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The map label for this gene is gcvT [H]

Identifier: 99081267

GI number: 99081267

Start: 1521820

End: 1524237

Strand: Reverse

Name: gcvT [H]

Synonym: TM1040_1426

Alternate gene names: 99081267

Gene position: 1524237-1521820 (Counterclockwise)

Preceding gene: 99081268

Following gene: 99081265

Centisome position: 47.62

GC content: 59.47

Gene sequence:

>2418_bases
ATGAAAACCACCACGCGTGTGGCGATTATCGGCGGTGGCGTTGTTGGCTGTTCCGTCCTCTATCATCTGACAAAACTTGG
CTGGTCCGATGTGATGCTGATCGAGCGGTCCGAGCTTACCTCGGGCTCGACCTGGCACGCCGCCGGTGGCTTTCACACGC
TCAACGGCGACACCAATATGGCGGCGCTTCAGGGCTATACCATCAAGCTCTACAAAGAGCTCGAGGCCATCACCGGCATG
TCGTGCGGCCTGCACCATGTGGGCGGCGTGACCCTTGCGGAGACGCAAGAGCGATTTGACATGTTGAAGGCAGAACGTGC
CAAACATCGCTTTATGGGACTTGAGACAGAGATCGTAAGCCCCGAAGAAATCAAGAAAATCGCGCCTGTCACGAATATTG
ATGGGATCATTGGCGGCCTCTATGATCCGCTCGACGGCCACCTGGACCCCTCCGGTACCACGCATGCCTATGCCAAGGCC
GCGCGGTTGGGCGGCGCCACGATCGAGACCCATTGCAAGGTGATCGAGACCAATCAACGCCCTGACGGAAGCTGGGACGT
GGTCACGGAAAAAGGCACCATCCACGCCGAGCACATCGTCAATGCAGGTGGGCTCTGGGCGCGCGAAGTGGGGGCAATGG
CGGGCATCTATTTTCCGCTGCACCCGATGGAGCACCAGTATATCGTCACCGACGAGGTGCCGCTTATCAAGGAGATCGTT
GAGGCGGGCGGCGAGCATCCGCATGTGATGGATCCCGCTGGTGAAAGCTATCTGCGTCAAGAGGGTCGCGGGCTCTGTAT
CGGTTTCTATGAACAACCCTGCCGGCCGTGGGCGGTTGACGGAACCCCGTGGAACTTTGGTCATGAACTCCTGCCGGATG
ACTTCGACAAGATCGAAGACAGTATTGATTTTGCGTATAAACGTTTCCCAGCGCTGGCCGAGGCTGGGGTGAAGTCCGTG
ATCCACGGCCCCTTTACCTTTGCGCCAGATGGCAATCCTCTGGTGGGGCCGGTTCCGGGCGTGCGCAATTACTGGTCGGC
CTGCGCCGTGATGGCCGGGTTCAGCCAGGGCGGCGGTGTCGGGTTGATGCTTGCGCAATGGATGGTCGATGGCGAGTGCG
AACGCGACACCGCAGCCATGGATGTGGCGCGCTATGGCGATTGGATCACCCCCGGCTACACGCGCCCCAAAGTGGTCGAG
AACTATCAGAAACGCTTCTCGATTTCTTATCCGAACGAAGAACTGCCTGCCGCGCGCCCCTTCCGCACAACGCCAATGTA
CGACATCTTTGATGAGATGGGCGCTGTCTGGGGGCACCAATATGGCATGGAGGTGCCCAACTATTTTGCCGCCGAGGGCG
AGGCGCGGTTCGAAACGCCCTCCTTCCGCCGCTCCAACGCCTTTGAGGCCACCGCCCGCGAGGTGAAAGCCGTGCGAGAA
GGCATTGGAATCAATGAGATTCACAACTTTGGCAAATATCGCATCACAGGCAGCGGTGCGCGCGCCTGGCTCGATCGCAT
CATGGCGGGCCGCGTGCCGCAACAGGGCCGTCTGAGCCTCACGCCGATGCTCTCACCCAAGGGACGCCTGATCGGGGATT
TCACGATTTCCTGCCTCTCGGAGGGGGAGTTCCAGTTGACGGCGTCATACGGTGCGCAGGCCTATCACATGCGCTGGTTC
CTGCAAAATCTCGATGCGAATGTTTCCATCGAGAATGTGTCGGATCAAGTGAATGGCTTTCAGATCGCAGGGCCAAAGGC
GGCAGCGGTGCTGCAGGCCTGCACGCGGACCGATATCTCCGACATGCGCTTTCTAGATGTGCGTCGCCTGACGGTCGGGA
TGGTGGACTGCGTGGTGCAGCGGGTCAGCTACACGGGTGATCTTGGGTATGAAATTTACTGCGACCTGCCGAGCCAGCGT
GCACTCTGGACGACCCTCTGGTGTGAAGGTCAGGGCCACGGGATGAAGCCCTTTGGCATGCGGGCCATGATGTCTTTGCG
CTTGGACAAGTTCTTTGGATCTTGGCTGTCGGAGTTTTCGCCGGATTACACGGCGGCAGAGACCGGTCTCGATCGCTTTA
TCTCCTTCAAGAAACCCGTTGAATTTATTGGGAGATCCGCTGCCGAAGCCGAGCGGGAAACCGGGGCGGAGCGAAAGCTC
TGCGCGTTTGAGGTCGACGCCGAAGACGCCGATGTGGTTGCCTATGAGCCGATCTGGCTCGATGGAGACGTCGTGGGGTT
CTGCACCTCAGGTGGTTACAGCCATTTTGCGCAGAAATCCATCGCGCTTGGTTTTGTTCCGGTTGAGCGCGCAACAGAAG
GTCTCGAGGTGGAGATCGAGATCCTCGGCAAGAAACAGCGCGCGCGGTTGATCACCGAGCCCCTGTTCGACGCGGATGGC
GCCCGTATGCGCGGCTAA

Upstream 100 bases:

>100_bases
GATTAGGCTATTGTGCGACATCGGCGGTCGTTTTTTGACTGGACTAATGAACACATGTGTCCAGAATGGGGGAAATCGGT
CCTGACAGGGAGATAAACCC

Downstream 100 bases:

>100_bases
GGATGCGCCGGTAACGTATTGATTTAAAGAAGAAGGCCCGACGTCTGTCGGGCCTTCTTGTTCCTGGCGAGATTTGTATC
TCGCGGAGCGTTTCCAAAAC

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 805; Mature: 805

Protein sequence:

>805_residues
MKTTTRVAIIGGGVVGCSVLYHLTKLGWSDVMLIERSELTSGSTWHAAGGFHTLNGDTNMAALQGYTIKLYKELEAITGM
SCGLHHVGGVTLAETQERFDMLKAERAKHRFMGLETEIVSPEEIKKIAPVTNIDGIIGGLYDPLDGHLDPSGTTHAYAKA
ARLGGATIETHCKVIETNQRPDGSWDVVTEKGTIHAEHIVNAGGLWAREVGAMAGIYFPLHPMEHQYIVTDEVPLIKEIV
EAGGEHPHVMDPAGESYLRQEGRGLCIGFYEQPCRPWAVDGTPWNFGHELLPDDFDKIEDSIDFAYKRFPALAEAGVKSV
IHGPFTFAPDGNPLVGPVPGVRNYWSACAVMAGFSQGGGVGLMLAQWMVDGECERDTAAMDVARYGDWITPGYTRPKVVE
NYQKRFSISYPNEELPAARPFRTTPMYDIFDEMGAVWGHQYGMEVPNYFAAEGEARFETPSFRRSNAFEATAREVKAVRE
GIGINEIHNFGKYRITGSGARAWLDRIMAGRVPQQGRLSLTPMLSPKGRLIGDFTISCLSEGEFQLTASYGAQAYHMRWF
LQNLDANVSIENVSDQVNGFQIAGPKAAAVLQACTRTDISDMRFLDVRRLTVGMVDCVVQRVSYTGDLGYEIYCDLPSQR
ALWTTLWCEGQGHGMKPFGMRAMMSLRLDKFFGSWLSEFSPDYTAAETGLDRFISFKKPVEFIGRSAAEAERETGAERKL
CAFEVDAEDADVVAYEPIWLDGDVVGFCTSGGYSHFAQKSIALGFVPVERATEGLEVEIEILGKKQRARLITEPLFDADG
ARMRG

Sequences:

>Translated_805_residues
MKTTTRVAIIGGGVVGCSVLYHLTKLGWSDVMLIERSELTSGSTWHAAGGFHTLNGDTNMAALQGYTIKLYKELEAITGM
SCGLHHVGGVTLAETQERFDMLKAERAKHRFMGLETEIVSPEEIKKIAPVTNIDGIIGGLYDPLDGHLDPSGTTHAYAKA
ARLGGATIETHCKVIETNQRPDGSWDVVTEKGTIHAEHIVNAGGLWAREVGAMAGIYFPLHPMEHQYIVTDEVPLIKEIV
EAGGEHPHVMDPAGESYLRQEGRGLCIGFYEQPCRPWAVDGTPWNFGHELLPDDFDKIEDSIDFAYKRFPALAEAGVKSV
IHGPFTFAPDGNPLVGPVPGVRNYWSACAVMAGFSQGGGVGLMLAQWMVDGECERDTAAMDVARYGDWITPGYTRPKVVE
NYQKRFSISYPNEELPAARPFRTTPMYDIFDEMGAVWGHQYGMEVPNYFAAEGEARFETPSFRRSNAFEATAREVKAVRE
GIGINEIHNFGKYRITGSGARAWLDRIMAGRVPQQGRLSLTPMLSPKGRLIGDFTISCLSEGEFQLTASYGAQAYHMRWF
LQNLDANVSIENVSDQVNGFQIAGPKAAAVLQACTRTDISDMRFLDVRRLTVGMVDCVVQRVSYTGDLGYEIYCDLPSQR
ALWTTLWCEGQGHGMKPFGMRAMMSLRLDKFFGSWLSEFSPDYTAAETGLDRFISFKKPVEFIGRSAAEAERETGAERKL
CAFEVDAEDADVVAYEPIWLDGDVVGFCTSGGYSHFAQKSIALGFVPVERATEGLEVEIEILGKKQRARLITEPLFDADG
ARMRG
>Mature_805_residues
MKTTTRVAIIGGGVVGCSVLYHLTKLGWSDVMLIERSELTSGSTWHAAGGFHTLNGDTNMAALQGYTIKLYKELEAITGM
SCGLHHVGGVTLAETQERFDMLKAERAKHRFMGLETEIVSPEEIKKIAPVTNIDGIIGGLYDPLDGHLDPSGTTHAYAKA
ARLGGATIETHCKVIETNQRPDGSWDVVTEKGTIHAEHIVNAGGLWAREVGAMAGIYFPLHPMEHQYIVTDEVPLIKEIV
EAGGEHPHVMDPAGESYLRQEGRGLCIGFYEQPCRPWAVDGTPWNFGHELLPDDFDKIEDSIDFAYKRFPALAEAGVKSV
IHGPFTFAPDGNPLVGPVPGVRNYWSACAVMAGFSQGGGVGLMLAQWMVDGECERDTAAMDVARYGDWITPGYTRPKVVE
NYQKRFSISYPNEELPAARPFRTTPMYDIFDEMGAVWGHQYGMEVPNYFAAEGEARFETPSFRRSNAFEATAREVKAVRE
GIGINEIHNFGKYRITGSGARAWLDRIMAGRVPQQGRLSLTPMLSPKGRLIGDFTISCLSEGEFQLTASYGAQAYHMRWF
LQNLDANVSIENVSDQVNGFQIAGPKAAAVLQACTRTDISDMRFLDVRRLTVGMVDCVVQRVSYTGDLGYEIYCDLPSQR
ALWTTLWCEGQGHGMKPFGMRAMMSLRLDKFFGSWLSEFSPDYTAAETGLDRFISFKKPVEFIGRSAAEAERETGAERKL
CAFEVDAEDADVVAYEPIWLDGDVVGFCTSGGYSHFAQKSIALGFVPVERATEGLEVEIEILGKKQRARLITEPLFDADG
ARMRG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI24797151, Length=814, Percent_Identity=38.5749385749386, Blast_Score=573, Evalue=1e-163,
Organism=Homo sapiens, GI197927446, Length=864, Percent_Identity=30.5555555555556, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI21361378, Length=864, Percent_Identity=30.5555555555556, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI194306651, Length=788, Percent_Identity=29.0609137055838, Blast_Score=337, Evalue=4e-92,
Organism=Homo sapiens, GI44662838, Length=335, Percent_Identity=24.4776119402985, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI257796256, Length=323, Percent_Identity=25.077399380805, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI257796258, Length=317, Percent_Identity=24.6056782334385, Blast_Score=78, Evalue=3e-14,
Organism=Homo sapiens, GI257796254, Length=243, Percent_Identity=26.7489711934156, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1789272, Length=341, Percent_Identity=25.8064516129032, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71994045, Length=793, Percent_Identity=27.9949558638083, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI71994052, Length=800, Percent_Identity=27.75, Blast_Score=281, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI32563613, Length=834, Percent_Identity=26.1390887290168, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI28571104, Length=797, Percent_Identity=30.1129234629862, Blast_Score=320, Evalue=2e-87,
Organism=Drosophila melanogaster, GI20130091, Length=863, Percent_Identity=28.3893395133256, Blast_Score=316, Evalue=4e-86,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 88761; Mature: 88761

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTTRVAIIGGGVVGCSVLYHLTKLGWSDVMLIERSELTSGSTWHAAGGFHTLNGDTNM
CCCCEEEEEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEECCCCEEEECCCCCE
AALQGYTIKLYKELEAITGMSCGLHHVGGVTLAETQERFDMLKAERAKHRFMGLETEIVS
EECCCCEEEHHHHHHHHHCCCCCHHHHCCEEEHHHHHHHHHHHHHHHHHHHCCCCEECCC
PEEIKKIAPVTNIDGIIGGLYDPLDGHLDPSGTTHAYAKAARLGGATIETHCKVIETNQR
HHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCEEEEECCCC
PDGSWDVVTEKGTIHAEHIVNAGGLWAREVGAMAGIYFPLHPMEHQYIVTDEVPLIKEIV
CCCCEEEEECCCCEEHHHHCCCCCHHHHHHHHHHEEEECCCCCCCCEEEECCCHHHHHHH
EAGGEHPHVMDPAGESYLRQEGRGLCIGFYEQPCRPWAVDGTPWNFGHELLPDDFDKIED
HCCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCCEECCCCCCCCCCCCCCCHHHHHHH
SIDFAYKRFPALAEAGVKSVIHGPFTFAPDGNPLVGPVPGVRNYWSACAVMAGFSQGGGV
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCH
GLMLAQWMVDGECERDTAAMDVARYGDWITPGYTRPKVVENYQKRFSISYPNEELPAARP
HHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCCC
FRTTPMYDIFDEMGAVWGHQYGMEVPNYFAAEGEARFETPSFRRSNAFEATAREVKAVRE
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GIGINEIHNFGKYRITGSGARAWLDRIMAGRVPQQGRLSLTPMLSPKGRLIGDFTISCLS
CCCHHHHHCCCCEEEECCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCEEEEEEEEEEC
EGEFQLTASYGAQAYHMRWFLQNLDANVSIENVSDQVNGFQIAGPKAAAVLQACTRTDIS
CCCEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEECCCHHHHHHHHHHCCCCC
DMRFLDVRRLTVGMVDCVVQRVSYTGDLGYEIYCDLPSQRALWTTLWCEGQGHGMKPFGM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHHH
RAMMSLRLDKFFGSWLSEFSPDYTAAETGLDRFISFKKPVEFIGRSAAEAERETGAERKL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHCCCCCCE
CAFEVDAEDADVVAYEPIWLDGDVVGFCTSGGYSHFAQKSIALGFVPVERATEGLEVEIE
EEEEECCCCCCEEEECCEEECCCEEEEEECCCHHHHHHHHHEEEEEEHHHCCCCCEEEEE
ILGKKQRARLITEPLFDADGARMRG
EECCHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKTTTRVAIIGGGVVGCSVLYHLTKLGWSDVMLIERSELTSGSTWHAAGGFHTLNGDTNM
CCCCEEEEEEECHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEECCCCEEEECCCCCE
AALQGYTIKLYKELEAITGMSCGLHHVGGVTLAETQERFDMLKAERAKHRFMGLETEIVS
EECCCCEEEHHHHHHHHHCCCCCHHHHCCEEEHHHHHHHHHHHHHHHHHHHCCCCEECCC
PEEIKKIAPVTNIDGIIGGLYDPLDGHLDPSGTTHAYAKAARLGGATIETHCKVIETNQR
HHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCEEEEECCCC
PDGSWDVVTEKGTIHAEHIVNAGGLWAREVGAMAGIYFPLHPMEHQYIVTDEVPLIKEIV
CCCCEEEEECCCCEEHHHHCCCCCHHHHHHHHHHEEEECCCCCCCCEEEECCCHHHHHHH
EAGGEHPHVMDPAGESYLRQEGRGLCIGFYEQPCRPWAVDGTPWNFGHELLPDDFDKIED
HCCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCCCEECCCCCCCCCCCCCCCHHHHHHH
SIDFAYKRFPALAEAGVKSVIHGPFTFAPDGNPLVGPVPGVRNYWSACAVMAGFSQGGGV
HHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCH
GLMLAQWMVDGECERDTAAMDVARYGDWITPGYTRPKVVENYQKRFSISYPNEELPAARP
HHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCCC
FRTTPMYDIFDEMGAVWGHQYGMEVPNYFAAEGEARFETPSFRRSNAFEATAREVKAVRE
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
GIGINEIHNFGKYRITGSGARAWLDRIMAGRVPQQGRLSLTPMLSPKGRLIGDFTISCLS
CCCHHHHHCCCCEEEECCHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCEEEEEEEEEEC
EGEFQLTASYGAQAYHMRWFLQNLDANVSIENVSDQVNGFQIAGPKAAAVLQACTRTDIS
CCCEEEEECCCCCHHHHHHHHHHCCCCEEEECCCCCCCCEEECCCHHHHHHHHHHCCCCC
DMRFLDVRRLTVGMVDCVVQRVSYTGDLGYEIYCDLPSQRALWTTLWCEGQGHGMKPFGM
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHHH
RAMMSLRLDKFFGSWLSEFSPDYTAAETGLDRFISFKKPVEFIGRSAAEAERETGAERKL
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHCCCCCCE
CAFEVDAEDADVVAYEPIWLDGDVVGFCTSGGYSHFAQKSIALGFVPVERATEGLEVEIE
EEEEECCCCCCEEEECCEEECCCEEEEEECCCHHHHHHHHHEEEEEEHHHCCCCCEEEEE
ILGKKQRARLITEPLFDADGARMRG
EECCHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA