Click here to switch to the map view.

The map label for this gene is hpt [H]

Identifier: 99081209

GI number: 99081209

Start: 1461575

End: 1462117

Strand: Direct

Name: hpt [H]

Synonym: TM1040_1368

Alternate gene names: 99081209

Gene position: 1461575-1462117 (Clockwise)

Preceding gene: 99081207

Following gene: 99081210

Centisome position: 45.66

GC content: 56.17

Gene sequence:

>543_bases
ATGTCAGAGCGACCATATGTCATTGATGTAATGATCTCGGCCAAGGCCATCGCTGCACGAATCGAAGAGCTATGCGGCGA
CATCACGGCCGAGTTTGGCGATACCGACAAGCTCGTGGTCGTGGGCCTGCTGCGCGGAAGTTTTGTCTTTATCGCGGATC
TGGTGCGTGAGCTGGATCTCCCGATCGAGGTCGACTTCCTTGAGGCGTCCTCTTATGGCGACGGCATGGAAAGCAGCCGA
GAAGTGCGCATTCTCAAAGACTTGCGTGGCGCTATTGAAGGGCGCGATGTGCTGGTGGTTGAGGATATCGTCGACACGGG
CCATACCCTGAACCATGTGATCTCGCTCCTGAAGAGCCGCAAGCCTGCGCGTCTCAAATCCATTGCGCTTCTGGACAAAC
CCTCGCGTCGCGAAGTCGACTTTCGCGCAGATTGGATCGGCTTTGAGATCCCGGATGAATTTGTCGTGGGCTACGGAATC
GACTTTGCCCAACGCAACCGCAACCTGCCTCACATTGGCAAAGTGCGCTTCACCGAAGTGTGA

Upstream 100 bases:

>100_bases
GGTCGGGTTTCCGAATGTGTTGGCATCGCGGGTCCATTCGTCTTCTGTACAGGTGGCGCGTGGTGTCCTATGAACGCGTG
CGAAATTCAAGGGGGCAAGC

Downstream 100 bases:

>100_bases
CCCCAGACCAGCAAAGCCTTGCCGGTTTGCCTTGATGCAACCGGCGGCATCTGGCGCATGAGATTTGGCTCCGAACGGCC
TGTGCGACATATACTGACGC

Product: hypoxanthine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MSERPYVIDVMISAKAIAARIEELCGDITAEFGDTDKLVVVGLLRGSFVFIADLVRELDLPIEVDFLEASSYGDGMESSR
EVRILKDLRGAIEGRDVLVVEDIVDTGHTLNHVISLLKSRKPARLKSIALLDKPSRREVDFRADWIGFEIPDEFVVGYGI
DFAQRNRNLPHIGKVRFTEV

Sequences:

>Translated_180_residues
MSERPYVIDVMISAKAIAARIEELCGDITAEFGDTDKLVVVGLLRGSFVFIADLVRELDLPIEVDFLEASSYGDGMESSR
EVRILKDLRGAIEGRDVLVVEDIVDTGHTLNHVISLLKSRKPARLKSIALLDKPSRREVDFRADWIGFEIPDEFVVGYGI
DFAQRNRNLPHIGKVRFTEV
>Mature_179_residues
SERPYVIDVMISAKAIAARIEELCGDITAEFGDTDKLVVVGLLRGSFVFIADLVRELDLPIEVDFLEASSYGDGMESSRE
VRILKDLRGAIEGRDVLVVEDIVDTGHTLNHVISLLKSRKPARLKSIALLDKPSRREVDFRADWIGFEIPDEFVVGYGID
FAQRNRNLPHIGKVRFTEV

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4504483, Length=173, Percent_Identity=35.2601156069364, Blast_Score=107, Evalue=6e-24,
Organism=Homo sapiens, GI9910262, Length=173, Percent_Identity=37.5722543352601, Blast_Score=103, Evalue=7e-23,
Organism=Escherichia coli, GI87081689, Length=171, Percent_Identity=57.3099415204678, Blast_Score=192, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17510817, Length=171, Percent_Identity=37.4269005847953, Blast_Score=102, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005904
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.8 [H]

Molecular weight: Translated: 20186; Mature: 20055

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERPYVIDVMISAKAIAARIEELCGDITAEFGDTDKLVVVGLLRGSFVFIADLVRELDL
CCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHCCHHHHHHHHHHCCC
PIEVDFLEASSYGDGMESSREVRILKDLRGAIEGRDVLVVEDIVDTGHTLNHVISLLKSR
CEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHCCHHHHHHHHHHHCC
KPARLKSIALLDKPSRREVDFRADWIGFEIPDEFVVGYGIDFAQRNRNLPHIGKVRFTEV
CCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHEEECCCCHHHHCCCCCCCCCEEEECC
>Mature Secondary Structure 
SERPYVIDVMISAKAIAARIEELCGDITAEFGDTDKLVVVGLLRGSFVFIADLVRELDL
CCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHCCHHHHHHHHHHCCC
PIEVDFLEASSYGDGMESSREVRILKDLRGAIEGRDVLVVEDIVDTGHTLNHVISLLKSR
CEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEHHHHCCHHHHHHHHHHHCC
KPARLKSIALLDKPSRREVDFRADWIGFEIPDEFVVGYGIDFAQRNRNLPHIGKVRFTEV
CCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCHHEEECCCCHHHHCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1756169 [H]