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The map label for this gene is moeA [H]

Identifier: 99080977

GI number: 99080977

Start: 1222806

End: 1223978

Strand: Reverse

Name: moeA [H]

Synonym: TM1040_1136

Alternate gene names: 99080977

Gene position: 1223978-1222806 (Counterclockwise)

Preceding gene: 99080978

Following gene: 99080976

Centisome position: 38.24

GC content: 64.79

Gene sequence:

>1173_bases
ATGATCTCCGTCGCTGACGCCCGCGCCGCCCTTCTGGACCTTGTCGCGCCGCTCACGGTTGAAACCGTCCCACTGGCAGA
GGCCGCAGGGCGGGTGCTGGCCGAACCGGTCTCGGCCCGCCGCGACCAGCCGCCCTTTGCGGCCTCTGCGATGGATGGCT
ATGCGGTCAATGCGGACGAAGTCGAACGCCACGCGATGTTCAAGGTCATCGGCGAGGCCGCAGCCGGACATGGGTTCCAG
GGCCGTGTCGGCGCGGGACAAGCCGTGCGGATCTTTACCGGCGCCCCGGTGCCGGAGGGTGCAAGTTTCGTTGTGATTCA
AGAAGATGTGGACCGCAAAGGCGATCTGATCACAATCACGGACGCGCCGGGCGACAATGCCAATATCCGCGACCGTGGCC
GCGATTTTCGTGCCGGACAAACGATTGACGCGCCGCGCCTTTTGCGCCCGGCCGATATCGCGCTTCTGGCCGCGATGAAC
ATCGCCGAGGTACCCGTGCGGCGCCGTCCCGTGGTGGCCCTGATGTCGACCGGCGACGAGCTTGTGATGCCCGGCGAGAT
CCCCGGCCCCGATCAGATCATCGTCTCCAACACCTTTGGCCTGAAGGCCATGTTCGAAGAACACGGCGCCCATGTGCGGG
TGCTGCCGATTGCCCGCGACACAGAAGCCTCCTTGCAGACTGCCTTTGGATTGGCGCGGGAGGCCGATCTGATCGTCACC
ATCGGCGGCGCCTCCGTGGGAGATCACGATCTGGTTGCAGGCGTGGCCGAGAGCCTCGGGTTTGAGCGTGCCTTCTACAA
AGTCGCGATGCGCCCCGGTAAACCCTTGATGGCAGGTCGTTTTGGCGAAGAATCTTTGGTGGGGCTCCCCGGAAATCCGG
TCTCTGCCATGGTCTGCGGGCGGGTCTTTGTGGTCTCCATGATCGAAGCCATGCTTGGCCTTCCCACCAAGACGACGCCA
CTTGCACAAGCGCCCCTTGCCGCCCGACTGCCCGCCAATGGACCACGCCAGCACTACATGCGCGCCATATGGCGGGGCGC
AGACGTTCAGGCCTTCGACAGTCAGGACAGCTCGCTTTTGTCGGTCCTTGCTCAGGCCGAAGCGCTGATCGTGCGTCCCC
CCAATGACCCCGCGCGCGAGGCGGGCTCTCTGGTGGAGTATCTGCCGCTCTAG

Upstream 100 bases:

>100_bases
CTATGACATGGCCAAAGCCGTTGATAAGGCGATGGAAATCGGAGGCGTCCGGGTCCTGCTCAAAGACGGCGGCAAATCCG
GTCGGTATGAGGCGTGATCC

Downstream 100 bases:

>100_bases
CCTGAAATCTCTGATGTCTCTGCGCCTTAGCTGGGCTTTTTATGTTCCCCTTATGACCCGACCCGTTGACACAAAACGGG
AACATGAATAGAACATAAAC

Product: MoeA-likedomain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MISVADARAALLDLVAPLTVETVPLAEAAGRVLAEPVSARRDQPPFAASAMDGYAVNADEVERHAMFKVIGEAAAGHGFQ
GRVGAGQAVRIFTGAPVPEGASFVVIQEDVDRKGDLITITDAPGDNANIRDRGRDFRAGQTIDAPRLLRPADIALLAAMN
IAEVPVRRRPVVALMSTGDELVMPGEIPGPDQIIVSNTFGLKAMFEEHGAHVRVLPIARDTEASLQTAFGLAREADLIVT
IGGASVGDHDLVAGVAESLGFERAFYKVAMRPGKPLMAGRFGEESLVGLPGNPVSAMVCGRVFVVSMIEAMLGLPTKTTP
LAQAPLAARLPANGPRQHYMRAIWRGADVQAFDSQDSSLLSVLAQAEALIVRPPNDPAREAGSLVEYLPL

Sequences:

>Translated_390_residues
MISVADARAALLDLVAPLTVETVPLAEAAGRVLAEPVSARRDQPPFAASAMDGYAVNADEVERHAMFKVIGEAAAGHGFQ
GRVGAGQAVRIFTGAPVPEGASFVVIQEDVDRKGDLITITDAPGDNANIRDRGRDFRAGQTIDAPRLLRPADIALLAAMN
IAEVPVRRRPVVALMSTGDELVMPGEIPGPDQIIVSNTFGLKAMFEEHGAHVRVLPIARDTEASLQTAFGLAREADLIVT
IGGASVGDHDLVAGVAESLGFERAFYKVAMRPGKPLMAGRFGEESLVGLPGNPVSAMVCGRVFVVSMIEAMLGLPTKTTP
LAQAPLAARLPANGPRQHYMRAIWRGADVQAFDSQDSSLLSVLAQAEALIVRPPNDPAREAGSLVEYLPL
>Mature_390_residues
MISVADARAALLDLVAPLTVETVPLAEAAGRVLAEPVSARRDQPPFAASAMDGYAVNADEVERHAMFKVIGEAAAGHGFQ
GRVGAGQAVRIFTGAPVPEGASFVVIQEDVDRKGDLITITDAPGDNANIRDRGRDFRAGQTIDAPRLLRPADIALLAAMN
IAEVPVRRRPVVALMSTGDELVMPGEIPGPDQIIVSNTFGLKAMFEEHGAHVRVLPIARDTEASLQTAFGLAREADLIVT
IGGASVGDHDLVAGVAESLGFERAFYKVAMRPGKPLMAGRFGEESLVGLPGNPVSAMVCGRVFVVSMIEAMLGLPTKTTP
LAQAPLAARLPANGPRQHYMRAIWRGADVQAFDSQDSSLLSVLAQAEALIVRPPNDPAREAGSLVEYLPL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=399, Percent_Identity=34.3358395989975, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI66932975, Length=399, Percent_Identity=34.3358395989975, Blast_Score=163, Evalue=2e-40,
Organism=Escherichia coli, GI1787049, Length=380, Percent_Identity=37.6315789473684, Blast_Score=207, Evalue=7e-55,
Organism=Caenorhabditis elegans, GI25147659, Length=317, Percent_Identity=35.6466876971609, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17562606, Length=323, Percent_Identity=25.6965944272446, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17136978, Length=304, Percent_Identity=29.2763157894737, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24638841, Length=304, Percent_Identity=29.2763157894737, Blast_Score=105, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 41109; Mature: 41109

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISVADARAALLDLVAPLTVETVPLAEAAGRVLAEPVSARRDQPPFAASAMDGYAVNADE
CCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHCCCCEEECHHH
VERHAMFKVIGEAAAGHGFQGRVGAGQAVRIFTGAPVPEGASFVVIQEDVDRKGDLITIT
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCEEEEE
DAPGDNANIRDRGRDFRAGQTIDAPRLLRPADIALLAAMNIAEVPVRRRPVVALMSTGDE
CCCCCCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHCCCCCCCEEEEEECCCC
LVMPGEIPGPDQIIVSNTFGLKAMFEEHGAHVRVLPIARDTEASLQTAFGLAREADLIVT
EEECCCCCCCCEEEEECCCCHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEE
IGGASVGDHDLVAGVAESLGFERAFYKVAMRPGKPLMAGRFGEESLVGLPGNPVSAMVCG
ECCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCEECCCCCCCEECCCCCCHHHHHHH
RVFVVSMIEAMLGLPTKTTPLAQAPLAARLPANGPRQHYMRAIWRGADVQAFDSQDSSLL
HHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCCEECCCCCHHHH
SVLAQAEALIVRPPNDPAREAGSLVEYLPL
HHHHHCCEEEEECCCCHHHHHCCHHHHCCC
>Mature Secondary Structure
MISVADARAALLDLVAPLTVETVPLAEAAGRVLAEPVSARRDQPPFAASAMDGYAVNADE
CCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCHHCCCCEEECHHH
VERHAMFKVIGEAAAGHGFQGRVGAGQAVRIFTGAPVPEGASFVVIQEDVDRKGDLITIT
HHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCCCCCCEEEEE
DAPGDNANIRDRGRDFRAGQTIDAPRLLRPADIALLAAMNIAEVPVRRRPVVALMSTGDE
CCCCCCCCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHCCCCCCCEEEEEECCCC
LVMPGEIPGPDQIIVSNTFGLKAMFEEHGAHVRVLPIARDTEASLQTAFGLAREADLIVT
EEECCCCCCCCEEEEECCCCHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCCEEEE
IGGASVGDHDLVAGVAESLGFERAFYKVAMRPGKPLMAGRFGEESLVGLPGNPVSAMVCG
ECCCCCCCHHHHHHHHHHHCHHHHHHHHHCCCCCCCEECCCCCCCEECCCCCCHHHHHHH
RVFVVSMIEAMLGLPTKTTPLAQAPLAARLPANGPRQHYMRAIWRGADVQAFDSQDSSLL
HHHHHHHHHHHHCCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHCCCCCEECCCCCHHHH
SVLAQAEALIVRPPNDPAREAGSLVEYLPL
HHHHHCCEEEEECCCCHHHHHCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]