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The map label for this gene is zraS [C]

Identifier: 99081069

GI number: 99081069

Start: 1321904

End: 1324213

Strand: Direct

Name: zraS [C]

Synonym: TM1040_1228

Alternate gene names: 99081069

Gene position: 1321904-1324213 (Clockwise)

Preceding gene: 99081068

Following gene: 99081071

Centisome position: 41.3

GC content: 60.87

Gene sequence:

>2310_bases
ATGATTGGTCGCTCTTCTTCGATTGCCCCCAGCCTGAAGATCCAGACGCCGGAGCAGGCGCGCTTGGCGGCGACCTTTCT
GCTATCGGCGCTGTTGATCGTGTTGCCGTGGCTGTTGCCGGTGCCGGAGTGGATCGGGCGGGCGCTGGTGGCAGTCGGGC
TGACGCTGGGCGGTGTCTCTGCGATGATCTTGATACAGACCCGGGTCCGCATGGGCGCGCGCACGATGGCGAGCGAGTTG
CTGACGGGCTTTATCGACAAGGACGCATCCGCCAGCTTCGTCACCGACGAGGACGGGGTGATCCATGCCTGCAACACCGC
TGCGCTCAAGCGATTTGAGGGCAGCGAAAGTGATACGATCTCGGGCACATTGCGCTCGGTTCTGGCCAATCCGTCCGCGG
TGCTCTTCCGTTTGCAGAGCCGTGCCAAGCTCGAAGGGTCGGCCCGCGAGGACATCGTGACGCGGCGTGGAAACGTCCGC
ATTGCGGTGCATGAGATGGCCAATGGCAGCTTCTTGTGGCGAGTTGAGGACATGGGCGAACGCCCCTCCGGGCGCACGGC
GGATGCCAGCCCGGTGCCGATGATCTCGGTTGGACGCACGGGCGCCGTCCTGTTCATGAACGAATCCGCGCGCAGCCTGA
TCGGAGAGCGCGTGAAATCGACAGATCGGCTCTTTACGTCACTGCCGGTGATCCCGGGGCGGATCAACACGATCATGACC
AAAAGCGGCCCCGTTGAGGTGCTGGTCAGCGAACACGCGCGCGGCCAGGGGCGCAGCGAAATCTACTTCATGAAAGCCGT
TGTCGAGGACAGTGGGCCTCATACCGGGTTCGAGAGCCTGCCGGTGCCGCTCCTCAAGGTTCGCGCGGGTGGCGAGGTGA
TGGCGGTCAACCGCATGGCCATGCGGCTTTTGGGCATCGAAGAAGCCGAAGGCGTGCAGTTGGGGCAATTGATGGAGGGC
CTTGGCCGCCCCATGAACGATTGGCTGCAAGAAACGTCCAAGGGGCTTGCGCCGCATAAGTCCGAGTTCCTGCGGGTGTC
ACGCGACGACAAGGAAGTCTTTGTGCAGGTGACGCTCACGCGGATCATCGAGGATGGCGAGACGCTATTGCTGGCGGTTC
TGAACGATGCAACCGAGCTGAAAACCCTTGAGGCGCAATTTGTTCAAAGCCAGAAGATGCAGGCGATCGGTCAGCTCGCG
GGCGGCGTGGCACATGATTTCAACAATCTTTTGACTGCGATTTCAGGGCATTGCGACCTGCTTTTACTGCGTCACGATCA
GGGCGATCAGGATTATGGTGATCTGATCCAGATCCATGAAAACGCCAATCGCGCTGCTGCCTTGGTGAGCCAGTTGCTTG
CGTTTTCGCGCAAGCAGACCCTGCAACCCGAGGTGCTCGATGTGCGCGAGACGCTCTCGGATCTGACCCATCTGCTGAAC
CGTCTGGTGGGGGAGAAAGTCTCGCTCACGCTGAGCCATGACCCGGTTATGCGCTCCATTCGGGCTGACAAACGCCAGCT
TGAACAAGTTCTGATGAACCTCGTGGTGAATGCGCGGGACGCGATGCCACACGGGGGCGAAATCCGCGTGGAAACTGAGG
TAGTAGCGCTCGACACAGCACTTGAACGCGATCGCGCCCTTGTGCCGCCGGGCGAGTGGGTCACCATCCAGGTGAGCGAC
GAGGGCACAGGGATCTCGCCGGACAAGCTTCAAAAGGTGTTTGAGCCCTTCTACACCACCAAACGCACCGGCGAAGGCAC
GGGGCTTGGGCTTTCCACCGCCTATGGCATCATCAAACAGACTGGTGGCTTCATTTTTGTGGATTCCGTGCTCAATCAGG
GCACCAAGTTCACGCTCTATTTCCCGGTTTATCGCAGCGATGCGTCACACGACGTCGAAGAAGCGGTCGCACCGGCCAAG
ACCAAGGCACCGGCAGCACAACACGGCGAAGGCGTGGTTCTCTTGGTGGAGGACGAAGCTCCGGTTCGGGCCTTTGCATC
GCGCGCGCTGCGCATGCGCGGCTATACGGTCCTTGAGGCCGAATCCGCTGAAGAGGCGCTCGACACGCTCGAAGATCCAA
ACCTCAGCGTTGATGTCTTTGTGACCGATGTCATCATGCCCGGGATGGATGGGCCGACTTGGGTGCGGGAAGCCCTCAAA
ACCCGGCCCGGCACCAAGGTGGTCTTTGTGTCCGGGTACTCCGAAGGGGCCTTTGGCGATGCGGAGCCCGACGTGCCGAA
TTCGGTCTTCCTGGCCAAACCGTTCTCGCTCTCGCAGCTCACGGAAACCGTTCAGTCTCAACTTCAGTAA

Upstream 100 bases:

>100_bases
ATAAACGATTGTAAAGTTTCGCATTTCGGCGCTGTGGTTAACCTCGCTTTAACCATCCGTGTCATGATAGTGCGTCAATA
AGACTGTTAACGGAGCCGTA

Downstream 100 bases:

>100_bases
GCAAGCTCCGCGTTGTGCGGCGTGCCTGATTCAGGTGGTGATCGATTGATAGAGCTCAAACTCCTCAGGGTGTTTGCGCC
TGAATTTCTGCTCCGTGGCG

Product: multi-sensor hybrid histidine kinase

Products: NA

Alternate protein names: Blue-light-activated histidine kinase; Response regulator [H]

Number of amino acids: Translated: 769; Mature: 769

Protein sequence:

>769_residues
MIGRSSSIAPSLKIQTPEQARLAATFLLSALLIVLPWLLPVPEWIGRALVAVGLTLGGVSAMILIQTRVRMGARTMASEL
LTGFIDKDASASFVTDEDGVIHACNTAALKRFEGSESDTISGTLRSVLANPSAVLFRLQSRAKLEGSAREDIVTRRGNVR
IAVHEMANGSFLWRVEDMGERPSGRTADASPVPMISVGRTGAVLFMNESARSLIGERVKSTDRLFTSLPVIPGRINTIMT
KSGPVEVLVSEHARGQGRSEIYFMKAVVEDSGPHTGFESLPVPLLKVRAGGEVMAVNRMAMRLLGIEEAEGVQLGQLMEG
LGRPMNDWLQETSKGLAPHKSEFLRVSRDDKEVFVQVTLTRIIEDGETLLLAVLNDATELKTLEAQFVQSQKMQAIGQLA
GGVAHDFNNLLTAISGHCDLLLLRHDQGDQDYGDLIQIHENANRAAALVSQLLAFSRKQTLQPEVLDVRETLSDLTHLLN
RLVGEKVSLTLSHDPVMRSIRADKRQLEQVLMNLVVNARDAMPHGGEIRVETEVVALDTALERDRALVPPGEWVTIQVSD
EGTGISPDKLQKVFEPFYTTKRTGEGTGLGLSTAYGIIKQTGGFIFVDSVLNQGTKFTLYFPVYRSDASHDVEEAVAPAK
TKAPAAQHGEGVVLLVEDEAPVRAFASRALRMRGYTVLEAESAEEALDTLEDPNLSVDVFVTDVIMPGMDGPTWVREALK
TRPGTKVVFVSGYSEGAFGDAEPDVPNSVFLAKPFSLSQLTETVQSQLQ

Sequences:

>Translated_769_residues
MIGRSSSIAPSLKIQTPEQARLAATFLLSALLIVLPWLLPVPEWIGRALVAVGLTLGGVSAMILIQTRVRMGARTMASEL
LTGFIDKDASASFVTDEDGVIHACNTAALKRFEGSESDTISGTLRSVLANPSAVLFRLQSRAKLEGSAREDIVTRRGNVR
IAVHEMANGSFLWRVEDMGERPSGRTADASPVPMISVGRTGAVLFMNESARSLIGERVKSTDRLFTSLPVIPGRINTIMT
KSGPVEVLVSEHARGQGRSEIYFMKAVVEDSGPHTGFESLPVPLLKVRAGGEVMAVNRMAMRLLGIEEAEGVQLGQLMEG
LGRPMNDWLQETSKGLAPHKSEFLRVSRDDKEVFVQVTLTRIIEDGETLLLAVLNDATELKTLEAQFVQSQKMQAIGQLA
GGVAHDFNNLLTAISGHCDLLLLRHDQGDQDYGDLIQIHENANRAAALVSQLLAFSRKQTLQPEVLDVRETLSDLTHLLN
RLVGEKVSLTLSHDPVMRSIRADKRQLEQVLMNLVVNARDAMPHGGEIRVETEVVALDTALERDRALVPPGEWVTIQVSD
EGTGISPDKLQKVFEPFYTTKRTGEGTGLGLSTAYGIIKQTGGFIFVDSVLNQGTKFTLYFPVYRSDASHDVEEAVAPAK
TKAPAAQHGEGVVLLVEDEAPVRAFASRALRMRGYTVLEAESAEEALDTLEDPNLSVDVFVTDVIMPGMDGPTWVREALK
TRPGTKVVFVSGYSEGAFGDAEPDVPNSVFLAKPFSLSQLTETVQSQLQ
>Mature_769_residues
MIGRSSSIAPSLKIQTPEQARLAATFLLSALLIVLPWLLPVPEWIGRALVAVGLTLGGVSAMILIQTRVRMGARTMASEL
LTGFIDKDASASFVTDEDGVIHACNTAALKRFEGSESDTISGTLRSVLANPSAVLFRLQSRAKLEGSAREDIVTRRGNVR
IAVHEMANGSFLWRVEDMGERPSGRTADASPVPMISVGRTGAVLFMNESARSLIGERVKSTDRLFTSLPVIPGRINTIMT
KSGPVEVLVSEHARGQGRSEIYFMKAVVEDSGPHTGFESLPVPLLKVRAGGEVMAVNRMAMRLLGIEEAEGVQLGQLMEG
LGRPMNDWLQETSKGLAPHKSEFLRVSRDDKEVFVQVTLTRIIEDGETLLLAVLNDATELKTLEAQFVQSQKMQAIGQLA
GGVAHDFNNLLTAISGHCDLLLLRHDQGDQDYGDLIQIHENANRAAALVSQLLAFSRKQTLQPEVLDVRETLSDLTHLLN
RLVGEKVSLTLSHDPVMRSIRADKRQLEQVLMNLVVNARDAMPHGGEIRVETEVVALDTALERDRALVPPGEWVTIQVSD
EGTGISPDKLQKVFEPFYTTKRTGEGTGLGLSTAYGIIKQTGGFIFVDSVLNQGTKFTLYFPVYRSDASHDVEEAVAPAK
TKAPAAQHGEGVVLLVEDEAPVRAFASRALRMRGYTVLEAESAEEALDTLEDPNLSVDVFVTDVIMPGMDGPTWVREALK
TRPGTKVVFVSGYSEGAFGDAEPDVPNSVFLAKPFSLSQLTETVQSQLQ

Specific function: Photosensitive kinase and response regulator that is involved in increased bacterial virulence upon exposure to light [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790436, Length=244, Percent_Identity=32.3770491803279, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1788549, Length=280, Percent_Identity=30.7142857142857, Blast_Score=106, Evalue=7e-24,
Organism=Escherichia coli, GI1788713, Length=488, Percent_Identity=22.5409836065574, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1790300, Length=280, Percent_Identity=31.0714285714286, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI48994928, Length=378, Percent_Identity=24.8677248677249, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI87081816, Length=264, Percent_Identity=26.5151515151515, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI145693157, Length=285, Percent_Identity=23.859649122807, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786600, Length=363, Percent_Identity=23.6914600550964, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790346, Length=241, Percent_Identity=25.3112033195021, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 83559; Mature: 83559

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN ; PS00120 LIPASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGRSSSIAPSLKIQTPEQARLAATFLLSALLIVLPWLLPVPEWIGRALVAVGLTLGGVS
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AMILIQTRVRMGARTMASELLTGFIDKDASASFVTDEDGVIHACNTAALKRFEGSESDTI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCHHHHHHCCCCCCCHH
SGTLRSVLANPSAVLFRLQSRAKLEGSAREDIVTRRGNVRIAVHEMANGSFLWRVEDMGE
HHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCC
RPSGRTADASPVPMISVGRTGAVLFMNESARSLIGERVKSTDRLFTSLPVIPGRINTIMT
CCCCCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
KSGPVEVLVSEHARGQGRSEIYFMKAVVEDSGPHTGFESLPVPLLKVRAGGEVMAVNRMA
CCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEHHHHHH
MRLLGIEEAEGVQLGQLMEGLGRPMNDWLQETSKGLAPHKSEFLRVSRDDKEVFVQVTLT
HHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHEECCCCCEEEEEEEHH
RIIEDGETLLLAVLNDATELKTLEAQFVQSQKMQAIGQLAGGVAHDFNNLLTAISGHCDL
HHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEE
LLLRHDQGDQDYGDLIQIHENANRAAALVSQLLAFSRKQTLQPEVLDVRETLSDLTHLLN
EEEECCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RLVGEKVSLTLSHDPVMRSIRADKRQLEQVLMNLVVNARDAMPHGGEIRVETEVVALDTA
HHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEHHH
LERDRALVPPGEWVTIQVSDEGTGISPDKLQKVFEPFYTTKRTGEGTGLGLSTAYGIIKQ
HHCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
TGGFIFVDSVLNQGTKFTLYFPVYRSDASHDVEEAVAPAKTKAPAAQHGEGVVLLVEDEA
CCCEEEEEHHHCCCCEEEEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEEECCC
PVRAFASRALRMRGYTVLEAESAEEALDTLEDPNLSVDVFVTDVIMPGMDGPTWVREALK
CHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHH
TRPGTKVVFVSGYSEGAFGDAEPDVPNSVFLAKPFSLSQLTETVQSQLQ
CCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIGRSSSIAPSLKIQTPEQARLAATFLLSALLIVLPWLLPVPEWIGRALVAVGLTLGGVS
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
AMILIQTRVRMGARTMASELLTGFIDKDASASFVTDEDGVIHACNTAALKRFEGSESDTI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEECCHHHHHHCCCCCCCHH
SGTLRSVLANPSAVLFRLQSRAKLEGSAREDIVTRRGNVRIAVHEMANGSFLWRVEDMGE
HHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEEEEECCCCEEEEEECCCCC
RPSGRTADASPVPMISVGRTGAVLFMNESARSLIGERVKSTDRLFTSLPVIPGRINTIMT
CCCCCCCCCCCCCEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEE
KSGPVEVLVSEHARGQGRSEIYFMKAVVEDSGPHTGFESLPVPLLKVRAGGEVMAVNRMA
CCCCEEEEEECCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCEEHHHHHH
MRLLGIEEAEGVQLGQLMEGLGRPMNDWLQETSKGLAPHKSEFLRVSRDDKEVFVQVTLT
HHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHEECCCCCEEEEEEEHH
RIIEDGETLLLAVLNDATELKTLEAQFVQSQKMQAIGQLAGGVAHDFNNLLTAISGHCDL
HHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEE
LLLRHDQGDQDYGDLIQIHENANRAAALVSQLLAFSRKQTLQPEVLDVRETLSDLTHLLN
EEEECCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RLVGEKVSLTLSHDPVMRSIRADKRQLEQVLMNLVVNARDAMPHGGEIRVETEVVALDTA
HHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEEHHH
LERDRALVPPGEWVTIQVSDEGTGISPDKLQKVFEPFYTTKRTGEGTGLGLSTAYGIIKQ
HHCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
TGGFIFVDSVLNQGTKFTLYFPVYRSDASHDVEEAVAPAKTKAPAAQHGEGVVLLVEDEA
CCCEEEEEHHHCCCCEEEEEEEEECCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEEECCC
PVRAFASRALRMRGYTVLEAESAEEALDTLEDPNLSVDVFVTDVIMPGMDGPTWVREALK
CHHHHHHHHHHHCCCEEEECCCHHHHHHHHCCCCCEEEEEEEEECCCCCCCHHHHHHHHH
TRPGTKVVFVSGYSEGAFGDAEPDVPNSVFLAKPFSLSQLTETVQSQLQ
CCCCCEEEEEECCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA