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The map label for this gene is guaB [H]

Identifier: 99081065

GI number: 99081065

Start: 1315559

End: 1317007

Strand: Reverse

Name: guaB [H]

Synonym: TM1040_1224

Alternate gene names: 99081065

Gene position: 1317007-1315559 (Counterclockwise)

Preceding gene: 99081070

Following gene: 99081063

Centisome position: 41.14

GC content: 62.18

Gene sequence:

>1449_bases
ATGCAGATTCGTGAGGCTCTCACCTTTGACGATGTTTTGCTGGTTCCGGCCGCATCCAGTGTACTGCCAAATACGGCGGA
CACGCGCACGCGGGTGACCCGTGCTATCTCGCTCAATATCCCGCTGCTGAGTTCGGCAATGGACACGGTCACGGAATCGC
GCATGGCGATTACCATGGCGCAGGCCGGTGGCATGGGCGTGATCCACAAGAACCTCGACATCGAGGAGCAGGCCCGTCAG
GTGCGTCGCGTGAAGCGTTTCGAGAGCGGCATCGTCTACAACCCCATCACCCTGCGCGCCGACCAGACGCTGGCAGATGC
CAAGGCACTGCAAGAACGCTATCGCGTCACCGGGTTCCCGGTTGTGGATGACAGTGGCCGTGTCGTCGGGATCGTGACCA
ACCGCGACATGCGCTTTGCCTCCGATGACAAGACGCCGGTTTCGGTGATGATGACCTCTGACAATCTTGCAATGCTGCAA
GAACCGGCAGAACGCGACGAGGCGATCTCTTTGATGAAGGCGCGGCGGATCGAGAAGCTGCTCGTGACCGACAAGGACGG
CAAGCTGACGGGCCTCTTGACCCTCAAGGACACCGAACAGGCCGTCCTGAACCCGACAGCGGTGAAAGACGACCTGGGCC
GCCTTCGTGTTGCAGCAGCAAGCTCCGTCGGGGATAGCGGGTTCGAGCGTTCCGAGGCGTTGATTGATGCGGGCGTCGAC
GTGGTTGTGGTCGATACAGCCCACGGCCATTCCGCTGGCGTGATCGAAGCCGTGACACGCATCAAGGCGCTATCGAGCGA
TGTTCAGGTCATCGCAGGCAACGTCGCCACCGCGGCCGCAACACGGGCGCTCATCGATGCGGGCGCGGATGCGGTCAAGG
TCGGCATTGGTCCGGGCTCCATCTGCACCACCCGCATGGTGGCCGGCGTCGGCGTGCCTCAGCTGACGGCCATCATGGAT
TGCGCAAGCGCTGCGGGCGATACGCCTGTAATTGCAGATGGTGGCATCAAGTTCTCTGGTGACTTTGCCAAGGCCATCGC
CGCCGGCGCCTCCTGCGCCATGGTGGGGTCGATGATTGCGGGCACCGACGAGTCGCCCGGCGAAGTCATTCTCTACCAAG
GCCGCTCTTTCAAATCCTATCGCGGCATGGGCTCCATGGGTGCGATGGCGCGCGGGTCTGCGGATCGCTATTTCCAGAAA
GACGCTGCCAGCGACAAGCTGGTGCCCGAAGGTATCGAAGGCCAGGTTCCGTATAAGGGCGCCGCTGGCGCAGTGATCCA
CCAGCTCGTCGGCGGCCTGCGTGCAGCCATGGGCTATACCGGCTGCGCCACTGTCGATGACATGCGCACCTCTTGTGAAT
TTGTTCGCATCACGGGCGCAGGCCTCAAAGAGAGCCATGTGCACGATGTGCAGATCACCCGCGAATCCCCGAACTACCGG
ATCGGCTGA

Upstream 100 bases:

>100_bases
GCCGCCGCGATGCGGCGAAAAATGTCGCGCCCCCCTTCCCCCTTTCGCGGAACTGTGCAATAGGGTCACCGCCAAACGGT
GTTTTGCATGGGGAAGACAG

Downstream 100 bases:

>100_bases
TCACTCCAAATCACAGACAAAGAAAGAGCCGGAACCCACTGAGGTTCCGGCTCTTTTTACATCAGCGCCCCTTGAAGAGC
CCGCCCAGAATCCCGCGAAC

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MQIREALTFDDVLLVPAASSVLPNTADTRTRVTRAISLNIPLLSSAMDTVTESRMAITMAQAGGMGVIHKNLDIEEQARQ
VRRVKRFESGIVYNPITLRADQTLADAKALQERYRVTGFPVVDDSGRVVGIVTNRDMRFASDDKTPVSVMMTSDNLAMLQ
EPAERDEAISLMKARRIEKLLVTDKDGKLTGLLTLKDTEQAVLNPTAVKDDLGRLRVAAASSVGDSGFERSEALIDAGVD
VVVVDTAHGHSAGVIEAVTRIKALSSDVQVIAGNVATAAATRALIDAGADAVKVGIGPGSICTTRMVAGVGVPQLTAIMD
CASAAGDTPVIADGGIKFSGDFAKAIAAGASCAMVGSMIAGTDESPGEVILYQGRSFKSYRGMGSMGAMARGSADRYFQK
DAASDKLVPEGIEGQVPYKGAAGAVIHQLVGGLRAAMGYTGCATVDDMRTSCEFVRITGAGLKESHVHDVQITRESPNYR
IG

Sequences:

>Translated_482_residues
MQIREALTFDDVLLVPAASSVLPNTADTRTRVTRAISLNIPLLSSAMDTVTESRMAITMAQAGGMGVIHKNLDIEEQARQ
VRRVKRFESGIVYNPITLRADQTLADAKALQERYRVTGFPVVDDSGRVVGIVTNRDMRFASDDKTPVSVMMTSDNLAMLQ
EPAERDEAISLMKARRIEKLLVTDKDGKLTGLLTLKDTEQAVLNPTAVKDDLGRLRVAAASSVGDSGFERSEALIDAGVD
VVVVDTAHGHSAGVIEAVTRIKALSSDVQVIAGNVATAAATRALIDAGADAVKVGIGPGSICTTRMVAGVGVPQLTAIMD
CASAAGDTPVIADGGIKFSGDFAKAIAAGASCAMVGSMIAGTDESPGEVILYQGRSFKSYRGMGSMGAMARGSADRYFQK
DAASDKLVPEGIEGQVPYKGAAGAVIHQLVGGLRAAMGYTGCATVDDMRTSCEFVRITGAGLKESHVHDVQITRESPNYR
IG
>Mature_482_residues
MQIREALTFDDVLLVPAASSVLPNTADTRTRVTRAISLNIPLLSSAMDTVTESRMAITMAQAGGMGVIHKNLDIEEQARQ
VRRVKRFESGIVYNPITLRADQTLADAKALQERYRVTGFPVVDDSGRVVGIVTNRDMRFASDDKTPVSVMMTSDNLAMLQ
EPAERDEAISLMKARRIEKLLVTDKDGKLTGLLTLKDTEQAVLNPTAVKDDLGRLRVAAASSVGDSGFERSEALIDAGVD
VVVVDTAHGHSAGVIEAVTRIKALSSDVQVIAGNVATAAATRALIDAGADAVKVGIGPGSICTTRMVAGVGVPQLTAIMD
CASAAGDTPVIADGGIKFSGDFAKAIAAGASCAMVGSMIAGTDESPGEVILYQGRSFKSYRGMGSMGAMARGSADRYFQK
DAASDKLVPEGIEGQVPYKGAAGAVIHQLVGGLRAAMGYTGCATVDDMRTSCEFVRITGAGLKESHVHDVQITRESPNYR
IG

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=483, Percent_Identity=35.4037267080745, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI217035146, Length=457, Percent_Identity=36.5426695842451, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI156616279, Length=457, Percent_Identity=36.5426695842451, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI34328930, Length=483, Percent_Identity=35.6107660455487, Blast_Score=270, Evalue=3e-72,
Organism=Homo sapiens, GI34328928, Length=457, Percent_Identity=36.5426695842451, Blast_Score=269, Evalue=4e-72,
Organism=Homo sapiens, GI217035152, Length=451, Percent_Identity=36.5853658536585, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI217035148, Length=457, Percent_Identity=35.6673960612691, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI217035150, Length=457, Percent_Identity=33.6980306345733, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI50541956, Length=247, Percent_Identity=38.4615384615385, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI50541954, Length=247, Percent_Identity=38.4615384615385, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI50541952, Length=247, Percent_Identity=38.4615384615385, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI50541948, Length=247, Percent_Identity=38.4615384615385, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI156104880, Length=247, Percent_Identity=36.8421052631579, Blast_Score=157, Evalue=2e-38,
Organism=Escherichia coli, GI1788855, Length=482, Percent_Identity=60.1659751037344, Blast_Score=551, Evalue=1e-158,
Organism=Escherichia coli, GI1786293, Length=267, Percent_Identity=35.2059925093633, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI71994385, Length=479, Percent_Identity=36.9519832985386, Blast_Score=257, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71994389, Length=427, Percent_Identity=38.4074941451991, Blast_Score=245, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI17560440, Length=283, Percent_Identity=33.5689045936396, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322012, Length=489, Percent_Identity=37.0143149284254, Blast_Score=297, Evalue=3e-81,
Organism=Saccharomyces cerevisiae, GI6323585, Length=485, Percent_Identity=35.8762886597938, Blast_Score=296, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6323464, Length=493, Percent_Identity=36.9168356997972, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6319352, Length=344, Percent_Identity=38.0813953488372, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6319353, Length=117, Percent_Identity=38.4615384615385, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24641071, Length=484, Percent_Identity=34.7107438016529, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24641073, Length=484, Percent_Identity=34.7107438016529, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI28571163, Length=438, Percent_Identity=35.1598173515982, Blast_Score=248, Evalue=6e-66,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 50636; Mature: 50636

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIREALTFDDVLLVPAASSVLPNTADTRTRVTRAISLNIPLLSSAMDTVTESRMAITMA
CCHHHHCCCCCEEEECCCHHHCCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHEEEEEE
QAGGMGVIHKNLDIEEQARQVRRVKRFESGIVYNPITLRADQTLADAKALQERYRVTGFP
CCCCCEEEECCCCHHHHHHHHHHHHHHHCCCEECCEEEECCCHHHHHHHHHHHHCCCCCE
VVDDSGRVVGIVTNRDMRFASDDKTPVSVMMTSDNLAMLQEPAERDEAISLMKARRIEKL
EECCCCCEEEEEECCCCEECCCCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHH
LVTDKDGKLTGLLTLKDTEQAVLNPTAVKDDLGRLRVAAASSVGDSGFERSEALIDAGVD
EEECCCCCEEEEEEECCCCHHHCCCHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHCCCC
VVVVDTAHGHSAGVIEAVTRIKALSSDVQVIAGNVATAAATRALIDAGADAVKVGIGPGS
EEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCEEEEECCCCC
ICTTRMVAGVGVPQLTAIMDCASAAGDTPVIADGGIKFSGDFAKAIAAGASCAMVGSMIA
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCEEECCHHHHHHHCCCHHHHHHHHHC
GTDESPGEVILYQGRSFKSYRGMGSMGAMARGSADRYFQKDAASDKLVPEGIEGQVPYKG
CCCCCCCCEEEECCCCCHHHCCCCCCCCHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCC
AAGAVIHQLVGGLRAAMGYTGCATVDDMRTSCEFVRITGAGLKESHVHDVQITRESPNYR
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCCCC
IG
CC
>Mature Secondary Structure
MQIREALTFDDVLLVPAASSVLPNTADTRTRVTRAISLNIPLLSSAMDTVTESRMAITMA
CCHHHHCCCCCEEEECCCHHHCCCCCCHHHHEEEEEEECCCHHHHHHHHHHHHHEEEEEE
QAGGMGVIHKNLDIEEQARQVRRVKRFESGIVYNPITLRADQTLADAKALQERYRVTGFP
CCCCCEEEECCCCHHHHHHHHHHHHHHHCCCEECCEEEECCCHHHHHHHHHHHHCCCCCE
VVDDSGRVVGIVTNRDMRFASDDKTPVSVMMTSDNLAMLQEPAERDEAISLMKARRIEKL
EECCCCCEEEEEECCCCEECCCCCCCEEEEEECCCHHHHCCCHHHHHHHHHHHHHHHHHH
LVTDKDGKLTGLLTLKDTEQAVLNPTAVKDDLGRLRVAAASSVGDSGFERSEALIDAGVD
EEECCCCCEEEEEEECCCCHHHCCCHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHCCCC
VVVVDTAHGHSAGVIEAVTRIKALSSDVQVIAGNVATAAATRALIDAGADAVKVGIGPGS
EEEEECCCCCCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCEEEEECCCCC
ICTTRMVAGVGVPQLTAIMDCASAAGDTPVIADGGIKFSGDFAKAIAAGASCAMVGSMIA
HHHHHHHHCCCCHHHHHHHHHHHCCCCCCEEECCCEEECCHHHHHHHCCCHHHHHHHHHC
GTDESPGEVILYQGRSFKSYRGMGSMGAMARGSADRYFQKDAASDKLVPEGIEGQVPYKG
CCCCCCCCEEEECCCCCHHHCCCCCCCCHHCCCCHHHHHHHCCCCCCCCCCCCCCCCCCC
AAGAVIHQLVGGLRAAMGYTGCATVDDMRTSCEFVRITGAGLKESHVHDVQITRESPNYR
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEECCCCCCCCCEEEEEEECCCCCC
IG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]