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The map label for this gene is aphA [H]

Identifier: 99081057

GI number: 99081057

Start: 1304451

End: 1306760

Strand: Reverse

Name: aphA [H]

Synonym: TM1040_1216

Alternate gene names: 99081057

Gene position: 1306760-1304451 (Counterclockwise)

Preceding gene: 99081058

Following gene: 99081056

Centisome position: 40.82

GC content: 55.5

Gene sequence:

>2310_bases
TTGACCAGCTCCGCCAGAAAGTCGATCAGCGCAAAGGTGCGCAAAATTGCCGTGATCGTGGCCGTTGCAGCGGTGACGTC
CCTCACCTTGGCCAGCGCCTTGGTCACCCGAAACCTTGAATTGCAGCATGCCAACATTCTAACACGGGAAACGGCCGACA
AAATCAGCCGCGCGAGTGCGGATGCCACCGCGGCCATCATTACCGACGCCGAAATCCTTGCGAATATGCCCCCGGTCGCT
GCATTGATCAGGGCGCATTACAATAATGGGATCGATCCAGTGAGTGGCGATACCACCGAGGAATGGAAAGAACGGCTGAC
AACGATTTTCTCCTCGTTTCACGCGCTTCGCCCGAATTACCTGCAAATCCGCTTTGTCGGCTTTGCGGACAACGCTCAGG
AGATCCTGCGTGTTGACAAAGTCGGGGAACGGATAGAGCGGGTTCCTGATCACCGGCTCCAGCAAAAGGGAAACGAACCC
TATGTCGAGGCTGCGAGGACGGTTCCCATCGGTCAGGCAGTACCGCTGCCTCCCTCCTACAACCGCGAAAATGGCATCAT
CCAGGAACCCAAAACCCTGATGTATCGGGTGCTTGTGCCCGTGTTGGAACCGGCAGGCTACAAATTCGAGGGTCATAGAT
TTGGCTTTATCGTTATCAACGTCGACCTGTTGAAACATAACCAAGCCGCGTACAAGCCGCTCAATCTGGCATCAAGTTTC
GTCATACACAACTCCAAGGGGAGCAGCTACGTCTGGGATGCAGAGGCGCAATCGGGACAGTATCACGGCGGCATGGTCGT
TGGATTGCCAGAAATCGTGCGCACCGACCTATCCCGGGCCAATGCAGAGCAGCCGCTCCGGCTCGTGAACGAGGGCGCGG
AATACATCACCCTCAAGCTCGAGAGCGTGAGCTCAGCCACACACAGCGTATTTCTCACACTGATCAAGGAGCGGCATTTC
TTTTCCAATATACTGCCGTTCAGCACACTCAATCTCATCGTCTTGGGGCTTTTGCTCATTTTCTGCAGCTACGCCTTTGC
GAGACGCGGCATTGAAACGGCACTGGCGCCAATGCAAACCATGCGCGGCAATATTCTCGCATCGGCAGAAACCGGGCAGG
ATCCCGTTCTCCCCATCCATCTTGAGGATGAGGTCGGCGATCTCGCGCAATCCTTCAAAGGTCTGATCACCCGCCTGCGC
AGCCAGGAATCCGACGCTCGCCAAGTCTTTGACGGCACCACCGATGGCATGGTTCTGGTCACCTCCAATGGCCTGATACA
GCAGTCCAACGCGGCCTTTGGTGCATTGTTTGGCCCGGTCGTCATGGGGGAGAGCACCCTAACGGACTACTTCGCCTCAG
GGGACGCCCAGGCGATTGAGGCCAAAGTCAAACTTCTGGCCTCCGGCAACGCCGGAAAACATTTTGCGGAGGCCGTATTA
TGCCGCGGCAAAAGAGACGCAAAAGATGGCAGCTCGAACTGGTTCGAAGTCACCCTCGCCCTGCTCAGGGAGGCCGAGCA
AAAACTGGCGCTGGTGGTGATCCGGGACGTGACGGAACGCGAGGCGATGTCGAAATCTCAAAAGGACCTGATCGAGCAGC
TCAACCGGTCCAACAAGGATCTCGAGGAATTTGCATATGTGGCCTCGCATGATCTGAAAGCCCCGCTGAGAGCAGTCTCT
CACGCCGCTACCTGGCTTGAGGAGGATCTCGAGGAACATCTTACAGAGGAAACCACAGAGCATCTTCACTACATGAAATC
CCGCATCCTGCGGATGTCTGGCTTGCTGGACGATCTGCTTGCGCACTCCAAGATTGGGACAAGGGATTTTGATCCAAAAT
CCAACATCATGTCCGGTTTGGATCTGTCGCATAACATTGCCGATCTTTGCGGCTCCGGCCAGGATACTCAGCTCGAGTTT
TCGCAGGACTTCCTTGCTGCGCAGATGAACCAGATGCCGTTGCAGGTCGTTTTGCTCAATCTGGTGTCCAATGCCTTCAA
GCACAATGACAAGGCACAGGGCCATGTTCTCGTGGCGCTCAAGGATCAAGGCGATCACTTCGAGATTTCAGTCAAGGACA
ATGGCCCCGGCATTCACCCGAAATTCCAGGAGGCTATCTTTGGCCTGTTCCGCACCCTGAAATCCAAGGACGAAGTCGAG
GGCAGCGGGATGGGTCTCGCCTTTGTCGCCAAGCACCTCGCGGTCCTTGGTCAGTCGATCAAAGTGATTTCAGAAGGCGA
TGGCAACGGTGCGGAGTTCGTTTTCACCTGGCCAAAACCAAATTTGGAGGAGGTACAAAATGTTGCATGA

Upstream 100 bases:

>100_bases
CGCCTGCTGTGTTAACCTTTGCTTGACCACTCCTGCGCAGGCTTTCCAATGCAAGCCTCAATGAGATGTCTTGCGCGCCG
CTCACATAGGTTCTCGGACA

Downstream 100 bases:

>100_bases
AAACGCGATGGAGGGTTTGCAGAAGGCAAATATCCTTCTCGTTGAGGACGATGATTTTGAGGCAAAGGCCGTGCGCCGCG
CATTTCACAAAGCCCGCATC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 769; Mature: 768

Protein sequence:

>769_residues
MTSSARKSISAKVRKIAVIVAVAAVTSLTLASALVTRNLELQHANILTRETADKISRASADATAAIITDAEILANMPPVA
ALIRAHYNNGIDPVSGDTTEEWKERLTTIFSSFHALRPNYLQIRFVGFADNAQEILRVDKVGERIERVPDHRLQQKGNEP
YVEAARTVPIGQAVPLPPSYNRENGIIQEPKTLMYRVLVPVLEPAGYKFEGHRFGFIVINVDLLKHNQAAYKPLNLASSF
VIHNSKGSSYVWDAEAQSGQYHGGMVVGLPEIVRTDLSRANAEQPLRLVNEGAEYITLKLESVSSATHSVFLTLIKERHF
FSNILPFSTLNLIVLGLLLIFCSYAFARRGIETALAPMQTMRGNILASAETGQDPVLPIHLEDEVGDLAQSFKGLITRLR
SQESDARQVFDGTTDGMVLVTSNGLIQQSNAAFGALFGPVVMGESTLTDYFASGDAQAIEAKVKLLASGNAGKHFAEAVL
CRGKRDAKDGSSNWFEVTLALLREAEQKLALVVIRDVTEREAMSKSQKDLIEQLNRSNKDLEEFAYVASHDLKAPLRAVS
HAATWLEEDLEEHLTEETTEHLHYMKSRILRMSGLLDDLLAHSKIGTRDFDPKSNIMSGLDLSHNIADLCGSGQDTQLEF
SQDFLAAQMNQMPLQVVLLNLVSNAFKHNDKAQGHVLVALKDQGDHFEISVKDNGPGIHPKFQEAIFGLFRTLKSKDEVE
GSGMGLAFVAKHLAVLGQSIKVISEGDGNGAEFVFTWPKPNLEEVQNVA

Sequences:

>Translated_769_residues
MTSSARKSISAKVRKIAVIVAVAAVTSLTLASALVTRNLELQHANILTRETADKISRASADATAAIITDAEILANMPPVA
ALIRAHYNNGIDPVSGDTTEEWKERLTTIFSSFHALRPNYLQIRFVGFADNAQEILRVDKVGERIERVPDHRLQQKGNEP
YVEAARTVPIGQAVPLPPSYNRENGIIQEPKTLMYRVLVPVLEPAGYKFEGHRFGFIVINVDLLKHNQAAYKPLNLASSF
VIHNSKGSSYVWDAEAQSGQYHGGMVVGLPEIVRTDLSRANAEQPLRLVNEGAEYITLKLESVSSATHSVFLTLIKERHF
FSNILPFSTLNLIVLGLLLIFCSYAFARRGIETALAPMQTMRGNILASAETGQDPVLPIHLEDEVGDLAQSFKGLITRLR
SQESDARQVFDGTTDGMVLVTSNGLIQQSNAAFGALFGPVVMGESTLTDYFASGDAQAIEAKVKLLASGNAGKHFAEAVL
CRGKRDAKDGSSNWFEVTLALLREAEQKLALVVIRDVTEREAMSKSQKDLIEQLNRSNKDLEEFAYVASHDLKAPLRAVS
HAATWLEEDLEEHLTEETTEHLHYMKSRILRMSGLLDDLLAHSKIGTRDFDPKSNIMSGLDLSHNIADLCGSGQDTQLEF
SQDFLAAQMNQMPLQVVLLNLVSNAFKHNDKAQGHVLVALKDQGDHFEISVKDNGPGIHPKFQEAIFGLFRTLKSKDEVE
GSGMGLAFVAKHLAVLGQSIKVISEGDGNGAEFVFTWPKPNLEEVQNVA
>Mature_768_residues
TSSARKSISAKVRKIAVIVAVAAVTSLTLASALVTRNLELQHANILTRETADKISRASADATAAIITDAEILANMPPVAA
LIRAHYNNGIDPVSGDTTEEWKERLTTIFSSFHALRPNYLQIRFVGFADNAQEILRVDKVGERIERVPDHRLQQKGNEPY
VEAARTVPIGQAVPLPPSYNRENGIIQEPKTLMYRVLVPVLEPAGYKFEGHRFGFIVINVDLLKHNQAAYKPLNLASSFV
IHNSKGSSYVWDAEAQSGQYHGGMVVGLPEIVRTDLSRANAEQPLRLVNEGAEYITLKLESVSSATHSVFLTLIKERHFF
SNILPFSTLNLIVLGLLLIFCSYAFARRGIETALAPMQTMRGNILASAETGQDPVLPIHLEDEVGDLAQSFKGLITRLRS
QESDARQVFDGTTDGMVLVTSNGLIQQSNAAFGALFGPVVMGESTLTDYFASGDAQAIEAKVKLLASGNAGKHFAEAVLC
RGKRDAKDGSSNWFEVTLALLREAEQKLALVVIRDVTEREAMSKSQKDLIEQLNRSNKDLEEFAYVASHDLKAPLRAVSH
AATWLEEDLEEHLTEETTEHLHYMKSRILRMSGLLDDLLAHSKIGTRDFDPKSNIMSGLDLSHNIADLCGSGQDTQLEFS
QDFLAAQMNQMPLQVVLLNLVSNAFKHNDKAQGHVLVALKDQGDHFEISVKDNGPGIHPKFQEAIFGLFRTLKSKDEVEG
SGMGLAFVAKHLAVLGQSIKVISEGDGNGAEFVFTWPKPNLEEVQNVA

Specific function: Photoreceptor which exists in two forms that are reversibly interconvertible by light:the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=275, Percent_Identity=24.7272727272727, Blast_Score=73, Evalue=8e-14,
Organism=Escherichia coli, GI48994928, Length=263, Percent_Identity=27.3764258555133, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=294, Percent_Identity=25.1700680272109, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1786600, Length=258, Percent_Identity=29.0697674418605, Blast_Score=67, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003018
- InterPro:   IPR013654
- InterPro:   IPR016132
- InterPro:   IPR001294
- InterPro:   IPR013515
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01590 GAF; PF02518 HATPase_c; PF00512 HisKA; PF08446 PAS_2; PF00360 Phytochrome [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 84417; Mature: 84286

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSARKSISAKVRKIAVIVAVAAVTSLTLASALVTRNLELQHANILTRETADKISRASA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
DATAAIITDAEILANMPPVAALIRAHYNNGIDPVSGDTTEEWKERLTTIFSSFHALRPNY
CCCEEEEECHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCE
LQIRFVGFADNAQEILRVDKVGERIERVPDHRLQQKGNEPYVEAARTVPIGQAVPLPPSY
EEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHCCCCCCCCCCCCCC
NRENGIIQEPKTLMYRVLVPVLEPAGYKFEGHRFGFIVINVDLLKHNQAAYKPLNLASSF
CCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCEEEEEEEEEEEEECCCHHCCCHHHHCEE
VIHNSKGSSYVWDAEAQSGQYHGGMVVGLPEIVRTDLSRANAEQPLRLVNEGAEYITLKL
EEECCCCCCEEEECCCCCCCCCCCEEECCHHHHHHHHHHCCHHHHHHHHHCCCEEEEEEE
ESVSSATHSVFLTLIKERHFFSNILPFSTLNLIVLGLLLIFCSYAFARRGIETALAPMQT
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
MRGNILASAETGQDPVLPIHLEDEVGDLAQSFKGLITRLRSQESDARQVFDGTTDGMVLV
HCCCEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEE
TSNGLIQQSNAAFGALFGPVVMGESTLTDYFASGDAQAIEAKVKLLASGNAGKHFAEAVL
ECCCCEEECCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHEEECCCCCHHHHHHHH
CRGKRDAKDGSSNWFEVTLALLREAEQKLALVVIRDVTEREAMSKSQKDLIEQLNRSNKD
HCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEHEEHHHHHHHHHHHHHHHHHHHHCCCCCC
LEEFAYVASHDLKAPLRAVSHAATWLEEDLEEHLTEETTEHLHYMKSRILRMSGLLDDLL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHSKIGTRDFDPKSNIMSGLDLSHNIADLCGSGQDTQLEFSQDFLAAQMNQMPLQVVLLN
HHCCCCCCCCCCHHHHHHCCCCCCCHHHHHCCCCCCEEHHHHHHHHHHHHCCHHHHHHHH
LVSNAFKHNDKAQGHVLVALKDQGDHFEISVKDNGPGIHPKFQEAIFGLFRTLKSKDEVE
HHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC
GSGMGLAFVAKHLAVLGQSIKVISEGDGNGAEFVFTWPKPNLEEVQNVA
CCCCHHHHHHHHHHHHCCHHEEEECCCCCCCEEEEECCCCCHHHHHCCC
>Mature Secondary Structure 
TSSARKSISAKVRKIAVIVAVAAVTSLTLASALVTRNLELQHANILTRETADKISRASA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCC
DATAAIITDAEILANMPPVAALIRAHYNNGIDPVSGDTTEEWKERLTTIFSSFHALRPNY
CCCEEEEECHHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCE
LQIRFVGFADNAQEILRVDKVGERIERVPDHRLQQKGNEPYVEAARTVPIGQAVPLPPSY
EEEEEEEECCCHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHCCCCCCCCCCCCCC
NRENGIIQEPKTLMYRVLVPVLEPAGYKFEGHRFGFIVINVDLLKHNQAAYKPLNLASSF
CCCCCCCCCHHHHHHHHHHHHHCCCCCEECCCEEEEEEEEEEEEECCCHHCCCHHHHCEE
VIHNSKGSSYVWDAEAQSGQYHGGMVVGLPEIVRTDLSRANAEQPLRLVNEGAEYITLKL
EEECCCCCCEEEECCCCCCCCCCCEEECCHHHHHHHHHHCCHHHHHHHHHCCCEEEEEEE
ESVSSATHSVFLTLIKERHFFSNILPFSTLNLIVLGLLLIFCSYAFARRGIETALAPMQT
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
MRGNILASAETGQDPVLPIHLEDEVGDLAQSFKGLITRLRSQESDARQVFDGTTDGMVLV
HCCCEEEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEE
TSNGLIQQSNAAFGALFGPVVMGESTLTDYFASGDAQAIEAKVKLLASGNAGKHFAEAVL
ECCCCEEECCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHEEECCCCCHHHHHHHH
CRGKRDAKDGSSNWFEVTLALLREAEQKLALVVIRDVTEREAMSKSQKDLIEQLNRSNKD
HCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEHEEHHHHHHHHHHHHHHHHHHHHCCCCCC
LEEFAYVASHDLKAPLRAVSHAATWLEEDLEEHLTEETTEHLHYMKSRILRMSGLLDDLL
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AHSKIGTRDFDPKSNIMSGLDLSHNIADLCGSGQDTQLEFSQDFLAAQMNQMPLQVVLLN
HHCCCCCCCCCCHHHHHHCCCCCCCHHHHHCCCCCCEEHHHHHHHHHHHHCCHHHHHHHH
LVSNAFKHNDKAQGHVLVALKDQGDHFEISVKDNGPGIHPKFQEAIFGLFRTLKSKDEVE
HHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCCC
GSGMGLAFVAKHLAVLGQSIKVISEGDGNGAEFVFTWPKPNLEEVQNVA
CCCCHHHHHHHHHHHHCCHHEEEECCCCCCCEEEEECCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]