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The map label for this gene is rnd [H]

Identifier: 99081315

GI number: 99081315

Start: 1574347

End: 1575504

Strand: Reverse

Name: rnd [H]

Synonym: TM1040_1474

Alternate gene names: 99081315

Gene position: 1575504-1574347 (Counterclockwise)

Preceding gene: 99081316

Following gene: 99081313

Centisome position: 49.22

GC content: 59.67

Gene sequence:

>1158_bases
ATGAAAACTCTGACCACCACCGACGAGCTGCGCGCCTTTTGCCAAGAGGCCGCGAAATACCCTTATGTGACGGTGGACAC
CGAGTTTCTGCGAGAGCGCACCTATTACTCTAAGCTTTGCCTGATCCAGATTGCCTATCGCGGTGATGGGGAAACCGACG
CCGTGCTGGTTGACCCGCTTTCCGGGGATTTGTCGCTCGAACCCTTGTACGAGCTTTTCCGCAATGAGGATGTGGTAAAG
GTCTTTCACGCCGCGCGGCAGGATCTGGAGATTTTCTGGGTGGATGCGGGCGTTTTTCCAAAACCGCTGTTTGACACCCA
GGTTGCGGCCATGGTGTGCGGCTTTGGCGAGCAGGTCGGCTACGAGACGCTGGTGCGCAAGATTTGCAAGCAAGGCCTTG
ATAAGACATCCCGCTTTACAGACTGGTCCCGCCGTCCACTCTCGGATGCGCAAAAGACTTATGCTCTGGCGGATGTCACC
CATCTGCGCCAGATATACGAGCATCTGCGCAAAGAGCTCGACAAGACCAAGCGCAGCCATTGGGTTGCCGAGGAGTTGCA
GGTCCTGACCGACCCCGCAACCTATAACATTCAGCCGCGTGAGGCTTGGCGCCGGGTGAAAACCCGCACCAACTCCGGGC
GTTTCCTTGCAGTGGTGCGCGAGCTGGCGGCCTTTCGCGAAGAATATGCGCAAACCAACAATGTGCCGCGCAATCGCGTC
TACAAGGATGATGCCCTGGTGGAACTGGCTTCCACCAAGCCCCGGACCGCGTCGGATCTGGGGGGATCACGCCTGTTGCT
GCGGGAGGCGCGCAAAGGCGCCATTGCCGAAGGCATTCTAAAAGCGGTCGAGCGCGGTGTGAACTGTCCGCAGGACGACA
TGCCTCAGGCGGATCGCTCGCGCGAGAAAATGCAGATCAATGGCGCACTTGCCGATCTGCTGCGGGTCCTGCTCAAGGCC
AAGACCGAGACCTCTGGCGTGGCGGCGAAACTGATCGCCCCTTCGGCGGATCTGGATGCAATCGCCGCCGGGGAGCGCGA
TGTTCCTGCGCTAAAAGGCTGGCGGCACGAGGTCTTTGGCGCGGATGCGTTGCGCCTGTGCAATGGAGAGATTGCGCTCG
CGGCCAAAGGCCAGCAGGTGAAGGTTGTTGACCTCTAG

Upstream 100 bases:

>100_bases
CCTGAGCTGAGCCGAAGCCTTTAGGGGGTTTGCAACCGCCTCTTGGTCGTCGTATCAACGGGAAACCGAGCGGCAGAAAC
CCTTAAAAAAGACCCAGTTG

Downstream 100 bases:

>100_bases
CGACACTCCTGTCGACATCCGACGTCGAACACTCTGACACCAAAAAACGCGCCCAGAAGCCTGTGGCGCGTTTTTTGATG
TGATTACCCGGTGCAAGCTC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKTLTTTDELRAFCQEAAKYPYVTVDTEFLRERTYYSKLCLIQIAYRGDGETDAVLVDPLSGDLSLEPLYELFRNEDVVK
VFHAARQDLEIFWVDAGVFPKPLFDTQVAAMVCGFGEQVGYETLVRKICKQGLDKTSRFTDWSRRPLSDAQKTYALADVT
HLRQIYEHLRKELDKTKRSHWVAEELQVLTDPATYNIQPREAWRRVKTRTNSGRFLAVVRELAAFREEYAQTNNVPRNRV
YKDDALVELASTKPRTASDLGGSRLLLREARKGAIAEGILKAVERGVNCPQDDMPQADRSREKMQINGALADLLRVLLKA
KTETSGVAAKLIAPSADLDAIAAGERDVPALKGWRHEVFGADALRLCNGEIALAAKGQQVKVVDL

Sequences:

>Translated_385_residues
MKTLTTTDELRAFCQEAAKYPYVTVDTEFLRERTYYSKLCLIQIAYRGDGETDAVLVDPLSGDLSLEPLYELFRNEDVVK
VFHAARQDLEIFWVDAGVFPKPLFDTQVAAMVCGFGEQVGYETLVRKICKQGLDKTSRFTDWSRRPLSDAQKTYALADVT
HLRQIYEHLRKELDKTKRSHWVAEELQVLTDPATYNIQPREAWRRVKTRTNSGRFLAVVRELAAFREEYAQTNNVPRNRV
YKDDALVELASTKPRTASDLGGSRLLLREARKGAIAEGILKAVERGVNCPQDDMPQADRSREKMQINGALADLLRVLLKA
KTETSGVAAKLIAPSADLDAIAAGERDVPALKGWRHEVFGADALRLCNGEIALAAKGQQVKVVDL
>Mature_385_residues
MKTLTTTDELRAFCQEAAKYPYVTVDTEFLRERTYYSKLCLIQIAYRGDGETDAVLVDPLSGDLSLEPLYELFRNEDVVK
VFHAARQDLEIFWVDAGVFPKPLFDTQVAAMVCGFGEQVGYETLVRKICKQGLDKTSRFTDWSRRPLSDAQKTYALADVT
HLRQIYEHLRKELDKTKRSHWVAEELQVLTDPATYNIQPREAWRRVKTRTNSGRFLAVVRELAAFREEYAQTNNVPRNRV
YKDDALVELASTKPRTASDLGGSRLLLREARKGAIAEGILKAVERGVNCPQDDMPQADRSREKMQINGALADLLRVLLKA
KTETSGVAAKLIAPSADLDAIAAGERDVPALKGWRHEVFGADALRLCNGEIALAAKGQQVKVVDL

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=301, Percent_Identity=24.9169435215947, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI50301240, Length=301, Percent_Identity=24.9169435215947, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788105, Length=378, Percent_Identity=31.2169312169312, Blast_Score=150, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17531757, Length=273, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324574, Length=175, Percent_Identity=34.2857142857143, Blast_Score=84, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 43276; Mature: 43276

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLTTTDELRAFCQEAAKYPYVTVDTEFLRERTYYSKLCLIQIAYRGDGETDAVLVDPL
CCCCCCHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHEEEEEEEECCCCCCCEEEEECC
SGDLSLEPLYELFRNEDVVKVFHAARQDLEIFWVDAGVFPKPLFDTQVAAMVCGFGEQVG
CCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCHHCC
YETLVRKICKQGLDKTSRFTDWSRRPLSDAQKTYALADVTHLRQIYEHLRKELDKTKRSH
HHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVAEELQVLTDPATYNIQPREAWRRVKTRTNSGRFLAVVRELAAFREEYAQTNNVPRNRV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCE
YKDDALVELASTKPRTASDLGGSRLLLREARKGAIAEGILKAVERGVNCPQDDMPQADRS
ECCHHHHEECCCCCCCHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHH
REKMQINGALADLLRVLLKAKTETSGVAAKLIAPSADLDAIAAGERDVPALKGWRHEVFG
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCCCCCCCHHHCCHHHHCC
ADALRLCNGEIALAAKGQQVKVVDL
CHHHHHCCCCEEEEECCCEEEEEEC
>Mature Secondary Structure
MKTLTTTDELRAFCQEAAKYPYVTVDTEFLRERTYYSKLCLIQIAYRGDGETDAVLVDPL
CCCCCCHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHEEEEEEEECCCCCCCEEEEECC
SGDLSLEPLYELFRNEDVVKVFHAARQDLEIFWVDAGVFPKPLFDTQVAAMVCGFGEQVG
CCCCCHHHHHHHHCCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCHHCC
YETLVRKICKQGLDKTSRFTDWSRRPLSDAQKTYALADVTHLRQIYEHLRKELDKTKRSH
HHHHHHHHHHHCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVAEELQVLTDPATYNIQPREAWRRVKTRTNSGRFLAVVRELAAFREEYAQTNNVPRNRV
HHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCE
YKDDALVELASTKPRTASDLGGSRLLLREARKGAIAEGILKAVERGVNCPQDDMPQADRS
ECCHHHHEECCCCCCCHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCHHH
REKMQINGALADLLRVLLKAKTETSGVAAKLIAPSADLDAIAAGERDVPALKGWRHEVFG
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHCCCCCCCHHHCCHHHHCC
ADALRLCNGEIALAAKGQQVKVVDL
CHHHHHCCCCEEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]