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The map label for this gene is acdA [H]

Identifier: 99081096

GI number: 99081096

Start: 1352244

End: 1353467

Strand: Reverse

Name: acdA [H]

Synonym: TM1040_1255

Alternate gene names: 99081096

Gene position: 1353467-1352244 (Counterclockwise)

Preceding gene: 99081098

Following gene: 99081094

Centisome position: 42.28

GC content: 59.07

Gene sequence:

>1224_bases
ATGCTGGATGACAAACCCACACTTCGCGCAAAAGATGCACCTGACCTTGGCCGCTTTGCTTGGGACGACCCGCTGCGCCT
GAGCGATCAGCTGACCGAAGACGAACGCATGATTGAAGCCTCTGCACGCGCTTACGCACAGGAAAAACTGCAAAGCCGTG
TGACTGAGGCCTATGAGACCGAACAGACCGATCCCGAGATTTTCCGCGAAATGGGCGAAATGGGGCTTCTGGGCACCACG
ATCCCAGAGGAATACGGCGGCCTCGGTGGCGGTTATGTCTCCTACGGCCTGGTGGCACGCGAAGTGGAACGTGTCGACAG
CGGCTATCGCTCCATGATGTCGGTGCAAAGCTCGCTGGTGATGTACCCGATCTACGCTTATGGCAGCGAGGAGCAGCGCC
AGAAATATCTGCCGAAACTCGCCTCCGGTGAGTGGATCGGTTGTTTTGGTTTGACCGAACCCGATGCGGGCTCAGATCCG
GCCGGCATGAAAACACGCGCCGAAAAGACCGCAGATGGCTATCGCCTCACGGGCTCCAAAATGTGGATTTCGAACGCGCC
CATCGCCGATGTCTTTGTGGTTTGGGCAAAATCCGAAGCCCACGGCGGCAAGATCCGCGGATTTGTGCTCGATAAGGGCA
CCAAGGGCCTGTCGGCTCCGAAAATTCAACAGAAGATGTCACTGCGCGCTTCGATCACGGGTGAGATCGTCCTGGATGGG
GTCGAGGTTGGCGAAGAGGCGCTGCTGCCACATGTCGAAGGACTGAAGGGACCCTTTGGCTGTTTGAACCGCGCGCGTTA
CGGGATCAGCTGGGGTGTCATGGGGGCGGCGGAAGCCTGCTGGCATGCGGCGCGCCAGTATGGCCTCGACCGCCATCAGT
TTGGGCGCCCTCTGGCGAACACGCAGCTCTTCCAGTTGAAACTGGCCAATATGCAAACCGAGATCGCGTTGGGCCTGCAA
GCCTCCTTGCGTGTTGGGCGTCTCATGGATGAGGCCAATGCCGCGCCGGAGATGATCTCCATCGTAAAGCGCAACAACTG
CGGCAAGGCTCTCGAAATTGCACGGCATGCGCGTGACATGCACGGCGGCAACGGCATCAGCCTTGAGTTCCAGGTCATTC
GTCACATGATGAACCTTGAGACCGTGAACACCTACGAAGGCACGCATGACGTCCATGCCCTGATCCTTGGGCGCGCGCAG
ACCGGCCTGCAGGCGTTCTTCTAA

Upstream 100 bases:

>100_bases
GACATGTATGATTTTTTGTCATACATTCTTTCCAAAGTCTCGCTGTTTTTTGCGGCCAGCCGCGCTTAAGCTCTCGTCAA
CACTTTGATTGGAGGCCCAC

Downstream 100 bases:

>100_bases
GCCTTAACGAGGCTCAAAAACGCAAAGCCGCCCTTGCAGGAATGCAAGGGCGGCTATTTTGCGGGGATTCCGCGACGCAA
GGGGCGCCAACACTCACGGG

Product: acyl-CoA dehydrogenase-like

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MLDDKPTLRAKDAPDLGRFAWDDPLRLSDQLTEDERMIEASARAYAQEKLQSRVTEAYETEQTDPEIFREMGEMGLLGTT
IPEEYGGLGGGYVSYGLVAREVERVDSGYRSMMSVQSSLVMYPIYAYGSEEQRQKYLPKLASGEWIGCFGLTEPDAGSDP
AGMKTRAEKTADGYRLTGSKMWISNAPIADVFVVWAKSEAHGGKIRGFVLDKGTKGLSAPKIQQKMSLRASITGEIVLDG
VEVGEEALLPHVEGLKGPFGCLNRARYGISWGVMGAAEACWHAARQYGLDRHQFGRPLANTQLFQLKLANMQTEIALGLQ
ASLRVGRLMDEANAAPEMISIVKRNNCGKALEIARHARDMHGGNGISLEFQVIRHMMNLETVNTYEGTHDVHALILGRAQ
TGLQAFF

Sequences:

>Translated_407_residues
MLDDKPTLRAKDAPDLGRFAWDDPLRLSDQLTEDERMIEASARAYAQEKLQSRVTEAYETEQTDPEIFREMGEMGLLGTT
IPEEYGGLGGGYVSYGLVAREVERVDSGYRSMMSVQSSLVMYPIYAYGSEEQRQKYLPKLASGEWIGCFGLTEPDAGSDP
AGMKTRAEKTADGYRLTGSKMWISNAPIADVFVVWAKSEAHGGKIRGFVLDKGTKGLSAPKIQQKMSLRASITGEIVLDG
VEVGEEALLPHVEGLKGPFGCLNRARYGISWGVMGAAEACWHAARQYGLDRHQFGRPLANTQLFQLKLANMQTEIALGLQ
ASLRVGRLMDEANAAPEMISIVKRNNCGKALEIARHARDMHGGNGISLEFQVIRHMMNLETVNTYEGTHDVHALILGRAQ
TGLQAFF
>Mature_407_residues
MLDDKPTLRAKDAPDLGRFAWDDPLRLSDQLTEDERMIEASARAYAQEKLQSRVTEAYETEQTDPEIFREMGEMGLLGTT
IPEEYGGLGGGYVSYGLVAREVERVDSGYRSMMSVQSSLVMYPIYAYGSEEQRQKYLPKLASGEWIGCFGLTEPDAGSDP
AGMKTRAEKTADGYRLTGSKMWISNAPIADVFVVWAKSEAHGGKIRGFVLDKGTKGLSAPKIQQKMSLRASITGEIVLDG
VEVGEEALLPHVEGLKGPFGCLNRARYGISWGVMGAAEACWHAARQYGLDRHQFGRPLANTQLFQLKLANMQTEIALGLQ
ASLRVGRLMDEANAAPEMISIVKRNNCGKALEIARHARDMHGGNGISLEFQVIRHMMNLETVNTYEGTHDVHALILGRAQ
TGLQAFF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=390, Percent_Identity=65.6410256410256, Blast_Score=518, Evalue=1e-147,
Organism=Homo sapiens, GI7669494, Length=370, Percent_Identity=64.5945945945946, Blast_Score=481, Evalue=1e-136,
Organism=Homo sapiens, GI4501859, Length=365, Percent_Identity=31.5068493150685, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI226958412, Length=377, Percent_Identity=31.2997347480106, Blast_Score=185, Evalue=5e-47,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=32.3699421965318, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI4557233, Length=374, Percent_Identity=29.6791443850267, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=31.0526315789474, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=31.0526315789474, Blast_Score=171, Evalue=8e-43,
Organism=Homo sapiens, GI4557235, Length=347, Percent_Identity=32.2766570605187, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI76496475, Length=347, Percent_Identity=32.2766570605187, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI21361497, Length=372, Percent_Identity=29.3010752688172, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI4501857, Length=382, Percent_Identity=29.0575916230367, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI7656849, Length=379, Percent_Identity=28.2321899736148, Blast_Score=140, Evalue=2e-33,
Organism=Escherichia coli, GI1786223, Length=378, Percent_Identity=24.8677248677249, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87081958, Length=379, Percent_Identity=25.3298153034301, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87081702, Length=144, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17534353, Length=388, Percent_Identity=65.7216494845361, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI17538396, Length=375, Percent_Identity=33.6, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=32.7077747989276, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17506239, Length=373, Percent_Identity=29.7587131367292, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17569725, Length=380, Percent_Identity=30, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17534899, Length=380, Percent_Identity=29.4736842105263, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=35.5212355212355, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17570075, Length=375, Percent_Identity=29.3333333333333, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71985184, Length=401, Percent_Identity=29.6758104738155, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI71985192, Length=304, Percent_Identity=31.9078947368421, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=35.0649350649351, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=29.5620437956204, Blast_Score=134, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17533517, Length=376, Percent_Identity=24.7340425531915, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=249, Percent_Identity=25.3012048192771, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17505929, Length=290, Percent_Identity=25.5172413793103, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19920834, Length=393, Percent_Identity=61.323155216285, Blast_Score=472, Evalue=1e-133,
Organism=Drosophila melanogaster, GI24666513, Length=365, Percent_Identity=33.1506849315069, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI21356377, Length=372, Percent_Identity=30.6451612903226, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI24660351, Length=385, Percent_Identity=30.6493506493506, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24646207, Length=373, Percent_Identity=30.8310991957105, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21355753, Length=377, Percent_Identity=29.4429708222812, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI281363737, Length=371, Percent_Identity=29.9191374663073, Blast_Score=156, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 44814; Mature: 44814

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDDKPTLRAKDAPDLGRFAWDDPLRLSDQLTEDERMIEASARAYAQEKLQSRVTEAYET
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EQTDPEIFREMGEMGLLGTTIPEEYGGLGGGYVSYGLVAREVERVDSGYRSMMSVQSSLV
CCCCHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
MYPIYAYGSEEQRQKYLPKLASGEWIGCFGLTEPDAGSDPAGMKTRAEKTADGYRLTGSK
EEEEEECCCHHHHHHHCCHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCEEECCCE
MWISNAPIADVFVVWAKSEAHGGKIRGFVLDKGTKGLSAPKIQQKMSLRASITGEIVLDG
EEECCCCHHHEEEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEC
VEVGEEALLPHVEGLKGPFGCLNRARYGISWGVMGAAEACWHAARQYGLDRHQFGRPLAN
HHHCHHHHCCHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCC
TQLFQLKLANMQTEIALGLQASLRVGRLMDEANAAPEMISIVKRNNCGKALEIARHARDM
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
HGGNGISLEFQVIRHMMNLETVNTYEGTHDVHALILGRAQTGLQAFF
CCCCCCEEEHHHHHHHHCCCCEECCCCCCCEEHHEEHHHHHHHHHCC
>Mature Secondary Structure
MLDDKPTLRAKDAPDLGRFAWDDPLRLSDQLTEDERMIEASARAYAQEKLQSRVTEAYET
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
EQTDPEIFREMGEMGLLGTTIPEEYGGLGGGYVSYGLVAREVERVDSGYRSMMSVQSSLV
CCCCHHHHHHHHHCCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
MYPIYAYGSEEQRQKYLPKLASGEWIGCFGLTEPDAGSDPAGMKTRAEKTADGYRLTGSK
EEEEEECCCHHHHHHHCCHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHCCCCEEECCCE
MWISNAPIADVFVVWAKSEAHGGKIRGFVLDKGTKGLSAPKIQQKMSLRASITGEIVLDG
EEECCCCHHHEEEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEC
VEVGEEALLPHVEGLKGPFGCLNRARYGISWGVMGAAEACWHAARQYGLDRHQFGRPLAN
HHHCHHHHCCHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCCCC
TQLFQLKLANMQTEIALGLQASLRVGRLMDEANAAPEMISIVKRNNCGKALEIARHARDM
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHH
HGGNGISLEFQVIRHMMNLETVNTYEGTHDVHALILGRAQTGLQAFF
CCCCCCEEEHHHHHHHHCCCCEECCCCCCCEEHHEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]