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The map label for this gene is rmlD [H]

Identifier: 99081326

GI number: 99081326

Start: 1586750

End: 1587571

Strand: Reverse

Name: rmlD [H]

Synonym: TM1040_1485

Alternate gene names: 99081326

Gene position: 1587571-1586750 (Counterclockwise)

Preceding gene: 99081327

Following gene: 99081325

Centisome position: 49.6

GC content: 60.34

Gene sequence:

>822_bases
ATGAGCCAGCCCCTTCGCATATTTCTGACCGGCAGTGGCGGCATCCTTGGCAGGCATGTTTCAACCGCGCTCCTGGCTCA
TGCGCCAGGCGCGCAGGTTTTGCGCAATACTGCGGATCTCACGGATTTGGCCGCGACCACGCGGGTGGTGCAGAGGGCAG
GCCCGCTTGATCTGGTGATCCATCTCGCTGCTTTGGTTCCCGTGGACGAGGTCTGCGCTGATCCGGCGCGCGGCTATGCT
GTCAACGCGGGCGGAACGATCAATCTACTCGCCGCTTTGGCTGCTGCAGAAGTAGGGCAGGCGACACCTGCGCGCCTGCT
GCATTGCTCGTCCGGTCATGTCTACGCCGCCCAGGACCGCCCCATCTCTGAGGAGGATCCAACAGATCCGGTCTCGGTCT
ATGGAAAGACCAAACTGATGGGAGAACAGGCCGCTCGCGACATCTGCGCCCAAGTCGGGCGCGCTCTCTGCGTGGCGCGT
CTATTCTCGATCCATGATCCTGCGCAGGAGGGAAACTACCTGCGCCCATCACTGGAACGTCGCCTTGCAAAAGCCAGCCC
AGAAACGGAATTCGAACTATATGGTGCTGGCAGCTTGCGCGATTTCCTCACCGCTGAGGCGGCTGCGCAGCAGCTTGTGC
GCCTGGCTATTTCTTCCTTTGAAGGGGTGGTGAACCTCGGTTCCGGTCGCGCCCAGACTGTCGCCGAGTTCGCCCAGAGC
TTTGCGCCTTTTCCTCTCAAAATCAAAGCCATGGGAGCCGATAACAATCTGGTTCCCGACGTCTCCCTCCTGCATGACAT
CCTTGGAGAAGCAAATGACTGA

Upstream 100 bases:

>100_bases
CAAAATCGCGCAACGCAATAGAAAACGAAAGCCAGGCTCTCGCGCTAAAATATCTTGGTCTTCTGGGCCATGGCACTCCG
GCCGCGTCACATCCCCGAGC

Downstream 100 bases:

>100_bases
GTCCGTATCCATTGTCATCCCGACGTTTAACCGCGCAGAGATGCTCCCCAAGGCGATCGACAGCGCCTTGGCGCAGACCC
ATAGCTGCGAGGTGATTGTG

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: dTDP-4-keto-L-rhamnose reductase; dTDP-6-deoxy-L-lyxo-4-hexulose reductase; dTDP-6-deoxy-L-mannose dehydrogenase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSQPLRIFLTGSGGILGRHVSTALLAHAPGAQVLRNTADLTDLAATTRVVQRAGPLDLVIHLAALVPVDEVCADPARGYA
VNAGGTINLLAALAAAEVGQATPARLLHCSSGHVYAAQDRPISEEDPTDPVSVYGKTKLMGEQAARDICAQVGRALCVAR
LFSIHDPAQEGNYLRPSLERRLAKASPETEFELYGAGSLRDFLTAEAAAQQLVRLAISSFEGVVNLGSGRAQTVAEFAQS
FAPFPLKIKAMGADNNLVPDVSLLHDILGEAND

Sequences:

>Translated_273_residues
MSQPLRIFLTGSGGILGRHVSTALLAHAPGAQVLRNTADLTDLAATTRVVQRAGPLDLVIHLAALVPVDEVCADPARGYA
VNAGGTINLLAALAAAEVGQATPARLLHCSSGHVYAAQDRPISEEDPTDPVSVYGKTKLMGEQAARDICAQVGRALCVAR
LFSIHDPAQEGNYLRPSLERRLAKASPETEFELYGAGSLRDFLTAEAAAQQLVRLAISSFEGVVNLGSGRAQTVAEFAQS
FAPFPLKIKAMGADNNLVPDVSLLHDILGEAND
>Mature_272_residues
SQPLRIFLTGSGGILGRHVSTALLAHAPGAQVLRNTADLTDLAATTRVVQRAGPLDLVIHLAALVPVDEVCADPARGYAV
NAGGTINLLAALAAAEVGQATPARLLHCSSGHVYAAQDRPISEEDPTDPVSVYGKTKLMGEQAARDICAQVGRALCVARL
FSIHDPAQEGNYLRPSLERRLAKASPETEFELYGAGSLRDFLTAEAAAQQLVRLAISSFEGVVNLGSGRAQTVAEFAQSF
APFPLKIKAMGADNNLVPDVSLLHDILGEAND

Specific function: Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose. Involved in the biosynthesis of the dTDP-L-rhamnose which is a component of the critical linker, D-N-acetylglucosamine-L-rhamnose disaccharide, which connects the galacta

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786974, Length=283, Percent_Identity=26.1484098939929, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19923002, Length=236, Percent_Identity=29.6610169491525, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005913
- InterPro:   IPR016040 [H]

Pfam domain/function: PF04321 RmlD_sub_bind [H]

EC number: =1.1.1.133 [H]

Molecular weight: Translated: 28666; Mature: 28535

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPLRIFLTGSGGILGRHVSTALLAHAPGAQVLRNTADLTDLAATTRVVQRAGPLDLVI
CCCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
HLAALVPVDEVCADPARGYAVNAGGTINLLAALAAAEVGQATPARLLHCSSGHVYAAQDR
HHHHHCCHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCHHEEEECCCCEEEECCC
PISEEDPTDPVSVYGKTKLMGEQAARDICAQVGRALCVARLFSIHDPAQEGNYLRPSLER
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHH
RLAKASPETEFELYGAGSLRDFLTAEAAAQQLVRLAISSFEGVVNLGSGRAQTVAEFAQS
HHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHH
FAPFPLKIKAMGADNNLVPDVSLLHDILGEAND
CCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SQPLRIFLTGSGGILGRHVSTALLAHAPGAQVLRNTADLTDLAATTRVVQRAGPLDLVI
CCCEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
HLAALVPVDEVCADPARGYAVNAGGTINLLAALAAAEVGQATPARLLHCSSGHVYAAQDR
HHHHHCCHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCHHEEEECCCCEEEECCC
PISEEDPTDPVSVYGKTKLMGEQAARDICAQVGRALCVARLFSIHDPAQEGNYLRPSLER
CCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHH
RLAKASPETEFELYGAGSLRDFLTAEAAAQQLVRLAISSFEGVVNLGSGRAQTVAEFAQS
HHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHH
FAPFPLKIKAMGADNNLVPDVSLLHDILGEAND
CCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA