGAAACTGGCCGCCTGACGCCCAATGAGTTTGTCGCGGTGACCTCGACCAATATTGCCAAGATCCTGA
ACTGCTATCCCAAGAAGGGGGCTGTGCTTGTGGGGGCGGATGCAGATCTGGTGGTCTGGGATCCCAAGAAAACCAAGACG
ATCTCTGCCGAGAGCCAGCAATCTGCCATTGATTACAACGTGTTCGAGGGCAAAGAGGTGAAGGGCCTGCCGCGCTACAC
CCTGACCCGTGGACAGGTCGCCGTGATGGACGGTGAGATCAAGACCCAGGAAGGTCACGGCAAATTTGTGGAGCGCGCGC
CCAACACCGTGGTGAACAAGGCGCTCAGCACCTGGAAAGAGCTGACCGCGCCGCGCCCGGTTGAGCGCAGCGGCATTCCC
GCCACTGGCGTCTAA

Upstream 100 bases:

>100_bases
GTTCCCGCGACTCCCCCGGGATATTTGGAGTTAGAAGAAACTCTGCCGGGAGCTCAATAACAAAACGGCGCAAAAGTCGC
CGGACCACAGGGAGTTTGAT

Downstream 100 bases:

>100_bases
ACGCATGAAAACGGGGGCCTCTGCGCCCCCGTTTGTTTGATCAAGGCTATGAAATGAATATGCAAATGACCTCAGAGGTA
GAACAAGCCATCGATCGGGA

Product: phenylhydantoinase

Products: NA

Alternate protein names: DHPase [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MTTVIKNGTIVTADLTYKADVLIEGGVITEIGPDLKGDEVLDASGCYVMPGGIDPHTHLEMPFMGTYSSDDFESGTRAGL
AGGTTMVVDFALPQPGESLLDALKRWDNKSTRANCDYSFHMAVTWWGEQVFDEMKTVIETRGINTFKHFMAYKGALMVND
DELYASFQRLAELGGIAMVHAENGDVVAELSAKLLAEGNTGPEAHAYSRPPQVEGEATNRAVMIADMAGVPLYVVHTSCE
ESHEAIRRARMLGKRVWGEPLIQHLTLDESEYFNPDWDHAARRVMSPPFRNKQHQDSLWAGLQSGSLSVVATDHCAFSTE
QKRYGVGDFTKIPNGTGGLEDRMPMLWTHGVETGRLTPNEFVAVTSTNIAKILNCYPKKGAVLVGADADLVVWDPKKTKT
ISAESQQSAIDYNVFEGKEVKGLPRYTLTRGQVAVMDGEIKTQEGHGKFVERAPNTVVNKALSTWKELTAPRPVERSGIP
ATGV

Sequences:

>Translated_484_residues
MTTVIKNGTIVTADLTYKADVLIEGGVITEIGPDLKGDEVLDASGCYVMPGGIDPHTHLEMPFMGTYSSDDFESGTRAGL
AGGTTMVVDFALPQPGESLLDALKRWDNKSTRANCDYSFHMAVTWWGEQVFDEMKTVIETRGINTFKHFMAYKGALMVND
DELYASFQRLAELGGIAMVHAENGDVVAELSAKLLAEGNTGPEAHAYSRPPQVEGEATNRAVMIADMAGVPLYVVHTSCE
ESHEAIRRARMLGKRVWGEPLIQHLTLDESEYFNPDWDHAARRVMSPPFRNKQHQDSLWAGLQSGSLSVVATDHCAFSTE
QKRYGVGDFTKIPNGTGGLEDRMPMLWTHGVETGRLTPNEFVAVTSTNIAKILNCYPKKGAVLVGADADLVVWDPKKTKT
ISAESQQSAIDYNVFEGKEVKGLPRYTLTRGQVAVMDGEIKTQEGHGKFVERAPNTVVNKALSTWKELTAPRPVERSGIP
ATGV
>Mature_483_residues
TTVIKNGTIVTADLTYKADVLIEGGVITEIGPDLKGDEVLDASGCYVMPGGIDPHTHLEMPFMGTYSSDDFESGTRAGLA
GGTTMVVDFALPQPGESLLDALKRWDNKSTRANCDYSFHMAVTWWGEQVFDEMKTVIETRGINTFKHFMAYKGALMVNDD
ELYASFQRLAELGGIAMVHAENGDVVAELSAKLLAEGNTGPEAHAYSRPPQVEGEATNRAVMIADMAGVPLYVVHTSCEE
SHEAIRRARMLGKRVWGEPLIQHLTLDESEYFNPDWDHAARRVMSPPFRNKQHQDSLWAGLQSGSLSVVATDHCAFSTEQ
KRYGVGDFTKIPNGTGGLEDRMPMLWTHGVETGRLTPNEFVAVTSTNIAKILNCYPKKGAVLVGADADLVVWDPKKTKTI
SAESQQSAIDYNVFEGKEVKGLPRYTLTRGQVAVMDGEIKTQEGHGKFVERAPNTVVNKALSTWKELTAPRPVERSGIPA
TGV

Specific function: Catalyzes the hydrolysis of dihydropyrimidines and of the structurally related DL-5-mono-substituted hydantoins, to produce N-carbamoyl-D-amino acids [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503375, Length=484, Percent_Identity=48.1404958677686, Blast_Score=470, Evalue=1e-132,
Organism=Homo sapiens, GI4503379, Length=459, Percent_Identity=43.5729847494553, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI190194363, Length=454, Percent_Identity=45.1541850220264, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI4503377, Length=456, Percent_Identity=42.9824561403509, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI4503051, Length=454, Percent_Identity=42.7312775330396, Blast_Score=399, Evalue=1e-111,
Organism=Homo sapiens, GI62422571, Length=454, Percent_Identity=42.7312775330396, Blast_Score=398, Evalue=1e-111,
Organism=Homo sapiens, GI19923821, Length=481, Percent_Identity=43.035343035343, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI18105007, Length=274, Percent_Identity=27.007299270073, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI87082175, Length=462, Percent_Identity=39.3939393939394, Blast_Score=332, Evalue=2e-92,
Organism=Escherichia coli, GI1786722, Length=441, Percent_Identity=28.5714285714286, Blast_Score=167, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17539558, Length=483, Percent_Identity=47.6190476190476, Blast_Score=457, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI71989490, Length=482, Percent_Identity=43.9834024896266, Blast_Score=425, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI86575075, Length=458, Percent_Identity=32.9694323144105, Blast_Score=255, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI193204318, Length=431, Percent_Identity=24.1299303944316, Blast_Score=89, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6322218, Length=448, Percent_Identity=26.3392857142857, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI221377917, Length=455, Percent_Identity=45.2747252747253, Blast_Score=423, Evalue=1e-118,
Organism=Drosophila melanogaster, GI17137462, Length=453, Percent_Identity=44.8123620309051, Blast_Score=414, Evalue=1e-116,
Organism=Drosophila melanogaster, GI24644287, Length=294, Percent_Identity=44.8979591836735, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24644289, Length=252, Percent_Identity=46.031746031746, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24642586, Length=422, Percent_Identity=26.0663507109005, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI18859883, Length=420, Percent_Identity=23.0952380952381, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.2 [H]

Molecular weight: Translated: 52940; Mature: 52809

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVIKNGTIVTADLTYKADVLIEGGVITEIGPDLKGDEVLDASGCYVMPGGIDPHTHLE
CCEEEECCEEEEEEEEEEEEEEEECCEEEECCCCCCCCCEECCCCCEEECCCCCCCCEEC
MPFMGTYSSDDFESGTRAGLAGGTTMVVDFALPQPGESLLDALKRWDNKSTRANCDYSFH
CCEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEE
MAVTWWGEQVFDEMKTVIETRGINTFKHFMAYKGALMVNDDELYASFQRLAELGGIAMVH
EEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCEEEEE
AENGDVVAELSAKLLAEGNTGPEAHAYSRPPQVEGEATNRAVMIADMAGVPLYVVHTSCE
ECCCCEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCH
ESHEAIRRARMLGKRVWGEPLIQHLTLDESEYFNPDWDHAARRVMSPPFRNKQHQDSLWA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHH
GLQSGSLSVVATDHCAFSTEQKRYGVGDFTKIPNGTGGLEDRMPMLWTHGVETGRLTPNE
HCCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCC
FVAVTSTNIAKILNCYPKKGAVLVGADADLVVWDPKKTKTISAESQQSAIDYNVFEGKEV
EEEEECCCHHHHHHCCCCCCCEEEECCCCEEEECCCCCEEECCCCHHCCCCEEEECCCCC
KGLPRYTLTRGQVAVMDGEIKTQEGHGKFVERAPNTVVNKALSTWKELTAPRPVERSGIP
CCCCCEEECCCEEEEECCCEEECCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCC
ATGV
CCCC
>Mature Secondary Structure 
TTVIKNGTIVTADLTYKADVLIEGGVITEIGPDLKGDEVLDASGCYVMPGGIDPHTHLE
CEEEECCEEEEEEEEEEEEEEEECCEEEECCCCCCCCCEECCCCCEEECCCCCCCCEEC
MPFMGTYSSDDFESGTRAGLAGGTTMVVDFALPQPGESLLDALKRWDNKSTRANCDYSFH
CCEECCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCEEEE
MAVTWWGEQVFDEMKTVIETRGINTFKHFMAYKGALMVNDDELYASFQRLAELGGIAMVH
EEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHCCEEEECCHHHHHHHHHHHHHCCEEEEE
AENGDVVAELSAKLLAEGNTGPEAHAYSRPPQVEGEATNRAVMIADMAGVPLYVVHTSCE
ECCCCEEEHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCH
ESHEAIRRARMLGKRVWGEPLIQHLTLDESEYFNPDWDHAARRVMSPPFRNKQHQDSLWA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHH
GLQSGSLSVVATDHCAFSTEQKRYGVGDFTKIPNGTGGLEDRMPMLWTHGVETGRLTPNE
HCCCCCEEEEEECCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCC
FVAVTSTNIAKILNCYPKKGAVLVGADADLVVWDPKKTKTISAESQQSAIDYNVFEGKEV
EEEEECCCHHHHHHCCCCCCCEEEECCCCEEEECCCCCEEECCCCHHCCCCEEEECCCCC
KGLPRYTLTRGQVAVMDGEIKTQEGHGKFVERAPNTVVNKALSTWKELTAPRPVERSGIP
CCCCCEEECCCEEEEECCCEEECCCCCHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCC
ATGV
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]