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The map label for this gene is lpxB [H]

Identifier: 99081243

GI number: 99081243

Start: 1495642

End: 1496802

Strand: Reverse

Name: lpxB [H]

Synonym: TM1040_1402

Alternate gene names: 99081243

Gene position: 1496802-1495642 (Counterclockwise)

Preceding gene: 99081244

Following gene: 99081241

Centisome position: 46.76

GC content: 62.36

Gene sequence:

>1161_bases
TTGGGCCTCAGGGTGTTTGTCCTTGCGGGGGAGCCTTCGGGTGACCGCCTTGGCGCGGCGCTCATGCGGGGCCTCAAAAC
GCTCGCGCCCGACGTTTCCTTTGAAGGCGTCGGCGGCAGTCTGATGCAGACCGAGGGGCTGAAGTCGCAATTTCCCATGG
AAGAGCTGTCCGTGATGGGGATTGCCGAGGTCTTGCCGAAGTATTTCGACCTCAAGCGCCGCATTCAGGAAACCGCCGAT
GCGGTGGTGGCGATGAAGCCTGACGTAATGATCACCATCGACAGCCCTGATTTTTCTCTGCGGGTGGCAAAGTTGGTGAA
AGACGCCAGCGATATTCGAACCGTTCATTATGTTGCGCCCTCCGTCTGGGCGTGGCGGCCGGGGCGCGCGACAAAGATGG
CGAAGGTCATCGATCATGTGCTGGCACTGTTGCCGTTCGAGCCGCCTTATATGGAAGCCGCCGGGATGGAGTGCGATTTT
GTCGGCCATCCGGTTGTGGCTGAGCCCAAGGCGAGCGAGGCGGAAATTGCAACGTTTCGCGCGGCGTTTGATCTGGGCGA
TGCGCCCGTTCTCTTGGCGCTGCCGGGCTCGCGGCGGTCCGAGGTGGAGCGCCTTGCTGATGTGTTCGGTGCAGCACTTG
CACAGTTCAAAGCCAAACACCCCGACCACCGGATCGTTGTCCCATCCGCATCACATGTGGCGCCTATGGTGCGCGAGGCA
CTGGCGAATTGGCCTGCGGACAGCCTCGTGCTGGATCCGGCGGATCATGCGCCCGCAGTGTTTGCCGCGCACAAGCGCGC
AGCCTTTGCCACTGCCGATCTGGCGCTGGCTGCGTCTGGGACTGTCTCGCTCGAATTGGCCGCGGCGCGTACACCGATGG
TGATTGCCTATCGGTTCAACTGGCTCACCTGGCAGATCATGAAGCGCATGGCGCTGATTGATACGGTGACATTGGTCAAT
CTGGTGAGCGACACCCGCGTGGTGCCGGAATGCCTTGGTCCCAATTGCACCGCCGAAACCATTGCGGCGCGTCTCGATCA
GGTGTCGATGGCACCCGAGGCGCAGCAAGATGCCATGCGCCTCACGATGGAACGGGTGGGGGAAGGCGGTGAAGCGCCGG
GTCTACGTGCCGCCCGCGCAGTTCTCGCGCGGCTCCCATAA

Upstream 100 bases:

>100_bases
TGTGCTCGAGGCGGAGGGCGTGATTGTGCTCGACCGAGAAGAGGTAGTGGCCGCCTGCGACCGCCACGGCCTGTTCCTCT
GGTTGCGCGAGGCCTGAGCC

Downstream 100 bases:

>100_bases
GCCTGAGCCGGCCCTTTTTGTATCAAGCAAAAGAAAAGGGAGCCCGAAGGCTCCCGCATTTTTTGGTTTACTGACCCTTC
CAGATCCAACCGCCGCCATA

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MGLRVFVLAGEPSGDRLGAALMRGLKTLAPDVSFEGVGGSLMQTEGLKSQFPMEELSVMGIAEVLPKYFDLKRRIQETAD
AVVAMKPDVMITIDSPDFSLRVAKLVKDASDIRTVHYVAPSVWAWRPGRATKMAKVIDHVLALLPFEPPYMEAAGMECDF
VGHPVVAEPKASEAEIATFRAAFDLGDAPVLLALPGSRRSEVERLADVFGAALAQFKAKHPDHRIVVPSASHVAPMVREA
LANWPADSLVLDPADHAPAVFAAHKRAAFATADLALAASGTVSLELAAARTPMVIAYRFNWLTWQIMKRMALIDTVTLVN
LVSDTRVVPECLGPNCTAETIAARLDQVSMAPEAQQDAMRLTMERVGEGGEAPGLRAARAVLARLP

Sequences:

>Translated_386_residues
MGLRVFVLAGEPSGDRLGAALMRGLKTLAPDVSFEGVGGSLMQTEGLKSQFPMEELSVMGIAEVLPKYFDLKRRIQETAD
AVVAMKPDVMITIDSPDFSLRVAKLVKDASDIRTVHYVAPSVWAWRPGRATKMAKVIDHVLALLPFEPPYMEAAGMECDF
VGHPVVAEPKASEAEIATFRAAFDLGDAPVLLALPGSRRSEVERLADVFGAALAQFKAKHPDHRIVVPSASHVAPMVREA
LANWPADSLVLDPADHAPAVFAAHKRAAFATADLALAASGTVSLELAAARTPMVIAYRFNWLTWQIMKRMALIDTVTLVN
LVSDTRVVPECLGPNCTAETIAARLDQVSMAPEAQQDAMRLTMERVGEGGEAPGLRAARAVLARLP
>Mature_385_residues
GLRVFVLAGEPSGDRLGAALMRGLKTLAPDVSFEGVGGSLMQTEGLKSQFPMEELSVMGIAEVLPKYFDLKRRIQETADA
VVAMKPDVMITIDSPDFSLRVAKLVKDASDIRTVHYVAPSVWAWRPGRATKMAKVIDHVLALLPFEPPYMEAAGMECDFV
GHPVVAEPKASEAEIATFRAAFDLGDAPVLLALPGSRRSEVERLADVFGAALAQFKAKHPDHRIVVPSASHVAPMVREAL
ANWPADSLVLDPADHAPAVFAAHKRAAFATADLALAASGTVSLELAAARTPMVIAYRFNWLTWQIMKRMALIDTVTLVNL
VSDTRVVPECLGPNCTAETIAARLDQVSMAPEAQQDAMRLTMERVGEGGEAPGLRAARAVLARLP

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=338, Percent_Identity=38.1656804733728, Blast_Score=199, Evalue=3e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41520; Mature: 41388

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLRVFVLAGEPSGDRLGAALMRGLKTLAPDVSFEGVGGSLMQTEGLKSQFPMEELSVMG
CCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHCCHHHHHHHH
IAEVLPKYFDLKRRIQETADAVVAMKPDVMITIDSPDFSLRVAKLVKDASDIRTVHYVAP
HHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHEEEEEECC
SVWAWRPGRATKMAKVIDHVLALLPFEPPYMEAAGMECDFVGHPVVAEPKASEAEIATFR
CCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
AAFDLGDAPVLLALPGSRRSEVERLADVFGAALAQFKAKHPDHRIVVPSASHVAPMVREA
HHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHH
LANWPADSLVLDPADHAPAVFAAHKRAAFATADLALAASGTVSLELAAARTPMVIAYRFN
HHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHEEECCCEEEEEEECCCCEEEEEEEC
WLTWQIMKRMALIDTVTLVNLVSDTRVVPECLGPNCTAETIAARLDQVSMAPEAQQDAMR
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
LTMERVGEGGEAPGLRAARAVLARLP
HHHHHHCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
GLRVFVLAGEPSGDRLGAALMRGLKTLAPDVSFEGVGGSLMQTEGLKSQFPMEELSVMG
CEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHCCHHHHHHHH
IAEVLPKYFDLKRRIQETADAVVAMKPDVMITIDSPDFSLRVAKLVKDASDIRTVHYVAP
HHHHHHHHHHHHHHHHHHHHEEEEECCCEEEEECCCCCHHHHHHHHHHHHHHEEEEEECC
SVWAWRPGRATKMAKVIDHVLALLPFEPPYMEAAGMECDFVGHPVVAEPKASEAEIATFR
CCEEECCCCHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
AAFDLGDAPVLLALPGSRRSEVERLADVFGAALAQFKAKHPDHRIVVPSASHVAPMVREA
HHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHH
LANWPADSLVLDPADHAPAVFAAHKRAAFATADLALAASGTVSLELAAARTPMVIAYRFN
HHCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHEEECCCEEEEEEECCCCEEEEEEEC
WLTWQIMKRMALIDTVTLVNLVSDTRVVPECLGPNCTAETIAARLDQVSMAPEAQQDAMR
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCHHHHHHH
LTMERVGEGGEAPGLRAARAVLARLP
HHHHHHCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA