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The map label for this gene is proA [H]

Identifier: 99081046

GI number: 99081046

Start: 1294988

End: 1296292

Strand: Direct

Name: proA [H]

Synonym: TM1040_1205

Alternate gene names: 99081046

Gene position: 1294988-1296292 (Clockwise)

Preceding gene: 99081045

Following gene: 99081048

Centisome position: 40.46

GC content: 62.45

Gene sequence:

>1305_bases
ATGGCTCGCACCCCGCCTGGGGAAGAAAAGGGCAAAGACATGAAAGATCTGGAAAATATTCCCGCGCTGATGGAAGACAT
CGGCAAGCGCGCCAAAGCGGCTGCGCAACAGCTTGCGACAGCCTCGGCGGCGCAAAAGGAGCAGGCGCTCAACGCGGCCG
CCGATGCGGTCTGGGCCCAGCGCGGCGAGATCATTGCCGCCAATGCCAAGGACCTGGAGTTCGGGCGCGACAAGGGCTTG
TCCTCGGCGATGATGGATCGCTTGATGCTGGATGAAGCCCGTATTCAGGGCATCGTGGACGGGTTGCGCGCCGTGGCTGC
GCAGGCGGACCCGGTCGGCGCCGTCCTGGACGAATGGACACAGCCCAGCGGTTTGCGCATTCAGCGCGTGCGCACGCCGC
TGGGTGTCATTGGTGTGATCTATGAGAGCCGTCCCAATGTTACCGCAGACGCAGGCGCGCTGTGTCTGAAATCCGGCAAC
GCGGTGATCCTGCGCGGCGGCTCCGAGAGCCTGCATTCCGCGCAGGCGATCCATGGCTGTCTTGCGGCGGGATTGCGCGC
TGCAGATCTGCCCGAGGATGCGGTGCAACTGGTGCCGACCCGCGATCGTGCGGCGGTGCAGGAGCTCCTGACGATGACCG
CGTATGTGGATGTGATCGTTCCGCGCGGTGGCAAAGGGCTGGTGGGGCTGGTGCAGCGCGAGGCCCGGGTGCCGGTCTTT
GCGCACCTCGAAGGGATCGTGCATATCTACCTCGACAAAGATGCCGATCGTAAAAAGGCAATCGACGTGGTCTTGAACGC
CAAGACCCGGCGTACCGGCATCTGTGGCGCGGCGGAGTGTCTGCTGATCCACGAGGACATTGCCGACAGCATCGGCAAGG
ATGTGCTGGATCTGCTTGCCATGGGCGGGGTCGAAATCCATGCCGAAGAGGGGCTGCCCGGCCCTGACAGCATGCAGGTC
GCCACGTCCGAGGATTGGGGTAAAGAATATCTCGACGCGATTATCGCCGCCAAAAAAGTGGCAAGCATCGACGAGGCAAT
TGCCCATATCCGCAGGTATCATTCGGCCCATACCGATTGCATCATTACCGAGAATGATGCTGCCGTGGCGCAGTTTTTCT
CTGAGCTCGACAGCGCGATCCTGATGCACAACGCCTCCACCCAGTTTGCCGATGGCGGCGAGTTTGGCATGGGAGCAGAG
ATTGGCATTGCAACGGGCAAGATGCACGCGCGCGGACCGGTTGGGGCGACGCAGCTGACGAGTTTCAAATATCTCGTGCG
CGGTGACGGCACCGTGCGCGCCTGA

Upstream 100 bases:

>100_bases
TATGCTGGACGTGCGGCCCTGATCCACCGGGATGACATGGCGCTTTGATCCTGTCATTCTGGCGCTAAGAAGACGTCCTG
CCGGCGCGTGATGTGGCGGT

Downstream 100 bases:

>100_bases
CCTGCGTGACGGATGTGACGCCTTGCTGAAACGCAAAAACGCCGCTGAGAGATCAGCGGCGTTTTTCATAGGTATGGCGA
CATGATTAGAAGCTGATCGA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MARTPPGEEKGKDMKDLENIPALMEDIGKRAKAAAQQLATASAAQKEQALNAAADAVWAQRGEIIAANAKDLEFGRDKGL
SSAMMDRLMLDEARIQGIVDGLRAVAAQADPVGAVLDEWTQPSGLRIQRVRTPLGVIGVIYESRPNVTADAGALCLKSGN
AVILRGGSESLHSAQAIHGCLAAGLRAADLPEDAVQLVPTRDRAAVQELLTMTAYVDVIVPRGGKGLVGLVQREARVPVF
AHLEGIVHIYLDKDADRKKAIDVVLNAKTRRTGICGAAECLLIHEDIADSIGKDVLDLLAMGGVEIHAEEGLPGPDSMQV
ATSEDWGKEYLDAIIAAKKVASIDEAIAHIRRYHSAHTDCIITENDAAVAQFFSELDSAILMHNASTQFADGGEFGMGAE
IGIATGKMHARGPVGATQLTSFKYLVRGDGTVRA

Sequences:

>Translated_434_residues
MARTPPGEEKGKDMKDLENIPALMEDIGKRAKAAAQQLATASAAQKEQALNAAADAVWAQRGEIIAANAKDLEFGRDKGL
SSAMMDRLMLDEARIQGIVDGLRAVAAQADPVGAVLDEWTQPSGLRIQRVRTPLGVIGVIYESRPNVTADAGALCLKSGN
AVILRGGSESLHSAQAIHGCLAAGLRAADLPEDAVQLVPTRDRAAVQELLTMTAYVDVIVPRGGKGLVGLVQREARVPVF
AHLEGIVHIYLDKDADRKKAIDVVLNAKTRRTGICGAAECLLIHEDIADSIGKDVLDLLAMGGVEIHAEEGLPGPDSMQV
ATSEDWGKEYLDAIIAAKKVASIDEAIAHIRRYHSAHTDCIITENDAAVAQFFSELDSAILMHNASTQFADGGEFGMGAE
IGIATGKMHARGPVGATQLTSFKYLVRGDGTVRA
>Mature_433_residues
ARTPPGEEKGKDMKDLENIPALMEDIGKRAKAAAQQLATASAAQKEQALNAAADAVWAQRGEIIAANAKDLEFGRDKGLS
SAMMDRLMLDEARIQGIVDGLRAVAAQADPVGAVLDEWTQPSGLRIQRVRTPLGVIGVIYESRPNVTADAGALCLKSGNA
VILRGGSESLHSAQAIHGCLAAGLRAADLPEDAVQLVPTRDRAAVQELLTMTAYVDVIVPRGGKGLVGLVQREARVPVFA
HLEGIVHIYLDKDADRKKAIDVVLNAKTRRTGICGAAECLLIHEDIADSIGKDVLDLLAMGGVEIHAEEGLPGPDSMQVA
TSEDWGKEYLDAIIAAKKVASIDEAIAHIRRYHSAHTDCIITENDAAVAQFFSELDSAILMHNASTQFADGGEFGMGAEI
GIATGKMHARGPVGATQLTSFKYLVRGDGTVRA

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=429, Percent_Identity=35.6643356643357, Blast_Score=261, Evalue=1e-69,
Organism=Homo sapiens, GI21361368, Length=429, Percent_Identity=35.6643356643357, Blast_Score=260, Evalue=1e-69,
Organism=Escherichia coli, GI1786438, Length=417, Percent_Identity=42.9256594724221, Blast_Score=343, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17569969, Length=423, Percent_Identity=37.5886524822695, Blast_Score=269, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17569967, Length=423, Percent_Identity=37.5886524822695, Blast_Score=269, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6324899, Length=431, Percent_Identity=38.9791183294664, Blast_Score=267, Evalue=3e-72,
Organism=Drosophila melanogaster, GI21357643, Length=408, Percent_Identity=38.4803921568627, Blast_Score=278, Evalue=6e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45943; Mature: 45812

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARTPPGEEKGKDMKDLENIPALMEDIGKRAKAAAQQLATASAAQKEQALNAAADAVWAQ
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGEIIAANAKDLEFGRDKGLSSAMMDRLMLDEARIQGIVDGLRAVAAQADPVGAVLDEWT
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
QPSGLRIQRVRTPLGVIGVIYESRPNVTADAGALCLKSGNAVILRGGSESLHSAQAIHGC
CCCCCEEEEHHCCHHEEEEEEECCCCCCCCCCCEEEECCCEEEEECCCHHHHHHHHHHHH
LAAGLRAADLPEDAVQLVPTRDRAAVQELLTMTAYVDVIVPRGGKGLVGLVQREARVPVF
HHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHCCCCHH
AHLEGIVHIYLDKDADRKKAIDVVLNAKTRRTGICGAAECLLIHEDIADSIGKDVLDLLA
EECCCEEEEEECCCCCHHHHHHHEEECCCCCCCCCCHHHHEEEHHHHHHHHHHHHHHHHH
MGGVEIHAEEGLPGPDSMQVATSEDWGKEYLDAIIAAKKVASIDEAIAHIRRYHSAHTDC
HCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IITENDAAVAQFFSELDSAILMHNASTQFADGGEFGMGAEIGIATGKMHARGPVGATQLT
EEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHH
SFKYLVRGDGTVRA
HEEEEEECCCCCCC
>Mature Secondary Structure 
ARTPPGEEKGKDMKDLENIPALMEDIGKRAKAAAQQLATASAAQKEQALNAAADAVWAQ
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGEIIAANAKDLEFGRDKGLSSAMMDRLMLDEARIQGIVDGLRAVAAQADPVGAVLDEWT
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCC
QPSGLRIQRVRTPLGVIGVIYESRPNVTADAGALCLKSGNAVILRGGSESLHSAQAIHGC
CCCCCEEEEHHCCHHEEEEEEECCCCCCCCCCCEEEECCCEEEEECCCHHHHHHHHHHHH
LAAGLRAADLPEDAVQLVPTRDRAAVQELLTMTAYVDVIVPRGGKGLVGLVQREARVPVF
HHHCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHCCCCHH
AHLEGIVHIYLDKDADRKKAIDVVLNAKTRRTGICGAAECLLIHEDIADSIGKDVLDLLA
EECCCEEEEEECCCCCHHHHHHHEEECCCCCCCCCCHHHHEEEHHHHHHHHHHHHHHHHH
MGGVEIHAEEGLPGPDSMQVATSEDWGKEYLDAIIAAKKVASIDEAIAHIRRYHSAHTDC
HCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
IITENDAAVAQFFSELDSAILMHNASTQFADGGEFGMGAEIGIATGKMHARGPVGATQLT
EEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHH
SFKYLVRGDGTVRA
HEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA