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The map label for this gene is purQ

Identifier: 99081304

GI number: 99081304

Start: 1564590

End: 1565258

Strand: Reverse

Name: purQ

Synonym: TM1040_1463

Alternate gene names: 99081304

Gene position: 1565258-1564590 (Counterclockwise)

Preceding gene: 99081305

Following gene: 99081303

Centisome position: 48.9

GC content: 62.03

Gene sequence:

>669_bases
ATGAAGGCTGCTGTCGTCGTTTTCCCCGGATCCAACTGCGACCGTGACCTTGCCGTAGCTTTTGAGCAGGCCGGTTTCGA
TGTCTCGATGGTGTGGCACAAGGACAGCGAACTGCCCGAGGGGGTGGACATCGTTGGCGTGCCCGGTGGGTTTTCTTATG
GGGACTATCTGCGCTGCGGTGCGATCGCGGCGCAGTCACCGATCTGCAAGGCCGTGGTCGCGCATGCCGAGCGCGGCGGA
TATGCGCTTGGGGTCTGCAACGGGTTTCAGATCCTGACCGAGACCGGCGTTCTGCCCGGCGCACTGCTGCGCAATGCGGG
GCTCAAATATATCTGCAAGACCGTCGACCTGGCGGTTGCGACCTCCGACAGTGCCTTCACCCAAGGTTACAACGCAGGCG
ATGTGATCGGCGTGCCGATCGCGCATCACGATGGCAACTACTATGCGGATGACGCCACGGTTCAGATGCTGAAGGATCAG
GACCGCGTCGCGTTCACCTATGTGGACAATCCCAACGGTTCGGTCGCAGACATTGCGGGGATCCTGTCGGAAAACCGTCG
AGTCCTGGGCATGATGCCTCACCCCGAACGCGCCGCCGACGAAGGCCATGGCGGCACCGACGGTGTGGCGATGTTCCGCG
CATTGTCCGGACTTCTCACGGACGCCTGA

Upstream 100 bases:

>100_bases
TGGAGCTGGCCGAGGGTGCCACTGAGGCCGACGTGACCGAGATGTGCGAAAAGCTGCTCGCCAATACTGTCATCGAATCC
TACAGCGTCGAGATCCAGTG

Downstream 100 bases:

>100_bases
CTTGAGCCTCAGAGGCGGTAAACCTAGTGTTGCGTCATGACTGCCTCTGAGGAGACTCCCGGCGCAAAGCCGCCTGCGCC
TTCTGAACGTCGTGCTGAGC

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MKAAVVVFPGSNCDRDLAVAFEQAGFDVSMVWHKDSELPEGVDIVGVPGGFSYGDYLRCGAIAAQSPICKAVVAHAERGG
YALGVCNGFQILTETGVLPGALLRNAGLKYICKTVDLAVATSDSAFTQGYNAGDVIGVPIAHHDGNYYADDATVQMLKDQ
DRVAFTYVDNPNGSVADIAGILSENRRVLGMMPHPERAADEGHGGTDGVAMFRALSGLLTDA

Sequences:

>Translated_222_residues
MKAAVVVFPGSNCDRDLAVAFEQAGFDVSMVWHKDSELPEGVDIVGVPGGFSYGDYLRCGAIAAQSPICKAVVAHAERGG
YALGVCNGFQILTETGVLPGALLRNAGLKYICKTVDLAVATSDSAFTQGYNAGDVIGVPIAHHDGNYYADDATVQMLKDQ
DRVAFTYVDNPNGSVADIAGILSENRRVLGMMPHPERAADEGHGGTDGVAMFRALSGLLTDA
>Mature_222_residues
MKAAVVVFPGSNCDRDLAVAFEQAGFDVSMVWHKDSELPEGVDIVGVPGGFSYGDYLRCGAIAAQSPICKAVVAHAERGG
YALGVCNGFQILTETGVLPGALLRNAGLKYICKTVDLAVATSDSAFTQGYNAGDVIGVPIAHHDGNYYADDATVQMLKDQ
DRVAFTYVDNPNGSVADIAGILSENRRVLGMMPHPERAADEGHGGTDGVAMFRALSGLLTDA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI48994899, Length=226, Percent_Identity=32.7433628318584, Blast_Score=79, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6321498, Length=237, Percent_Identity=32.9113924050633, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24582111, Length=234, Percent_Identity=29.4871794871795, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24582109, Length=234, Percent_Identity=29.4871794871795, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17137292, Length=234, Percent_Identity=29.4871794871795, Blast_Score=83, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_SILST (Q1GGM0)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613458.1
- ProteinModelPortal:   Q1GGM0
- SMR:   Q1GGM0
- STRING:   Q1GGM0
- GeneID:   4077760
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1463
- NMPDR:   fig|292414.1.peg.3436
- eggNOG:   COG0047
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BioCyc:   SSP292414:TM1040_1463-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 23254; Mature: 23254

Theoretical pI: Translated: 4.51; Mature: 4.51

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 86-86 ACT_SITE 194-194 ACT_SITE 196-196

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVVVFPGSNCDRDLAVAFEQAGFDVSMVWHKDSELPEGVDIVGVPGGFSYGDYLRCG
CCEEEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCEEEECCCCCCCCCHHHHC
AIAAQSPICKAVVAHAERGGYALGVCNGFQILTETGVLPGALLRNAGLKYICKTVDLAVA
HHHCCCHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCCHHHHHHCCHHEEHHHHEEEEE
TSDSAFTQGYNAGDVIGVPIAHHDGNYYADDATVQMLKDQDRVAFTYVDNPNGSVADIAG
ECCCHHHCCCCCCCEEEEEEEECCCCEEECCHHEEEECCCCCEEEEEEECCCCCHHHHHH
ILSENRRVLGMMPHPERAADEGHGGTDGVAMFRALSGLLTDA
HHHCCCEEEEECCCCCHHCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKAAVVVFPGSNCDRDLAVAFEQAGFDVSMVWHKDSELPEGVDIVGVPGGFSYGDYLRCG
CCEEEEEECCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCEEEECCCCCCCCCHHHHC
AIAAQSPICKAVVAHAERGGYALGVCNGFQILTETGVLPGALLRNAGLKYICKTVDLAVA
HHHCCCHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCCHHHHHHCCHHEEHHHHEEEEE
TSDSAFTQGYNAGDVIGVPIAHHDGNYYADDATVQMLKDQDRVAFTYVDNPNGSVADIAG
ECCCHHHCCCCCCCEEEEEEEECCCCEEECCHHEEEECCCCCEEEEEEECCCCCHHHHHH
ILSENRRVLGMMPHPERAADEGHGGTDGVAMFRALSGLLTDA
HHHCCCEEEEECCCCCHHCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA